MEIS1 Rabbit Recombinant mAb
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使用信息
| 抗体应用 | wb,ELISA | ||
|---|---|---|---|
| 稀释比例 |
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| 反应性 | Human Mouse Rat | ||
| MW (kDa) | 47kDa | ||
| 抗体类型 | Rabbit | ||
| 浓度 | 1mg/ml | ||
| 储存液配方 | 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. | ||
| 储存条件 (自收到货起) |
Store at –20°C. |
生物描述
| 特异性 | MEIS1 Rabbit Recombinant mAb detects endogenous levels of total MEIS1. |
|---|---|
| 背景 | Meis1, a TALE family homeodomain transcription factor involved in numerous embryonic developmental processes, is selectively expressed in hematopoietic stem/progenitor cells. Meis1 functions as a DNA-binding cofactor of Hox proteins through interaction with Pbx, a member of another TALE homeodomain subfamily of transcription factors. Meis1 cooperates with Hoxa9 to significantly accelerate Hox-induced leukemogenesis. Moreover, Meis1 as well as Hoxa9 have been shown to be the most critical downstream targets of Mixed Lineage Leukemia (MLL) fusion proteins, and their co-expression is sufficient to induce acute myeloid leukemia, recapitulating MLL-ENL-induced immortalization of myeloid progenitor cells. In addition, Meis1 regulates the differentiation arrest, cycling activity and self-renewal of MLL leukemia cells, a critical rate-limiting determinant for establishing leukemia stem cell potential. Meis1 also functions in maintaining long-term hematopoiesis via regulating the cell cycle status of HSC/HPCs. |
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