UAMC-3203

目录号：S8792 批次号：S879201

化学数据

	别名	N/A	储存条件 (自收到货起)	3年 -20°C 粉状
	化学式	C₂₅H₃₇N₅O₂S
	分子量	471.66	CAS号	2271358-64-4
Solubility (25°C)*	体外	DMSO	94 mg/mL (199.29 mM)
		Ethanol	94 mg/mL (199.29 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

生物活性

产品描述

UAMC-3203是ferroptosis抑制剂，在 IMR-32 Neuroblastoma Cells中的IC50为10 nM。

靶点

Ferroptosis ^[1]
(IMR-32 Neuroblastoma Cells)

10 nM

体外研究

将UAMC-3203与人源微粒体或大鼠微粒体共同孵育，其T_1/2分别为20.5 h和16.5 h。而与小鼠微粒体共孵育时，UAMC-3203的稳定性相对较差，T_1/2为3.46 h^[1]。

体内研究

在小鼠中，UAMC-3203可显著地降低乳酸脱氢酶的血浆浓度。给药后，它快速地从血液中移除、进入多种组织。在所检测的组织，如肝脏、肾脏和肺部中都可检测到显著的UAMC-3203水平^[1]。

动物实验	动物模型	由Gpx4 fl/fl小鼠生育的野生型后代
剂量	20 μmol/kg
给药处理	IV

参考文献

[1] Devisscher L, et al. J Med Chem. 2018, 61(22):10126-10140.

UAMC-3203在文献中得到引用

Interferon alpha promotes caspase-8 dependent ultraviolet light-mediated keratinocyte apoptosis via interferon regulatory factor 1 [ Front Immunol, 2024, 15:1384606]	PubMed: 38660315
ALKBH5 modulation of ferroptosis in recurrent miscarriage: implications in cytotrophoblast dysfunction [ PeerJ, 2024, 12:e18227]	PubMed: 39434797
Targeting N-glycosylation of 4F2hc mediated by glycosyltransferase B3GNT3 sensitizes ferroptosis of pancreatic ductal adenocarcinoma [ Cell Death Differ, 2023, 30(8):1988-2004]	PubMed: 37479744
Genome-wide CRISPR screening reveals ADCK3 as a key regulator in sensitizing endometrial carcinoma cells to MPA therapy [ Br J Cancer, 2023, 129(4):601-611]	PubMed: 37402867
Genome-wide CRISPR screening reveals ADCK3 as a key regulator in sensitizing endometrial carcinoma cells to MPA therapy [ Br J Cancer, 2023, 129(4):601-611]	PubMed: 37402867
Ferroptosis signaling promotes the release of misfolded proteins via exosomes to rescue ER stress in hepatocellular carcinoma [ Free Radic Biol Med, 2023, 202:110-120]	PubMed: 36997100
p53 status modifies cytotoxic activity of lactoferrin under hypoxic conditions [ Front Pharmacol, 2022, 13:988335]	PubMed: 36199689
UAMC-3203 or/and Deferoxamine Improve Post-Resuscitation Myocardial Dysfunction Through Suppressing Ferroptosis in a Rat Model of Cardiac Arrest [ Shock, 2022, 57(3):344-350]	PubMed: 34618729
Myostatin/HIF2α-Mediated Ferroptosis is Involved in Skeletal Muscle Dysfunction in Chronic Obstructive Pulmonary Disease [ Int J Chron Obstruct Pulmon Dis, 2022, 17:2383-2399]	PubMed: 36185172
HSF1 functions as a key defender against palmitic acid-induced ferroptosis in cardiomyocytes [ J Mol Cell Cardiol, 2021, 150:65-76]	PubMed: 33098823

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如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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