Plectin Rabbit Recombinant mAb
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使用信息
| 抗体应用 | wb,ELISA | ||
|---|---|---|---|
| 稀释比例 |
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| 反应性 | Human Mouse Rat | ||
| MW (kDa) | 531kDa | ||
| 抗体类型 | Rabbit | ||
| 浓度 | 1mg/ml | ||
| 储存液配方 | 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. | ||
| 储存条件 (自收到货起) |
Store at –20°C. |
生物描述
| 特异性 | Plectin Rabbit Recombinant mAb detects endogenous levels of total Plectin. |
|---|---|
| 背景 | Plectin, a major linker and scaffolding protein of the cytoskeleton, has been shown to be essential for the mechanical integrity of skin, skeletal muscle, and heart. In various cell types and tissues plectin has been localized at specific cytoskeleton-plasma membrane junctional complexes, including epidermal hemidesmosomes, dense plaques of smooth muscle, and focal adhesion contacts of cultured cells. Plectin interacts with membrane skeleton proteins, such as fodrin and α-spectrin, the hemidesmosome integrin receptor subunit protein β4, and desmosome-associated desmoplakin. Other prominent locations of plectin are Z-lines, intracellular junctional structures of striated muscle, and intercalated discs of cardiac muscle. It is essential for the mechanical integrity of skin and muscle cells. |
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