96 Well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode

Tyrosine Kinase Inhibitor Library

提供171种酪氨酸激酶抑制剂的集合

规格 价格  
预溶于DMSO
100uL/well (10mM solution) RMB 34802.60
2x100uL/well (10mM solution) RMB 59541.79
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产品详情

产品描述及优势

    • 171种酪氨酸激酶抑制剂的独特集合,可用于高通量筛选和高内涵筛选
    • 通过前期临床研究和临床实验,生物活性和安全性得到验证
    • 其中一些抑制剂已经得到FDA批准
    • 作用于酪氨酸激酶,如EGFR,VEGFR,SRC,c-Met和JAK
    • 结构多样,药效显著,可渗透细胞
    • 具有充分详细的结构说明,IC50值,及客户反馈资料
    • NMR和HPLC技术保证产品高纯度

产品详细信息

配制: 171种酪氨酸激酶抑制剂预溶在DMSO溶液中
96-孔板: 96 Well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode
稳定性:
1年 -20°C 溶于DMSO
2年 -80°C 溶于DMSO
发货: 蓝冰物流
包装: 惰性气体

化合物库组成成份

Chemical Library Composition

客户使用Selleck产品的实验数据 (10)

AS-605240 Review
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数据来源 Nature,2011, 478(7369):349-55. Sunitinib Malate purchased from Selleck
方法 Western immunoblots
细胞系 Mouse pancreatic stem cells
浓度 12 uM
处理时间 2 days
结果 Increased Ezh2 expression and β-cell BrdU incorporation were eliminated by simultaneous treatment with the receptor tyrosine kinase inhibitors Sunitinib.
Axitinib and PF2341066(Crizotinib) Reviews
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数据来源 Nature 2011, 478(7369):349-55. Sunitinib Malate purchased from Selleck
方法 Immunofluorescent staining
细胞系 Mouse pancreatic stem cells
浓度 12 uM
处理时间 2 days
结果 Compared to vehicle-exposed controls, juvenile islets exposed to PDGF-AA had a sixfold increase of β-cell BrdU incorporation, an effect eliminated by simultaneous exposure to Sunitinib or U0126.
Axitinib and PF2341066(Crizotinib) Reviews
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数据来源 Science 2011, 331(6019), 912-6. PD173074 purchased from Selleck
方法 Immunohistochemistry
细胞系 uterine horn
浓度
处理时间
结果 The epithelia of vehicle-treated horn showed prominent expression of p-FRS2 and p-ERK1/2 (Fig. A, a and c). However, the levels of both p-FRS2 and p-ERK1/2 were reduced in the epithelia of PD173074-treated horn on day 4 of pregnancy (Fig. A, b and d). We also observed a marked decline in the proliferative activity of Hand2-null uterine epithelia, as indicated by decreased Ki-67 staining (Fig. A, e and f). Administration of either PD173074 (Fig. C, a to d) or PD184352 (Fig. C, e to h) to Hand2-null uterine horns blocked the phosphorylation of epithelial ER a at Ser118 and the expression of Muc-1.
Axitinib and PF2341066(Crizotinib) Reviews
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数据来源 Nat Genet 2012, 44(8):852-60. Erlotinib HCl (OSI-744) purchased from Selleck
方法 Western blot
细胞系 HHCC827 ER1 and ER2 cells
浓度 0.1 uM
处理时间 48 h
结果 It sought to validate genetic findings using pharmacologic inhibitors of AXL. As expected, erlotinib decreased pEGFR, pERK, pAKT, pRelA and increased the levels of cleaved Parp in parental HCC827 cells irrespective of concurrent treatment with MP-470. In contrast, these effects of erlotinib treatment were observed only upon concurrent treatment with MP-470 in the HCC827 ER1 and ER2 cells.
Axitinib and PF2341066(Crizotinib) Reviews
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数据来源 2012, Dr. Yong-Weon Yi from Georgetown University Medical Center. CP-724714 purchased from Selleck
方法 MTT assays
细胞系 UWB1.289 cells
浓度 0-10 μM
处理时间 72 h
结果 CP-724714 inhibited the survival of UWB1.289 cells in a dose-dependent manner.
Axitinib and PF2341066(Crizotinib) Reviews
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数据来源 Nat Med 2011, 17, 1116-1120. Crizotinib (PF-02341066) purchased from Selleck
方法 Western blot
细胞系 RCT-E565 transplanted tumors
浓度 25 mg/kg/d, 50 mg/kg/d
处理时间 0-21 d
结果 We then treated mice bearing RCT-E565 tumor transplants with PF02341066, a c-Met inhibitor currently in clinical development. PF02341066 abrogated both p-Akt and p-S6RP signals as well as tumor growth.
Axitinib and PF2341066(Crizotinib) Reviews
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数据来源 Cancer Cell 2012, 22(5), 656-667 . Ponatinib (AP24534) purchased from Selleck
方法 Western blot
细胞系 RCH-ACV cells
浓度 50 nM
处理时间 1-24 h
结果 Treatment of these cells with a CSK inhibitor (BMS-599626) or a BTK inhibitor (PCI-32765) did not recapitulate the dasatinib/ponatinib phenotype.
Axitinib and PF2341066(Crizotinib) Reviews
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数据来源 Cancer Cell 2011, 19, 679–690. Crizotinib (PF-02341066) purchased from Selleck
方法 Cell Growth Inhibition Assay
细胞系 Ba/F3 cells
浓度
处理时间 48 h
结果 The sensitivities of L1196M-driven Ba/F3 cell clones to PF-02341066 were lower, closely resembling that of the Ba/F3 parental cells. The therapeutic indexes of CH5424802 and PF-02341066, the IC50 ratio of EML4-ALK L1196M-driven cell clones to the parental cells, were 7- to 12-fold and 1- to 2-fold.
Axitinib and PF2341066(Crizotinib) Reviews
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数据来源 Cancer Discov 2014, 4(7), 816-27. Cabozantinib (XL184, BMS-907351) purchased from Selleck
方法 Western blot
细胞系 A-375 melanoma cells
浓度 3 uM
处理时间
结果 XL184 combined with PLX4720, compared to PLX 4720 alone, abrogated AXL-mediated induction of AKT phosphorylation and rescue of ERK phosphorylation but had no effect on AKT or ERK levels in A-375 cell lines.
Axitinib and PF2341066(Crizotinib) Reviews
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数据来源 Cancer Discov 2013, 3(6), 636-47. PD173074 purchased from Selleck
方法 Western blot
细胞系 SW780 cells
浓度 10, 40 mg/kg
处理时间
结果 Similar results for FGFR fusion-positive lines were obtained in vivo. SW780 xenografts exhibited decreased tumor growth with increasing doses of PD173074.

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