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别名 | Rubraca, AG014699 Camsylate, PF01367338 Camsylate | 储存条件 (自收到货起) |
3年 -20°C 粉状 |
化学式 | C29H34FN3O5S |
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分子量 | 555.66 | CAS号 | 1859053-21-6 | |
Solubility (25°C)* | 体外 | DMSO | 100 mg/mL (179.96 mM) | |
Water | Insoluble | |||
Ethanol | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
产品描述 | Rucaparib (Rubraca, AG014699, PF01367338) Camsylate 是一种 PARP 的抑制剂,在无细胞试验中对PARP1的Ki值为1.4 nM,也显示了对其他八个PARP域的结合亲和力。 | ||
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靶点 |
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Co-Targeting of DTYMK and PARP1 as a Potential Therapeutic Approach in Uveal Melanoma [ Cells, 2024, 13(16)1348] | PubMed: 39195238 |
Vanguard is a Glucose Deprivation-Responsive Long Non-Coding RNA Essential for Chromatin Remodeling-Reliant DNA Repair [ Adv Sci (Weinh), 2022, 9(30):e2201210] | PubMed: 36047643 |
Inhibition of BAD-Ser99 phosphorylation synergizes with PARP inhibition to ablate PTEN-deficient endometrial carcinoma [ Cell Death Dis, 2022, 13(6):558] | PubMed: 35725817 |
Cancer Cells Haploinsufficient for ATM Are Sensitized to PARP Inhibitors by MET Inhibition [ Int J Mol Sci, 2022, 23(10)5770] | PubMed: 35628590 |
Combined inhibition of BADSer99 phosphorylation and PARP ablates models of recurrent ovarian carcinoma [ Commun Med (Lond), 2022, 2:82] | PubMed: 35791346 |
Chemoresistance is mediated by ovarian cancer leader cells in vitro [ J Exp Clin Cancer Res, 2021, 40(1):276] | PubMed: 34470672 |
BKM120 sensitizes glioblastoma to the PARP inhibitor rucaparib by suppressing homologous recombination repair [ Cell Death Dis, 2021, 12(6):546] | PubMed: 34039959 |
Pharmacological Poly (ADP-Ribose) Polymerase Inhibitors Decrease Mycobacterium tuberculosis Survival in Human Macrophages [ Front Immunol, 2021, 12:712021] | PubMed: 34899683 |
Synergistic targeting of BRCA1 mutated breast cancers with PARP and CDK2 inhibition [ NPJ Breast Cancer, 2021, 7(1):111] | PubMed: 34465787 |
Role of pyruvate in maintaining cell viability and energy production under high-glucose conditions [ Sci Rep, 2021, 11(1):18910] | PubMed: 34556698 |
特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品,在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同,大多数建议储存在-20°C,抑制剂属于化学试剂,可在常温下运输储存两周左右。即使如此,我们保证产品的出货量将保持产品质量的条件下,一般都会放入冰袋。望阁下收到产品后,请按照产品数据表建议适当存储。
如果需要长期保存,请于零下二十度低温保存。禁止用于人体及治疗!
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