96 Well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode

GPCR Compound Library

提供280种GPCR小分子化合物的独特集合

规格 价格  
预溶于DMSO
100uL/well (10mM solution) RMB 26425.55
2x100uL/well (10mM solution) RMB 38787.33
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selleck分子库在文献中的引用

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产品详情

产品描述及优势

    • 280种G蛋白偶联受体小分子的独特集合,通过制药和生物技术公司的各项研究和药物开发项目可用于GPCR筛选
    • GPCR化合物库中的所有小分子都具有良好的生物和药学活性
    • 一项发现GPCR药物是最丰富信号受体的有力工具
    • 据估计大约200个“孤儿”GPCR功能是未知的,因此,使用我们的GPCR小分子化合物库来筛选功能未知的GPCR可能会产生潜在的新型GPCR候选药
    • GPCR化合物库含有与受体相关的小分子, 包括5-HT 受体, 多巴胺受体, 阿片受体,肾上腺素受体,大麻素受体, mGluR, 和 ETA-受体,等等
    • 结构多样,药效显著,可渗透细胞
    • 具有充分详细的结构说明,IC50值,及客户反馈资料
    • NMR和HPLC技术保证产品高纯度

产品详细信息

配制: 280种GPCR小分子预溶在DMSO溶液中
96-孔板: 96 Well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode
稳定性:
1年 -20°C 溶于DMSO
2年 -80°C 溶于DMSO
发货: 蓝冰物流
包装: 惰性气体

化合物库组成成份

Chemical Library Composition

客户使用Selleck产品的实验数据 (10)

AS-605240 Review
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数据来源 Gastroenterology,2012, 143, 1319-29. Vismodegib (GDC-0449) purchased from Selleck
方法 qRT-PCR/immunostaining
细胞系 MF-HSCs
浓度 1 μM
处理时间 4 d
结果 Conditional deletion of SMO in MF-HSCs recapitulated the effects of GDC-0449, causing significant down-regulation of glyco-lytic genes and MF genes.
Axitinib and PF2341066(Crizotinib) Reviews
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数据来源 Gastroenterology 2012, 143, 1319-29. Vismodegib (GDC-0449) purchased from Selleck
方法 Immunohistochemistry
细胞系 MDR2 -/- mice
浓度 1 μM
处理时间 4 d
结果 We found that treating year-old MDR2 -/- mice with a 9-day course of GDC-0449 substantially reduced the numbers of PKM2-positive cells despite the ongoing genetic stimulus for liver repair.
Axitinib and PF2341066(Crizotinib) Reviews
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数据来源 J Clin Invest 2013, 123(12), 5119-34. Doxazosin Mesylate purchased from Selleck
方法
细胞系 Abca4 –/– Rdh8 –/– mice
浓度 0-3 mg/kg
处理时间 24 h
结果 Doxazosin (an antagonist of the Gq pathway) protected the retinas of Abca4 –/– Rdh8 –/– mice from developing bright light–induced degeneration in a dose-dependent fashion.
Axitinib and PF2341066(Crizotinib) Reviews
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数据来源 Nat Chem Biol 2013, 9, 247-9. LDE225 (NVP-LDE225,Erismodegib) purchased from Selleck
方法 Luciferase assay
细胞系 NIH 3T3
浓度 10 μM
处理时间 24 h
结果 Notably, addition of 10 μM RU-SKI 43 or LDE225, a Smoothened (Smo) inhibitor13, blocked luciferase activation, consistent with Shh pathway inhibition, whereas C-2 had no effect.
Axitinib and PF2341066(Crizotinib) Reviews
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数据来源 Mol Cancer Ther 2014, 13(1), 230-8. Fulvestrant purchased from Selleck
方法 Colony formation
细胞系 T47D, MCF-7 cells
浓度 10, 100 nM
处理时间 2 weeks
结果 Resultant cells were cultured with and without TAM for about 2 weeks for their colony forming activities as previously described. PTPH1 overexpression in both cell lines significantly increases the growth inhibition by fulvestrant as compared with their respective controls.
Axitinib and PF2341066(Crizotinib) Reviews
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数据来源 J Med Chem 2014, 57(3), 632-41. Raloxifene HCl purchased from Selleck
方法 Western blot
细胞系 SUM159 cells
浓度 15-50 uM
处理时间 24 h
结果 In human breast cancer cells(SUM159, ER negative) expressing IL-6 and GP130, raloxifene (15 − 50 μ M) downregulated the constitutive STAT3 phosphorylation (P-STAT3)activity level.
Axitinib and PF2341066(Crizotinib) Reviews
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数据来源 J Med Chem 2014, 57(3), 632-41. Bazedoxifene HCl purchased from Selleck
方法 Western blot
细胞系 SUM159 cells
浓度 10-30 uM
处理时间 24 h
结果 In human breast cancer cells(SUM159, ER negative) expressing IL-6 and GP130, bazedoxifene (10 − 30 μ M) inhibited the constitutive P-STAT3 activity levels induced by the expressed IL-6 and GP130.
Axitinib and PF2341066(Crizotinib) Reviews
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数据来源 Eur J Cancer 2014, 50(7), 1310-20. Forskolin purchased from Selleck
方法 cAMP measurement
细胞系 HBL, HBL-R, LND1, MM098 cells
浓度 10 uM
处理时间 30 min
结果 Phosphodiesterase inhibitor (IBMX) or the adenyl cyclase stimulator (FSK) caused a significant increase in all linesexcept in one, MM098, suggesting a defective cAMP signalling in the latter line.
Axitinib and PF2341066(Crizotinib) Reviews
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数据来源 Br J Cancer 2014, 111(6), 1168-79. LDE225 (NVP-LDE225,Erismodegib) purchased from Selleck
方法 Western blot
细胞系 786-O, 786-P, 786-O SuR cells
浓度 0-5 uM
处理时间 24 h
结果 Western blot revealed that NVP-LDE225 at a concentration of 5 mM not only moderately reduced Gli-1 expression by B60%, but also moderately inhibited the activity of two well-known transducers of cell proliferation and survival, Akt and MAPK, by B40%. Moreover, Gli-2 expression decreased by NVP-LDE225 in a concentration-dependent manner.
Axitinib and PF2341066(Crizotinib) Reviews
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数据来源 J Biol Chem 2014, 289(42), 28835-45. NPS-2143 purchased from Selleck
方法 Peroxy-Orange 1
细胞系 MPEK-BL6 cells
浓度 1 uM
处理时间 30 min
结果 The pretreatment of epidermal keratinocytes with NPS2143, a non-competitive antagonist of GPRC6A, resulted in significantly reduced testosterone-induced H2O2 generation.

Selleck产品在文献中的引用 (32)

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