Z-IETD-FMK

目录号：S7314 批次号：S731403

打印

化学数据

别名

Caspase-8 Inhibitor, Z-IE(OMe)TD(OMe)-FMK

储存条件
(自收到货起)

3年 / -20°C / 粉状
1年 / -80°C / 溶于溶剂

化学式

C₃₀H₄₃FN₄O₁₁

分子量

654.68

CAS号

210344-98-2

Solubility (25°C)*

体外

DMSO

100 mg/mL (152.74 mM)

Water

Insoluble

Ethanol

Insoluble

体内（现配现用）

澄清溶液

5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O

5mg/ml (7.64mM)

以 1 mL 工作液为例，取50μL100mg/ml的澄清DMSO储备液加到 400μL PEG300中，混合均匀使其澄清；向上述体系中加入50μLTween80，混合均匀使其澄清；然后继续加入500μL ddH2O定容至 1 mL。工作液请现配现用！

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

生物活性

产品描述

Z-IETD-FMK (Caspase-8 Inhibitor, Z-IE(OMe)TD(OMe)-FMK)是一种特异性Caspase-8抑制剂。Z-IETD-FMK也是颗粒酶B（granzyme B）抑制剂。

靶点

Caspase-8 ^[1]

参考文献

[4] Monnier PP, et al. J Neurosci. 2011, 31(29), 10494-10505.

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客户使用selleck产品的实验数据

: 数据来源于[Data independently produced by , , Cell Physiol Biochem, 2017, 42(5):1822-1836]

: 数据来源于[Data independently produced by , , Int J Oncol, 2018, 52(3):1023-1032]

: 数据来源于[Data independently produced by , , Drug Des Devel Ther, 2017, 11:2841-2850]

: 数据来源于[Data independently produced by , , PLoS One, 2017, 12(2):e0171840]

Z-IETD-FMK在文献中得到引用

GZMK-expressing CD8+ T cells promote recurrent airway inflammatory diseases [ Nature, 2025, 10.1038/s41586-024-08395-9]	PubMed: 39814882
Homologous recombination promotes non-immunogenic mitotic cell death upon DNA damage [ Nat Cell Biol, 2025, 27(1):59-72]	PubMed: 39805921
EFHD2 suppresses intestinal inflammation by blocking intestinal epithelial cell TNFR1 internalization and cell death [ Nat Commun, 2024, 15(1):1282]	PubMed: 38346956
PARP inhibitors enhance antitumor immune responses by triggering pyroptosis via TNF-caspase 8-GSDMD/E axis in ovarian cancer [ J Immunother Cancer, 2024, 12(10)e009032]	PubMed: 39366751
RIPK1 is dispensable for cell death regulation in β-cells during hyperglycemia [ Mol Metab, 2024, 87:101988]	PubMed: 39004142
Interferon alpha promotes caspase-8 dependent ultraviolet light-mediated keratinocyte apoptosis via interferon regulatory factor 1 [ Front Immunol, 2024, 15:1384606]	PubMed: 38660315
Receptor-interacting protein kinase 1 confers autophagic promotion of gasdermin E-mediated pyroptosis in aristolochic acid-induced acute kidney injury [ Ecotoxicol Environ Saf, 2024, 284:116944]	PubMed: 39208575
The mechanosensitive Piezo1 channel exacerbates myocardial ischaemia/reperfusion injury by activating caspase-8-mediated PANoptosis [ Int Immunopharmacol, 2024, 139:112664]	PubMed: 39008937
ERK mediates interferon gamma-induced melanoma cell death [ Mol Cancer, 2023, 10.1186/s12943-023-01868-x]	PubMed: 37803324
THADA inhibition in mice protects against type 2 diabetes mellitus by improving pancreatic β-cell function and preserving β-cell mass [ Nat Commun, 2023, 14(1):1020]	PubMed: 36823211

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20°C，抑制剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。

如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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