ROC1 Rabbit Recombinant mAb

生物描述

特异性

ROC1 Rabbit Recombinant mAb detects endogenous level of total ROC1.

背景

ROC1, a highly conserved RING finger protein, is a regulator cullins. ROC1 can also interact with cullins 1, 2, and 5. The complex of ROC1-cullins is the core of SCF ubiquitin ligases, which regulate diverse cellular processes by targeting a variety of substrates for degradation. In yeast, ROC1 is required for ubiquitination of the cyclin-dependent kinase inhibitor Sic1 during the G1 to S cell cycle transition; In Caenorhabditis elegans, ROC1 is essential for cell cycle progression and chromosome metabolism; In Drosophila, ROC1a is required for cell proliferation and embryo development. ROC1 is overexpressed in a number of solid human primary tumor tissues and many human cancer cell lines.

使用信息

抗体应用	WB, IHC, IF,ELISA,ELISA
稀释比例	WB IHC IF 1:1000 1:50 1:50
反应性	Human
MW (kDa)	12kDa
抗体类型	Rabbit
储存液配方	10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
储存条件 (自收到货起)	Store at –20°C.

文献参考

[1] Ohta T, et al. Mol Cell. 1999, 3(4):535-41. [2] Jia L, et al. Cancer Res. 2009, 69(12):4974-82.

Application Data

WB

IHC

IF