Anti-infection Compound Library

目录号 L3100

A unique collection of 142 anti-infection compounds under clinical trials

规格 价格  
预溶于DMSO
100uL/well (10mM solution) RMB 30237.48
2x100uL/well (10mM solution) RMB 45356.22
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Anti-infection Compound Library目录

selleck分子库在文献中的引用(66

客户使用selleck产品的实验数据(10

  • (A) KMS11 and (B) L363 cells were plated in 5mM glucose medium with ritonavir or DMSO (D) for 17 hours. Glucose consumption rates are normalized to untreated cells (not shown). (C) KMS11 and (D) L363 cells were treated with ritonavir or DMSO for 72 hours. Relative viable cell numbers were determined by MTS assay and normalized to untreated cells (not shown).

    Blood 2012 119, 4686-97. Ritonavir purchased from Selleck

    Primary myeloma cells were treated with DMSO or ritonavir for 72 hours before annexin V/DAPI staining. Values are normalized to DMSO-treated samples (n=1 for each patient sample).

    Blood 2012 119, 4686-97. Ritonavir purchased from Selleck

  • CCR5 antagonists block FBS-induced breast cancer cell invasion. 3D reconstruction of FBS-induced invasion into collagen gels by Hs578T (A) or SUM-159 (C) breast cancer cells in presence of CCR5 antagonists (100 nmol/L). The corresponding quantifications (mean ±SEM, n = 3) and analysis (Bonferronit test) are displayed in B and D.

    Cancer Res 2012 72(15), 3839-50. Maraviroc purchased from Selleck

    Ciprofoxacin (Cipro) reduces cancer cell survival in combination with chemotherapy. A and B, colony formation was conducted with A549 and SW48 cells treated with the clinically relevant chemotherapeutics cisplatin or 5-FU in the presence or absence of 2 μmol/L cipro floxacin. C, cipro fl oxacin at 2 μmol/L decreased proliferation of KG-1 cells and slightly enhanced the effect of etoposide (Etop). *, P < 0.05; **, P < 0.01 ( t tests).

    Cancer Res 2012 72(23), 6200-8. Ciprofloxacin purchased from Selleck

  • J Med Chem 2014 57(3), 632-41. Bazedoxifene HCl purchased from Selleck

    Effect of antiretrovirals and positive control rifampicin (at 10 μmol/L) on ABCB1 function in LS180 cells after 3 and 7 days (d) of treatment. ABCB1 function was normalized to the medium control. Data are expressed as means+SEM for n¼4. **P<0.01.

    J Antimicrob Chemother 2011 66, 802-812. Elvitegravir (GS-9137, JTK-303) purchased from Selleck

  • PhA efflux in MDCKII-BCRP cells. Concentration-dependent inhibition of BCRP/ABCG2 by elvitegravir and vicriviroc. Each curve depicts one representative experiment of a series of three or four; each concentration was tested in 30000 cells.

     

     

    J Antimicrob Chemother 2011 66, 802-812. Elvitegravir (GS-9137, JTK-303) purchased from Selleck

    Strand transfer was carried out with RSV IN(1-269) (4 uM) and GU320R(2 uM)in the presence of 50mM NDSB201. Increasing concentrations of STIs were added as indicated at the top; DTG(Dolutegravir) in lanes 3-5, MK-2048 in lanes 6-8, and RAL in lanes 9-11. No STI was present in lane 2, and lane 1 contains the molecular weight markers. Strand transfer products and ODN substrate are identified on the right. CHS, circular half-site; OC target and SC target, open circular and supercoiled target DNA, respectively.

    J Biol Chem 2014 289(28), 19648-58. Dolutegravir (GSK1349572) purchased from Selleck

  • Low-micromolar amounts of chloroquine, chlorpromazine, loperamide, and lopinavir inhibit MERS-CoV-induced cytopathology. Huh7 cells in 96-well plates were infected with MERS-CoV isolate EMC/2012 (MOI, 0.005) in the presence of 0 to 20 uM LPV. Cells were incubated for 2 days, and cell viability was monitored using an MTS assay. In addition, the potential toxicity of compound treatment only was monitored in parallel mock-infected Huh7 cell cultures. Graphs show the results (averages and standard deviations [SD]) of a representative experiment that was performed in quadruplicate. All experiments were repeated at least twice. For each compound, the calculated EC50, CC50, and SI values are given.

    Antimicrob Agents Chemother 2014 58(8), 4875-84. Lopinavir purchased from Selleck

    HCV replicon genotype 1b cells were passaged in the presence of G418 alone (medium 694 control) or G418 with miravirsen, SPC4729 (oligonucleotide negative control) or telaprevir for 28 days in fixed concentrations at a multiple (X) of the EC50 of miravirsen or telaprevir. Colony formation was assessed by staining surviving cells with crystal violet.

    Antimicrob Agents Chemother 2014 10.1128/AAC.04220-14. Telaprevir (VX-950) purchased from Selleck

描述及优势

• A unique collection of 142 anti-infective small molecules with biological activity of antibiotics,antifungal drugs,anti-HIV,etc.
• The compounds in this library mainly include sulfonamides, aminoglycosides, tetracyclines and macrolides
• A useful tool to research infectious disease for academic institutions, medical research organizations, and the pharmaceutical industry.
• Structurally diverse, medicinally active, and cell permeable.
• Rich documentation with structure, IC50, and customer reviews.
• NMR and HPLC validated to ensure high purity.

详细信息

配制: A unique collection of 142 anti-infection compounds supplied as pre-dissolved DMSO solutions
容器: 96 Well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode
稳定性: 溶于DMSO
溶于DMSO
发货: 蓝冰物流
包装: 惰性气体

Anti-infection Compound Library组成

HTS Facility Partners

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