96 Well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode

Apoptosis Compound Library

A unique collection of 101 small molecules used for apoptosis research targeting Bcl-2,Caspase,p53,TNF-alpha,Mdm2,survin, etc.

规格 价格  
预溶于DMSO
100uL/well (10mM solution) RMB 22029.38
2x100uL/well (10mM solution) RMB 31433.22
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产品详情

产品描述及优势

    A unique collection of 101 small molecules used for apoptosis research.
    • Targets Bcl-2,Caspase,p53,TNF-alpha,Mdm2,survin, etc.
    • Structurally diverse, medicinally active, and cell permeable.
    • Rich documentation with structure, IC50, and customer reviews.
    NMR and HPLC validated to ensure high purity.

产品详细信息

配制: A unique collection of 101 small molecules used for apoptosis research supplied as pre-dissolved DMSO solutions
96-孔板: 96 Well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode
稳定性:
1年 -20°C 溶于DMSO
2年 -80°C 溶于DMSO
发货: 蓝冰物流
包装: 惰性气体

化合物库组成成份

Chemical Library Composition

客户使用Selleck产品的实验数据 (10)

AS-605240 Review
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数据来源 Nat Med,2013, 19(11), 1478-88. ABT-737 purchased from Selleck
方法 Western blot
细胞系 MCF-7 cells
浓度 0/0.1/1/10 uM
处理时间 12 h
结果 Mst1 inhibition of autophagy was dose-dependently reversed by treatment with ABT-737.
Axitinib and PF2341066(Crizotinib) Reviews
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数据来源 J Clin Invest 2011, 121, 1053-1063. ABT-737 purchased from Selleck
方法 Apoptosis assays
细胞系 PMNs
浓度 1-10 μM
处理时间 20 h
结果 ABT-737 completely abrogated the enhanced survival of neutrophils under hypoxia at a concentration that also reversed the survival effect of GM-CSF, a pro-survival stimulus known to induce BCL-XL but was without effect upon constitutive apoptosis.
Axitinib and PF2341066(Crizotinib) Reviews
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数据来源 Blood 2011, 118, 4771-4779. Pomalidomide purchased from Selleck
方法 MTT assay
细胞系 OPM2 cells
浓度 0-1000 nM
处理时间 3 d
结果 OPM2 was subsequently tested with other anti-myeloma drugs, showing resistance to lenalidomide and pomalidomide.
Axitinib and PF2341066(Crizotinib) Reviews
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数据来源 Leukemia 2012, 26, 623-632. YM155 (Sepantronium Bromide) purchased from Selleck
方法 MTS assay
细胞系 REH/RCH/SUPB15/HAL01 cell lines
浓度 0-10000 nM
处理时间 72 h
结果 Each of the cell lines tested showed a dose-dependent sensitivity to YM155 as measured by cell viability 72 h after exposure
Axitinib and PF2341066(Crizotinib) Reviews
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数据来源 Leukemia 2012, 26, 623-632. YM155 (Sepantronium Bromide) purchased from Selleck
方法 Small interfering RNA knockdown
细胞系 SUPB15 cells
浓度 100 nM
处理时间 96 h
结果 Knock-down of p53 did not rescue the effects on cell viability of either imatinib or ABL siRNA. In contrast, silencing of p53 did rescue the effects of both survivin siRNA and YM155.
Axitinib and PF2341066(Crizotinib) Reviews
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数据来源 Cancer Res 2011, 71(13), 4494-505. HA14-1 purchased from Selleck
方法 Western blot
细胞系 H1975
浓度 2 uM
处理时间 2 d
结果 BH3-mimetic BCL-2 family inhibitors tested in our study,obatoclax and HA14-1, showed efficacy to further induce apoptosis.
Axitinib and PF2341066(Crizotinib) Reviews
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数据来源 Clin Cancer Res 2010, 16, 4217-4225. ABT-263 (Navitoclax) purchased from Selleck
方法 Mitochondrial membrane potential assay/Immunoprecipitation/electron microscopy/apoptosis assays
细胞系 CLL cells/murine embryonic fibroblasts
浓度 10-100 nmol/L/0.3-30 μmol/L
处理时间 2-48 h
结果 To gain in sight into the mechanism of ABT-263-induced cell death, we asked whether ABT-263 induced activation of apoptotic signaling pathways. ABT-263 induced a rapid cleavage of caspase-3 and loss of mitochondrial membrane potential, but was a gain less potent than ABT-737 ( Fig.A).To investigate the activity of both compounds at the level of BCL2 inhibition, we immunoprecipitated BCL2 upon drug treatment and measured the levels of BAK displaced by ABT-737 and ABT-263.BAK was shown to be associated with BCL2 (Fig. B). ABT-737 (10 or 100 nmol/L) efficiently d isplaced BAK from BCL2, whereas higher concentrations of ABT-263 (100 nmol /L) were required to induce release of BAK (Fig. B).ABT-263 (100 nmol/L) induced similar ultrastructural changes to ABT-737 (10 nmol/L), including condensed chromatin, rupture of the outer mitochondrial membrane, and loss of mitochondrial matrix d ensity (Fig. C).Finally, ABT-263-induced apoptosis was compl et ely inhibited in murine embryonic fibroblasts deficient for Bax and Bak (Fig. D), suggesting that ABT-263, like ABT-737 is a specific inhibitor of BCL2 proteins.
Axitinib and PF2341066(Crizotinib) Reviews
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数据来源 Clin Cancer Res 2010, 16, 4217-4225. ABT-263 (Navitoclax) purchased from Selleck
方法 Apoptosis assays
细胞系 CLL cells
浓度 1-1000 nmol/L
处理时间 4 h
结果 In our study we identify two factors that affect the efficacy of the ABT-263: high cell density and plasma protein binding. In leukemic patients, the high circulating cell densities might contribute to the resistance of CLL cells to ABT-263 that we observed in whole blood as compared with standard cell culture (Fig. B).We also describe that the ABT-263 is extensively bound to albumin and that in the presence of albumin higher drug concentrations are required for apoptosis induction (Fig. D)
Axitinib and PF2341066(Crizotinib) Reviews
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数据来源 Oncogene 2014, 10.1038/onc.2014.37. RITA (NSC 652287) purchased from Selleck
方法 Trypan blue exclusion
细胞系 D556-WIP1 cells
浓度 25 nM
处理时间 48 h
结果 Treatment with either RITA also inhibited the increase in viability of D556-WIP1 cells following SDF1α stimulation that was seen in vehicle-treated D556-WIP1 cells.
Axitinib and PF2341066(Crizotinib) Reviews
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数据来源 Cell Death Differ 2013, 20, 1475-84. TW-37 purchased from Selleck
方法 electron microscopy
细胞系 BAK-R Jurkats cells,BAK-def Jurkats cells
浓度 10 uM
处理时间 0-24 h
结果 The ultrastructural changes were significantly inhibited in BAK-deficient Jurkat cells

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