96 Well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode

Anti-diabetic Compound Library

A unique collection of 33 anti-diabetes compounds under clinical trials

规格 价格  
预溶于DMSO
100uL/well (10mM solution) RMB 7657.65
2x100uL/well (10mM solution) RMB 11081.07
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产品详情

产品描述及优势

    • A unique collection of 33 small molecules affecting the development of diabetes.
    • Targets including both type 1 and type 2 diabetes modulators: DPP-4, GPR, Potassium Channel, PPAR, SGLT, etc.
    • Structurally diverse, medicinally active, and cell permeable.
    • Rich documentation with structure, IC50, and customer reviews.
    • NMR and HPLC validated to ensure high purity.

产品详细信息

配制: A unique collection of 33 anti-diabetes compounds supplied as pre-dissolved DMSO solutions
96-孔板: 96 Well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode
稳定性:
1年 -20°C 溶于DMSO
2年 -80°C 溶于DMSO
发货: 蓝冰物流
包装: 惰性气体

化合物库组成成份

Chemical Library Composition

客户使用Selleck产品的实验数据 (10)

AS-605240 Review
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数据来源 Stroke,2013, 44(12), 3498-508. Rosiglitazone maleate purchased from Selleck
方法 Immunofluorescence
细胞系 C57BL mice
浓度 3 mg/kg
处理时间 24/48 h
结果 RSG-treated mice showed more number of N2 neutrophils as Ym1+, NIMP-R14+ cells in the ischemic core, 24 and 48 hours after pMCAO, compared with VEH.
Axitinib and PF2341066(Crizotinib) Reviews
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评级
数据来源 Eur J Cancer 2014, 50(15), 2725-34. Rucaparib (AG-014699,PF-01367338) purchased from Selleck
方法 Clonogenic assays
细胞系 BT474 cells
浓度 500, 1000 nM
处理时间 10-15 days
结果 Rucaparib significantly reduced clonogenic growth and PAR production at the concentration of 300 nM, and the effect was greater at a higher concentration of 1000 nM. Of note, pharmacokinetic data from a phase I trial suggest that these are clinically achievable plasma concentrations.
Axitinib and PF2341066(Crizotinib) Reviews
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数据来源 Eur J Cancer 2014, 50(15), 2725-34. Rucaparib (AG-014699,PF-01367338) purchased from Selleck
方法 Western blot
细胞系 BT-474 cells
浓度 0.01-1000 nM
处理时间 6 h
结果 It tested the drug rucaparib, which target PARP. It decided to test two different PARP inhibitors to reasonably study whether effects on cell growth were class-dependent instead of drug dependent. It confirmed that rucaparib inhibited PARP activity, as assayed by western blot of its product (poly ADP-ribose (PAR) levels), at starting concentrations of 500 nM of rucaparib.
Axitinib and PF2341066(Crizotinib) Reviews
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数据来源 J Biol Chem 2014, 289(19), 13575-88. TAK-875 purchased from Selleck
方法
细胞系 INS-1 cells
浓度 5 uM
处理时间 30 min
结果 It found that, in the presence of [U-13C]glucose and 50 uM palmitate, TAK-875 reduced the levels of fructose bisphosphate (I), and NADH/NAD+ ratio (J), whereas it increased the M+3 isotopologues of DAG and further reduced the levels of CDP-ethanolamine, indicative of increased activity of glycerolipid cycle and opposite that seen in the presence of the inhibitor.
Axitinib and PF2341066(Crizotinib) Reviews
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评级
数据来源 J Leukoc Biol 2014, 95(4), 587-98. Rosiglitazone purchased from Selleck
方法 Immunofluorescence
细胞系 Alox5<SUP> -/-</SUP> mice
浓度 3 mg/kg
处理时间 48h
结果 Microglial/macrophage reactivity in vehicle and RSG-treated Alox5<SUP> -/-</SUP> mice was more intense than in vehicle-treated WT mice.
Axitinib and PF2341066(Crizotinib) Reviews
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评级
数据来源 J Leukoc Biol 2014, 95(4), 587-98. Rosiglitazone purchased from Selleck
方法 Western blot
细胞系 PGC1β-FAT-KO mice
浓度 10mg/kg
处理时间 2 weeks
结果 Treatment with rosiglitazone notably enhanced insulin-dependent phosphorylation of Akt in all tissues, including WAT, but nosignificant differences were observed between Wt and PGC1 b -FAT-KOmice.
Axitinib and PF2341066(Crizotinib) Reviews
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评级
数据来源 J Leukoc Biol 2014, 95(4), 587-98. Rosiglitazone HCl purchased from Selleck
方法 Western blot
细胞系 PGC1β-FAT-KO mice
浓度 10mg/kg
处理时间 2 weeks
结果 Treatment with rosiglitazone notably enhanced insulin-dependent phosphorylation of Akt in all tissues, including WAT, but nosignificant differences were observed between Wt and PGC1 b -FAT-KOmice.
Axitinib and PF2341066(Crizotinib) Reviews
点击放大
评级
数据来源 J Leukoc Biol 2014, 95(4), 587-98. Rosiglitazone HCl purchased from Selleck
方法 Immunofluorescence
细胞系 Alox5<SUP> -/-</SUP> mice
浓度 3 mg/kg
处理时间 48h
结果 Microglial/macrophage reactivity in vehicle and RSG-treated Alox5<SUP> -/-</SUP> mice was more intense than in vehicle-treated WT mice.
Axitinib and PF2341066(Crizotinib) Reviews
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评级
数据来源 Mol Metab 2013, 2(3), 215-26. Rosiglitazone maleate purchased from Selleck
方法 Western blot
细胞系 C57BL/6J mice
浓度 10 mg/kg
处理时间 2 weeks
结果 As shown,insulin administration similarly stimulated the phosphorylation of Akt in inguinal WAT, liver and skeletal muscle of Wt and PGC1β-FAT-KO mice. Treatment with rosiglitazone notably enhanced insulin-dependent phosphorylation of Akt in all tissues.
Axitinib and PF2341066(Crizotinib) Reviews
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数据来源 J Surg Res 2014, 188(2):451-8. TAK-875 purchased from Selleck
方法 absorbance-based cell viability assay
细胞系 Hs27, A2058, A375, SK-Mel 3, MCF-7
浓度 0-0.4 uM
处理时间 72 h
结果 The selective GPR40 agonist, TAK-875, also has a selective inhibitory effect on the growth of all three human melanoma cell lines tested without negativelyeffecting the growth of the control fibroblast or human breast cancer cell lines even at very high concentrations.

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