XRCC1 Rabbit Recombinant mAb

生物描述

特异性

XRCC1 Rabbit Recombinant mAb detects endogenous level of total XRCC1.

背景

The X-ray repair cross complementing 1 (XRCC1) protein is required for viability and efficient repair of DNA single-strand breaks (SSBs) in rodents. XRCC1 has been shown to physically interact with several enzymes known to be involved in the repair of SSBs, including DNA ligase IIIα, DNA polymerase β, APE1, polynucleotide kinase/phosphatase, poly(ADP-ribose) polymerases 1 and 2 (PARP-1 and 2) and 8-oxoguanine DNA glycosylase (OGG1). It may play a role in DNA processing during meiogenesis and recombination in germ cells. The XRCC1 protein does not have enzymatic activity, but acts as a scaffolding protein that interacts with multiple repair enzymes.

使用信息

抗体应用	WB, IF,ELISA,ELISA
稀释比例	WB IF 1:1000 1:50
反应性	Human Mouse Rat
MW (kDa)	90kDa
抗体类型	Rabbit
储存液配方	10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
储存条件 (自收到货起)	Store at –20°C.

文献参考

[1] Brem R, et al. Nucleic Acids Res. 2005, 33(8):2512-20. [2] London RE, et al. DNA Repair (Amst). 2015, 30:90-103.

Application Data

WB

IF