Thapsigargin

目录号：S7895 批次号：S789502

打印

化学数据

别名

N/A

储存条件
(自收到货起)

3年 -20°C 粉状

化学式

C₃₄H₅₀O₁₂

分子量

650.75

CAS号

67526-95-8

Solubility (25°C)*

体外

DMSO

100 mg/mL (153.66 mM)

Ethanol

100 mg/mL (153.66 mM)

Water

Insoluble

体内（现配现用）

澄清溶液

5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O

5mg/ml (7.68mM)

以 1 mL 工作液为例，取50μL100mg/ml的澄清DMSO储备液加到400μL PEG300中，混合均匀使其澄清；向上述体系中加入50μLTween80，混合均匀使其澄清；然后继续加入500μL ddH2O定容至 1 mL。工作液请现配现用！

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

生物活性

产品描述

Thapsigargin 是一种有效的、非竞争性的 the sarco/endoplasmic reticulum Ca²⁺ ATPase (SERCA) 的抑制剂，对carbachol诱导的[Ca2+]i瞬变在存不存在KCl预刺激条件下的IC50值分别为0.353 nM和0.448 nM。Thapsigargin 可诱导细胞凋亡。Thapsigargin 提取自植物Thapsia garganica。

靶点

SERCA ^[1]

参考文献

Thapsigargin在文献中得到引用

TANGO6 regulates cell proliferation via COPI vesicle-mediated RPB2 nuclear entry [ Nat Commun, 2024, 15(1):2371]	PubMed: 38490996
Stress granules affect the dual PI3K/mTOR inhibitor response by regulating the mitochondrial unfolded protein response [ Cancer Cell Int, 2024, 24(1):38]	PubMed: 38238825
ER stress induces caspase-2-tBID-GSDME-dependent cell death in neurons lytically infected with herpes simplex virus type 2 [ EMBO J, 2023, e113118.]	PubMed: 37646198
Combination of RUNX1 inhibitor and gemcitabine mitigates chemo-resistance in pancreatic ductal adenocarcinoma by modulating BiP/PERK/eIF2α-axis-mediated endoplasmic reticulum stress [ J Exp Clin Cancer Res, 2023, 42(1):238]	PubMed: 37697370
Combination of RUNX1 inhibitor and gemcitabine mitigates chemo-resistance in pancreatic ductal adenocarcinoma by modulating BiP/PERK/eIF2α-axis-mediated endoplasmic reticulum stress [ J Exp Clin Cancer Res, 2023, 42(1):238]	PubMed: 37697370
HRS mediates tumor immune evasion by regulating proteostasis-associated interferon pathway activation [ Cell Rep, 2023, 10.1016/j.celrep.2023.113352]	PubMed: 37948180
Porcine reproductive and respiratory syndrome virus infection triggers autophagy via ER stress-induced calcium signaling to facilitate virus replication [ PLoS Pathog, 2023, 19(3):e1011295]	PubMed: 36972295
Simultaneous proteome localization and turnover analysis reveals spatiotemporal dynamics of unfolded protein responses [ bioRxiv, 2023, 2023.01.04.521821]	PubMed: 36711879
Protein palmitoylation-mediated palmitic acid sensing causes blood-testis barrier damage via inducing ER stress [ Redox Biol, 2022, 54:102380]	PubMed: 35803125
Silica nanoparticles induce cardiac injury and dysfunction via ROS/Ca2+/CaMKII signaling [ Sci Total Environ, 2022, 837:155733]	PubMed: 35526619

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如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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