TIA1 Rabbit Recombinant mAb detects endogenous levels of total TIA1.

TIA1 (T-cell-restricted intracellular antigen 1) family proteins are ubiquitously expressed and contain three N-terminal RNA recognition motifs (RRMs) as well as a C-terminal glutamine-rich prion-like domain (PrLD). TIA1 proteins are localized in the nucleus and cytoplasm and poised to contribute to nuclear and cytosolic RNA metabolic processes. TIA1 proteins are suggested to regulate alternative splicing (AS) by binding to U-rich mRNA segments and promoting recognition of the 5' splice site (SS) by U1 small nuclear ribonucleoprotein particles (snRNPs). In the cytoplasm, TIA1 proteins function as translational repressors of tumor necrosis factor mRNA and a variety of other mRNA targets. TIA1 proteins regulate cellular proliferation and inflammation, tumor growth, apoptosis and the recruitment of cytoplasmic mRNAs to SGs in stress situations.