目录号:A5891

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生物描述

特异性 S100A10 Rabbit Recombinant mAb detects endogenous levels of total Mutant S100A10.
背景 S100A10 is a key regulator of cellular plasmin production. It acts as a plasminogen receptor. S100A10 is constitutively expressed in many cells and is also induced by many diverse factors and physiological stimuli including dexamethasone, epidermal growth factor, transforming growth factor-α, interferon-γ, nerve growth factor, keratinocyte growth factor, retinoic acid, and thrombin. Therefore, S100A10 is utilized by cells to regulate plasmin proteolytic activity in response to a wide diversity of physiological stimuli. In the absence of S100A10, endothelial cells fail to produce sufficient plasmin to maintain vascular patency and as a consequence fibrin clots accumulate in the tissues. S100A10 also regulates the movement of macrophages to the site of inflammation. S100A10 also plays a key role in oncogenesis by regulating the plasmin proteolytic activity of cancer cells and by regulating the migration of macrophages to the tumor site.

使用信息

抗体应用 WB, IHC,ELISA,ELISA
稀释比例
WB IHC
1:1000 1:50
反应性 Human Mouse
MW (kDa) 11kDa
抗体类型
储存液配方 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
储存条件
(自收到货起)
Store at –20°C.

Application Data

WB

Validated by Selleck

IHC

Validated by Selleck