生物描述

特异性

SOD1 Rabbit Recombinant mAb detects endogenous levels of total SOD1.

背景

Superoxide dismutase 1 (SOD1) is an abundant copper/zinc enzyme found in the cytoplasm that converts superoxide into hydrogen peroxide and molecular oxygen, thus maintaining low steady-state levels of superoxide. Excess superoxide is toxic and superoxide has very poor membrane permeability. SOD is ubiquitously present in different organelles within the cell. SOD1 could be present in the cytosol, nucleus and the intermembrane space of mitochondria while SOD2 is present in the mitochondrial matrix, and ecSOD (SOD3), a secreted copper containing protein, is found in the extracellular matrix of tissues. SOD1 is essential for growth factor signaling in endothelial and tumor cells. SOD1 is a therapeutic target for the inhibition of angiogenesis and tumor growth.

使用信息

抗体应用	WB, IHC,ELISA,ELISA
稀释比例	WB IHC 1:1000 1:50
反应性	Human Rat
MW (kDa)	18kDa
抗体类型
储存液配方	10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
储存条件 (自收到货起)	Store at –20°C.

文献参考

[1] Juarez JC, et al. Proc Natl Acad Sci U S A. 2008, 105(20):7147-52.

Application Data

WB

IHC