• Bcl-2
  • Bcl-B
  • Bcl-w
  • Bcl-xL
  • Mcl-1
  • Bax
  • Bfl-1
  • Bad
  • Bcl-xL

Bad 调节剂

目录号 产品名 产品描述 Selective / Pan IC50 / Ki
S0563 10-Deacetyl-7-xylosyl paclitaxel 10-Deacetyl-7-xylosyl paclitaxel (10-Deacetyl-7-xylosyltaxol, 7-xylosyl-10-deacetylpaclitaxel), a derivative of paclitaxel and naturally occurring xyloside isolated from Taxus chinensis, causes significant mitotic arrest in PC-3 cells followed by up-regulating expression of pro-apoptotic Bax and Bad protein, as well as down-regulating expression of anti-apoptotic Bcl-2 and Bcl-XL , which leads to a disturbance of the mitochondrial membrane permeability and to the activation Pan
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