Sortilin Rabbit Recombinant mAb detects endogenous levels of total Sortilin.

Sortilin is a type-1 receptor expressed in neurons of the central and peripheral nervous systems. It is produced in the constitutive secretory pathway of the cell and synthesized as a precursor protein that acts as an intrinsic chaperone for the correct folding and transport of the receptor. Sortilin has emerged as a key player in the regulation of neuronal viability and function. It acts as a receptor of neurotrophic factors and neuropeptides, but also as a co-receptor to cytokine receptors, tyrosine receptor kinases, G-protein coupled receptors and ion-channels. Sortilin has activities for being a receptor for pro-nerve growth factor (proNGF) and pro-brain derived neurotrophic factor (proBDNF) required for induction of neuronal cell death by these pro-apoptotic molecules. It is a major neuronal pathway involved in brain APOE and Aβ metabolism.