SAG (Smoothened Agonist)

目录号：S6384 批次号：S638401

化学数据

	别名	N/A	储存条件 (自收到货起)	3年 -20°C 粉状
	化学式	C₂₈H₂₈ClN₃OS
	分子量	490.06	CAS号	912545-86-9
Solubility (25°C)*	体外	DMSO	98 mg/mL (199.97 mM)
		Ethanol	98 mg/mL (199.97 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

生物活性

产品描述

SAG (Smoothened Agonist)是 Smoothened (Smo) 的有效激动剂。Smoothened Agonist 在 Shh-LIGHT2 细胞中诱导萤火虫荧光素酶表达，EC50 为 3 nM。

靶点

Smo ^[1]
(in Shh-LIGHT2 cells)

3 nM(EC50)

参考文献

SAG (Smoothened Agonist)在文献中得到引用

Identification of a distal enhancer regulating hedgehog interacting protein gene in human lung epithelial cells [ EBioMedicine, 2024, 101:105026]	PubMed: 38417378
Sonic hedgehog restrains the ubiquitin-dependent degradation of SP1 to inhibit neuronal/glial senescence associated phenotypes in chemotherapy-induced peripheral neuropathy via the TRIM25-CXCL13 axis [ J Adv Res, 2024, S2090-1232(24)00106-1]	PubMed: 38479571
Single-cell RNA sequencing reveals the developmental program underlying proximal-distal patterning of the human lung at the embryonic stage [ Cell Res, 2023, 33(6):421-433]	PubMed: 37085732
Highly reproducible and cost-effective one-pot organoid differentiation using a novel platform based on PF-127 triggered spheroid assembly [ Biofabrication, 2023, 15(4).]	PubMed: 37552975
Triptolide inhibits epithelial ovarian tumor growth by blocking the hedgehog/Gli pathway [ Aging (Albany NY), 2023, 10.18632/aging.205110]	PubMed: 37851362
Primary cilia support cartilage regeneration after injury [ Int J Oral Sci, 2023, 15(1):22]	PubMed: 37268650
Protocol for the rapid intravenous in ovo injection of developing amniote embryos [ STAR Protoc, 2023, 4(2):102324]	PubMed: 37210721
Transcription Factor 4 loss-of-function is associated with deficits in progenitor proliferation and cortical neuron content [ Nat Commun, 2022, 13(1):2387]	PubMed: 35501322
The PROTAC selectively degrading Bcl-xL represents a novel Hedgehog pathway inhibitor with capacity of combating resistance to Smoothened inhibitors while sparing bone growth [ Theranostics, 2022, 12(17):7476-7490]	PubMed: 36438482
CK2 blockade alleviates liver fibrosis by suppressing activation of hepatic stellate cells via the Hedgehog pathway [ Br J Pharmacol, 2022, 10.1111/bph.15945]	PubMed: 36070072

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