TRK fused gene Rabbit Recombinant mAb Datasheet

生物描述

特异性	TRK fused gene Rabbit Recombinant mAb detects endogenous level of total TRK fused gene.
背景	Trk-fused gene (TFG) is was initially identified as an oncogene causing thyroid cancer, in which the N-terminal half of TFG was fused with neurotrophic tyrosine kinase receptor 1 (NTRK1, also known as TrkA). Subsequently, TFG was also reported to be a fusion partner of the anaplastic lymphoma kinase (ALK) gene in anaplastic large cell lymphoma, though the function of TFG itself remained essentially unknown until quite recently. It was reported localized at endoplasmic reticulum (ER) exit sites (ERES) and to be crucial in transport from the ER to the Golgi apparatus via COPII vesicle. TFG is important for retention of COPII vesicles between the ER and ER-Golgi intermediate compartments (ERGIC), and in the absence of TFG, COPII-coated carriers become dispersed throughout the cytoplasm. On the other hand, TFG was recently identified as a causative gene for several neurodegenerative diseases, such as hereditary motor and sensory neuropathy with proximal dominant involvement (HMSN-P), the axonal type of Charcot-Marie-Tooth disease and hereditary spastic paraplegia (HSP).

特异性

TRK fused gene Rabbit Recombinant mAb detects endogenous level of total TRK fused gene.

背景

Trk-fused gene (TFG) is was initially identified as an oncogene causing thyroid cancer, in which the N-terminal half of TFG was fused with neurotrophic tyrosine kinase receptor 1 (NTRK1, also known as TrkA). Subsequently, TFG was also reported to be a fusion partner of the anaplastic lymphoma kinase (ALK) gene in anaplastic large cell lymphoma, though the function of TFG itself remained essentially unknown until quite recently. It was reported localized at endoplasmic reticulum (ER) exit sites (ERES) and to be crucial in transport from the ER to the Golgi apparatus via COPII vesicle. TFG is important for retention of COPII vesicles between the ER and ER-Golgi intermediate compartments (ERGIC), and in the absence of TFG, COPII-coated carriers become dispersed throughout the cytoplasm. On the other hand, TFG was recently identified as a causative gene for several neurodegenerative diseases, such as hereditary motor and sensory neuropathy with proximal dominant involvement (HMSN-P), the axonal type of Charcot-Marie-Tooth disease and hereditary spastic paraplegia (HSP).

使用信息

抗体应用

WB,ELISA,ELISA

稀释比例

WB

1:1000

反应性

Human Mouse Rat

MW (kDa)

55kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

[1] T Yamamotoya, et al. Scientific Reports. 2017, 7: 13026.

Application Data

WB

Validated by Selleck