VPA (Valproic acid)

目录号：S3944 批次号：S394405

化学数据

	别名	2-Propylvaleric Acid, Valproate	储存条件 (自收到货起)	2年 -80°C 液体
	化学式	C₈H₁₆O₂
	分子量	144.21	CAS号	99-66-1
Solubility (25°C)*	体外	DMSO	29 mg/mL (201.09 mM)
		Water	29 mg/mL (201.09 mM)
		Ethanol	29 mg/mL (201.09 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

生物活性

产品描述

VPA (Valproic acid)是一种具有抗惊厥性质的脂肪酸，可用于治疗癫痫。它也是一种 histone deacetylase (HDAC) 抑制剂，正用于研究治疗HIV和各种癌症的方法。Valproic acid (VPA) 通过上调 BNIP3 诱导自噬和线粒体自噬，并通过上调 PGC-1α 来诱导线粒体的生物合成。Valproic acid (VPA) 可激活 Notch-1 信号传递。

靶点

HDAC ^[1]	HDAC1 ^[1] (Cell-free assay)
	0.4 mM

密度

0.9 g/mL at 25 °C

参考文献

VPA (Valproic acid)在文献中得到引用

Self-renewing human naïve pluripotent stem cells dedifferentiate in 3D culture and form blastoids spontaneously [ Nat Commun, 2024, 15(1):668]	PubMed: 38253551
RNA m6A modification regulates L1 retrotransposons in human spermatogonial stem cell differentiation in vitro and in vivo [ Cell Mol Life Sci, 2024, 81(1):92]	PubMed: 38363375
Molecular mechanism underlying miR-204-5p regulation of adipose-derived stem cells differentiation into cells from three germ layers [ Cell Death Discov, 2024, 10(1):95]	PubMed: 38388551
Modeling post-implantation stages of human development into early organogenesis with stem-cell-derived peri-gastruloids [ Cell, 2023, S0092-8674(23)00794-8]	PubMed: 37478861
Establishing extended pluripotent stem cells from human urine cells [ Cell Biosci, 2023, 13(1):88]	PubMed: 37194020
Derivation of totipotent-like stem cells with blastocyst-like structure forming potential [ Cell Res, 2022, 10.1038/s41422-022-00668-0]	PubMed: 35508506
Direct chemical reprogramming of human cord blood erythroblasts to induced megakaryocytes that produce platelets [ Cell Stem Cell, 2022, 29(8):1229-1245.e7]	PubMed: 35931032
Dynamic reprogramming of H3K9me3 at hominoid-specific retrotransposons during human preimplantation development [ Cell Stem Cell, 2022, 29(7):1031-1050.e12]	PubMed: 35803225
Recapitulating early human development with 8C-like cells [ Cell Rep, 2022, 39(12):110994]	PubMed: 35732112
Establishment and characterization of adult human gastric epithelial progenitor-like cell lines [ Cell Prolif, 2022, e13355.]	PubMed: 36331058

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20°C，抑制剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。

如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

退换货政策

Selleck提供宽松的退换货承诺，努力为您营造最优的购物体验。每个订单Selleck只提供一次退换货服务，为了确保您的权益，请您仔细阅读以下内容：

1. 请在返还样品之前事先与我们取得联系，以确保产品是直接向我们或者当地代理商购买的；

2. 自收到货物起七天内，如因运输过程有问题或其他任何问题，您可以提出退换货要求；自收到货物起365天内，如因产品质量有问题，您可以提出退换货要求。

3. 请使用我们的快递账号进行退换货，您无需为此承担任何费用。

4. 如您已收到由Selleck开具的发票，则办理退货或订单金额发生变更的换货时，请将发票随商品一同返还给Selleck。请您妥善保管发票，如发票丢失，将无法办理退换货手续。