Vitamin D Receptor Rabbit Recombinant mAb

生物描述

特异性

Vitamin D Receptor Rabbit Recombinant mAb detects endogenous level of total Vitamin D Receptor.

背景

The vitamin D receptor (VDR) is a member of the nuclear receptor superfamily and plays a central role in the biological actions of vitamin D. VDR regulates the expression of numerous genes involved in calcium/phosphate homeostasis, cellular proliferation and differentiation, and immune response, largely in a ligand-dependent manner. It normally functions to control gene expression. Following ligand activation, the VDR binds directly to specific sequences located near promoters and recruits a variety of coregulatory complexes that perform the additional functions required to modify transcriptional output. VDR is highest in intestinal enterocytes, pancreatic islets, renal distal tubules, osteoblasts and is not found in mature muscle including heart and liver.

使用信息

抗体应用	WB, IF,ELISA,ELISA
稀释比例	WB IF 1:1000 1:50
反应性	Human Mouse Rat
MW (kDa)	48kDa
抗体类型	Rabbit
储存液配方	10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
储存条件 (自收到货起)	Store at –20°C.

文献参考

[1] Pike JW, et al. Endocrinol Metab Clin North Am. 2010, 39(2):255-69. [2] Wang Y, et al. Arch Biochem Biophys. 2012, 523(1):123-33.

Application Data

WB

IF