SIS3

目录号：S3552 批次号：S355202

化学数据

	别名	N/A	储存条件 (自收到货起)	3年 -20°C 粉状
	化学式	C₂₈H₂₇N₃O₃
	分子量	453.53	CAS号	1009104-85-1
Solubility (25°C)*	体外	DMSO	91 mg/mL (200.64 mM)
		Ethanol	91 mg/mL (200.64 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

生物活性

产品描述

SIS3是Smad3的细胞渗透性抑制剂，可选择性抑制TGF-β1依赖的Smad3磷酸化和Smad3介导的细胞信号传导。在正常真皮成纤维细胞和硬皮病成纤维细胞中，SIS3减少TGF-β1诱导的1型前胶原表达和肌成纤维细胞分化。

靶点

Smad3 ^[1]

参考文献

[1] Jinnin M, et al. Mol Pharmacol. 2006 Feb;69(2):597-607.

SIS3在文献中得到引用

Linc00673-V3 positively regulates autophagy by promoting Smad3-mediated LC3B transcription in NSCLC [ Life Sci Alliance, 2024, 7(6)e202302408]	PubMed: 38527804
Drug-loaded hybrid hydrogels for sonodynamic-chemodyanmic therapy and tumor metastasis suppression [ Front Bioeng Biotechnol, 2023, 11:1281157]	PubMed: 37790250
Drug-loaded hybrid hydrogels for sonodynamic-chemodyanmic therapy and tumor metastasis suppression [ Front Bioeng Biotechnol, 2023, 11:1281157]	PubMed: 37790250
Transforming growth factor-β1 promotes early odontoblastic differentiation of dental pulp stem cells via activating AKT, Erk1/2 and p38 MAPK pathways [ J Dent Sci, 2023, 18(1):87-94]	PubMed: 36643229
Cholesterol promotes EGFR-TKIs resistance in NSCLC by inducing EGFR/Src/Erk/SP1 signaling-mediated ERRα re-expression [ Mol Cancer, 2022, 21(1):77]	PubMed: 35303882
Induction of Pro-Fibrotic CLIC4 in Dermal Fibroblasts by TGF-β/Wnt3a Is Mediated by GLI2 Upregulation [ Cells, 2022, 11(3)530]	PubMed: 35159339
Hypoxia Selectively Increases a SMAD3 Signaling Axis to Promote Cancer Cell Invasion [ Cancers (Basel), 2022, 14(11)2751]	PubMed: 35681731
Growth differentiation factor 10 induces angiogenesis to promote wound healing in rats with diabetic foot ulcers by activating TGF-β1/Smad3 signaling pathway [ Front Endocrinol (Lausanne), 2022, 13:1013018]	PubMed: 36714584
Sodium Fluoride and Sulfur Dioxide Derivatives Induce TGF-β1-Mediated NBCe1 Downregulation Causing Acid-Base Disorder of LS8 Cells [ Biol Trace Elem Res, 2022, 10.1007/s12011-022-03169-8]	PubMed: 35304687
Induction of CD4+ regulatory T cells by stimulation with Staphylococcal Enterotoxin C2 through different signaling pathways [ Biomed Pharmacother, 2021, 143:112204]	PubMed: 34560552

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20°C，抑制剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。

如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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