Vincristine

目录号：S9555 批次号：S955503

打印

化学数据

别名

Leurocristine, NSC-67574, 22-Oxovincaleukoblastine

储存条件
(自收到货起)

3年 -20°C 粉状

化学式

C₄₆H₅₆N₄O₁₀

分子量

824.96

CAS号

57-22-7

Solubility (25°C)*

体外

DMSO

100 mg/mL (121.21 mM)

Water

Insoluble

Ethanol

Insoluble

体内（现配现用）

澄清溶液	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O	5mg/ml (6.06mM)	以 1 mL 工作液为例,取50μL100mg/ml的澄清DMSO储备液加到400μLPEG300中,混合均匀使其澄清;向上述体系中加入50μLTween80,混合均匀使其澄清;然后继续加入500μLddH2O定容至1mL。工作液请现配现用!
澄清溶液	5% DMSO 1 95% Corn oil	0.8mg/ml (0.97mM)	以1 mL工作液为例，取50μL 16mg/ml的澄清DMSO储备液加到950μL玉米油中，混合均匀。工作液请现配现用！

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

生物活性

产品描述	Vincristine (Leurocristine, NSC-67574, 22-Oxovincaleukoblastine) 是长春花中的生物碱，具有抗肿瘤活性。Vincristine 可抑制有丝分裂纺锤体中的微管 microtubule 形成，其结合微管的Ki值为85 nM。

参考文献

Vincristine在文献中得到引用

Engineering redirected NF-κB/OIP5 expression programs to enhance tumor responses to chemotherapy in bladder cancer [ Sci Bull (Beijing), 2023, 10.1016/j.scib.2023.11.027]	PubMed: 37993335
Patient- and xenograft-derived organoids recapitulate pediatric brain tumor features and patient treatments [ EMBO Mol Med, 2023, 15(12):e18199]	PubMed: 38037472
TPX2 enhances the transcription factor activation of PXR and enhances the resistance of hepatocellular carcinoma cells to antitumor drugs [ Cell Death Dis, 2023, 14(1):64]	PubMed: 36707511
Targeting MCL-1 triggers DNA damage and an anti-proliferative response independent from apoptosis induction [ Cell Rep, 2023, 42(10):113176]	PubMed: 37773750
Benzimidazole carbamate induces cytotoxicity in breast cancer cells via two distinct cell death mechanisms [ Cell Death Discov, 2023, 9(1):162]	PubMed: 37179350
PTC596-Induced BMI-1 Inhibition Fights Neuroblastoma Multidrug Resistance by Inducing Ferroptosis [ Antioxidants (Basel), 2023, 13(1)3]	PubMed: 38275623
Monoclonal antibodies binding to different epitopes of CD20 differentially sensitize DLBCL to different classes of chemotherapy [ Front Oncol, 2023, 13:1159484]	PubMed: 37601699
FGF1 Protects MCF-7 Cells against Taltobulin through Both the MEKs/ERKs and PI3K/AKT Signaling Pathway [ Biomedicines, 2023, 11(7)1856]	PubMed: 37509496
Novel Biologically Active N-Substituted Benzimidazole Derived Schiff Bases: Design, Synthesis, and Biological Evaluation [ Molecules, 2023, 28(9)3720]	PubMed: 37175129
α-Mangostin Suppresses Melanoma Growth, Migration, and Invasion and Potentiates the Anti-tumor Effect of Chemotherapy [ Int J Med Sci, 2023, 20(9):1220-1234]	PubMed: 37575275

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如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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