Y-27632

目录号：S6390 批次号：S639001

打印

化学数据

别名

N/A

储存条件
(自收到货起)

3年 -20°C 粉状

化学式

C₁₄H₂₁N₃O

分子量

247.34

CAS号

146986-50-7

Solubility (25°C)*

体外

DMSO

49 mg/mL (198.1 mM)

Ethanol

49 mg/mL (198.1 mM)

Water

Insoluble

体内
（现配现用）

均匀悬浊液

CMC-NA

≥5mg/ml

以 1 mL 工作液为例，取 5 mg该产品加到 1 ml CMC-NA 溶液中，混合均匀，即可得工作液浓度为 5 mg/ml的均匀悬浊液。

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

生物活性

产品描述

Y-27632是一种选择性ROCK1和ROCK2抑制剂，无细胞试验中Ki分别为140 nM和300nM，比对其他激酶包括PKC，cAMP依赖性蛋白激酶，MLCK和PAK的作用强200多倍。

靶点

ROCK1 (Cell-free assay)	ROCK2 (Cell-free assay)
140 nM(Ki)	300 nM(Ki)

参考文献

Y-27632在文献中得到引用

MeCP2 gene dosage-dependent neurodevelopmentally restricted defects arise by aberrant activation of cell fate-determining bivalent genes [ Nat Commun, 2026, 17(1)3225]	PubMed: 42026056
zAvatar-test-A functional precision model to personalize ovarian cancer treatments: Results from a co-clinical study [ Cell Rep Med, 2026, 7(1):102530]	PubMed: 41475339
BMP4 initiates and patterns ventral-caudal structures in zebrafish and human pluripotent stem cell aggregates [ EMBO J, 2026, 45(1):210-242]	PubMed: 41286028
CRISPR-MiX: A pooled single-stranded donor strategy to enhance HDR efficiency in human iPSCs [ Mol Ther Nucleic Acids, 2026, 37(1):102820]	PubMed: 41674724
Pharmacological strategies to enhance the response of hepatoblastoma to chemotherapy through MDR1 inhibition [ Acta Pharmacol Sin, 2026, 10.1038/s41401-026-01791-z]	PubMed: 42026237
NAD+ augmentation by nicotinamide riboside engages SLIT2/ROBO1 signaling to attenuate Th17 inflammation in psoriasis [ JCI Insight, 2026, e203826]	PubMed: 42048163
Early hypoxia treatment and oxygen-concentration alteration promote the retinal progenitor proliferation and ganglion cell maturation in human retinal organoid development [ Stem Cell Res Ther, 2026, 17(1)109]	PubMed: 41664121
Head and Neck Squamous Cell Carcinoma Patient-Derived Cancer-Associated Fibroblasts Undergo Senescence While Retaining Protumorigenic Properties After Ex Vivo Irradiation [ Int J Radiat Oncol Biol Phys, 2026, S0360-3016(26)00395-0]	PubMed: 41698472
Spatially Resolved Proteomic Mapping in Skin Organoid for Hair Follicle Development [ Mol Cell Proteomics, 2026, 25(1):101482]	PubMed: 41380997
ADAMDEC1-driven CCL2-CCR2-PD-1 axis in esophageal squamous cell carcinoma: a dual threat of O-GlcNAcylation and m6A methylation in neoadjuvant therapy resistance and immune evasion [ Cell Oncol (Dordr), 2026, 49(2)68]	PubMed: 41944985

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20°C，抑制剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。

如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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