天然产物

早在高通量筛选和基因组学时代来临之前,天然化合物是药物发现最主要的灵感源泉。事实上,目前许多仍在使用的药物也含有天然产物的活性成份。回顾1994年以来的新药诞生过程,几乎一半的药物是基于天然产物研发出来的。而在2005至2007年这段时间内,共有13个从天然产物中开发的新药进入市场。其中包括以下五种新产品:小分子药物伊沙匹隆(Ixabepilone)、Retapamulin和曲贝替定(Trabectedin)以及蛋白药物Exenatide和齐考诺肽(Ziconotide)。可以预见,从天然产物中寻找和发现新型的临床治疗药物在生物制药领域依然充满前景。

作为科研用化合物产品和服务的优秀供应商,我们为客户提供全面丰富的天然产物产品。Selleck产品结构完善包含来自多种植物、海洋生物和微生物的天然化学产物。在官方网站selleck.cn上,您可以获得最广泛的、高品质的和有价格优势的产品。

天然产物库
目录号 产品目录 产品描述
S2387 Lappaconite HBr Lappaconite HBr是从Aconitum sinomontanum Nakai 提取的一种生物碱,具有抗炎作用。
S3068 Guanosine Hydrate Guanosine Hydrate在多种生化过程中具有重要作用,包括核酸和蛋白质合成,光合作用,肌肉收缩以及细胞内信号传导(cGMP)。
S2253 3-Indolebutyric acid (IBA) 3-Indolebutyric acid(IBA)是一种植物激素,用于使许多商业植物生根园艺产品。
S2424 Hypoxanthine Hypoxanthine是天然存在的嘌呤类衍生物,是尿酸合成的中间产物,由腺嘌呤核苷酸代谢而来,为黄嘌呤前体。
S2442 Inosine Inosine是一种核苷,由次黄嘌呤通过β-N9-糖苷键结合到核糖环上形成。
S2382 Evodiamine Evodiamine 是Evodiae Fructus中提取的一种生物碱。它能通过抑制IkB kinase活性抑制NF-kB的激活。
S2386 Indirubin Indirubin是一种有效的细胞周期依赖性激酶和GSK-3β抑制剂,IC50约为 5 μM和0.6 μM。
S2267 Azomycin Azomycin是Nocardia mesenterica产生的抗生素。
S2271 Berberine chloride Berberine chloride是异喹啉类生物碱的季铵盐。
S2282 Cinchonidine Cinchonidine是一种生物碱,在有机化学中用于不对称合成。
S2423 (S)-10-Hydroxycamptothecin (S)-10-Hydroxycamptothecin是DNA拓扑异构酶I抑制剂,具有有效的抗肿瘤活性。
S2437 Rotundine Rotundine是一种选择性多巴胺D1受体拮抗剂, IC50为166 nM。
S2287 Cytisine Cytisine是一种烟碱型乙酰胆碱受体激动剂。
S2385 Hordenine Hordenine是一种苯乙胺生物碱 具有抗菌特性。
S1973 Cyclocytidine HCl Cyclocytidine HCl 是Cytarabine的前体药物,是一种嘧啶核苷类似物,抑制DNA synthesis,主要用于治疗白血病。
S2397 Palmatine chloride Palmatine chloride 是Palmatine的盐酸盐,是一种小檗碱类生物碱。
S2402 Cyclovirobuxin D Cyclovirobuxin D 是从Buxus microphylla中提取的活性化合物,用于治疗急性心肌缺血。
S2304 Gramine Gramine是在一些植物物种中天然存在的吲哚类生物碱。
S2403 Tetrandrine Tetrandrine是来源于千金藤根部的一种双苯基异喹啉,一种钙离子通道抑制剂。
S2405 Sophocarpine Sophocarpine 是人类ether-à-go-go相关基因(HERG)抑制剂,IC(50)为0.2 mM。
S2313 Indole-3-carbinol Indole-3-carbinol是通过降解硫代葡萄糖酸盐芸苔葡萄糖硫苷而来的,广泛存在于十字花科蔬菜中。它能够抑制NF-κBIκBα激酶的激活。
S2316 Kinetin Kinetin是一种细胞分裂素,是一类植物激素,促进细胞分裂。通常用于植物组织培养,诱导愈伤组织形成(与生长素联用),且诱导再生芽的发生。
S2322 (+)-Matrine (+)-Matrine是一种在植物Sophora属中发现的生物碱,具有多种药理作用,包括抗癌作用,是κ阿片受体激动剂。
S2439 Guanosine Guanosine是一种嘌呤核苷。
S2336 Orotic acid (6-Carboxyuracil) Orotic acid (6-Carboxyuracil) 是杂环化合物,是一种酸。
S2338 Oxymatrine Oxymatrine是一种从Sophora flavescens的根部分离的喹唑啉生物碱,具有抗炎症、抗纤维化、抗肿瘤活性,抑制iNOS表达和TGF-β/Smad通路。被用于治疗病毒性肝炎、癌症、病毒性心肌炎、胃肠出血和皮肤疾病。
S2344 Piperine Piperine是一种生物碱,是造成黑胡椒和长胡椒辛辣的原因,也用于一些传统医学领域,且作为杀虫剂。
S2349 Rutaecarpine Rutaecarpine是从 Evodia rutaecarpa和相关草药中分离的indolopyridoquinazolinone生物碱。是一种新型的COX2抑制剂。
S3190 N6-methyladenosine (m6A) N6-methyladenosine (m6A)是碱基修饰的腺苷类似物,在天然RNAs中作为稀有核苷。N6-methyladenosine(m6A)是mRNA的第五种碱基。
S2359 Sinomenine Sinomenine 是一种传统中草药,用于治疗风湿病和关节炎。
S2367 Tetrahydropapaverine HCl Tetrahydropapaverine HCl 是TIQs的一种,是Salsolinol 和 Tetrahydropapaveroline的类似物,对多巴胺神经元具有神经毒性作用。
S2368 Theobromine Theobromine 是黄嘌呤生物碱,作为一种支气管扩张剂,血管扩张剂。
S2373 Yohimbine HCl Yohimbine HCl 是一种瞳孔放大剂,用于治疗阳痿,也是一种春药。
目录号 产品目录 产品描述
S2295 Emodin Emodin 是Rhubarb, Buckthorn 和 Japanese Knotweed (Fallopia japonica)中的一种泻药树脂,是6-甲基-1,3,8-三羟蒽醌.
S4033 Sennoside A Sennoside A,一种从大黄根茎中分离得到的刺激性泻药,在肠道中引起通便作用。
S4018 Sennoside B Sennoside B,一种从大黄根茎中分离得到的刺激性泻药,抑制PDGF刺激的细胞增殖。
S2375 Aloin Aloin是有效的酪氨酸酶抑制剂,作用于HeLaS3细胞,IC50为97 μM。
S2259 Aloe-emodin Aloe-emodin是一种干扰素诱导剂,作用于JEV,IC50为1 μg/mL,作用于EV71,IC50为0.33 μg/mL。
S2395 Rheochrysidin Rheochrysidin 是大承气汤的主要成分之一,用于治疗炎症。
S2400 Rheic Acid Rheic Acid 是Rhubarb的组成部分,是从Rheum coreanum Nakai新鲜根茎分离得到的。
S2406 Chrysophanic Acid Chrysophanic Acid是Dianella longifolia中的一种天然蒽醌,是一种EGFR/mTOR通道抑制剂。
目录号 产品目录 产品描述
S2369 Troxerutin Troxerutin 是一种黄酮醇类,是一种黄酮类化合物。
S2320 Luteolin Luteolin是一种非选择性的PDE抑制剂,作用于PDE1-5Ki分别为15.0 μM, 6.4 μM, 13.9 μM, 11.1 μM和9.5 μM。Phase 2.
S8036 Butein Butein,一种从漆树中分离的植物多酚,可以抑制酪氨酸激酶NF-κBSTAT3EGFR活化。
S2377 Biochanin A Biochanin A 是O-甲基异黄酮,是黄酮类的一种天然有机化合物。
S2380 Diosmetin Diosmetin 是在Spearmint, Oregano, 和许多其他植物中发现的生物类黄酮。
S2262 Apigenin Apigenin是一种有效的CYP2C9抑制剂,Ki为2 μM.。
S2268 Baicalein Baicalein是CYP2C9和脯氨酰肽链内切酶抑制剂。
S2269 Baicalin Baicalin 是一种脯氨酰肽链内切酶抑制剂,影响GABA受体。
S2389 Naringin Dihydrochalcone Naringin Dihydrochalcone 是一种新型甜味剂,是来自柚皮苷的一种人工甜味剂。也是一种CYP enzymes的抑制剂。
S2270 Bergenin Bergenin是三羟基酸苷和4-O-甲基没食子酸的C-苷。
S2391 Quercetin Quercetin是蔬菜水果和白酒中的天然黄酮类化合物,是一种体外重组Sirt1蛋白的激活剂同时也是PI3K抑制剂,IC50为2.4 – 5.4 μM。
S2281 Chrysin Chrysin 是一种天然存在的Flavone,是由Passiflora caerulea花化学提取而来的。
S2422 Ipriflavone (Osteofix) Ipriflavone (Osteofix)是小分子物质,用于抑制骨吸收。
S2289 Daidzin Daidzin,一种植物天然有机化合物,也是一种异黄酮,是有效的、选择性的人类线粒体醛脱氢酶抑制剂,选择性抑制ALDH-I(Ki=20 nM);而对ALDH-Ⅱ的效力至少低500倍(Ki=10 μM)。
S2394 Naringenin Naringenin是来自于食用植物的一种天然的主要黄酮类化合物,有益人体健康,具有生物活性,是一种抗氧化剂,自由基清除剂,抗炎,碳水化合物代谢启动子及免疫系统的调制剂。
S2292 Diosmin Diosmin 是一种半合成的Phlebotropic药,属于黄酮类。
S2298 Fisetin Fisetin 是有效的Sirtuin活化化合物(STAC),可以调节Sirtuin
S2299 Formononetin Formononetin是Astragalus根部的一种植物雌激素,是O-甲基异黄酮。
S2399 Dihydromyricetin Dihydromyricetin 是具有良好性能的天然抗氧化剂。
S2308 Hesperetin Hesperetin是一种生物类黄酮,更具体而言,是一种二氢黄酮。
S2309 Hesperidin Hesperidin是在柑橘类水果中广泛存在的黄酮苷。
S2404 Isoliquiritigenin Isoliquiritigenin 是Glycyrrhiza glabra根系分泌的一种类黄酮,能抑制醛糖还原酶,IC50为320 nM。具有抗肿瘤活性。
S2312 Icariin Icariin是一种cGMP特异性的PDE5抑制剂,IC50为0.432 μM,作用于PDE5比作用于PDE4选择性高167倍。
S2314 Kaempferol Kaempferol是一种黄酮,是ERRαERRγ的反向激动剂。抑制topoisomerase I催化的DNA再连接和fatty acid synthase的活性。
S2332 Neohesperidin Neohesperidin 是一种抗氧化剂,在1,1-diphenyl-2-picryldydrazyl(DPPH)自由基清除测定中,IC50为22.31 μg/ml。
S2323 Methyl-Hesperidin Methyl-Hesperidin 是一种在柑橘类水果中广泛存在的黄酮苷(黄酮)(C28H34O15),其苷元形式被称为橙皮素。
S2325 Morin Hydrate Morin Hydrate是一种化学化合物,用来检测溶液中的铝或锡的存在,因为Morin hydrate(Aurantica)与铝或锡可以形成特有的荧光配位络合物。
S2326 Myricetin Myricetin, 一种具有抗氧化和抗肿瘤活性的天然黄酮,是新型的MEK1抑制剂,抑制JB6 P+小鼠表皮细胞的转化。它还能抑制PI3Kγ,Kd=0.17 μM。
S2327 Myricitrin Myricitrin是一种化学化合物,可从Myrica cerifera (Bayberry属, 小乔木,原产于北美)的根皮中分离得到。
S2329 Naringin Naringin 是一种黄酮苷,是葡萄柚中的主要的类黄酮,具有柚子汁的苦味。具有抗氧化,降血脂,抗肿瘤活性,并且对cytochrome P450有抑制作用。
S2331 Neohesperidin Dihydrochalcone (Nhdc) Neohesperidin dihydrochalcone(Nhdc) 是源于柑橘类的一种人造甜味剂。
S2333 Nobiletin Nobiletin 是O-甲基黄酮,是从柑橘果皮如橘子分离的一种黄酮类化合物。具有抗炎和抗肿瘤活性。
S2342 Phloretin Phloretin 是一种二氢查尔酮,含有多元酚。
S2343 Phlorizin Phlorizin 是有毒的2'-葡萄糖苷根皮素,属于二氢查尔酮,是一种黄酮类化合物。
S2346 Puerarin Puerarin 是一种5-HT2C受体和苯二氮位点拮抗剂。
S2347 Quercetin Dihydrate Quercetin Dihydrate是一种广泛分布于植物的黄酮类,是一种抗氧化剂,与许多其他酚类杂环化合物类似。
S2350 Rutin Rutin是在许多植物中发现的一种黄酮苷,包括Buckwheat; Tobacco; Forsythia; Hydrangea; Viola, 等。
S2357 Silibinin Silibinin 是Silymarin的主要活性成分。
S2358 Silymarin Silymarin是一种强效的新型自由基清除剂,用于治疗急性脑梗死患者。
S2363 Tangeretin Tangeretin 是一种柑橘类黄酮。
S2366 Taxifolin (Dihydroquercetin) Taxifolin(Dihydroquercetin)是一种二氢黄酮醇类,是一种黄酮类化合物。是I型VEGFR2 kinase的抑制剂。
目录号 产品目录 产品描述
S2383 Gastrodin Gastrodin是一种多元酚,是4-羟基苄醇的葡糖苷。
S2250 (-)-Epigallocatechin Gallate (-)-Epigallocatechin Gallate是从绿茶中分离的一种有效的抗氧化剂Polyphenol flavonoid。抑制telomeraseDNA methyltransferase, 阻滞EGF受体HER-2受体的激活,抑制脂肪酸合成酶以及谷氨酸脱氢酶的活性。
S3071 Vanillin Vanillin,香草醛,是一种食品添加剂。
S2263 Arbutin Arbutin是一种酪氨酸酶抑制剂,IC50为1.09 mM。
S2390 Polydatin Polydatin, 3,4’,5-trihydroxystilbene-3-β-mono-D-glucoside, 是从多年生草本Polygonum Cuspidatum Sieb.et Zucc的根茎提取的一种结晶组分。
S2425 Apocynin Apocynin是一种选择性NADPH氧化酶抑制剂,IC50 为10 μM.
S2396 Salidroside Salidroside 是一种糖苷类化合物,作用于SACC-2细胞增殖,IC50为4.99±0.23 μg/mL。
S2303 gossypol-Acetic acid Gossypol Acetate 是多酚醛,可渗透细胞,是一些脱氢酶(如乳酸脱氢酶、NAD-linked enzymes)的抑制剂。
S2339 Paeonol Paeonol是从中草药牡丹皮和Cynanchum paniculatum中提取的主要成分。
S2351 Salicin Salicin是一种醇-β-糖苷,含有D-葡萄糖。是柳树皮产生的一种抗炎剂。它是一种天然的、非选择性的COX1COX2抑制剂。
S2356 Shikimic Acid Shikimic Acid通常所知的是其阴离子形式Shikimate,在植物和微生物中,是一种重要的生化中间体。
S2362 Synephrine Synephrine是从苦橘及其他柑橘属植物中提取的一种不饱和的植物甾醇,常用于减肥。
S2371 Vanillylacetone Vanillylacetone在化学结构上与其他香料,如Vanillin 和 Eugenol类似,用来作为一种香味味添加剂。
目录号 产品目录 产品描述
S3880 Schisantherin A Schisantherin A,也被称作Gomisin C,是一种五味子红素,具有止咳、镇静、消炎、抗骨质疏松、神经保护、增强认知和心脏保护活性。
S3882 Brassinolide Brassinolide是来源于Brassica napus pollen的植物类脂醇,可促进细胞延长、细胞分裂,从而调节植物生长和发育。
S3776 Sophoricoside Sophoricoside (SOPH)是一种分离自槐花(豆科)的异黄酮,具有多种药理作用,如消炎、抗癌、抑制免疫力等效应。
S5249 Coptisine chloride Coptisine是一种分离自黄连的吲哚联啶生物碱,具有抗糖尿病、抗菌、抗病毒、抗肝癌和抗白血病效应。
S5220 D-Pantethine Pantethine是一种天然产物,在体内由泛酸(维生素B5)通过半胱胺的加入合成,被用作一种食品添加剂,降低血胆固醇和三酸甘油脂。
S5151 Gypenoside Gypenoside (GP)是绞股蓝中的主要有效成分,具有消炎和抗氧化活性。
S3814 Tubeimoside I Tubeimoside I (TBMS1), a triterpenoid saponin, isolated from the tubers of Bolbostemma paniculatum, shows potent antitumor and antitumor-promoting effects.
S3790 Methyl gallate Methyl Gallate is a plant polyphenol with antioxidant, anticancer, and anti-inflammatory activities.
S5090 4-Isopropylbenzyl Alcohol 4-Isopropylbenzyl Alcohol,分离自赤桉,是一种具有杀虫作用的化合物。
S5091 Geranyl acetate Geranyl acetate是一种天然有机化合物,主要用作面霜和肥皂的香料或是调味成分。
S5083 Lentinan Lentinan,分离纯化自香菇子实体水煮提取物,是一种真菌多糖免疫调制剂,具有抗肿瘤活性。
S5089 4-Isopropylbenzaldehyde Cuminaldehyde (4-Isopropylbenzaldehyde),一种天然有机化合物,是一种药物中间体,具有宜人的香味,有助于香精油中的香气。
S5086 p-Anisaldehyde p-Anisaldehyde (4-methoxybenzaldehyde),茴芹种子提取物,具有抗真菌活性,对很多酵母和实验室培养基、果泥和果汁中的霉菌菌株具有活性。
S3843 Madecassoside Madecassoside是积雪草草药的主要活性三萜烯成分,积雪草是一种传统中药,用于治疗创伤修复和疤痕管理。
S4937 4'-Hydroxychalcone 4'-Hydroxychalcone,存在于草药、香料和茶叶中,是一种刺甘草查尔酮。它具有多种生物活性,能够抑制TNF-α诱导的NF-κB通路激活、并激活BMP信号通路。
S4972 Choline Glycerophosphate Choline Glycerophosphate是胆碱衍生物,是胞浆中两种主要的胆碱储存形式之一。
S3879 kaempferide Kaempferide是一种从山柰根中提取的天然产物,具有多种生物活性,包括抗癌、抗炎、抗氧化、抗菌抗病毒等活性。
S4981 Cyclogalegenol Cyclogalegenol是astragaloside A的糖苷配基衍生物,存在于多种紫云英属物种中,可能可激活端粒酶
S4982 2,2':5',2''-Terthiophene 2,2':5',2''-Terthiophene是来源于金盏花的天然产物,具有受紫外线增强的抗菌活性。
S4983 Sorbic acid  
S5049 Thiocolchicoside Thiocolchicoside是一种天然存在的配糖体,来源于嘉兰百合的花种中,具有抗炎和止痛活性,同时具有显著的惊厥作用。它也是GABAA receptor的拮抗剂。
S3983 Caryophyllene oxide Caryophyllene oxide是存在于多种植物精油中的氧化萜类化合物,在食物、药物和化妆品中被用作防腐剂,具有消炎、抗癌和增强皮肤渗透活性。
S3654 Tauroursodeoxycholic Acid (TUDCA) Tauroursodeoxycholic acid (TUDCA)是乌索脱氧胆酸的牛磺酸共轭产物,在多种神经退行性疾病,如阿尔茨海默病、帕金森疾病和亨廷顿疾病中,可作为线粒体稳定剂和抗凋亡试剂。
S8279 Shikonin Shikonin,是一种Pyruvate kinase M2 (PKM2)有效的、特异的抑制剂。它是紫草的主要成分,紫草是一种中草药,具有多种生物活性。在细胞荧光淬灭试验中,Shikonin也是TMEM16A氯离子通道的抑制剂。
S3822 Schisandrin A Schisandrin A (Sch A) is an active component of Schisandrae Fructus with liver-protective, antitumor, and antioxidant activities. It is an agonist of the adiponectin receptor 2 (AdipoR2) with the IC50 value of 3.5 μM.
S4738 Arctiin Arctiin是脂联素受体1的激动剂,具有抗肿瘤活性。
S3807 Dehydroandrographolide Dehydroandrographolide, isolated from Andrographis paniculata (Burm. F.) Nees (Chuan-xin-lian), is a novel TMEM16A inhibitor and possesses multiple pharmacological activities, including anti-inflammation, anti-cancer, anti-bacterial, anti-virus and anti-hepatitis activity.
S8132 Deguelin Deguelin,一种从植物中分离出来的天然产物,是PI3K/Akt的抑制剂。
S3942 Cardamonin Cardamonin天然存在于良姜属物种的果实中,具有抗炎和抗肿瘤活性。它是一种新型的hTRPA1离子通道拮抗剂,IC50为454 nM,而不与TRPV1和TRPV4相互作用。
S5157 Thymol Thymol, a naturally occurring monocyclic phenolic compound derived from Thymus vulgaris (Lamiaceae), has been reported to exhibit anti-inflammatory property in vivo and vitro.
S3824 Quercitrin Quercitrin (3-rhamnosyl quercetin), a glycoside of quercetin, has been found as a main bioactive constituent in T. sinensis leaves and has antioxidant, anti-inflammatory, and anti-allergic activities.
S4959 Skatole Skatole (3-Methylindole)是一种具有轻度毒性的白色结晶有机化合物,天然存在于排泄物中,具有相当广泛的抑菌作用。
S4966 4-Methylesculetin 4-methylesculetin是香豆素衍生物,具有强大的抗氧化和抗炎活性。
S3761 Eucalyptol Eucalyptol is a natural organic compound which controls airway mucus hypersecretion and asthma via anti-inflammatory cytokine inhibition.
S3681 Vitamin E Acetate Vitamin E Acetate is the stable form of Vitamin E most often used in cosmetic formulations for its skin care benefits. It protects the cells against free radicals and prevents the peroxidation of body fats as an in-vivo antioxidant.
S3860 Allicin Allicin, the main biologically active component of the freshly crushed garlic extracts, possesses various biological activities including antibacterial, antifungal and antiparasitic effects.
S3980 Pyridoxine Pyridoxine, also known as vitamin B6, is a form of vitamin B6 found commonly in food and used as dietary supplement. It is a cofactor for both glutamic acid decarboxylase and GABA transaminase.
S3910 4',7-Dimethoxyisoflavone 4',7-Dimethoxyisoflavone, isolated from the leaves of Albizzia lebbeck, shows antifungal activity in vitro.
S4811 VitaMin U Vitamin U (Methylmethionine chloride) is a vitamin found in green vegetables. It is used in the treatment of peptic ulcers, colitis, and gastritis and has an effect on secretory, acid-forming, and enzymatic functions of the intestinal tract.
S3832 Euphorbiasteroid Euphorbiasteroid是Euphorbia lathyris L.的成分之一,通过激活AMPK信号通路抑制3T3-L1细胞的脂肪形成,并通过促进Bcl-2/Bax信号通路诱导HL-60细胞凋亡。
S4893 Cytosine Cytosine是存在于DNA和RNA中的四种主要碱基中的一种,被细胞用于储存和传输遗传信息。
S4958 Glycocholic acid Glycocholic acid是一种天然的次级胆汁酸,参与脂肪的乳化。
S4820 Diastase Diastase是天然存在的、可催化淀粉分解为麦芽糖的酶。
S4963 Purpurin Purpurin是从茜草根和其他茜草科植物家族中分离出的天然色素。它具有抗血管生成、抗菌、抗氧化活性。
S4968 Cholesteryl Acetate Cholesteryl Acetate,天然存在于不同液体、器官和食物中,是一种正常的人类胆甾醇酯。
S4830 Maltose Maltose,一种能够提供能量的非必需营养物,是糖原和淀粉的肠道消化过程中的中间产物,存在于发芽的谷物或其他植物、蔬菜中。
S4954 Djenkolic Acid Djenkolic Acid is a naturally occurring sulfur-containing amino acid extracted from djenkol beans. It is toxic to humans, often causing kidney failure.
S4884 Trans-Zeatin Trans-Zeatina是植物生长激素的成员之一,属于细胞分裂素,可调节细胞分裂、发育和营养加工。
S4828 Sodium carbonate Sodium Carbonate是碳酸的二钠盐形式,具有碱化特性。
S4938 Cedrol Cedrol是一种天然存在的倍半萜烯醇,是有效的、竞争性的抑制剂,抑制CYP2B6介导的安非他酮羟化酶(bupropion hydroxylase),Ki值为0.9 μM。它还能抑制CYP3A4介导的咪达唑仑羟基化,Ki为3.4 μM。对CYP2C8, CYP2C9和CYP2C19的活性仅有微弱的抑制作用。
S4939 cis-Aconitic acid Cis-Aconitic acid是三羧酸循环中的中间产物,由柠檬酸脱水形成。
S4946 2,3-Dihydroxybenzoic acid 2,3-Dihydroxybenzoic acid是一种天然酚类,存在于西印度醋栗和水生蕨类Salvinia molesta,也是人体中阿司匹林的代谢产物。它是一种潜在的铁螯合药物,具有抗菌特性。
S4962 Agmatine sulfate Agmatine sulfate是精氨酸的活性代谢产物,能够提高一氧化氮水平、减少血糖水平并提高生长激素水平。
S4969 Tropine Tropine是一种天然存在的莨菪烷生物碱,是多种具有生物活性的生物碱合成的中间体,这些生物碱大多具有有效的神经学作用。
S4940 Maltol Maltol是一种天然有机化合物,可作为香味增强剂和调味剂。
S4859 TriacetonaMine TriacetonaMine,作为一种哌啶酮(Piperidinone),是一种具有极弱酸性的化合物,存在于绿色植物和茶中。
S4863 4-Hydroxyphenylacetic acid 4-Hydroxyphenylacetic acid是一种存在于橄榄油和啤酒中的化合物,作为一种化学中间体用于合成阿替洛尔(atenolol)和3,4-dihydroxyphenylacetic acid。
S4864 2-Furoic acid 2-Furoic acid是一种广泛用于食品生产的有机化合物,作为防腐剂和增味剂。
S4949 Nonanoic acid Nonanoic acid是一种天然存在于蔬菜和动物脂肪中的脂肪酸。
S4862 Squalene Squalene,自然存在于植物、动物和人体中,是一种添加在疫苗中佐剂,用于增强免疫反应。
S4943 Isovanillin Isovanillin是醛脱氢酶(aldehyde oxidase)的可逆性抑制剂。它被广泛用作药物中间体,应用于食物和饮料行业、化学合成香料和化学分析领域。
S4951 L-Threonine L-Threonine是一种必需氨基酸,处于活化形式。它对于胶原蛋白、弹性蛋白和牙釉质的形成十分重要,连同天冬氨酸、甲硫氨酸一起发挥滋养肝脏、抗脂肪肝的作用。
S4952 Fumaric acid Fumaric acid是三羧酸循环中的中间产物。细胞利用三羧酸循环从食物中产生能量(ATP形式)。Fumaric acid还是尿素循环的产物。
S4953 Usnic acid Usnic acid是存在于lichen(地衣)中的一种呋喃二酮,广泛应用于化妆品、除臭剂、牙膏和药用霜、中草药成品中。它具有抗病毒、抗原生动物、抗增殖和抗炎、止痛活性。
S4960 Jasmone Jasmone是一种天然有机化合物,分离自茉莉花油的挥发成分。
S4957 Linalool Linalool是一些芳香剂中的香精油的主要成分。它是NMDA receptors的竞争性拮抗剂。
S4941 Farnesol Farnesol是一种天然的倍半萜烯醇,有效地治疗抗代谢障碍、具有抗炎、抗氧化、抗肿瘤和抗菌活性。
S3867 (E)-Cardamoni Cardamonin is a naturally occurring chalcone with strong anti-inflammatory activity. It is a novel TRPA1 antagonist with IC50 of 454 nM and also a NF-kB inhibitor.
S3687 E-Cardamoni Urea是一种溶解度高的有机化合物,源自肝脏中由氨基酸脱氨基作用形成的氨。它是蛋白质分解代谢中的主要最终产物。
S3818 Tectoridin Tectoridin, an isoflavone isolated from flowers of Pueraria thunbergiana, has several pharmacological effects including anti-cancer, anti-inflammatory, antioxidant, and hepatoprotectivy.
S4827 Manganese chloride Manganese chloride在自然界中以矿物质形式存在。它常被用作其他锰化合物的合成前体。
S3756 Methyl salicylate Methyl salicylate is an organic ester naturally produced by many species of plants, particularly wintergreens. It is an agonist for TRPA1 and TRPV1.
S3998 (+)-α-Lipoic acid R(+)-α-lipoic acid是thioctic acid的生理形式之一,是一种强效的抗氧化剂,可减轻糖尿病神经性症状。它比其外消旋体具有更优越的抗氧化性。
S3991 Ketoisophorone Ketoisophorone, also known as 4-Oxoisophorone, is the major component of saffron spice.
S3992 D-(+)-Trehalose dihydrate Trehalose是一种非还原糖,提高植物和动物对脱水的抵抗力。
S3993 Ethyl Vanillate Ethyl vanillin, a vanillin analog, is a flavouring agent that exhibits strong antioxidant activity.
S3994 Methyl Cholate Methyl Cholate is methyl ester form of Cholic acid that is a primary bile acid mainly produced by the liver.
S3995 Guaiazulene Guaiazulene是一种双环倍半萜烯,是一些精油的组成成分。
S3996 Thioctic acid Thioctic acid (DL-α-Lipoic acid)是环状二硫抗氧化剂,可与其还原性二硫酚形式相互转换。
S3986 L(+)-Arabinose  
S3987 L-Tryptophan L-tryprophan是必需氨基酸,是一种天然的情绪调节剂,为婴幼儿正常生长、成人氮平衡所必需。
S3989 L-Hisidine L-Hisidine是一种α-氨基酸,是人类生长和组织修复所必需,被用于蛋白质的生物合成。
S3990 Trans-Anethole Trans-anethole是苯丙烯衍生物,存在于多种香精油、包括茴香油中。它具有神经调节、抗焦虑、抗氧化、抗真菌、抗炎症和免疫调节活性。
S4603 Gallic acid Gallic acid是一种在多种食物和草药中发现的有机酸,是有效的抗氧化剂。
S3959 (+)-Borneol (+)-Borneol is one of enantiomers of borneol which is a valuable medical material, senior aromatic spice, and chemical material and has been used in food and also folk medicine.
S3821 Nuciferine Nuciferine is a major active aporphine alkaloid from the leaves of N. nucifera Gaertn and possesses anti-hyperlipidemia, anti-hypotensive, anti-arrhythmic, and insulin secretagogue activities.
S3823 Schizandrol A Schizandrol A is one of the effective components in the dried fruit of Schizandra chinensis Bail and works by increasing dopamine, a neurotransmitter, in the brain.
S3841 Eleutheroside B Eleutheroside B (syringin) is a phenylpropanoid glycoside first isolated from A. senticosus and has neuroprotective, tonic, adaptogenic, and immune-modulating properties.
S3845 Panaxadiol Panaxadiol is a triterpene sapogenin originally found in species of Panax (ginseng) and exhibits anticancer, cardioprotective, anti-arrhythmic, and antioxidative activities. It inhibits Ca2+ channels, decreasing channel open time and open state probability in vitro and displaying anti-arrhythmic potential.
S3847 Panaxatriol Panaxatriol is a triterpene sapogenin originally found in species of Panax (ginseng) and exhibits anti-inflammatory, hepatoprotective, anti-arrhythmic, and antioxidative activities.
S3848 Hydroxytyrosol Acetate Hydroxytyrosol acetate (HTy-Ac), an extra virgin olive oil (EVOO) polyphenol, exhibits antioxidant and anti-inflammatory effects.
S3973 L-SelenoMethionine L-SelenoMethionine (SeMet), a naturally occurring amino acid, is a major food-form of selenium. It has been used as a supplement, and exhibits some important functions like cancer prevention and antioxidative defense.
S3778 Patchouli alcohol Patchouli alcohol, an ingredient in pogostemonis herba, has various pharmacological activities and acts as an inhibitor of asexual fungal propagation, inflammation, the influenza virus, and tumorigenesis.
S3912 Cephalotaxine Cephalotaxine is a naturally occurring alkaloid which is the structural motif of a number of compounds and has shown promising anti-cancer properties.
S3930 Liquiritin Liquiritin (LIQ) is a main component among the licorice flavonoids, and possesses anti-inflammatory and anti-cancer abilities.
S3754 4-Hydroxybenzoic acid 4-Hydroxybenzoic acid, also known as p-hydroxybenzoic acid (PHBA), is a phenolic derivative of benzoic acid and widely used in organic synthesis. It is the most widely distributed aromatic organic acid in the vegetable kingdom.
S3893 Bornyl acetate Bornyl acetate, the main volatile constituent in numerous conifer oils and some Chinese traditional herbs, exhibits anti-inflammatory property and it is used as an analgesic.
S3755 Betaine Betaine, a methyl derivative of glycine first isolated from sugar beets, has been shown to have potential benefits for fighting heart disease, improving body composition, and helping promote muscle gain and fat loss because of its abilities to promote protein synthesis in the body.
S4758 Crocin Crocin是藏红花中的一种水溶性类胡萝卜色素,被用于调味品和着色食品中的香料。在传统中药中,被用作止痛剂或镇定剂。
S3767 10,11-Dimethoxystrychnine 10,11-Dimethoxystrychnine (Brucine) is the major active pharmacological component of Strychnos nuxvomica seeds with anti-inflammatory and analgesic activities.
S3874 Curcumenol Curcumenol, a sesquiterpene isolated from Curcuma zedoaria, is known to possess a variety of health and medicinal values which includes neuroprotection, anti-inflammatory, anti-tumor and hepatoprotective activities. It inhibits NF-κB activation by suppressing the nuclear translocation of the NF-κB p65 subunit and blocking IκBα phosphorylation and degradation.
S3877 Lysionotin Lysionotin is a natural flavonoid predominantly found in fewflower lysionotus herbs and possesses many pharmacological properties, such as antibacterial, anti-inflammatory, antihypertensive, and free radical scavenging activities.
S3809 Imperatorin Imperatorin, a naturally occurring psoralen-type furanocoumarin, is a potent myorelaxant agent and acts as a calcium antagonist on vascular smooth muscle.
S3892 Isopsoralen Isopsoralen, also known as angelicin, is a constituent of roots and leaves of angelica with anti-inflammatory activity and regulates LPS-induced inflammation via inhibiting MAPK/NF-κB pathways. It also shows antiviral activity against gammaherpesviruses.
S3895 Sophoridine Sophoridine, a natural product obtained from medicinal plants, has a variety of pharmacological effects, including anti-cancer and anti-arrhythmia, and affects the immune and central nervous systems.
S3902 Ursonic acid Ursonic acid, present in many plants, is a pentacyclic triterpenoid that can be used as a cosmetics additive and serve as a starting material for synthesis of more potent bioactive derivatives, such as experimental antitumor agents.
S3870 D-Pinitol D-pinitol is a naturally occurring compound derived from soy and has significant pharmacological activitites such as inhibition of the T-helpercell-1 response, antiviral, larvicidal, antiinflammatory, antihyperlipidemic, cardioprotective, inhibition of ovalbumin-induced airway inflammation and antioxidant.
S3908 4'-Demethylpodophyllotoxin 4'-Demethylpodophyllotoxin is isolated from the herb of Dysosma pleiantha (Hance) Woodson with remarkable cytotoxic potential in diverse cancer cell lines.
S3938 Bisdemethoxycurcumin (BDMC) Bisdemethoxycurcumin (BDMC)是一种天然纯在的姜黄素去甲氧基衍生物,具有多种生物活性,如消炎和抗癌活性。
S3796 Rebaudioside A Rebaudioside A (Stevia Extract), an natural sweetening ingredient extracted from the stevia leaf, is used in powder or liquid form to heighten sweetening intensity and improve taste.
S3890 Leonurine Leonurine, an active alkaloid extracted from Traditional Chinese Medicine Herba leonuri, exerts several biological effects, such as antidiabetic, cardiovascular, and bovine mastitis protection.
S3849 D-Galactose D-Galactose is an aldohexose that occurs naturally in the D-form in lactose, cerebrosides, gangliosides, and mucoproteins and is converted enzymatically into D-glucose for metabolism or polysaccharides for storage. It accelerates senescence in invertebrates and mammals and has been used as a model for aging.
S3977 (-)-Borneol (-)-Borneol, one of enantiomers of borneol, has a camphoraceous and evident woody odor.
S3774 Dehydroandrographolide Succinate Potasium Salt Dehydroandrographolide Succinate (DAS), extracted from herbal medicine Andrographis paniculata (Burm f) Nees, is widely used for the treatment of viral pneumonia and viral upper respiratory tract infections because of its immunostimulatory, anti-infective and anti-inflammatory effect.
S3868 Harmine Harmine is an alkaloid of the β-carboline family that regulates PPARγ expression through inhibition of the Wnt signaling pathway. It also selectively binds to MAO-A and reversibly inhibits monoamine oxidase A (MAO-A) but not the variant MAO-B.
S2254 4-Demethylepipodophyllotoxin(NSC-122819,VM-26) 4'-Demethylepipodophyllotoxin is an antimitotic agent which binds to monomeric tubulin, preventing micro-tubule polymerization. It is a potent inhibitor of microtubule assembly.
S3779 cis-Anethole Anethole has two isomers, the cis(Z) isomer being 15-38 times more toxic to animal than the trans(E) isomer. cis-Anethole is found in anise and Only a low level is permitted in flavours.
S3782 Neomangiferin Neomangiferin, a natural xanthone C-glycoside mainly obtained from the well-known traditional Chinese medicine rhizoma of Anemarrhena asphodeloides, exhibits antidiabetic activity and antiosteoporotic action.
S3783 Echinacoside Echinacoside, a natural polyphenolic compound, has various biological activities, such as antioxidative, anti-inflammatory, neuroprotective, hepatoprotective, nitric oxide radical-scavenging and vasodilative actions.
S3777 Gentiopicroside Gentiopicroside (GE), a naturally occurring iridoid glycoside, inhibits CYP2A6 and CYP2E1 with IC50 values of 21.8μg/ml and 594μg/ml, respectively in human liver microsomes, and dose not inhibit CYP2C9, CYP2D6, CYP1A2 or CYP3A4 activities.
S3784 Obacunone Obacunone, a natural compound present in citrus fruits, has been demonstrated for various biological activities including anti-cancer and anti-inflammatory properties. It significantly inhibits aromatase activity in an in vitro enzyme assay with an IC50 value of 28.04 μM; also a novel activator of Nrf2.
S3786 Glabridin Glabridin, one of the active phytochemicals in licorice extract, binds to and activates the ligand binding domain of PPARγ, as well as the full length receptor. It is also a GABAA receptor positive modulator promoting fatty acid oxidation and improving learning and memory.
S3787 Picroside I Picroside I, an iridoid glycoside, is a hepatoprotective agent which is reported to be antimicrobial and used against hepatitis B.
S3780 Secoisolariciresinol diglucoside Secoisolariciresinol diglucoside (SDG), a plant lignan isolated from flaxseed, has strong antioxidant activity, cardioprotective effects, reduces the blood levels of low-density lipoprotein cholesterol, and reduces the risk of hormone related cancer.
S3911 Veratramine Veratramine, a major alkaloid from Veratrum nigrum L., has distinct anti-tumor and anti-hypertension effects. It is a good membrane permeant, undergoes rapid passive diffusion, and has a good stability in the gastrointestinal tract during its absorption.
S3914 α-Hederin α-hederin is a water-soluble pentacyclic triterpenoid saponin which has shown hemolytic and apoptotic properties.
S3929 Liquiritigenin Liquiritigenin, the most active estrogenic compound from the root of Glycyrrhizae uralensis Fisch, selectively binds to ERβ with an IC50 value of 7.5 μM and activates multiple ER regulatory elements and native target genes with Erβ but not ERα.
S3932 Astilbin Astilbin, a flavonoid compound isolated from the rhizome of Smilax glabra Roxb, displays anticancer, antioxidative, anti-inflammatory, and immunosuppressive activities.
S3752 isoleucine Isoleucine is a non-polar, uncharged (at physiological pH), aliphatic amino acid that is used in the biosynthesis of proteins.
S3753 L-Leucine Leucine is one of nine essential amino acids in humans which is important for protein synthesis and many metabolic functions. It contributes to regulation of blood-sugar levels; growth and repair of muscle and bone tissue; growth hormone production; and wound healing.
S3758 Sinomenine hydrochloride Sinomenine (SN), extracted from the Chinese medicinal plant, sinomenium acutum, is a potent anti-inflammatory and neuroprotective agent.
S3760 Stachydrine hydrochloride Stachydrine is isolated from seed husk and the pulp of the fruit of C. Leonurus, and many other Asian plants and fruits. It has potent anti-metastatic activity and cardioprotective effects.
S3764 Isoferulic Acid Isoferulic acid, a major active ingredient of Cimicifuga heracleifolia, shows anti-inflammatory, antiviral, antioxidant, and antidiabetic properties.
S3757 2'-Deoxyinosine 2'-deoxyguanosine is a nucleoside consisting of the base guanine and the sugar deoxyribose.
S3766 Tanshinone IIA sulfonate (sodium) Sodium tanshinone IIA sulfonate (STS) is a water-soluble derivative of tanshinone IIA isolated as the main pharmacologically active natural compound from a traditional Chinese herbal medicine, the dried root of Salvia miltiorrhiza Bunge known as Danshen; a potent negative allosteric modulator of the human purinergic receptor P2X7.
S3769 Palmatine Palmatine, an isoquinoline alkaloid, has sedative, antidepressant, antioxidative, anti-ulcerative, antacid, anticancer, and anti-metastatic activities.
S3770 Sodium Aescinate Sodium aescinate (SA) is a widely-applied triterpene saponin product derived from horse chestnut seeds, possessing vasoactive and organ-protective activities with oral or injection administration in the clinic.
S3771 Stachydrine Stachydrine, also known as N,N-dimethylproline or proline betaine, is a quaternary ammonium derivative of proline that occurs widely in Medicago species. It is an osmoprotective compound found in urine.
S3773 Tyrosol Tyrosol is an antioxidant that is naturally present in several foods such as wines and green tea and is present most abundantly in olives.
S3775 Ligustrazine hydrochloride Tetramethylpyrazine, also known as ligustrazine, is a chemical compound found in natto and in fermented cocoa beans with anti-inflammation, antioxidant, antiplatelet, and antiapoptosis activities.
S5101 Tabersonine hydrochloride Tabersonine, an ingredient extracted from the bean of Voacanga africana, is a potent inhibitor against Aβ(1−42) aggregation and toxicity.
S2318 Lappaconitine Lappaconitine (LC) is a natural diterpenoid alkaloid (DTA), acting as a human heart sodium channel blocker and possessing a wide range of biological activities, including anti-arrhythmic, anti-inflammatory, antioxidative, anticancer, epileptiform etc.
S3788 Carvacrol Carvacrol, monoterpenic phenol isomeric with thymol, has diverse activities such as antimicrobial, antitumor, an-timutagenic, antigenotoxic, analgesic, antispasmodic, anti-inflammatory, angiogenic, antiparasitic, antiplatelet, AChE inhibitory, antielastase, insecticidal, antihepatotoxic and hepatoprotective activities.
S3956 Tetramethylpyrazine Tetramethylpyrazine (ligustrazine, TMP) is a natural compound isolated from Chinese herbal medicine Ligusticum wallichii (Chuan Xiong) with anti-inflammation, antioxidant, antiplatelet, and antiapoptosis activities.
S3763 Cinnamaldehyde Cinnamaldehyde is a flavonoid that is naturally synthesized by the shikimate pathway. Its supplementation can improve glucose and lipid homeostasis in diabetic animals; a TRPA1 agonist.
S3605 Borneol Borneol是一种分离自药用植物如艾纳香、芳味冰片香木的双环类单萜化合物。它是TRPM8的激动剂,能够增加眼部表面湿润。
S5103 lutein Lutein is a vitamin-like carotenoid produced by plants, which contributes to the colour of some fruit and vegetables. It is a lipid-soluble antioxidant that can circulate in the plasma and confer cardioprotective, anti-inflammatory, and anti-angiogenic effects.
S3943 Lycopene Lycopene is a linear, unsaturated hydrocarbon carotenoid, the major red pigment in fruits such as tomatoes, pink grapefruit, apricots, red oranges, watermelon, rosehips, and guava. It is a natural antioxidant.
S5119 Olivetol Olivetol is a naturally occurring organic compound being a precursor in various syntheses of tetrahydrocannabinol. It acts as a competitive inhibitor of the cannabinoid receptors CB1 and CB2.
S3960 Higenamine hydrochloride Higenamine, also known as Norcoclaurine HCl, is a non-selective β2 adrenoceptor agonist which is a chemical compound naturally occurring in a number of plants.
S5140 Cinene Cinene (Limonene, Dipentene) is a clear, colorless liquid hydrocarbon classified as a cyclic monoterpene, and is the major component in oil of citrus fruit peels. It is usually used to make fragrances and flavors.
S5120 Elemicin Elemicin is a constituent of the oleoresin and the essential oil of Canarium luzonicum.
S5121 Phytol Phytol, a diterpene alcohol from chlorophyll widely used as a food additive and in medicinal fields, shows antinociceptive and antioxidant activities as well as anti-inflammatory and antiallergic effects. It is a specific activator of PPARα.
S5139 Methyl Dihydrojasmonate Methyl dihydrojasmonate is a flavouring ingredien with the smell vaguely similar to jasmin.
S5138 Citral  
S2360 Solanesol (Nonaisoprenol) Solanesol is a long-chain polyisoprenoid alcohol compound with inhibitory activities toward FAK. It mainly accumulates in solanaceous crops, including tobacco, tomato, potato, eggplant, and pepper plants.
S3941 Pinocembrin Pinocembrin是制药工业中多功能黄酮类分子,它具有很多药学活性,如抗菌、消炎、抗氧化和抗癌活性。
S3981 Sinapinic Acid Sinapinic acid是一种天然存在的羟基肉桂酸,属于类苯基丙烷家族,常在MALDI mass spectrometry中用作基质(matirx)。
S3984 Nordihydroguaiaretic acid (NDGA) Nordihydroguaiaretic acid (NDGA)是一种天然存在的酚类防老剂。它是公认的脂肪氧合酶 lipoxygenase抑制剂,具有抗氧化、清除自由基的活性。
S5148 2-Methylenebutyrolactone 2-Methylenebutyrolactone,也被称作α-methylene-γ-butyrolactone (MBL) 或Tulipalin A,是一种倍半萜内酯,被认为是最常见乙烯基单体甲基丙烯酸甲酯(MMA)的环状类似物。
S5104 Tea polyphenol Tea polyphenols are chemical compounds such as flavanoids and tannins found naturally in tea. Several biological properties have been associated to tea polyphenols (TP), including antioxidant, anti-carcinogenic and antimicrobial activities.
S5149 Soybean isoflavones Soy isoflavones are phytochemicals of intense interest due to their association with a variety of health protective effects.
S5150 Phytosterols Phytosterols,也被称作植物甾醇或醇酯,存在于植物中,结构类似于人体中胆固醇。
S3939 4'-Methoxyresveratrol 4-Methoxyresveratrol is a stibenoid found in the Chinese herb Gnetum cleistostachyum.
S3940 3'-Hydroxypterostilbene 3'-Hydroxypterostilbene (3'-HPT)是苦马豆和紫檀木心中的活性成分之一,可能对治疗不同类型的恶性血液肿瘤有效。
S3614 Lupeol Lupeol是一种显著的白桦脂酸型三萜烯,存在于植物、真菌和动物中,具有抗癌、抗原生动物、化学预防、消炎作用。
S2283 Cinchonine(LA40221) Cinchonine是一种生物碱,是cinchonidine的立体异构体和假对映异构体。.
S2348 Rotenone (Barbasco) Rotenone is a botanical insecticide that is an inhibitor of mitochondrial electron transport.
S3747 Levothyroxine sodium Levothyroxine是源于甲状腺的主要激素,是甲状腺激素受体α和β的激动剂。
S3679 Flavanone Flavanones具有较强的抗氧化和清除自由基活性,可能可减少某些慢性疾病的风险、阻滞一些心血管疾病以及某些癌症。Flavanones还具有抗病毒、抗菌、消炎活性,对毛细管脆性有一定改善效果、抑制人血小板凝聚、抗溃疡、降低过敏反应。
S3675 Umbelliferone Umbelliferone is a 7-hydroxycoumarin that is a pharmacologically active agent. It is a fluorescing compound used as a sunscreen agent and shows good inhibitions of DPPH, hydroxyl, superoxide anion and ABTS radicals with anti-inflammatory, anti-hyperglycaemic, molluscicidal and anti-tumor activities.
S3677 Cinnamic acid Cinnamic acid, a naturally occurring aromatic fatty acid of low toxicity, induces cytostasis and a reversal of malignant properties of human tumor cells in vitro.
S3661 2-Methoxy-1,4-naphthoquinone 2-Methoxy-1,4-naphthoquinone, isolated from the leaves of Impatiens glandulifera, specifically suppressed the expression of PKC βI, δ, and ζ in a concentration-dependent manner in Raji cells.
S3652 3-Nitropropionic acid  
S3653 Spermidine trihydrochloride Spermidine是一种从腐胺和dcSAM中,通过亚精胺合成酶合成的天然聚胺。它是新型的自噬诱导剂,负向调控N-methyl-d-aspartate (NMDA)
S3668 Thymopentin Thymopentin has immuno-regulatory activities. The immuno-regulatory actions of thymopentin on peripheral T cells are mediated by intracellular cyclic GMP elevations in contrast to the intracellular cyclic AMP elevations induced in precursor T cells that trigger their further differentiation to T cells.
S2416 Chondroitin sulfate Chondroitin sulfate是一种硫酸化糖胺多糖(GAG),组成交替糖分包括乙酰半乳糖胺和葡萄糖醛酸。
S3717 Testosterone Enanthate Testosterone Enanthate是一种雄激素和合成代谢类固醇,用于治疗雄性素补疗。
S3742 Cholic acid Cholic acid是一种天然胆汁酸,在水中不可溶,用来治疗具有合成胆汁酸遗传缺陷的患者。
S3608 Demethylzeylasteral (T-96) Demethylzeylasteral (T-96)是从Tripterygium wilfordii Hook F.中分离出的活性成分,能够抑制UDP-glucuronosyltransferase (UGT)的亚型UGT1A6UGT2B7,具有免疫抑制活性。
S3622 Diammonium Glycyrrhizinate Diammonium glycyrrhizinate (DG)是一种传统的中草药,从甘草中提取纯化而来。它具有抗炎活性,对生物氧化具有抗性、对膜具有保护性。DG通过抑制NF-κB、TNF-α和细胞间黏附分子1来减少炎症损伤。
S3610 Cordycepin Cordycepin is an adenosine analogue, which is readily phosphorylated to its mono-, di-, and triphosphate intracellularly. It has a very potent anti-cancer, anti-oxidant and anti-inflammatory activities.
S3627 Tryptamine Tryptamine是一种单胺生物碱,可能作为神经调节剂和神经递质发挥作用。它是hTAAR1的激动剂,还是非选择性的serotonin receptor激动剂和羟色胺-去甲肾上腺素-多巴胺释放剂(SNDRA)。
S3626 Sesamol Sesamol是一种天然有机化合物,是油中主要的抗氧化成分,具有化学防癌、抗诱变剂和抗毒肝素活性。它能诱导癌细胞和心血管细胞凋亡。
S3625 Tyramine Tyramine是一种来源于氨基酸酪氨酸的天然微量胺,是一种儿茶酚胺释放试剂。
S3624 Quinolinic acid Quinolinic Acid是犬尿氨酸途径中的具有神经活性的代谢物,是N-methyl-D-aspartate (NMDA)受体的激动剂。
S3613 Scoparone Scoparone是一种天然的有机化合物,是从中草药猪毛蒿中提取而来,具有抗凝、降血脂、抗氧化和抗炎作用。
S3615 Dehydrocostus Lactone Dehydrocostus lactone (DHE)是一种天然的倍半萜内酯,抑制IKKβ活性、IκBα的磷酸化和降解、共激活子p300的招募、p50/p65 NF-κB的核转位及它们结合于COX2启动子上的能力。DHE具有抗炎、抗溃疡、抗肿瘤作用和免疫调节活性。
S3616 Asiaticoside Asiaticoside是Centella asiatica(积雪草)中的主要活性成分,通过抑制紫外线A诱导的ROS生成、阻止紫外线A依赖性的光老化。它还能通过MITF减少DNA结合。
S3629 Syringic acid Syringic acid (SYRA)是一种有效的抗氧化中草药,是一种新兴的营养食品。它具有潜在的抗血管生成、抗糖基化、抗高血糖、神经保护和增强记忆的活性。
S3630 Methyl Vanillate Methyl Vanillate是枳椇子成分之一,在体外能激活Wnt/β-catenin信号通路并诱导成骨分化。
S3607 Sarsasapogenin Sarsasapogenin (SAR)是一种甾体皂甙元,能够诱发ROS的产生并激活unfolded protein response (UPR)信号通路。SAR能够有效地抑制NF-κBMAPK的激活,在LPS刺激的巨噬细胞中抑制IRAK1、TAK1和IκBα的磷酸化。
S3606 Fangchinoline Fangchinoline是双苄基异喹啉类生物碱,是HIV-1的新型抑制剂,具有缓解疼痛、降低血压和抗菌活性。
S3619 Citicoline sodium Citicoline是细胞膜主要的磷脂--卵磷脂合成的必要中间产物。它能够提高血浆促肾上腺皮质激素水平以及强化血清促甲状腺素水平。
S4757 Dihydrotestosterone(DHT) Dihydrotestosterone是一种内源性的雄激素性类固醇和激素,是雄激素受体的激动剂,其亲和力比睾酮高2-3倍,诱导雄激素受体信号的效力比睾酮高3倍。
S3612 Rosmarinic acid Rosmarinic acid (RA)是一种天然的羟化化合物。它具有阻止补体结合、抑制脂肪氧合酶和环氧煤活性的功能,通过抑制NF-κB激活信号中IKK-β的活性、抑制CCL11和CCR3的表达。
S3609 Berbamine (dihydrochloride) Berbamine (BBM)是一种从中草药黄芦木中分离而来的双苄基异喹啉类天然产物。它是bcr/abl的新型抑制剂,具有有效的抗白血病活性,是NF-κB的抑制剂。
S4752 Corticosterone Corticosterone是主要的压力激素,一种肾上腺皮质类固醇,具有作为盐皮质激素和糖皮质激素的活性。
S8291 Atractylenolide I Atractylenolide I 是A. macrocephala根茎的主要类倍半萜烯类化合物。具有广谱的药理活性,如抗炎、促消化、抗氧化作用。
S4742 Rebaudioside C Rebaudioside C属于甜菊糖苷(Steviol Glycosides)家族。它是甜叶菊Stevia rebaudiana Bertoni中的天然组分,是糖尿病患者和控制碳水化合物的治疗饮食中的天然甜味剂。
S4743 Wogonin Wogonin,在植物中发现的天然活性黄酮类化合物,是CDK9的抑制剂。在抑制CDK9的浓度下,对CDK2、CDK4和CDK6没有抑制作用。也可抑制N-acetyltransferase
S4741 Danshensu Danshensu(丹参素),是一种传统中药中的中草药,具有潜在的抗肿瘤和抗血管生成的效果。
S4739 Oxyresveratrol Oxyresveratrol是从Morus alba L.发现的天然化合物,对酪氨酸酶的多巴氧化酶活性具有有效抑制作用,能催化黑色素生物合成的限速步骤。
S4746 (20S)-Protopanaxadiol 20(S)-Protopanaxadiol (PPD),人参皂苷在肠道的主要代谢物,是人参中的活性成分之一。
S4735 Salvianolic acid B Salvianolic acid B (Sal B)是一种抗氧化剂和自由基清除化合物,是从丹参中提取出来的最丰富的生物活性化合物。
S8318 Alantolactone Alantolactone,一种天然的桉烷类倍半萜内酯,能诱导activin/SMAD3信号、干扰Cripto-1/activin受体ⅡA型受体的相互作用。
S4707 Oleic Acid 油酸(Oleic acid)是一种天然存在于多种动物和植物脂肪和油类中的脂肪酸。它常被用作制作油酸和乳液,并作为一种药物溶剂。
S4726 Lauric Acid Lauric Acid(月桂酸)是饱和中链脂肪酸,在多种植物、动物油脂中都天然存在,是椰子油和棕榈仁油的主要成分。
S4711 Esculetin Esculetin是在很多种天然植物产物中发现的香豆素衍生物,具有抗水肿、抗炎、抗肿瘤的生物和药理学特性,能抑制脂肪氧合酶。
S4728 3,3'-Diindolylmethane 3,3'-Diindolylmethane(DIM)是indole-3-carbinol的主要消化产物,而indole-3-carbinol是十字花科蔬菜中一种潜在的抗癌物质。
S4708 Palmitoylethanolamide Palmitoylethanolamide(PEA)是一种内源性的脂肪酸酰胺,能在体外选择性激活PPAR-α,EC50为3.1±0.4 μM。
S4690 Escin Escin是在欧洲七叶树中所发现的皂苷混合物,具有抗炎、血管收缩的、血管保护作用。
S4706 Eugenol Eugenol是一种自然存在的香味化合物,发现于丁香油和其他植物中。Eugenol通过增加组胺释放和细胞免疫发挥其生理作用。
S4507 17-Hydroxyprogesterone 17-Hydroxyprogesterone(17-OHP)是一种内源性孕激素,是其他类固醇激素生物合成过程中的化学中间体。
S7939 Chetomin Chetomin是HIF-1的抑制剂,减弱HIF-1转录活性。在微摩尔浓度下,破坏 HIF-1α和HIF-2α与p300的结合。
S7594 Abscisic Acid (Dormin) Abscisic Acid是一种植物激素,参与许多植物发育过程,调节离子平衡和新陈代谢,并且抑制植物发芽和幼苗生长。
S7582 Anacardic Acid Anacardic Acid是一个有效的p300及p300/CBP相关因子 histone acetyltranferases的抑制剂,也具有抗细菌和抗微生物活性,抑制前列腺素合成,并抑制酪氨酸酶和脂肪氧合酶。
S2256 4-Methylumbelliferone (4-MU) 4-Methylumbelliferone (4-MU)是透明质酸(HA)合成抑制剂,IC50为0.4 mM。
S2258 Esculin Esculin 是一种在Horse chestnuts中发现的葡萄糖苷。
S2384 Hematoxylin Hematoxylin易与某些金属离子,尤其是Fe(III)和Al(Ⅲ)盐,形成有色络合物。
S3600 Schisandrin B (Sch B) Schisandrin B (Sch B)是中草药五味子(Turcz.)中含量最丰富的二苯并环辛二烯木酚素。它是一种安全的ATRP-gp抑制剂。
S2392 Sesamin Sesamin 是从Fagara植物的树皮和芝麻油中分离的一种木脂素。
S2277 Caffeic Acid Caffeic Acid是一种羟基肉桂酸,是一种天然存在的有机化合物。
S2280 Chlorogenic Acid Chlorogenic Acid是一种羟基肉桂酸,是天然存在的有机化合物。
S2300 Ferulic Acid Ferulic Acid 是一种羟基肉桂酸,是在Ferula assafoetida L或Ligusticum chuanxiong中发现的一种有机化合物。
S2301 Genistin (Genistoside) Genistin(Genistoside)是在很多可以食用植物(如大豆和野葛)中发现的一种异黄酮。
S2401 Sodium Danshensu Sodium Danshensu是丹参素的单钠盐,是从Salvia miltiorrhiza Bge中分离的天然酚酸,是咖啡酸衍生物。
S2321 Magnolol Magnolol 是一种在Houpu magnolia (Magnolia officinalis) 树皮中发现的生物活性化合物。它能抑制TNFα诱导的NF-KB的激活。
S2337 Osthole Osthole 是一种香豆素类化合物。
S2341 (-)-Parthenolide (-)-Parthenolide, Nuclear Factor-κB抑制剂,可特异性地耗尽HDAC1蛋白,而不影响其他I/II类 HDACs。促进MDM2的泛素化并激活p53的细胞功能。
目录号 产品目录 产品描述
S7025 Embelin Embelin,从矮地茶中分离的一种醌类化合物,是一种细胞凋亡的X染色体抑止剂(XIAP)的抑制剂,无细胞试验中IC50为4.1 μM。
S2252 (+)-Usniacin (+)-Usniacin是在一些地衣中发现的天然存在的二苯并呋喃类衍生物。
S2285 Cryptotanshinone Cryptotanshinone是一种STAT3抑制剂,无细胞试验中IC50为4.6 μM,强烈抑制STAT3 Tyr705磷酸化,对STAT3 Ser727作用效果弱,对STAT1和STAT5没有作用效果。
S2364 Tanshinone I Tanshinone I 由丹参分离而来的。
S2365 Tanshinone IIA Tanshinone IIA是丹参和Salviae miltiorrhizae Radix中最丰富的二萜醌类,用于治疗心血管疾病和炎症性疾病。是天然的monoacylglycerol lipase抑制剂。
目录号 产品目录 产品描述
S2291 Diosgenin Diosgenin 是一种类固醇皂甙元,为半合成孕激素的前体,在早期与口服避孕药一起使用。
S2273 β-Sitosterol β-Sitosterol 是一种植物甾醇,与胆固醇具有相似的化学结构。
S2297 Ergosterol Ergosterol是甾醇,是vitamin D2的生物前体(一种维生素原)。
S2311 Hyodeoxycholic acid (HDCA) Hyodeoxycholic (HDCA) acid 是一种次要的胆汁酸,是肠道细菌的代谢产物之一。
目录号 产品目录 产品描述
S2290 Dihydroartemisinin (DHA) Dihydroartemisinin (DHA)是一种Artemisinin 的半合成衍生物,从传统中药Artemisia annua分离而来的。
S2302 Glycyrrhizin (Glycyrrhizic Acid) Glycyrrhizin (Glycyrrhizic Acid)是一种直接的高迁移率族蛋白1(HMGB1)的抑制剂,抑制依赖于HMGB1的炎症分子表达和氧化应激反应。调节p38和p-JNK信号通路,而不影响p-ERK信号通路。同时也能抑制11 beta-hydroxysteroid dehydrogenase
S2379 Dioscin Dioscin 是皂苷提取的,Polygonatum Zanlanscianense Pamp分离的,抑制MDA-MB-435, H14, HL60, 和 HeLa 细胞系,IC50分别为 2.6, 0.8, 7.5, 和 4.5 μM。
S2261 Andrographolide Andrographolide是一种Labdane类二萜,是药用植物Andrographis paniculata的主要生物活性成分
S2265 Artesunate Artesunate 是一种抗疟类药,作用于小细胞肺癌细胞系H69,IC50为< 5 μM。它是一种潜在的STAT3抑制剂,在体外对癌细胞有选择性细胞毒性作用;是有效的EXP1抑制剂。
S2266 Asiatic Acid Asiatic acid是积雪草苷的糖苷配基,从植物积雪草中分离而来的,常用于伤口愈合。
S2276 Bilobalide Bilobalide 是一种存在于Ginkgo biloba中的有生物活性的萜内酯。
S2296 Enoxolone Enoxolone是一种通过甘草酸水解得到的β-香树脂醇型五环三萜衍生物。
S2306 Gynostemma Extract Gynostemma Extract是一种从Gynostemma pentaphyllum提取而得的皂甙。
S2407 Curcumol Curcumol是常见的传统中药,具有抗肿瘤活性。
S2319 Limonin Limonin又称Limonoate D-ring-lactone 和 Limonoic acid di-delta-lactone,化学上属于Furanolactone类化合物。
S2415 Astragaloside A Astragaloside A是从黄芪中分离的一种纯化的皂苷,广泛应用于治疗心血管疾病。
S2334 Oleanolic Acid Oleanolic Acid是一种天然存在的三萜类,广泛分布于食用和药用植物,与桦木酸相关,具有相对无毒的,抗肿瘤,保肝,及抗病毒的特性。
S2335 Oridonin Oridonin是从Rabdosia rubescens中分离的对映贝壳杉烷二萜,是一种重要的传统中药。
S3603 Betulinic acid Betulinic acid是一种天然的五环三萜类化合物,具有抗病毒,抗疟药,抗发炎和抗肿瘤的特性。Phase 1/2
S3604 Triptolide (PG490) Triptolide (PG490) 是一种三环氧二萜类化合物,是从中草药雷公藤中提取的免疫抑制剂。它是一种NF-κB抑制剂,抑制NF-κB转录活性,破坏p65/CBP的相互作用,减少p65蛋白。
S2354 Sclareol Sclareol 是一种芳香化合物,在Clary sage(Salvia sclarea)中发现而因此命名,被归类为双环二萜醇。
S2355 Sclareolide Sclareolide是一种倍半萜内酯天然产物,来源于各种植物,包括Salvia sclarea, Salvia yosgadensis, 和 cigar tobacco。
S2370 Ursolic Acid Ursolic Acid 是一种五环三萜酸,在化妆品中使用。
目录号 产品目录 产品描述
S2448 Gambogic Acid Gambogic Acid激活caspasesEC50为0.78 - 1.64 μM,且完全抑制Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1Mcl-1IC50分别为1.47 μM, 1.21 μM, 2.02 μM, 0.66 μM, 1.06 μM 和 0.79 μM。
S2372 Xanthone Xanthone是一种有机化合物,可以由加热水杨酸苯酯制备而得到。
目录号 产品目录 产品描述
S2317 L-(+)-Rhamnose Monohydrate L-(+)-Rhamnose Monohydrate是一种天然存在的脱氧糖。
S2352 Salinomycin Salinomycin是一种抗肿瘤抗生素,对癌症干细胞具有选择性抑制作用。
S2374 5-hydroxytryptophan (5-HTP) 5-Hydroxytryptophan(5-HTP),在Vitamin B6存在时,通过酶芳香族-L-氨基酸脱羧酶脱羧成羟色胺(5-hydroxytryptamine 或5-HT)。
S2260 Amygdalin Amygdalin 最初从Prunus dulcis树的种子中分离的一种糖苷,也被称为苦杏仁。
S2398 Coenzyme Q10 (CoQ10) Coenzyme Q10 (CoQ10) 组成电子传递链,并参与细胞有氧呼吸。
S2324 Sodium Monensin Sodium Monensin从 Streptomyces cinnamonensis中分离的, 是一种众所周知的天然的聚醚 类离子载体抗生素的代表。
S2353 Sapogenins Glycosides Sapogenins Glycosides是糖苷配基或非糖类,属于天然产品Saponins部分家族。