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目录号:A5891
特异性 | S100A10 Rabbit Recombinant mAb detects endogenous levels of total Mutant S100A10. |
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背景 | S100A10 is a key regulator of cellular plasmin production. It acts as a plasminogen receptor. S100A10 is constitutively expressed in many cells and is also induced by many diverse factors and physiological stimuli including dexamethasone, epidermal growth factor, transforming growth factor-α, interferon-γ, nerve growth factor, keratinocyte growth factor, retinoic acid, and thrombin. Therefore, S100A10 is utilized by cells to regulate plasmin proteolytic activity in response to a wide diversity of physiological stimuli. In the absence of S100A10, endothelial cells fail to produce sufficient plasmin to maintain vascular patency and as a consequence fibrin clots accumulate in the tissues. S100A10 also regulates the movement of macrophages to the site of inflammation. S100A10 also plays a key role in oncogenesis by regulating the plasmin proteolytic activity of cancer cells and by regulating the migration of macrophages to the tumor site. |
抗体应用 | WB, IHC,ELISA,ELISA | ||||
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稀释比例 |
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反应性 | Human Mouse | ||||
MW (kDa) | 11kDa | ||||
抗体类型 | |||||
储存液配方 | 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. | ||||
储存条件 (自收到货起) |
Store at –20°C. |
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WB
Validated by Selleck
IHC
Validated by Selleck