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别名 | N/A | 储存条件 (自收到货起) |
3年 / -20°C / 粉状 1年 / -80°C / 溶于溶剂 |
化学式 | C93H144ClN23O21S2 |
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分子量 | 2019.86 | CAS号 | 1659305-78-8 | |
Solubility (25°C)* | 体外 | DMSO | 100 mg/mL (49.5 mM) | |
Water | 100 mg/mL (49.5 mM) | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
产品描述 | YAP-TEAD Inhibitor 1 (Peptide 17) 是YAP-TEAD间蛋白相互作用的抑制剂,在YAP相关的癌症中有其潜在应用价值,IC50为25 nM。 | ||
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靶点 |
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体外研究 | Peptide 17在体外实验中非常有效地破坏YAP-TEAD的相互作用,对TEAD的亲和力十分强(个位数微摩尔级别)[2]。 |
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数据来源于[Data independently produced by , , J Exp Clin Cancer Res. 2018, 37(1):228]
Targeting Latent HIV Reservoirs: Effectiveness of Combination Therapy with HDAC and PARP Inhibitors [ Viruses, 2025, 17(3)400] | PubMed: 40143326 |
Spatial cell fate manipulation of human pluripotent stem cells by controlling the microenvironment using photocurable hydrogel [ Development, 2024, 151(6)dev201621] | PubMed: 38512805 |
Histological characteristics of exercise-induced skeletal muscle remodelling [ J Cell Mol Med, 2023, 27(21):3217-3234] | PubMed: 37517049 |
NOX4-derived ROS Regulates Aerobic Glycolysis of Breast Cancer through YAP Pathway [ J Cancer, 2023, 14(13):2562-2573] | PubMed: 37670970 |
NOX4-derived ROS Regulates Aerobic Glycolysis of Breast Cancer through YAP Pathway [ J Cancer, 2023, 14(13):2562-2573] | PubMed: 37670970 |
Downregulation of circ-ZNF609 Promotes Heart Repair by Modulating RNA N6-Methyladenosine-Modified Yap Expression [ Research (Wash D C), 2022, 2022:9825916] | PubMed: 35474903 |
Optimization of TEAD P-Site Binding Fragment Hit into In Vivo Active Lead MSC-4106 [ J Med Chem, 2022, 65(13):9206-9229] | PubMed: 35763499 |
Aurintricarboxylic acid is a canonical disruptor of the TAZ-TEAD transcriptional complex [ PLoS One, 2022, 17(4):e0266143] | PubMed: 35417479 |
Targeting the Hippo/YAP/TAZ signalling pathway: Novel opportunities for therapeutic interventions into skin cancers [ Exp Dermatol, 2022, 31(10):1477-1499] | PubMed: 35913427 |
mTORC1 Promotes ARID1A Degradation and Oncogenic Chromatin Remodeling in Hepatocellular Carcinoma [ Cancer Res, 2021, 81(22):5652-5665] | PubMed: 34429326 |
特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品,在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同,大多数建议储存在-20°C,抑制剂属于化学试剂,可在常温下运输储存两周左右。即使如此,我们保证产品的出货量将保持产品质量的条件下,一般都会放入冰袋。望阁下收到产品后,请按照产品数据表建议适当存储。
如果需要长期保存,请于零下二十度低温保存。禁止用于人体及治疗!
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