FOXO1 Rabbit Recombinant mAb
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使用信息
| 抗体应用 | wb,ELISA | ||
|---|---|---|---|
| 稀释比例 |
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| 反应性 | Human Mouse Rat | ||
| MW (kDa) | 69-82kDa | ||
| 抗体类型 | Rabbit | ||
| 浓度 | 1mg/ml | ||
| 储存液配方 | 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. | ||
| 储存条件 (自收到货起) |
Store at –20°C. |
生物描述
| 特异性 | FOXO1 Rabbit Recombinant mAb detects endogenous levels of total FOXO1 |
|---|---|
| 背景 | FOXO1 is expressed globally and abundantly located in hepatic, fatty tissue and pancreatic β cells. The nuclear compart mentalization and transcriptional function of FOXO1 can be modified by phosphorylation, acetylation, ubiquitination, arginine methylation, O-glycosylation acetylation, ubiquitination, glycosylation and methylation. FOXO1 is the key member among the ‘O’ subfamily, in controlling equilibrium of cardiac cells. Global loss of FOXO1 is fatal as it initiates embryonic cell death because of inadequate vascular growth. From the embryo to adulthood, FOXO factors play an important role in maintaining cardiac homeostasis. Furthermore, FOXO1 is concerned in controlling cellular responses like oxidative stress response, cell multiplication, immune homeostasis, cell death, and metabolism in diverse kinds of tissues. |
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