Skp1 Rabbit Recombinant mAb
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使用信息
| 抗体应用 | wb,ELISA | ||
|---|---|---|---|
| 稀释比例 |
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| 反应性 | Human Mouse Rat | ||
| MW (kDa) | 19kDa | ||
| 抗体类型 | Rabbit | ||
| 浓度 | 1mg/ml | ||
| 储存液配方 | 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. | ||
| 储存条件 (自收到货起) |
Store at –20°C. |
生物描述
| 特异性 | Skp1 Rabbit Recombinant mAb detects endogenous levels of total Skp1 |
|---|---|
| 背景 | The post-translational modification of degradation of cellular proteins is carried out by E3 ubiquitin ligases. The best-studied E3 complexes are the SCF ligases, which are composed of 3 core components—Cdc53, Skp1, Rbx1—that assemble to the functional ligase complex by binding to one of the multiple substrate adaptors—the F-box proteins. Functioning as adaptors, FBPs bind the Skp1 component of the SCF using a conserved 50 amino acid motif known as the F-box domain (FBD) and recruit post-translationally modified protein substrates to the holoenzyme for ubiquitination via additional protein-protein interaction domains. |
实验方法
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