Thapsigargin

目录号：S7895 批次号：S789503

化学数据

	别名	N/A	储存条件 (自收到货起)	3年 -20°C 粉状
	化学式	C₃₄H₅₀O₁₂
	分子量	650.75	CAS号	67526-95-8
Solubility (25°C)*	体外	DMSO	100 mg/mL (153.66 mM)
		Ethanol	100 mg/mL (153.66 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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生物活性

产品描述

Thapsigargin 是一种有效的、非竞争性的 the sarco/endoplasmic reticulum Ca²⁺ ATPase (SERCA) 的抑制剂，对carbachol诱导的[Ca2+]i瞬变在存不存在KCl预刺激条件下的IC50值分别为0.353 nM和0.448 nM。Thapsigargin 可诱导细胞凋亡。Thapsigargin 提取自植物Thapsia garganica。

靶点

SERCA ^[1]

参考文献

Thapsigargin在文献中得到引用

The integrated stress response drives MET oncogene overexpression in cancers [ EMBO J, 2025, 44(4):1107-1130]	PubMed: 39774381
Disruption of mitochondrial homeostasis and permeability transition pore opening in OPA1 iPSC-derived retinal ganglion cells [ Acta Neuropathol Commun, 2025, 13(1):28]	PubMed: 39948685
Mitochondrial translation regulates terminal erythroid differentiation by maintaining iron homeostasis [ Sci Adv, 2025, 11(8):eadu3011]	PubMed: 39983002
Simultaneous proteome localization and turnover analysis reveals spatiotemporal features of protein homeostasis disruptions [ Nat Commun, 2024, 15(1):2207]	PubMed: 38467653
TANGO6 regulates cell proliferation via COPI vesicle-mediated RPB2 nuclear entry [ Nat Commun, 2024, 15(1):2371]	PubMed: 38490996
Leptin-mediated suppression of lipoprotein lipase cleavage enhances lipid uptake and facilitates lymph node metastasis in gastric cancer [ Cancer Commun (Lond), 2024, 10.1002/cac2.12583]	PubMed: 38958445
Cetylpyridinium chloride triggers paraptosis to suppress pancreatic tumor growth via the ERN1-MAP3K5-p38 pathway [ iScience, 2024, 27(8):110598]	PubMed: 39211547
Stress granules affect the dual PI3K/mTOR inhibitor response by regulating the mitochondrial unfolded protein response [ Cancer Cell Int, 2024, 24(1):38]	PubMed: 38238825
Cannabinoid-Induced Immunogenic Cell Death of Colorectal Cancer Cells Through De Novo Synthesis of Ceramide Is Partially Mediated by CB2 Receptor [ Cancers (Basel), 2024, 16(23)3973]	PubMed: 39682160
ER stress induces caspase-2-tBID-GSDME-dependent cell death in neurons lytically infected with herpes simplex virus type 2 [ EMBO J, 2023, e113118.]	PubMed: 37646198

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如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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