96 Well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode

Anti-infection Compound Library

A unique collection of 142 anti-infection compounds under clinical trials

规格 价格  
预溶于DMSO
100uL/well (10mM solution) RMB 30237.48
2x100uL/well (10mM solution) RMB 45356.22
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产品详情

产品描述及优势

    • A unique collection of 142 anti-infective small molecules with biological activity of antibiotics,antifungal drugs,anti-HIV,etc.
    • The compounds in this library mainly include sulfonamides, aminoglycosides, tetracyclines and macrolides
    • A useful tool to research infectious disease for academic institutions, medical research organizations, and the pharmaceutical industry.
    • Structurally diverse, medicinally active, and cell permeable.
    • Rich documentation with structure, IC50, and customer reviews.
    • NMR and HPLC validated to ensure high purity.

产品详细信息

配制: A unique collection of 142 anti-infection compounds supplied as pre-dissolved DMSO solutions
96-孔板: 96 Well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode
稳定性:
1年 -20°C 溶于DMSO
2年 -80°C 溶于DMSO
发货: 蓝冰物流
包装: 惰性气体

化合物库组成成份

Chemical Library Composition

客户使用Selleck产品的实验数据 (10)

AS-605240 Review
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数据来源 Blood,2012, 119, 4686-97. Ritonavir purchased from Selleck
方法 Western blot
细胞系 KMS11 and L363 cells
浓度 1-50 uM
处理时间 17, 72 h
结果 As shown in Figure A through D, ritonavir treatment elicits dose-dependent abrogation of both glucose transport and proliferation in KMS11 and L363 cells.
Axitinib and PF2341066(Crizotinib) Reviews
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数据来源 Blood 2012, 119, 4686-97. Ritonavir purchased from Selleck
方法 annexin V/DAPI staining
细胞系 Primary myeloma cells
浓度 20 uM
处理时间 24 h
结果 A range of cell death induction is seen in patient samples after incubation with a concentration of ritonavir (20 μM).
Axitinib and PF2341066(Crizotinib) Reviews
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数据来源 Cancer Res 2012, 72(15), 3839-50. Maraviroc purchased from Selleck
方法 3D invasion assays
细胞系 Hs578T, SUM-159 cells
浓度 100 nM
处理时间 24 h
结果 To evaluate the functional relevance of CCR5 in cellular migration and invasion, it tested the effects of maraviroc and vicriviroc in 3D invasion assays. Using 2 different cell lines, we found that both Maraviroc inhibited FBS-induced breast cancer cell invasion at the clinically relevant concentration of 100 nmol/L.
Axitinib and PF2341066(Crizotinib) Reviews
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数据来源 Cancer Res 2012, 72(23), 6200-8. Ciprofloxacin purchased from Selleck
方法 Colony formation assay
细胞系 A549, SW48, KG-1
浓度 2 uM
处理时间 0-4 d
结果 Ciprofoxacin reduces cancer cell survival in combinationwith chemotherapy. Ciprofloxacin can potentiatethe effects of 3 different chemotherapeutic drugs on 3 differenttypes of cognate cancer cells.
Axitinib and PF2341066(Crizotinib) Reviews
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数据来源 J Med Chem 2014, 57(3), 632-41. Bazedoxifene HCl purchased from Selleck
方法 Western blot
细胞系 SUM159 cells
浓度 10-30 uM
处理时间 24 h
结果 In human breast cancer cells(SUM159, ER negative) expressing IL-6 and GP130, bazedoxifene (10 − 30 μ M) inhibited the constitutive P-STAT3 activity levels induced by the expressed IL-6 and GP130.
Axitinib and PF2341066(Crizotinib) Reviews
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数据来源 J Antimicrob Chemother 2011, 66, 802-812. Elvitegravir (GS-9137, JTK-303) purchased from Selleck
方法 PhA Flow Cytometry Efflux Assay
细胞系 MDCKII-BCRP cells
浓度 0.001-1000 µM
处理时间
结果 Elvitegravir and Vicriviroc increased PhA fluorescence in MDCKII-BCRP cells.
Axitinib and PF2341066(Crizotinib) Reviews
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数据来源 J Antimicrob Chemother 2011, 66, 802-812. Elvitegravir (GS-9137, JTK-303) purchased from Selleck
方法 Calcein assay
细胞系 P388/dx cells
浓度 0.001-100 µM
处理时间
结果 Vicriviroc and Elvitegravir clearly increased calcein fluorescence in P388dx and L-MDR1 cells, but not in the corresponding parental cell lines, which served as negative controls, indicating inhibition of ABCB1.
Axitinib and PF2341066(Crizotinib) Reviews
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数据来源 J Biol Chem 2014, 289(28), 19648-58. Dolutegravir (GSK1349572) purchased from Selleck
方法 Protein-Protein Cross-linking
细胞系 Rous sarcoma virus integrase
浓度 1-100 uM
处理时间
结果 All three INs effectively utilize 20R for concerted integration, lanes 8-10, respectively). The concerted products formed by RSV IN with 20R were efficiently inhibited by DTG(Dolutegravir), MK-2048, and RAL.
Axitinib and PF2341066(Crizotinib) Reviews
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数据来源 Antimicrob Agents Chemother 2014, 58(8), 4875-84. Lopinavir purchased from Selleck
方法 MTS assay
细胞系 Huh7 cells
浓度 0-20 uM
处理时间 48 h
结果 The fourth hit was the human immunodeficiency virus type 1 (HIV-1) protease inhibitor lopinavir (LPV), which was previously shown to inhibit SARS-CoV main protease activity and SARS-CoV replication in vitro. LPV inhibited MERS-CoV-induced CPE with an EC50 of 8.0 uM.
Axitinib and PF2341066(Crizotinib) Reviews
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数据来源 Antimicrob Agents Chemother 2014, 10.1128/AAC.04220-14. Telaprevir (VX-950) purchased from Selleck
方法 Crystal violet
细胞系 HCV replicon genotype 1b cells
浓度 0.6, 1.5, 3, 6 uM
处理时间 28 days
结果 The presence of miravirsen resulted in the decrease in the rate of cell expansion and a reduction in HCV RNA without the emergence of distinct clonal populations following the initial 25 days of passage at concentrations up to 20-fold the average EC50 (10 uM). In contrast, selection in the presence of telaprevir resulted in the decrease in the rate of cell expansion with the appearance of distinct individual resistant clonal populations.

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