Datasheet

生物描述

特异性	TMS1 Rabbit Recombinant mAb detects endogenous levels of total TMS1.
背景	TMS1 (target of methylation-induced silencing) is a novel CpG island-associated gene that becomes hypermethylated and silenced in cells overexpressing DNA cytosine-5-methyltransferase-1. TMS1 belongs to a growing family of apoptotic signaling molecules that contain a CARD. TMS1 is likely to function as an adapter protein, acting in the initiation phase of an apoptotic pathway by coupling death receptors at the cell surface or intrinsic death signals to the activation of the caspase cascade. TMS1 promotes apoptosis directly, and that this apoptosis requires the activation of downstream caspases.

特异性

TMS1 Rabbit Recombinant mAb detects endogenous levels of total TMS1.

背景

TMS1 (target of methylation-induced silencing) is a novel CpG island-associated gene that becomes hypermethylated and silenced in cells overexpressing DNA cytosine-5-methyltransferase-1. TMS1 belongs to a growing family of apoptotic signaling molecules that contain a CARD. TMS1 is likely to function as an adapter protein, acting in the initiation phase of an apoptotic pathway by coupling death receptors at the cell surface or intrinsic death signals to the activation of the caspase cascade. TMS1 promotes apoptosis directly, and that this apoptosis requires the activation of downstream caspases.

使用信息

抗体应用

wb,ELISA,ELISA

稀释比例

WB

1:1000

反应性

Human

MW (kDa)

22kDa

抗体类型

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

[1] Conway KE, et al. Cancer Res. 2000, 60(22):6236-42.

Application Data

WB

Validated by Selleck