Datasheet

生物描述

特异性	TBPL1 Rabbit Recombinant mAb detects endogenous levels of total TBPL1.
背景	TBP-like factor (TLF, also known as TBPL1 and TRF2) is the only member of TBP family which lacks the ability to bind the TATA box. TBP is a key component of the eukaryotic transcription initiation machinery. TLF can interact with TFIIA and TFIIB, forms a complex with TFIIA in HeLa cells but can also interact with TFIIA-like factor (ALF), which is a germ cell-specific paralog of TFIIA. TLF is also shown to negatively modulate transcription by sequestering TFIIA. TBPL1 is crucial for spermiogenesis and supposed to be significant in expression of developmentally regulated genes.

特异性

TBPL1 Rabbit Recombinant mAb detects endogenous levels of total TBPL1.

背景

TBP-like factor (TLF, also known as TBPL1 and TRF2) is the only member of TBP family which lacks the ability to bind the TATA box. TBP is a key component of the eukaryotic transcription initiation machinery. TLF can interact with TFIIA and TFIIB, forms a complex with TFIIA in HeLa cells but can also interact with TFIIA-like factor (ALF), which is a germ cell-specific paralog of TFIIA. TLF is also shown to negatively modulate transcription by sequestering TFIIA. TBPL1 is crucial for spermiogenesis and supposed to be significant in expression of developmentally regulated genes.

使用信息

抗体应用

wb,ELISA,ELISA

稀释比例

WB

1:500

反应性

Human Mouse Rat

MW (kDa)

23kDa

抗体类型

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

Application Data

WB

Validated by Selleck