Alpha Sarcoglycan Rabbit Recombinant mAb
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使用信息
| 抗体应用 | wb,ELISA | ||
|---|---|---|---|
| 稀释比例 |
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| 反应性 | Human Mouse Rat | ||
| MW (kDa) | 50kDa | ||
| 抗体类型 | Rabbit | ||
| 浓度 | 1mg/ml | ||
| 储存液配方 | 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. | ||
| 储存条件 (自收到货起) |
Store at –20°C. |
生物描述
| 特异性 | Alpha Sarcoglycan Rabbit Recombinant mAb detects endogenous levels of total Alpha Sarcoglycan. |
|---|---|
| 背景 | In skeletal muscle, the dystrophin-associated glycoprotein complex forms a link between the actin cytoskeleton and the extracellular matrix that is critical for muscle integrity. Within this complex resides the sarcoglycan subcomplex, which consists of four transmembrane glycoproteins (alpha-, beta-, gamma-, and delta-sarcoglycan). During assembly, beta-sarcoglycan tightly associates with delta-sarcoglycan to form a functional core that then recruits gamma- and alpha-sarcoglycan to form the sarcoglycan complex. Together with sarcospan, the sarcoglycan complex binds other components of the dystrophin-associated glycoprotein complex and integrates into the myofibre’s membrane. Once integrated, the sarcoglycan complex plays a pivotal role in mechanically stabilising the sarcolemma as well as the dystrophin-associated glycoprotein complex. Additionally, the sarcoglycan complex undergoes chemical modifications in response to muscle contractions, thereby transducing mechanical information into a cellular signal. The sarcoglycans are a group of transmembrane glycoproteins with a large extracellular and a short intracellular domain. In skeletal and cardiac muscle, the sarcoglycan complex is comprised of four subunits at an equal stoichiometric ratio: α-, β-, γ-, and δ-sarcoglycan. In smooth muscle, ε- and ζ-sarcoglycan are incorporated into the sarcoglycan complex and replace α- and γ-sarcoglycan, respectively. α-sarcoglycan may be an important factor for the differentiation of myofibres. |
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