CD276 Rabbit Recombinant mAb
Filter:
使用信息
| 抗体应用 | wb,ELISA | ||
|---|---|---|---|
| 稀释比例 |
|
||
| 反应性 | Human Mouse | ||
| MW (kDa) | 100kDa | ||
| 抗体类型 | Rabbit | ||
| 浓度 | 1mg/ml | ||
| 储存液配方 | 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. | ||
| 储存条件 (自收到货起) |
Store at –20°C. |
生物描述
| 特异性 | CD276 Rabbit Recombinant mAb detects endogenous levels of total CD276. |
|---|---|
| 背景 | B7-H3 (CD276) is an important immune checkpoint member of the B7 and CD28 families. Induced on antigen presenting cells, CD276 plays an important role in the inhibition of T cell function. At the mRNA level, CD276 is ubiquitously found in non-lymphoid and lymphoid organs as liver, heart, prostate, spleen and thymus. Despite broad mRNA expression, protein expression is limited at steady state. CD276 is constitutively found on non-immune resting fibroblasts, endothelial cells (EC), osteoblasts, and amniotic fluid stem cells. Its expression is induced on immune cells, specifically antigen-presenting cells. The B7-H3 (CD276) pathway has a dual role in contributing to the regulation of innate immune responses: neuroblastoma cells are found to express B7-H3 on their cell surface, which protect them from NK cell-mediated lysis; CD276 also costimulates innate immunity by augmenting proinflammatory cytokines release from LPS-stimulated monocytes/macrophages, in both a Toll like receptor 4- and 2-dependent manner. Beyond the immune system, the B7-H3 pathway has a non-immunological role in promoting osteoblastic differentiation and bone mineralization in mice, ensuring normal bone formation. |
技术支持
在订购、运输、储存和使用我们的产品的任何阶段，您遇到的任何问题，均可以通过拨打我们的热线电话400-668-6834，或者技术支持邮箱tech@selleck.cn，直接联系到我们。我们会在24小时内尽快联系您。
* 必填项
