GPCR Compound Library

目录号 L2200


规格 价格  
100uL/well (10mM solution) RMB 26425.55
2x100uL/well (10mM solution) RMB 38787.33


GPCR Compound Library目录



  • (B) qRT-PCR analysis and immunostaining of murine HSCs treated with GDC-0449 on culture days 4 through 7 (to inhibit SMO) or culture day 7 SMO-LoxP HSCs treated with adenoviral Cre on day 4 (to disrupt the Smo gene).

    Gastroenterology 2012 143, 1319-29. Vismodegib (GDC-0449) purchased from Selleck

    Hh signaling controls metabolic reprogramming during liver injury in vivo. Immunohistochemistry identifies cells expressing the M2 isozyme of PKM2, a specific marker of glycolytic activity, ( C) inhibited in aged MDR2 -/- mice by GDC-0449.

    Gastroenterology 2012 143, 1319-29. Vismodegib (GDC-0449) purchased from Selleck

  • J Clin Invest 2013 123(12), 5119-34. Doxazosin Mesylate purchased from Selleck

    RU-SKI 43 blocks Shh signaling. (a) RU-SKI 43 blocks Gli activation. NIH 3T3 cells were cotransfected with vectors encoding 8× Gli-binding site (GliBS)-Firefly luciferase (unless indicated otherwise), Renilla luciferase reporter (pRL-TK) and Shh. Confluent cells were treated with DMSO, 10 μM LDE225, 10 μM RU-SKI 43 or 10 μM C-2. The firefly luciferase (FL)/Renilla luciferase (RL) ratio in cell lysates was calculated and normalized to that measured in DMSO-treated samples; error bars represent mean ± s.d. (n = 2–3). 

    Nat Chem Biol 2013 9, 247-9. LDE225 (NVP-LDE225,Erismodegib) purchased from Selleck

  • PTPH1 confers breast cancer cell sensitivity to fulvestrant. E and F, PTPH1 overexpression increases the growth inhibition by fulvestrant. PTPH1 was overexpressed by a Tet-on system or a stable transfection, and resultant cells were incubated with fulvestrant as indicated for about 2 weeks. Colony formed was stained and counted. Results shown are normalized to its own solvent control of Vector and PTPH1-overexpressed cells, respectively (means ± SD; n = 3–5) with insets showing PTPH1 overexpression. *, versus vector or no Tet cells for E and F.

    Mol Cancer Ther 2014 13(1), 230-8. Fulvestrant purchased from Selleck

    J Med Chem 2014 57(3), 632-41. Raloxifene HCl purchased from Selleck

  • J Med Chem 2014 57(3), 632-41. Bazedoxifene HCl purchased from Selleck

    Eur J Cancer 2014 50(7), 1310-20. Forskolin purchased from Selleck

  • Western blot analysis on total cell lysates from renal cancer cell lines treated with NVP-LDE225 at different concentrations. Densitometric measurements were normalised to b-actin and reported under western blot images.

    Br J Cancer 2014 111(6), 1168-79. LDE225 (NVP-LDE225,Erismodegib) purchased from Selleck

    Tianeptine is a full agonist at μ-opioid receptors (MORs). The mouse MOR was co-expressed with GαoB, β1, γ2 and the BRET sensor CAMYEL to measure the inhibition of cAMP inhibition by tianeptine and the MOR agonist DAMGO. Naltrexone dose-dependently inhibits cAMP inhibition by both DAMGO and tianeptine with an IC50 of 35.3±2.3 and 23.3±3.9 nM, respectively. Data represent mean±s.e.m. of six independent experiments.

    Br J Haematol 2014 4, e411. Tianeptine sodium purchased from Selleck


• 280种G蛋白偶联受体小分子的独特集合,通过制药和生物技术公司的各项研究和药物开发项目可用于GPCR筛选
• GPCR化合物库中的所有小分子都具有良好的生物和药学活性
• 一项发现GPCR药物是最丰富信号受体的有力工具
• 据估计大约200个“孤儿”GPCR功能是未知的,因此,使用我们的GPCR小分子化合物库来筛选功能未知的GPCR可能会产生潜在的新型GPCR候选药
• GPCR化合物库含有与受体相关的小分子, 包括5-HT 受体, 多巴胺受体, 阿片受体,肾上腺素受体,大麻素受体, mGluR, 和 ETA-受体,等等
• 结构多样,药效显著,可渗透细胞
• 具有充分详细的结构说明,IC50值,及客户反馈资料
• NMR和HPLC技术保证产品高纯度


配制: A collection of 280 small molecules targeting GPCR supplied as pre-dissolved DMSO solutions
容器: 96 Well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode
稳定性: 溶于DMSO
发货: 蓝冰物流
包装: 惰性气体

GPCR Compound Library组成

HTS Facility Partners