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别名 | N/A | 储存条件 (自收到货起) |
3年 -20°C 粉状 | ||||||||
化学式 | C13H8Cl2N4S2 |
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分子量 | 355.27 | CAS号 | 448947-81-7 | ||||||||
Solubility (25°C)* | 体外 | DMSO | 18 mg/mL (50.66 mM) | ||||||||
Water | Insoluble | ||||||||||
Ethanol | Insoluble | ||||||||||
体内(现配现用) |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
产品描述 | Yoda1是人源和小鼠源Piezo1的激动剂。小鼠源EC50为17.1 μM,人源EC50为26.6 μM。 在没有其他细胞成分的情况下,Yoda1可激活纯化的Piezo1通道。 | ||||
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靶点 |
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Prolonged Piezo1 Activation Induces Cardiac Arrhythmia [ Int J Mol Sci, 2023, 24(7)6720] | PubMed: 37047693 |
Inhibition of Piezo1 ameliorates intestinal inflammation and limits the activation of group 3 innate lymphoid cells in experimental colitis [ J Innate Immun, 2023, 15(1):709-23] | PubMed: 37725937 |
Activation of Piezo1 promotes osteogenic differentiation of aortic valve interstitial cell through YAP-dependent glutaminolysis [ Sci Adv, 2023, 9(22):eadg0478] | PubMed: 37267365 |
Piezo1-mediated mechanosensation in bone marrow macrophages promotes vascular niche regeneration after irradiation injury [ Theranostics, 2022, 12(4): 1621-1638] | PubMed: N/A |
Piezo1-mediated mechanosensation in bone marrow macrophages promotes vascular niche regeneration after irradiation injury [ Theranostics, 2022, 12(4):1621-1638] | PubMed: 35198061 |
Ion channel Piezo1 activation promotes aerobic glycolysis in macrophages [ Front Immunol, 2022, 13:976482] | PubMed: 36119083 |
The function of Piezo1 in hepatoblastoma metastasis and its potential transduction mechanism [ Heliyon, 2022, 8(9):e10301] | PubMed: 36097495 |
Piezo1-mediated fluid shear stress promotes OPG and inhibits RANKL via NOTCH3 in MLO-Y4 osteocytes [ Channels (Austin), 2022, 16(1):127-136] | PubMed: 35754337 |
Targeting Mechanosensitive Piezo1 Alleviated Renal Fibrosis Through p38MAPK-YAP Pathway [ Front Cell Dev Biol, 2021, 9:741060] | PubMed: 34805150 |
Targeting Mechanosensitive Piezo1 Alleviated Renal Fibrosis Through p38MAPK-YAP Pathway [ Front Cell Dev Biol, 2021, 9:741060] | PubMed: 34805150 |
特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品,在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同,大多数建议储存在-20°C,抑制剂属于化学试剂,可在常温下运输储存两周左右。即使如此,我们保证产品的出货量将保持产品质量的条件下,一般都会放入冰袋。望阁下收到产品后,请按照产品数据表建议适当存储。
如果需要长期保存,请于零下二十度低温保存。禁止用于人体及治疗!
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