TrkA+B+C Rabbit Recombinant mAb Datasheet

生物描述

特异性	TrkA+B+C Rabbit Recombinant mAb detects endogenous level of total TrkA+B+C.
背景	Tropomyosin-receptor-kinase (Trk) receptors belong to a family of growth factor receptors with tyrosine kinase activity that controls synaptic strength and plasticity of the mammalian nervous system. Neuronal existence and differentiation are dependent on all Trk receptors, through numerous signal cascades. Trk receptor family is composed by three transmembrane receptors TrkA, TrkB, and TrkC. Receptors are activated by neurotrophic factors known as protein nerve growth factors or neurotrophins that are present in a family of growth factors, critically involved in the function of the nervous system. TrkA binds nerve growth factor (NGF) with a high affinity. The neurotrophin/TrkA complex promotes cell growth and survival via two major pathways: the Ras/MAPK and the PI3K/Akt signaling pathways. Referring to TrkB, it has the highest affinity to the binding of BDNF and NT-4. TrkC is reported to be activated by binding to NT-3 and to have little affinity for other ligands. Trks alterations are found in several human neoplasms: neuroblastoma, medulloblastoma, glioblastoma, prostate cancer, pancreatic carcinoma.

特异性

TrkA+B+C Rabbit Recombinant mAb detects endogenous level of total TrkA+B+C.

背景

Tropomyosin-receptor-kinase (Trk) receptors belong to a family of growth factor receptors with tyrosine kinase activity that controls synaptic strength and plasticity of the mammalian nervous system. Neuronal existence and differentiation are dependent on all Trk receptors, through numerous signal cascades. Trk receptor family is composed by three transmembrane receptors TrkA, TrkB, and TrkC. Receptors are activated by neurotrophic factors known as protein nerve growth factors or neurotrophins that are present in a family of growth factors, critically involved in the function of the nervous system. TrkA binds nerve growth factor (NGF) with a high affinity. The neurotrophin/TrkA complex promotes cell growth and survival via two major pathways: the Ras/MAPK and the PI3K/Akt signaling pathways. Referring to TrkB, it has the highest affinity to the binding of BDNF and NT-4. TrkC is reported to be activated by binding to NT-3 and to have little affinity for other ligands. Trks alterations are found in several human neoplasms: neuroblastoma, medulloblastoma, glioblastoma, prostate cancer, pancreatic carcinoma.

使用信息

抗体应用

WB ,ELISA,ELISA

稀释比例

WB

1:1000

反应性

Human Mouse Rat

MW (kDa)

140kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

[1] Bogdan STOLERU, et al. Maedica (Buchar). 2013, 8(1): 43–48.

Application Data

WB

Validated by Selleck