Survivin Rabbit Recombinant mAb
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使用信息
| 抗体应用 | wb,ELISA | ||
|---|---|---|---|
| 稀释比例 |
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| 反应性 | Human | ||
| MW (kDa) | 16kDa | ||
| 抗体类型 | Rabbit | ||
| 浓度 | 1mg/ml | ||
| 储存液配方 | 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. | ||
| 储存条件 (自收到货起) |
Store at –20°C. |
生物描述
| 特异性 | Survivin Rabbit Recombinant mAb detects endogenous levels of total Survivin. |
|---|---|
| 背景 | Survivin, a member of the inhibitor of apoptosis (IAP) protein family that inhibits caspases and blocks cell death, is highly expressed in most cancers and is associated with a poor clinical outcome. Survivin expression is minimal in normal tissues, therefore, it has become a lead target for both as a tumour diagnostic, prognostic and as well as for anti-cancer therapies. Survivin is expressed highly at G2/M phase and declines rapidly in G1 phase of cell cycle. This is largely transcriptionally controlled and involves cell cycle-dependent elements (CDEs) and cell cycle homology regions (CHRs) located in survivin gene promoter. Survivin is a target of p53 for its action and downregulation, and p53 may induce apoptosis by antagonizing the anti-apoptotic activity of survivin. In vivo, survivin is expressed in embryonic and foetal tissues, but is undetectable in normal adult tissues. The regulation of survivin expression and function is complex and can occur at various levels, including transcription, differential splicing, protein degradation, and intracellular sequestration via different ligands. The expression of survivin is up-regulated at a transcriptional level by the nuclear factor-κB, which, in turn, can be activated indirectly by growth factors via the phosphatidylinositol 3-kinase/Akt pathway. Additionally, insulin-like growth factor I/mTOR signaling has been reported to up-regulate survivin via rapid changes in mRNA translation. |
实验方法
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