CEBP Beta Rabbit Recombinant mAb
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使用信息
| 抗体应用 | wb,ELISA | ||
|---|---|---|---|
| 稀释比例 |
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| 反应性 | Human Mouse Rat | ||
| MW (kDa) | 33kDa | ||
| 抗体类型 | Rabbit | ||
| 浓度 | 1mg/ml | ||
| 储存液配方 | 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. | ||
| 储存条件 (自收到货起) |
Store at –20°C. |
生物描述
| 特异性 | CEBP Rabbit Recombinant mAb detects endogenous levels of total CEBP. |
|---|---|
| 背景 | CCAAT/enhancer binding proteins (C/EBPs) are a family of six proteins. Of the isoforms, the C/EBP-α and C/EBP-β isoforms are widely expressed and well studied. The expression of the C/EBPs is regulated at multiple levels during several physiological and pathophysiological conditions through the action of a range of factors, including hormones, mitogens, cytokines, nutrients and certain toxin. The role of C/EBP-α seems to be purely antiproliferative, and it is likely that this protein will emerge as a general tumor suppressor in both hematopoietic and nonhematopoietic cell types. By contrast, C/EBP-β might both inhibit and promote cell cycle progression, depending on the cellular context and C/EBP-β forms present. Association of C/EBPβ with NF-κB family members has been demonstrated in inflammatory responses. Sumoylation appears to be inhibitory for C/EBPα and C/EBPβ. Acetylation of C/EBPβ affects association with co-regulators such as histone deacetylase, and can present either inhibitory or activating effects. |
实验方法
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