Rucaparib Camsylate

目录号:S5195 批次号:S519501

打印

化学数据

化学结构式 别名 Rubraca, AG014699 Camsylate, PF01367338 Camsylate 储存条件
(自收到货起)
3年 -20°C 粉状
化学式

C29H34FN3O5S

分子量 555.66 CAS号 1859053-21-6
Solubility (25°C)* 体外 DMSO 100 mg/mL (179.96 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

生物活性

产品描述 Rucaparib (Rubraca, AG014699, PF01367338) Camsylate 是一种 PARP 的抑制剂,在无细胞试验中对PARP1的Ki值为1.4 nM,也显示了对其他八个PARP域的结合亲和力。
靶点
PARP1 [1]
(Cell-free assay)
1.4 nM(Ki)

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

Rucaparib Camsylate在文献中得到引用

Vanguard is a Glucose Deprivation-Responsive Long Non-Coding RNA Essential for Chromatin Remodeling-Reliant DNA Repair [ Adv Sci (Weinh), 2022, 9(30):e2201210] PubMed: 36047643
Inhibition of BAD-Ser99 phosphorylation synergizes with PARP inhibition to ablate PTEN-deficient endometrial carcinoma [ Cell Death Dis, 2022, 13(6):558] PubMed: 35725817
Cancer Cells Haploinsufficient for ATM Are Sensitized to PARP Inhibitors by MET Inhibition [ Int J Mol Sci, 2022, 23(10)5770] PubMed: 35628590
Combined inhibition of BADSer99 phosphorylation and PARP ablates models of recurrent ovarian carcinoma [ Commun Med (Lond), 2022, 2:82] PubMed: 35791346
Chemoresistance is mediated by ovarian cancer leader cells in vitro [ J Exp Clin Cancer Res, 2021, 40(1):276] PubMed: 34470672
BKM120 sensitizes glioblastoma to the PARP inhibitor rucaparib by suppressing homologous recombination repair [ Cell Death Dis, 2021, 12(6):546] PubMed: 34039959
Pharmacological Poly (ADP-Ribose) Polymerase Inhibitors Decrease Mycobacterium tuberculosis Survival in Human Macrophages [ Front Immunol, 2021, 12:712021] PubMed: 34899683
Synergistic targeting of BRCA1 mutated breast cancers with PARP and CDK2 inhibition [ NPJ Breast Cancer, 2021, 7(1):111] PubMed: 34465787
Role of pyruvate in maintaining cell viability and energy production under high-glucose conditions [ Sci Rep, 2021, 11(1):18910] PubMed: 34556698
Poly(ADP-Ribose) Polymerase Inhibitors for Arsenic Trioxide-Resistant Acute Promyelocytic Leukemia: Synergistic In Vitro Antitumor Effects with Hypomethylating Agents or High-Dose Vitamin C [ J Pharmacol Exp Ther, 2021, 377(3):385-397] PubMed: 33820831

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品,在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同,大多数建议储存在-20°C,抑制剂属于化学试剂,可在常温下运输储存两周左右。即使如此,我们保证产品的出货量将保持产品质量的条件下,一般都会放入冰袋。望阁下收到产品后,请按照产品数据表建议适当存储。

如果需要长期保存,请于零下二十度低温保存。禁止用于人体及治疗!

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