CD40L Rabbit Recombinant mAb
Filter:
使用信息
| 抗体应用 | wb,ELISA | ||
|---|---|---|---|
| 稀释比例 |
|
||
| 反应性 | Human Mouse | ||
| MW (kDa) | 36kDa | ||
| 抗体类型 | Rabbit | ||
| 浓度 | 1mg/ml | ||
| 储存液配方 | 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. | ||
| 储存条件 (自收到货起) |
Store at –20°C. |
生物描述
| 特异性 | CD40L Rabbit Recombinant mAb detects endogenous levels of total CD40L. |
|---|---|
| 背景 | During the generation of a successful adaptive immune response, a primary signal is the binding of cognate antigen to an antigen receptor expressed by T and B lymphocytes. Multiple secondary signals involve the engagement of costimulatory molecules expressed by T and B lymphocytes with their respective ligands. CD40, a type I transmembrane protein, is the costimulatory receptor. CD40 is initially characterized on B cells and is also expressed on dendritic cells (DCs), monocytes, platelets, and macrophages as well as by non-hematopoietic cells such as myofibroblasts, fibroblasts, epithelial, and endothelial cells. CD40 binds its ligand CD40L, which is transiently expressed on T cells and other non-immune cells under inflammatory conditions. CD40L is a type II transmembrane protein with a variable molecular weight between 32 and 39 kDa because of post-translation modifications. It is a member of the tumor necrosis factor (TNF) family of cell surface interaction molecules and is expressed primarily by activated T cells, as well as activated B cells and platelets. It represents an early activation marker of T lymphocytes. Under inflammatory conditions, CD40L is also induced on monocytic cells, natural killer cells, mast cells, and basophils. CD40L plays a critical role in controlling B-cell fat. The CD40-CD40L pathway enhances the antigen-specific T-cell response through the activation of dendritic cells and the induction of interleukin 12 (IL-12) production by these cells to focus the immune response on the antigen that has engaged the TCR, sustains this response for as long as the antigen remains in the system, and it induces effector functions of interacting CD40+ target cells. |
实验方法
技术支持
在订购、运输、储存和使用我们的产品的任何阶段，您遇到的任何问题，均可以通过拨打我们的热线电话400-668-6834，或者技术支持邮箱tech@selleck.cn，直接联系到我们。我们会在24小时内尽快联系您。
* 必填项
