Apoptosis Compound Library

目录号 L3300

A unique collection of 101 small molecules used for apoptosis research targeting Bcl-2,Caspase,p53,TNF-alpha,Mdm2,survin, etc.

规格 价格  
预溶于DMSO
100uL/well (10mM solution) RMB 22029.38
2x100uL/well (10mM solution) RMB 31433.22
询价/订购,请联系我们

为了满足您的特殊需求,您可以从我们产品中选择想要的分子,重量,形态(干粉或溶液),排列顺序等。

Apoptosis Compound Library目录

selleck分子库在文献中的引用(66

客户使用selleck产品的实验数据(10

  • Cardiomyocytes transduced with or without Ad-Mst1 were treated with ABT-737 (0, 0.1, 1, 10 uM) for 12 hours. Representative immunoblots with antibodies to p62/SQSTM1, LC3 and GAPDH are shown.

    Nat Med 2013 19(11), 1478-88. ABT-737 purchased from Selleck

    BCL-XL mediates human neutrophil survival. PMNs were preincubated with the BH3 mimetic ABT-737 (1–10 μM), then cultured in normoxia (gray bars) with or without GM-CSF (500 U/ml) or hypoxia (white bars)or 20 hours, and apoptosis was assessed by morphology (n = 4).

     

     

    J Clin Invest 2011 121, 1053-1063. ABT-737 purchased from Selleck

  • OPM2 cells stably expressing either NT or CRBN shRNA were seeded and incubated with pomalidomide at the indicated concentration, followed by MTT assay at day 3 after adding drugs. Each experimental condition was performed in triplicate and repeated at least once.

     

     

    Blood 2011 118, 4771-4779. Pomalidomide purchased from Selleck

    Dose response of ALL cell lines to YM155. Asynchronous populations of cells were treated with increasing doses of YM155 for 72 h. Then, viability was measured by MTS and normalized to no drug control. S.e.m. bars are inserted. Dotted line represents 50% viability.

    Leukemia 2012 26, 623-632. YM155 (Sepantronium Bromide) purchased from Selleck

  • Treatment of SUPB15 cells with imatinib or YM155. Top panel shows cells treated with siRNA in the presence of 500 nM imatinib. Cells were treated with siRNA, and then subsequently incubated in 500 nM imatinib for 96 h. Bottom panel shows the partial rescue of SUPB15 cells treated with 100 nM YM155 for 96 h. S.e.m. bars are inserted into each graph.

    Leukemia 2012 26, 623-632. YM155 (Sepantronium Bromide) purchased from Selleck

    ABT-737, Obatoclax, and HA14-1 eradicated the H1975 early tumor prosurvival resistance against dual-TKIs inhibition by erlotinib/SU11274 (ERL/SU). The experiment was carried out with H1975 cells , cells were pretreated with dual EGFR-MET inhibitors here, i.e., erlotinib (1 μmol/L)/SU11274 (1 μmol/L). BH3-mimetic used in treatment days 7-9 were all 2 μmol/L in concentration. Top, crystal violet cell survival staining assay. Bottom, BH3-mimetic treatment of the dual ERL/SU-resistant tumor cells induced a proapoptotic response.

    Cancer Res 2011 71(13), 4494-505. HA14-1 purchased from Selleck

  • Clin Cancer Res 2010 16, 4217-4225. ABT-263 (Navitoclax) purchased from Selleck

    Clin Cancer Res 2010 16, 4217-4225. ABT-263 (Navitoclax) purchased from Selleck

  • To determine the number of viable cells, cells were serum starved for 8 hours and treated with 25 nM RITA and stimulated with 1ug/mL SDF1α for 48 hours in serum-free media. After 48 hours, cells were harvested and counted by trypan blue exclusion, using standard methods.

    Oncogene 2014 10.1038/onc.2014.37. RITA (NSC 652287) purchased from Selleck

    (d) Electron micrographs of control and TW-37 (10 uM for 24 h); treated BAK-reconstituted and -deficient Jurkat cells reveal a dependence on BAK for TW-37- mediated apoptosis (scale bar, 5 um)

    Cell Death Differ 2013 20, 1475-84. TW-37 purchased from Selleck

描述及优势

A unique collection of 101 small molecules used for apoptosis research.
• Targets Bcl-2,Caspase,p53,TNF-alpha,Mdm2,survin, etc.
• Structurally diverse, medicinally active, and cell permeable.
• Rich documentation with structure, IC50, and customer reviews.
NMR and HPLC validated to ensure high purity.

详细信息

配制: A unique collection of 101 small molecules used for apoptosis research supplied as pre-dissolved DMSO solutions
容器: 96 Well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode
稳定性: 溶于DMSO
溶于DMSO
发货: 蓝冰物流
包装: 惰性气体

Apoptosis Compound Library组成

HTS Facility Partners

查看其他分子库