VASP Rabbit Recombinant mAb Datasheet

生物描述

特异性	VASP Rabbit Recombinant mAb detects endogenous level of toal VASP.
背景	Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena/VASP proteins are a conserved family of actin regulatory proteins made up of EVH1, EVH2 domains, and a proline-rich central region. They have been implicated in actin-based processes such as fibroblast migration, axon guidance, and T cell polarization and are important for the actin-based motility of the intracellular pathogen Listeria monocytogenes. Ena/VASP proteins localize within cells to areas of dynamic actin reorganization such as the leading edge of lamellipodia and at the tips of filopodia and other actin-dependent intracellular structures such as cell-cell contacts, focal adhesions, and in periodic puncta along stress fibers. Ena/VASP proteins can bind directly to F- and G-actin and the actin monomer-binding protein Profilin, suggesting that they could directly regulate actin dynamics.

特异性

VASP Rabbit Recombinant mAb detects endogenous level of toal VASP.

背景

Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena/VASP proteins are a conserved family of actin regulatory proteins made up of EVH1, EVH2 domains, and a proline-rich central region. They have been implicated in actin-based processes such as fibroblast migration, axon guidance, and T cell polarization and are important for the actin-based motility of the intracellular pathogen Listeria monocytogenes. Ena/VASP proteins localize within cells to areas of dynamic actin reorganization such as the leading edge of lamellipodia and at the tips of filopodia and other actin-dependent intracellular structures such as cell-cell contacts, focal adhesions, and in periodic puncta along stress fibers. Ena/VASP proteins can bind directly to F- and G-actin and the actin monomer-binding protein Profilin, suggesting that they could directly regulate actin dynamics.

使用信息

抗体应用

WB,ELISA,ELISA

稀释比例

WB

1:1000

反应性

Human

MW (kDa)

46kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

[1] Krause M, et al. Annu Rev Cell Dev Biol. 2003, 19:541-64.

Application Data

WB

Validated by Selleck