Stem Cell Signaling Compound Library

目录号 L2100

提供89种干细胞小分子化合物的独特集合

规格 价格  
预溶于DMSO
100uL/well (10mM solution) RMB 23847.06
2x100uL/well (10mM solution) RMB 37345.39
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Stem Cell Signaling Compound Library目录

selleck分子库在文献中的引用(66

客户使用selleck产品的实验数据(10

  • Effects of CP-690550 on NKTCL cell lines. NK-S1, KHYG-1 cells were treated with CP-690550 for 48 hours, and the effect on STAT5 phosphorylation was evaluated by Western blotting.

    Cancer Discov 2012 2(7), 591-7. Tofacitinib (CP-690550,Tasocitinib) purchased from Selleck

    (B) qRT-PCR analysis and immunostaining of murine HSCs treated with GDC-0449 on culture days 4 through 7 (to inhibit SMO) or culture day 7 SMO-LoxP HSCs treated with adenoviral Cre on day 4 (to disrupt the Smo gene).

    Gastroenterology 2012 143, 1319-29. Vismodegib (GDC-0449) purchased from Selleck

  • Hh signaling controls metabolic reprogramming during liver injury in vivo. Immunohistochemistry identifies cells expressing the M2 isozyme of PKM2, a specific marker of glycolytic activity, ( C) inhibited in aged MDR2 -/- mice by GDC-0449.

    Gastroenterology 2012 143, 1319-29. Vismodegib (GDC-0449) purchased from Selleck

    Tamoxifen was administered to adult Psmc1fl/wt and Psmc1fl/fl Pdgf-Cre-ER mice, followed by treatment with fasudil control (4 and 48 hours after tamoxifen). Representative images of Dylight 488-positive megakaryocytes present in crude bone marrow isolated from Psmc1fl/wt and Psmc1fl/flPdgf-Cre-ER mice immediately after euthanasia. Bone marrow for these studies was isolated from a subset of the mice in A (n=2 per treatment group). Scale bars: 100 um.

    J Clin Invest 2014 124(9), 3757-66. Fasudil (HA-1077) HCl purchased from Selleck

  • The ROCK inhibitors fasudil and Y27632 prevented SCP2 cell bone metastasis in nude mice (n = 10 per group). Shown are BLI images of bone metastases, IHC analyses of SMAD3 C-tail phosphorylation and PTHLH, osteoclast TRAP staining, and BLI quantitation.

    J Clin Invest 2014 124(4), 1646-59. Fasudil (HA-1077) HCl purchased from Selleck

    IL-6- supported INA-6 cells were treated with the JAK inhibitors ruxolitinib (Rux; 10 nM) or CYT387 (CYT; 50 nM) for 1 hour and assessed for inhibition of STAT3 phosphorylation by immunoblotting.

    J Clin Invest 2014 10.1172/JCI69094. Momelotinib (CYT387) purchased from Selleck

  • RU-SKI 43 blocks Shh signaling. (a) RU-SKI 43 blocks Gli activation. NIH 3T3 cells were cotransfected with vectors encoding 8× Gli-binding site (GliBS)-Firefly luciferase (unless indicated otherwise), Renilla luciferase reporter (pRL-TK) and Shh. Confluent cells were treated with DMSO, 10 μM LDE225, 10 μM RU-SKI 43 or 10 μM C-2. The firefly luciferase (FL)/Renilla luciferase (RL) ratio in cell lysates was calculated and normalized to that measured in DMSO-treated samples; error bars represent mean ± s.d. (n = 2–3). 

    Nat Chem Biol 2013 9, 247-9. LDE225 (NVP-LDE225,Erismodegib) purchased from Selleck

    Fluorescence microscopy of pSuper or Cdo shRNA expressing P19 cells at ITS1 immunostained withβ-tubulin III antibodies. Size bar=100 um. P19/control or P19/Cdo shRNA cells were treated with DMSO or XAV939 in the differentiation medium for 72 h followed by immunostaining.

    Nat Commun 2014 5, 5455. XAV-939 purchased from Selleck

  • STAT3 phosphorylation as determined by phospho flow, mixed lymphocyte reactions containing BALB/c spleen-derived CD4+ T cells co-cultured with or without C57BL/6 BM-derived DC preactivated with 20 ng/mL LPS.

    Blood 2014 123(24), 3832-42. Ruxolitinib (INCB018424) purchased from Selleck

    Colony-forming assay results showing that the Jak2 inhibitor TG101348 reduces CFU-GM colonies generated from mutant fetal liver R2 cells. Results from 4 independent control or mutant fetal livers treated with TG101348 or dimethylsulfoxide (DMSO) are shown (mean ?SD). ***P < .001.

    Blood 2014 123(20), 3175-84. Fedratinib (SAR302503, TG101348) purchased from Selleck

描述及优势

• 89种干细胞小分子化合物的独特集合,具有生物活性,用于干细胞调节和信号转导通路研究
• 干细胞库中的所有小分子抑制剂都具有良好的生物和药学活性
• 一项根据肿瘤干细胞研究干细胞再生疗法,药物筛选机制,和其他生物应用的有力工具
• 干细胞抑制剂库含有与调节干细胞功能的信号通路相关的小分子,如Wnt, Notch, SMAD, 和Hedgehog 信号
• 结构多样,药效显著,可渗透细胞
• 具有充分详细的结构说明,IC50值,及客户反馈资料
• NMR和HPLC技术保证产品高纯度

详细信息

配制: A collection of 89 small molecule inhibitors for stem cell research supplied as pre-dissolved DMSO solutions
容器: 96 Well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode
稳定性: 溶于DMSO
溶于DMSO
发货: 蓝冰物流
包装: 惰性气体

Stem Cell Signaling Compound Library组成

HTS Facility Partners

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