TRAM2 Rabbit Recombinant mAb Datasheet

生物描述

特异性	TRAM2 Rabbit Recombinant mAb detects endogenous level of total TRAM2.
背景	Translocating chain-associated membrane protein 2 is a translocon-associated protein. TRAM2 is a homologue of TRAM1 that has been shown to be an ER translocon-associated protein that facilitates translocation of certain signal peptides that are less hydrophobic than a typical signal sequence. TRAM2 is necessary for collagen type I synthesis and may couple the activity of the ER Ca2+ pump SERCA2B with the activity of the translocon. It also required for proper insertion of the first transmembrane helix N-terminus of TM4SF20 into the ER lumen and may act as a ceramide sensor for regulated alternative translocation (RAT).

特异性

TRAM2 Rabbit Recombinant mAb detects endogenous level of total TRAM2.

背景

Translocating chain-associated membrane protein 2 is a translocon-associated protein. TRAM2 is a homologue of TRAM1 that has been shown to be an ER translocon-associated protein that facilitates translocation of certain signal peptides that are less hydrophobic than a typical signal sequence. TRAM2 is necessary for collagen type I synthesis and may couple the activity of the ER Ca2+ pump SERCA2B with the activity of the translocon. It also required for proper insertion of the first transmembrane helix N-terminus of TM4SF20 into the ER lumen and may act as a ceramide sensor for regulated alternative translocation (RAT).

使用信息

抗体应用

WB ,ELISA,ELISA

稀释比例

WB

1:1000

反应性

Human Mouse Rat

MW (kDa)

43kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

Application Data

WB

Validated by Selleck