Datasheet

生物描述

特异性	SynGAP Rabbit Recombinant mAb detects endogenous levels of total SynGAP.
背景	SynGAP, a neuronal specific RasGAP that binds to the PDZ domains of PSD-95 and SAP102, is exclusively localized to excitatory synapses and is a major constituent of the PSD. SynGAP is phosphorylated during periods of heightened synaptic activity by kinases including calcium/calmodulin-dependent protein kinase (CaMKII). It regulates AMPAR trafficking, silent synapse number, and excitatory synaptic transmission in hippocampal and cortical cultured neurons. SynGAP is a potent regulator of the mitogen-activated protein kinase (MAPK) pathway and modifies synaptic strength by altering membrane trafficking of AMPARs through GTPase regulation.

特异性

SynGAP Rabbit Recombinant mAb detects endogenous levels of total SynGAP.

背景

SynGAP, a neuronal specific RasGAP that binds to the PDZ domains of PSD-95 and SAP102, is exclusively localized to excitatory synapses and is a major constituent of the PSD. SynGAP is phosphorylated during periods of heightened synaptic activity by kinases including calcium/calmodulin-dependent protein kinase (CaMKII). It regulates AMPAR trafficking, silent synapse number, and excitatory synaptic transmission in hippocampal and cortical cultured neurons. SynGAP is a potent regulator of the mitogen-activated protein kinase (MAPK) pathway and modifies synaptic strength by altering membrane trafficking of AMPARs through GTPase regulation.

使用信息

抗体应用

wb,ELISA,ELISA

稀释比例

WB

1:1000

反应性

Human Mouse Rat

MW (kDa)

147kDa

抗体类型

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

[1] Rumbaugh G, et al. Proc Natl Acad Sci U S A. 2006, 103(12):4344-51.

Application Data

WB

Validated by Selleck