96 Well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode

Stem Cell Signaling Compound Library

提供89种干细胞小分子化合物的独特集合

规格 价格  
预溶于DMSO
100uL/well (10mM solution) RMB 23847.06
2x100uL/well (10mM solution) RMB 37345.39
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selleck分子库在文献中的引用

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产品详情

产品描述及优势

    • 89种干细胞小分子化合物的独特集合,具有生物活性,用于干细胞调节和信号转导通路研究
    • 干细胞库中的所有小分子抑制剂都具有良好的生物和药学活性
    • 一项根据肿瘤干细胞研究干细胞再生疗法,药物筛选机制,和其他生物应用的有力工具
    • 干细胞抑制剂库含有与调节干细胞功能的信号通路相关的小分子,如Wnt, Notch, SMAD, 和Hedgehog 信号
    • 结构多样,药效显著,可渗透细胞
    • 具有充分详细的结构说明,IC50值,及客户反馈资料
    • NMR和HPLC技术保证产品高纯度

产品详细信息

配制: 89种干细胞小分子预溶在DMSO溶液中
96-孔板: 96 Well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode
稳定性:
1年 -20°C 溶于DMSO
2年 -80°C 溶于DMSO
发货: 蓝冰物流
包装: 惰性气体

化合物库组成成份

Chemical Library Composition

客户使用Selleck产品的实验数据 (10)

AS-605240 Review
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数据来源 Cancer Discov,2012, 2(7), 591-7. Tofacitinib (CP-690550,Tasocitinib) purchased from Selleck
方法 Western blot
细胞系 NK-S1, KHYG-1 cells
浓度 0-2 uM
处理时间 48 h
结果 To further confirm the involvement of JAK/STAT signaling in the survival of NKTCLs, we next evaluated the effect of a pan-JAK inhibitor, CP-690550, in NK-S1, KHYG-1, and K562 cells. As expected, both the NK-S1 and KHYG-1 cells showed a reduction of phosphorylated STAT5.
Axitinib and PF2341066(Crizotinib) Reviews
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数据来源 Gastroenterology 2012, 143, 1319-29. Vismodegib (GDC-0449) purchased from Selleck
方法 qRT-PCR/immunostaining
细胞系 MF-HSCs
浓度 1 μM
处理时间 4 d
结果 Conditional deletion of SMO in MF-HSCs recapitulated the effects of GDC-0449, causing significant down-regulation of glyco-lytic genes and MF genes.
Axitinib and PF2341066(Crizotinib) Reviews
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数据来源 Gastroenterology 2012, 143, 1319-29. Vismodegib (GDC-0449) purchased from Selleck
方法 Immunohistochemistry
细胞系 MDR2 -/- mice
浓度 1 μM
处理时间 4 d
结果 We found that treating year-old MDR2 -/- mice with a 9-day course of GDC-0449 substantially reduced the numbers of PKM2-positive cells despite the ongoing genetic stimulus for liver repair.
Axitinib and PF2341066(Crizotinib) Reviews
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数据来源 J Clin Invest 2014, 124(9), 3757-66. Fasudil (HA-1077) HCl purchased from Selleck
方法 Xenografts
细胞系 Psmc1<sup>fl/wt</sup>, Psmc1<sup>fl/fl</sup>Pdgf-Cre-ER mice
浓度 5 mg/kg
处理时间 4, 48 h
结果 The Aurk inhibitor PHA-739358 also blocked tumor growth and led to a reduction in tumor size and weight.
Axitinib and PF2341066(Crizotinib) Reviews
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数据来源 J Clin Invest 2014, 124(4), 1646-59. Fasudil (HA-1077) HCl purchased from Selleck
方法 Immunofluorescence
细胞系 Nude mice
浓度 50 mg/kg
处理时间 4 weeks
结果 The ROCK inhibitors fasudil and Y27632 prevented SCP2 cell bone metastasis in nude mice.
Axitinib and PF2341066(Crizotinib) Reviews
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数据来源 J Clin Invest 2014, 10.1172/JCI69094. Momelotinib (CYT387) purchased from Selleck
方法 Western blot
细胞系 IL-6- supported INA-6 cells
浓度 50 nM
处理时间 1 h
结果 To further establish that constitutive GP130 activation represents a model of IL-6–activated MM, it infected the human IL-6–dependent MM line INA-6. Treatment with JAK inhibitors (CYT387 and ruxolitinib) blocked STAT3 phosphorylation and caused cell cycle arrest.
Axitinib and PF2341066(Crizotinib) Reviews
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数据来源 Nat Chem Biol 2013, 9, 247-9. LDE225 (NVP-LDE225,Erismodegib) purchased from Selleck
方法 Luciferase assay
细胞系 NIH 3T3
浓度 10 μM
处理时间 24 h
结果 Notably, addition of 10 μM RU-SKI 43 or LDE225, a Smoothened (Smo) inhibitor13, blocked luciferase activation, consistent with Shh pathway inhibition, whereas C-2 had no effect.
Axitinib and PF2341066(Crizotinib) Reviews
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数据来源 Nat Commun 2014, 5, 5455. XAV-939 purchased from Selleck
方法 Immunostaining
细胞系 P19 cells
浓度 4 uM
处理时间 72 h
结果 P19 cells transfected with expression vectors for the control or ​Cdo-shRNA with Top-flash and β-galactosidase were treated with either ​dimethylsuphoxide (​DMSO) or ​XAV939 (4 uM) in differentiation medium for 24 h. ​P19/control or P19/​Cdo shRNA cells were treated with ​DMSO or ​XAV939 in the differentiation medium for 72 h followed by immunostaining. XAV939-treated control cells displayed a modest increase in ​β-tubulin III-positive cells, compared with the control-treated cells. Furthermore, ​Cdo-depleted P19 cells treated with ​DMSO exhibited a significant reduction in ​β-tubulin III-positive cells, while ​XAV939 treatment restored neuronal differentiation of these cells nearly to the control level.
Axitinib and PF2341066(Crizotinib) Reviews
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数据来源 Blood 2014, 123(24), 3832-42. Ruxolitinib (INCB018424) purchased from Selleck
方法 Flow cytometry
细胞系 CD4<sup>+</sup> T cells
浓度 0-1 uM
处理时间 24 h
结果 As shown in figure, STAT3 phosphorylation was significantly reduced when ruxolitinib exposed CD4+ T cells.
Axitinib and PF2341066(Crizotinib) Reviews
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数据来源 Blood 2014, 123(20), 3175-84. Fedratinib (SAR302503, TG101348) purchased from Selleck
方法 Colony-forming assay
细胞系 Mutant fetal liver R2 cells
浓度 500 nM
处理时间
结果 To test whether this altered signaling pathway in Rcor-/- erythroid cells contributed to their generation of myeloid colonies, the Jak/Stat pathway was blocked with a specific Jak2 inhibitor, TG101348. TG101348 reduced the number of myeloid colonies formed by mutant cells by 40%.

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