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别名 | L-Ascorbic acid | 储存条件 (自收到货起) |
3年 -20°C 粉末(密封) | |
化学式 | C6H8O6 |
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分子量 | 176.12 | CAS号 | 50-81-7 | |
Solubility (25°C)* | 体外 | DMSO | 35 mg/mL (198.72 mM) | |
Water | 35 mg/mL (198.72 mM) | |||
Ethanol | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
产品描述 | Vitamin C (L-Ascorbic acid) 是一种水溶性维生素,用于预防和治疗坏血病。 |
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体外研究 | Ascorbate与铜结合时快速减少DNA溶液的粘度,并且对移植到小鼠的肉瘤180肿瘤表现出一定的抑癌作用。[1] 暴露到HL-60细胞增加H2O2浓度,导致过氧化物在细胞内剂量依赖性积累,这伴随细胞内抗坏血酸的减少和细胞凋亡的增加。Ascorbic acid也会对无血清和无葡萄糖培养基中HL-60细胞相关的细胞凋亡产生强的保护作用。[2] Vitamin C被发现能够剂量依赖性保护GSH-缺失的HL-60细胞。Vitamin C抑制正常的和GSH-缺失的细胞中ROS的形成。[3] Ascorbate (1 mM)在Dulbecco改良的Eagle培养基中产生161 mM H2O2,并诱导50%的HL60细胞凋亡,而在RPMI 1640中,仅产生83 mM H2O2,并且没有检测到细胞凋亡。[4] |
体内研究 | 在使用顺铂之前,用Vitamin C处理大鼠10分钟,抑制顺铂介导的损伤。增加的血清肌酸肝,表明了肾损伤程度,在三个测试的Vitamin C剂量下显著降低。[5] |
RNA m6A modification regulates L1 retrotransposons in human spermatogonial stem cell differentiation in vitro and in vivo [ Cell Mol Life Sci, 2024, 81(1):92] | PubMed: 38363375 |
Combination of Vitamin C and Lenvatinib potentiates antitumor effects in hepatocellular carcinoma cells in vitro [ PeerJ, 2023, 11:e14610] | PubMed: 36718449 |
Long noncoding RNA Malat1 inhibits Tead3-Nfatc1–mediated osteoclastogenesis to suppress osteoporosis and bone metastasis [ Res Sq, 2023, rs.3.rs-2405644] | PubMed: 36993303 |
Long noncoding RNA Malat1 inhibits Tead3-Nfatc1-mediated osteoclastogenesis to suppress osteoporosis and bone metastasis [ Res Sq, 2023, rs.3.rs-2405644] | PubMed: 36993303 |
An organoid model of colorectal circulating tumor cells with stem cell features, hybrid EMT state and distinctive therapy response profile [ J Exp Clin Cancer Res, 2022, 41(1):86] | PubMed: 35260172 |
Untargeted Metabolomics Showed Accumulation of One-Carbon Metabolites to Facilitate DNA Methylation during Extracellular Matrix Detachment of Cancer Cells [ Metabolites, 2022, 12(3)267] | PubMed: 35323710 |
Transcription factor-based gene therapy to treat glioblastoma through direct neuronal conversion [ Cancer Biol Med, 2021, j.issn.2095-3941.2020.0499] | PubMed: 33755378 |
High throughput proteomic and metabolic profiling identified target correction of metabolic abnormalities as a novel therapeutic approach in head and neck paraganglioma [ Transl Oncol, 2021, 14(8):101146] | PubMed: 34118692 |
TRIM7 suppresses cell invasion and migration through inhibiting HIF-1α accumulation in clear cell renal cell carcinoma [ Cell Biol Int, 2021, 10.1002/cbin.11750] | PubMed: 34936717 |
HIF-1α-Mediated Mitophagy Determines ZnO Nanoparticle-Induced Human Osteosarcoma Cell Death both In Vitro and In Vivo [ ACS Appl Mater Interfaces, 2020, 12(43):48296-48309] | PubMed: 33054172 |
特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品,在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同,大多数建议储存在-20°C,抑制剂属于化学试剂,可在常温下运输储存两周左右。即使如此,我们保证产品的出货量将保持产品质量的条件下,一般都会放入冰袋。望阁下收到产品后,请按照产品数据表建议适当存储。
如果需要长期保存,请于零下二十度低温保存。禁止用于人体及治疗!
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