MIK665 (S64315)

目录号：S8836 批次号：S883602

打印

化学数据

别名

N/A

储存条件
(自收到货起)

3年 -20°C 粉状

化学式

C₄₇H₄₄ClFN₆O₆S

分子量

875.41

CAS号

1799631-75-6

Solubility (25°C)*

体外

DMSO

100 mg/mL (114.23 mM)

Water

Insoluble

Ethanol

Insoluble

体内
（现配现用）

均匀悬浊液	CMC-NA	≥5mg/ml	以 1 mL 工作液为例，取 5 mg该产品加到 1 ml CMC-NA 溶液中，混合均匀，即可得工作液浓度为 5 mg/ml的均匀悬浊液。
澄清溶液	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O 该配方已经过Selleck实验室实测。如果上述溶解方案不能满足您的需求，可联系Selleck销售提供定制化测试。	5.000mg/ml (5.71mM)	以 1 mL 工作液为例，取50μL100mg/ml的澄清DMSO储备液加到 400μL PEG300中，混合均匀使其澄清；向上述体系中加入50μLTween80，混合均匀使其澄清；然后继续加入500μL ddH2O定容至 1 mL。工作液请现配现用！

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

生物活性

产品描述

MIK665 (S64315)是Mcl的抑制剂，Ki值为1.2 nM。它具有潜在的促凋亡和抗肿瘤活性。

靶点

Mcl-1
(Cell-free assay)

1.2 nM(Ki)

参考文献

MIK665 (S64315)在文献中得到引用

The tubulin polymerization inhibitor gambogenic acid induces myelodysplastic syndrome cell apoptosis through upregulation of Fas expression mediated by the NF-κB signaling pathway [ Cancer Biology & Therapy, November 14, 2024, 2427374]	PubMed: 39540618
Copanlisib synergizes with conventional and targeted agents including venetoclax in B- and T-cell lymphoma models [ Blood Advances, March 10, 2020, 819-829]
Novel PI3kδ inhibitor roginolisib synergizes with venetoclax in hematologic malignancies [ Haematologica, June 19, 2025, 2974-2985]	PubMed: 40534489
MCL1 inhibitors S63845/MIK665 plus Navitoclax synergistically kill difficult-to-treat melanoma cells [ Cell Death & Disease, June 08, 2020, 443]	PubMed: 32513939
Inhibition of BCL-2 and MCL-1 disrupts mitochondrial respiration and overcomes radioresistance in choroidal melanoma [ Biochem Biophys Res Commun, 2025, 784:152650]	PubMed: 40983007
Structural optimization of siRNA conjugates for albumin binding achieves effective MCL1-directed cancer therapy [ Nature Communications, 2024, 1581]	PubMed: 38383524.0
Structural optimization of siRNA conjugates for albumin binding achieves effective MCL1-directed cancer therapy [ Nat Commun, 2024, 15(1):1581]	PubMed: 38383524
The tubulin polymerization inhibitor gambogenic acid induces myelodysplastic syndrome cell apoptosis through upregulation of Fas expression mediated by the NF-κB signaling pathway [ Cancer Biology & Therapy, 2024, 2427374]	PubMed: 39540618.0
The tubulin polymerization inhibitor gambogenic acid induces myelodysplastic syndrome cell apoptosis through upregulation of Fas expression mediated by the NF-κB signaling pathway [ Cancer Biol Ther, 2024, 25(1):2427374]	PubMed: 39540618
Targeting MCL-1 triggers DNA damage and an anti-proliferative response independent from apoptosis induction [ Cell Rep, 2023, 42(10):113176]	PubMed: 37773750

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20°C，抑制剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。

如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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