TBB

目录号：S5265 批次号：S526501

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化学数据

化学结构式 别名 4,5,6,7-tetrabromobenzotriazole 储存条件
(自收到货起)		 3年 -20°C 粉状
化学式

C6HBr4N3
分子量 434.71 CAS号 17374-26-4
Solubility (25°C)* 体外 DMSO 86 mg/mL (197.83 mM)
 
 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

生物活性

产品描述 TBB (4,5,6,7-tetrabromobenzotriazole) is a selective cell-permeable CK2 inhibitor with IC50 values of 0.9 and 1.6 μM for rat liver and human recombinant CK2 respectively.
靶点
CK2 [1]
(Cell-free assay)		 CK1 [1]
(Cel-free assay)
0.4 μM(Ki) 47 μM(Ki)

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

TBB在文献中得到引用

The ARID1A-METTL3-m6A axis ensures effective RNase H1-mediated resolution of R-loops and genome stability [ Cell Rep, 2024, 43(2):113779] PubMed: 38358891
Genome-scale mapping of DNA damage suppressors through phenotypic CRISPR-Cas9 screens [ Mol Cell, 2023, 83(15):2792-2809.e9] PubMed: 37478847
CK2-Mediated Phosphorylation Upregulates the Stability of USP13 and Promotes Ovarian Cancer Cell Proliferation [ Cancers (Basel), 2022, 15(1)200] PubMed: 36612196
Unphosphorylated Form of the PAQosome Core Subunit RPAP3 Binds Ribosomal Preassembly Complexes to Modulate Ribosome Biogenesis [ J Proteome Res, 2022, 21(4):1073-1082] PubMed: 35129352
The catalytic subunit of Plasmodium falciparum casein kinase 2 is essential for gametocytogenesis [ Commun Biol, 2021, 4(1):336] PubMed: 33712726
Development of a Cell-Based Luciferase Complementation Assay for Identification of SARS-CoV-2 3CLpro Inhibitors [ Viruses, 2021, 13(2)173] PubMed: 33498923
The unphosphorylated form of the PAQosome core subunit RPAP3 binds ribosomal preassembly complexes to modulate ribosome biogenesis [ bioRxiv, 2021, 10.1101/2021.03.17.435124] PubMed: None
GLP-catalyzed H4K16me1 promotes 53BP1 recruitment to permit DNA damage repair and cell survival. [ Nucleic Acids Res, 2019, 47(21):10977-10993] PubMed: 31612207
Protein Kinase CK2 Subunits Differentially Perturb the Adhesion and Migration of GN11 Cells: A Model of Immature Migrating Neurons [ Int J Mol Sci, 2019, 20(23)E5951] PubMed: 31779225
Raf-1/CK2 and RhoA/ROCK signaling promote TNF-α-mediated endothelial apoptosis via regulating vimentin cytoskeleton. [ Toxicology, 2017, 389:74-84] PubMed: 28743511

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20°C，抑制剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。

如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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