Raptor Rabbit Recombinant mAb
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使用信息
| 抗体应用 | wb,ELISA | ||
|---|---|---|---|
| 稀释比例 |
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| 反应性 | Human Mouse Rat | ||
| MW (kDa) | 149kDa | ||
| 抗体类型 | Rabbit | ||
| 浓度 | 1mg/ml | ||
| 储存液配方 | 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. | ||
| 储存条件 (自收到货起) |
Store at –20°C. |
生物描述
| 特异性 | Raptor Rabbit Recombinant mAb detects endogenous levels of total Raptor. |
|---|---|
| 背景 | Raptor is a mTOR binding protein that also binds 4EBP1 and p70α through which mTOR could control cell growth. The binding of raptor to mTOR is necessary for the mTOR-catalyzed phosphorylation of 4EBP1 in vitro, and it strongly enhances the mTOR kinase activity toward p70α. Raptor plays a pivotal role as a scaffold protein in the mTOR-signaling pathway that appears to be phylogenetically conserved. Raptor-mTOR complex positively regulates cell growth and its inhibition causes a large decrease in cell size. The raptor branch of the mTOR pathway modulates a stunning number of major processes, including mRNA translation, ribosome biogenesis, nutrient metabolism and autophagy. Raptor-mTOR activates S6K1, and likely the related S6K2, by phosphorylating it within the hydrophobic motif conserved in the AGC family of kinases. The raptor-mTOR pathway regulates cell growth (accumulation of cell mass) through S6K1 and 4E-BP1 as well as unknown effectors. It responds to nutrients and growth factors in part through the upstream regulators TSC1/2 and rheb. |
实验方法
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