Anti-diabetic Compound Library

目录号 L2900

A unique collection of 33 anti-diabetes compounds under clinical trials

规格 价格  
预溶于DMSO
100uL/well (10mM solution) RMB 7657.65
2x100uL/well (10mM solution) RMB 11081.07
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Anti-diabetic Compound Library目录

selleck分子库在文献中的引用(66

客户使用selleck产品的实验数据(10

  • Effect of rosiglitazone (RSG) treatment on neutrophil shift toward an N2 phenotype.Representative photomicrographs showing Ym1 (green) and neutrophils (red) double immunostaining 24 (upper) and 48 hours (lower) after permanent middle cerebral artery occlusion (pMCAO) in vehicle (VEH)- or RSG-treated mice.

    Stroke 2013 44(12), 3498-508. Rosiglitazone maleate purchased from Selleck

    For anchorage dependent clonogenic assays, HER2+ breast cancer BT474 cells were seeded at low density in 6-well plates and allowed to adhere overnight. The next day, olaparib and rucaparib were added at the indicated concentrations. Media and drugs were replenished every three days. After 10-15 days, depending on cell proliferation rate, cells were fixed and stained with crystal violet. Images and graphs indicate the results compared to control condition. Data are mean ± S.D. n.s.: non-significant, ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001.

    Eur J Cancer 2014 50(15), 2725-34. Rucaparib (AG-014699,PF-01367338) purchased from Selleck

  • Total cell extracts of BT-474 cells treated with increasing concentrations of olaparib or rucaparib were subjected to western blot analysis for PARP-1 and poly ADP-ribose (PAR) expression. β-tubulin was used as loading control. Representative images from two separate experiments are shown.

    Eur J Cancer 2014 50(15), 2725-34. Rucaparib (AG-014699,PF-01367338) purchased from Selleck

    INS-1 cells were incubated with 50 uM palmitate or BSA in the presence or absence of 5 uM TAK 875 for 30 min, followed by stimulation with 16.6 mm [U-13C]glucose for 30 min. Under these conditions, the following were measured: fructose bisphosphate (FBP) (I), NADH/NAD+ ratio (J). Error bars represent mean ?S.E. n = 3-4.

    J Biol Chem 2014 289(19), 13575-88. TAK-875 purchased from Selleck

  • J Leukoc Biol 2014 95(4), 587-98. Rosiglitazone purchased from Selleck

    J Leukoc Biol 2014 95(4), 587-98. Rosiglitazone purchased from Selleck

  • J Leukoc Biol 2014 95(4), 587-98. Rosiglitazone HCl purchased from Selleck

    J Leukoc Biol 2014 95(4), 587-98. Rosiglitazone HCl purchased from Selleck

  • Total and phosphorylated Akt were detected by western blot in protein lysates of liver, inguinal WAT and gastrocnemius muscle from mice that were treated with an insulin bolus after an overnight fast.

    Mol Metab 2013 2(3), 215-26. Rosiglitazone maleate purchased from Selleck

    The selective GPR40 agonist, TAK- 875, also has a selective inhibitory effect on the growth of all three human melanoma cell lines tested without negatively effecting the growth of the control fibroblast or human breast cancer cell lines even at very high concentrations.

    J Surg Res 2014 188(2):451-8. TAK-875 purchased from Selleck

描述及优势

• A unique collection of 33 small molecules affecting the development of diabetes.
• Targets including both type 1 and type 2 diabetes modulators: DPP-4, GPR, Potassium Channel, PPAR, SGLT, etc.
• Structurally diverse, medicinally active, and cell permeable.
• Rich documentation with structure, IC50, and customer reviews.
• NMR and HPLC validated to ensure high purity.

详细信息

配制: A unique collection of 33 anti-diabetes compounds supplied as pre-dissolved DMSO solutions
容器: 96 Well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode
稳定性: 溶于DMSO
溶于DMSO
发货: 蓝冰物流
包装: 惰性气体

Anti-diabetic Compound Library组成

HTS Facility Partners

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