NeuroD1 Rabbit Recombinant mAb
Filter:
使用信息
| 抗体应用 | wb,ELISA | ||
|---|---|---|---|
| 稀释比例 |
|
||
| 反应性 | Human Mouse Rat | ||
| MW (kDa) | 47kDa | ||
| 抗体类型 | Rabbit | ||
| 浓度 | 1mg/ml | ||
| 储存液配方 | 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. | ||
| 储存条件 (自收到货起) |
Store at –20°C. |
生物描述
| 特异性 | NeuroD1 Rabbit Recombinant mAb detects endogenous levels of total NeuroD1. |
|---|---|
| 背景 | NeuroD1 is a bHLH transcription factor that is predominantly expressed in the nervous system late in development and is therefore more likely to be involved in terminal differentiation, neuronal maturation and survival. It is cell-intrinsically required for the survival and maturation of adult-born neurons. NeuroD1 directly binds regulatory elements of neuronal genes that are developmentally silenced by epigenetic mechanisms. NeuroD1 also induces genes involved in the epithelial-to-mesenchymal transition, thereby promoting neuronal migration. In the absence of NeuroD1, its target promoters and enhancers are silenced by distinct combinations of regulatory factors and chromatin marks. When NeuroD1 is induced, it can target these regulatory sites in a sequence‐specific manner and induce another set of changes that confers transcriptional competence. NeuroD1 binding initiates events that confer transcriptional competence to neuronal fate genes including conversion of heterochromatin to euchromatin and reprogramming of the transcription factor landscape. |
实验方法
技术支持
在订购、运输、储存和使用我们的产品的任何阶段，您遇到的任何问题，均可以通过拨打我们的热线电话400-668-6834，或者技术支持邮箱tech@selleck.cn，直接联系到我们。我们会在24小时内尽快联系您。
* 必填项
