Flotillin 1 Rabbit Recombinant mAb
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使用信息
| 抗体应用 | wb,ELISA | ||
|---|---|---|---|
| 稀释比例 |
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| 反应性 | Human Mouse Rat | ||
| MW (kDa) | 48kDa | ||
| 抗体类型 | Rabbit | ||
| 浓度 | 1mg/ml | ||
| 储存液配方 | 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. | ||
| 储存条件 (自收到货起) |
Store at –20°C. |
生物描述
| 特异性 | Flotillin 1 Rabbit Recombinant mAb detects endogenous levels of total Flotillin 1. |
|---|---|
| 背景 | Flotillins are membrane proteins that form microdomains in the plasma membrane of all mammalian cell types. Flotillins have been implicated in myriad processes that include endocytosis, signal transduction and regulation of the cortical cytoskeleton. The flotillin family is composed of two highly homologous proteins, flotillin 1 and flotillin 2. Both flotillin 1 and flotillin 2 have been found in all mammalian cell types studied to date, and are likely to be expressed ubiquitously. They phosphorylated by Fyn and potentially other Src family kinase. Flotillins have been long considered markers of lipid rafts. Flotillin microdomains act as signalling platforms to function in insulin receptor signalling, T cell receptor signalling and (GPCR) signalling, etc. Flotillin microdomains, either directly or indirectly, are intricately associated with the cortical cytoskeleton. Flotillin microdomain dynamics depend on the actin cytoskeleton, and flotillins regulate the activity of cytoskeletal proteins like myosin II. Flotillins are directly involved in endocytosis. |
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