Vorinostat (SAHA, MK0683)

目录号:S1047 别名: SAHA, MK0683, suberoylanilide hydroxamic acid

Vorinostat (SAHA, MK0683) Chemical Structure

Molecular Weight(MW): 264.3

Vorinostat (suberoylanilide hydroxamic acid, SAHA)是一种HDAC抑制剂,无细胞试验中IC50为~10 nM。

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客户购买Selleck的此次产品后发表的文献100篇:

客户使用该产品的20个实验数据:

  • Activity of vorinostat in Jurkat and Peer T-ALL cell lines in an MTT cell viability assay. Cells were treated with increasing drug concentrations for 72 h. The data are plotted as the mean % of DMSO-treated control cells against the corresponding drug concentration. The error bars are the standard error. For each drug and cell line, 3-4 independent experiments were performed with 6 replicates at each drug concentration.

    Nature 2011 471, 235-9. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Differential effects of HDAC inhibitors on histone and tubulin acetylation. Immunofluorescence analysis of histone H3 (K9ac/K14ac) and tubulin acetylation in HeLa cells treated for 4 h with vehicle, SAHA (10 μM), tacedinaline (50 μM), PCI-24781 (20 μM. (a) Mapping of histone acetylation in K562 cells treated with HDAC inhibitors by LC-MS/MS. Cells were treated with TSA (10 μM), SAHA (5 μM), PCI-24781 (2 μM), tacedinaline (50 μM) for 6 h. Histones were extracted from cells and acetylated peptides were quantified after isobaric tagging.

    Nat Biotechnol 2011 29, 255-265. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Western blot analysis of histone H3 acetylation in the spleen of untreated and vorinostat-treated hNF-E2 tg mice (n = 4 of each genotype).

    J Exp Med 2012 209, 35-50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    SAHA down-regulates c-FLIP expression and increases the sensitivity of CaP cells to undergo apoptosis in the presence of bicalutamide (A) Bar graph illustrating the sub-G0/G1 cell population in 22Rv1 (left panel) and LNCaP (right panel) cells in the absence and presence of 10μM bicalutamide, administered as a single agent or in ombination with increasing concentrations of the HDAC inhibitor, SAHA. (B) Immunoblots demonstrating the single agent activity of bicalutamide or SAHA, or effect upon their combined administration on the expression of c-FLIP and/or the processing of PARP. Equal protein loading was confirmed by GAPDH. (C) Bar graph illustrating the effect of bicalutamide and SAHA upon the induction of caspase-8 or caspase-3/7 activity in 22Rv1 cells (left panel) and LNCaP cells (right panel). (D) Immunoblots characterizing the impact of SAHA and/or bicalutamide upon the induction of PARP cleavage, in the absence or presence of the pan-caspase inhibitor, ZIETD. ZIETD was incubated with the cells for 12 h prior to the experiment. All data points shown in (A) and (C) represent the mean ± S.E.M. value, calculated from four independent experiments.

    Clin Cancer Res 2012 18, 3822-33. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Analyses of efficacy, potency and IC50 of HDAC inhibitors point toward HDACs 1–3 as relevant candidates for beta cell protection. Ranking and raw data on ITF drugs (Table 3) and commercial HDAC inhibitors (Table 4) underlying the heat maps of Fig. 1 (A and B). The HDAC inhibitor compounds were tested using a HDAC activity kit and recombinant proteins to determine IC50 values on each individual HDAC (right part of the table). Each drug was further tested using Real-Time Cell Analysis (RTCA) to score their maximal effective concentration (ECmax) as well as the corresponding rescue percentage of cytokine treated INS-1 cells. The drugs were ranked according to % rescue. * DMSO alone controls were included in each experiment, but not shown here. The results indicate that the highest concentrations of DMSO used here (1:1,000) were slightly potentiating the proliferation of the cells. The effects observed in this group of compounds were ascribed to the DMSO.?

    Diabetologia 2012 55, 2421-2431. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Suberoylanilide hydroxyamic acid (SAHA) preserves CFP (+) expression in mouse optic nerves (MONs) from older mice. (a) CFP (+) mitochondria were longer and thicker in MONs from 12-month-old Thy-1 CFP mice (inset; scale bar = 2 μm). Oxygen–glucose deprivation (OGD) consistently reduced CFP pixel intensity in 12-month-old MONs despite longer and brighter CFP ( +) mitochondria (yellow arrows). (b) Blockade of AMPA/kain ate receptors with NBQX (30 μM), or pan-Histone deacetylase (HDAC) inhibition with SAHA (5 μM), effectively preserved CFP pixel intensity during OGD. The preservation of CFP (+) mitochondria correlates with protection of the CAP area during OGD and profound recovery.

    J Neurochem 2012 123 Suppl 2, 108-15. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • D and E, Regression of IL-13Ra 2-negative pancreatic tumors treated with SAHA and/or IL-13-PE. Mice were treated daily with i.p. injection of SAHA (25 mg/kg) from day 4 after tumor implantation for two weeks followed by i.t. injection of IL-13-PE (100 μ g/kg) from day 5 for two weeks. F and G, Regression of IL-13Ra 2-posotive pancreatic tumors (HS766T and MIA-PaCa2) treated with SAHA and/or IL-13-PE. The schedule of treatment was similar as in panel D and E. Statistical significances are shown by *: P < 0.05,†: P < 0.001.

    J Transl Med 2011 9, 37. Vorinostat (SAHA, MK0683) purchased from Selleck.

    IL-13Rα2 expression is upregulated in pancreatic tumors but not in organs of mice after treatment with HDAC inhibi tor, SAHA. A, qRT-PCR of human IL-13Rα2 in implanted pancreatic tumors after SAHA and IL-13-PE treatment. Tumors were harvested next day after IL-13-PE treatment and total RNA extracted. Data shown is ratio of human IL-13Rα2/β-actin expression and multiplied by 1000 for convenience. Bars , SD of triplicate determinations. B, qRT-PCR of mouse IL-13Rα2 in mice organs after SAHA and IL-13-PE treatment. Tissues were harvested at the same time point as in panel A and total RNA extracted. Data shown is ratio of mouse IL-13Rα2/β-actin expression and multiplied by 100 for convenience. C, IHC of human IL-13Rα2 in implanted pancreatic tumors after SAHA and IL-13-PE treatment. D, IHC of mouse IL-13Rα2 in mice organs after SAHA and IL-13-PE treatment. Liver, brain, kidney, pancreas, lung and spleen were fixed for immunostaining of mouse IL-13Rα2 as visualized by Alexa555. Nucleus was counterstained by DAPI.

    J Transl Med 2011 9, 37. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Proliferation o f HT29 and HCT116 cells after 48 h of butyrate or SAHA treatment. Proliferation measurements using the xCEL Ligence RTCA DP instrument (Roche) in cells treated with increasing doses of butyrate or SAHA, compared with control medium cells (0) (*P < 0.05). The mean ?SEM of three cell culture replicates is shown.

    Mol Carcinog 2012 52, 459-74. Vorinostat (SAHA, MK0683) purchased from Selleck.

    SAHA induces the down-regulation of cFLIP expression and promotes TRAIL-mediated activation of a mitochondrial-operated apoptotic pathway. a BT-474 cells were treated as indicated in Fig. 1 and the cells were then harvested to analyse caspase-8, Bid, caspase-9, caspase-3 and PARP expression, using GAPDH as the protein loading control. b BT-474 cells were treated with SAHA for 8 h at the doses indicated and subsequently, the cells were harvested and the apoptosis-related proteins were analysed in western blots as described in the "Materials and Methods". The results shown are representative of at least three independent experiments

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Treatment with SAHA sensitizes breast cancer cells to TRAILinduced apoptosis. BT-474 and MDA-MB-231 cells were incubated for 8 h with SAHA at the doses indicated. After this time, TRAIL (500 ng/ml) was added to some of the cultures for an additional 15 h. Apoptosis was measured as the percentage of cells with subG1 DNA content as described in the "Materials and methods". The results show the mean and S.E.M. of three independent experiments

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

    SAHA facilitates the Itch/AIP4-independent proteasomal degradation of cFLIP proteins in breast cancer cells. a BT-474 cells were treated with SAHA (5 μM) for 8 h in the presence or absence of the proteasome inhibitors MG132 or epoxomicin (at the doses indicated), and they were then harvested and the cFLIP content was analysed in western blots. b BT-474 cells were transfected with either the siRNA oligonucleotides targeting Itch/AIP4 or the non-targeting RNA oligonucleotide (scrambled) for 48 h as described in the "Materials and Methods". Subsequently, the cells were treated with SAHA (5 μM) for 8 h and then cFLIP and Itch/AIP4 expression was analysed in immunoblots

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • cFLIP down-regulation following SAHA treatment is responsible for the sensitization of breast cancer cells to TRAIL. a BT-474 cells were transfected with either different siRNAs directed against the cFLIP isoforms or the non-targeting RNA oligonucleotide (scrambled) as described in the "Materials and Methods". After 24 h, the cells were treated with TRAIL (500 ng/ml) for a further 15 h and apoptosis was then measured as the percentage of cells with subG1 DNA content. The results show the mean and S.E.M. of three independent experiments. To verify protein knockdown, cells were harvested 24 h after transfection and the cFLIP levels were assessed in immunoblots. b. BT-474 cells overexpressing Cflipl (pBABE-FLIPL) or control cells (pBABE) were treated with SAHA for 8 h at the doses indicated. After this time, TRAIL (500 ng/ml) was added to some cultures for 15 h. Apoptosis was measured as the percentage of cells with subG1 DNA content and the results show the mean and range of two independent experiments. Western blots show the cFLIP levels after SAHA treatment in pBABE and pBABE-FLIPL cells.

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Vorinostat inhibits the tumor growth. NOD ⁄ SCID-B2m-/-mice were injected s.c. with 1×106 MyLa2059 cells into both flanks. When the mice had developed established palpable tumors treatment was initiated (day 1). The mice received either vehicle (black line) or 60 mg ⁄ kg vorinostat (grey line) i.p. five days a week. In total, there were four mice in the group receiving vehicle and three mice in the group receiving vorinostat. The length and width of the tumors were measured continuously until the experiment was terminated on day 20 post treatment initiation. The tumor volume was calculated using the formula V = (a×b2)/2, where a defines the length (mm) and b the width (mm) of the tumor. The histogram shows the average tumor volume per flank ± SEM. * denotes a significant difference (P < 0.05) in the average tumor volume per flank between mice treated with vehicle and vorinostat at the given time-point both by using a one-tailed two samples test with Welch, scorrection and a Mann-Whitney U test.

     

     

    Exp Dermatol 2010 19, 1096-1102. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • (a) Western blot of whole cell extracts demonstrates SAHA and NaB treatment result in increased levels of acetylated histone H3 compared to vehicle controls. (b) Light micrographs of HDACi/vehicle treated cultures illustrate the paucity of neurospheres in HDACi-treated cultures. (c) Quantitative analysis confirms SAHA and NaB inhibit the formation of neurospheres (diameter ≥ 50 μm) and increase the prevalence of small cell clusters (≥ 4 cell, diameter < 50 μm). (d) Flow cytometry using LIVE/DEAD cell stain confirms SAHA and NaB are minimally toxic compared to vehicle controls (n = 3). Scale bar = 100 μm.

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    (a) EdU flow cytometry of live cell-gated adult mouse NSCs demonstrates SAHA (**p < 0.01) and NaB (***p < 0.001) significantly inhibit DNA synthesis. (b) Analysis of DNA content by flow cytometry reveals significant accumulation of adult mouse NSCs in G1phase of the cell cycle following SAHA (*p < 0.05) and NaB (*p < 0.05) treatment. (c) Correspondingly the proportion of cells in G2/M phase is significantly reduced following SAHA (*p < 0.05) and NaB (*p < 0.05) treatment. (d) Fluorescence micrographs of HDACi/vehicle treated adult NSCs pulse-labeled with EdU for flow cytometry. Scale bar = 50 μm. Statistical comparisons performed using one-way ANOVA with post hoc Newman-Keuls multiple comparison tests.

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • (a) Immunofluorescence labeling of NeuN, GFAP and Olig2 cell fate markers reveals reduced expression of GFAP (*p < 0.001) and Olig2 (*p < 0.05) in adult mouse NSCs treated with SAHA for 48 hours under proliferation culture conditions and then induced to differentiate for 14 days in culture (two-way ANOVA with Bonferroni post-tests). (b) Western blot of β-catenin protein in nuclear and cytoplasmic fractions of adult mouse NSCs treated with HDACi/vehicle control under proliferation culture conditions. Gapdh and lamin A/C blots are included as loading controls. (c) SAHA and NaB do not significantly alter nuclear/cytoplasmic levels of β-catenin in adult mouse NSCs. Histogram of β-catenin Western blot signal intensities normalized to loading controls (n = 4).

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Morphological changes and histone H3 phosphorylation of HB cells treated with a combination of VX-680 and SAHA. HUH6 and HepT1 were incubated with VX-680 (6 μM) and SAHA (0.5 μM). Nuclei diameter (a) and cell diameter (b) were determined 72 h later by DAPI staining and microscopy. Data represent mean±SD of the diameters from 20 cells in each experiment. (* Two-way ANOVA, Bonferroni test, p \0.05). c Western blot analysis on HUH6 and HepT1 cells were carried out with an anti-phospho-Histone H3 (Ser 10) antibody (p-H3) 24 h after incubation with VX-680 (10 μM), SAHA (0.2 μM) or a combination of both. Controls were left untreated. Western blot analysis showed a decrease in p–H3 after treatment with VX-680 ( lane 2 ) relative to controls ( lane 1 ) and an increase when SAHA was added ( lane 3 ). For the combination of VX-680 and SAHA (lane 4 ) no p-H3 was detected.

    Pediatr Surg Int 2012 28, 579-89. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Vorinostat promotes C2C12 differentiation.In the image, the red is the myotube indicating differentiation ,the blue is the nuclei.

     

     

    Dr. Akihiko Yoshimura of Akihiko Yoshimura. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Western blot analysis of Acetyl-H3 and H3. 0-20μM SAHA was added.

     

     

    Dr. Zhang of Tianjin Medical University. Vorinostat (SAHA, MK0683) purchased from Selleck.

产品安全说明书

HDAC抑制剂选择性比较

生物活性

产品描述 Vorinostat (suberoylanilide hydroxamic acid, SAHA)是一种HDAC抑制剂,无细胞试验中IC50为~10 nM。
特性 Vorinostat是广谱HDAC活性抑制剂,抑制I和II类酶 。
靶点
HDAC [1]
(Cell-free assay)
~10 nM
体外研究

Vorinostat是小分子量(<300)线性肟酸,抑制HDAC活性,包括乙酰化组蛋白和非组蛋白的积累,抑制培养细胞的增殖,且抑制肿瘤生长。Vorinostat通过结合到酶的活性位点而抑制 HDAC活性。Vorinostat 抑制多种转化细胞增殖(包括 淋巴瘤,多发性骨髓瘤,白血病,和非小细胞肺癌),与对照组相比抑制生长达50% 时的浓度为0.5 到10μM。Vorinostat作用于淋巴瘤和白血病细胞,包括 Burkitt, B-细胞急性淋巴细胞白血病 (B-ALL), MCL, DLBCL, ATL和T-细胞,不同程度抑制细胞增殖。除了抑制转化细胞增殖, Vorinostat 也抑制正常细胞增殖,通过比较Vorinostat 作用于一组细胞系–正常人非纤维细胞(WI-38)和 SV40巨大T抗原转化WI-38(VA-13细胞)而得到证明。Vorinostat 抑制两种类型细胞增殖,这种作用存在剂量依赖性。但发现Vorinostat 对转化细胞具有选择毒性,包括使肿瘤细胞死亡,而对正常细胞只起抑制作用,不会使其死亡。[1] Genistein 和Vorinostat 联用效果比5-aza和Vorinostat 联用作用于诱导细胞死亡有效很多。Genistein和Vorinostat联用作用于ARCaP-E使增殖降低 80 %,作用于ARCaP-M细胞,增殖降低60 %以上。Genistein和Vorinostat 联用抑制细胞增殖具有协同效应。作用于ARCaP-E 细胞(820个基因 诱导和1046个基因抑制) ARCaP-M 细胞,Vorinostat比Genistein 影响更多基因。[2] Vorinostat作用于肿瘤细胞表面,提高Fas蛋白水平,这种作用存在剂量依赖性,且按0.75 μM剂量处理,提高达到一个稳定水平。[3] Vorinostat 抑制肿瘤细胞生长,包括NB4, H460 和HCT-116,IC50分别为0.7μM, 3.4μM和1.2 μM。[4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
A20 NGHkWpFMcW6jc3WgRZN{[Xl? M4PaVlEhcA>? NELwVo5FVVOR NHLTWplidnSrLVjERWMyKGGldHn2bZR6KHerdHigTWM2OCCxZjCwMlEyOiEQvF2= NFX6RYwyOTl4MES4PS=>
Friend leukemic cell NX\IRolCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2TPOFUxKM7:TR?= MlW3O|IhcA>? MYXEUXNQ Mom0TWM2OD1yLkm5JO69VQ>? NHn4boYyOjFyOUmxNy=>
K562 NHzUTlhMcW6jc3WgRZN{[Xl? NX21W5BbPiCq MlTYSG1UVw>? NEHKTJpKdmirYnn0bY9vKG:oIHj1cYFvKGirc4TvcoUh\GWjY3X0fYxie2ViKH3pfJR2emVib3[gTGRCSzFiYX7kJGhFSUN{KTD3bZRpKEmFNUCgc4YhOC5yMTFOwG0> MWGxNlQyQTN6MB?=
HT1080 NHvJZWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjoXlF1PzJiaB?= M3TnZmROW09? MV7JR|UxRTJwNDFOwG0> MnzQNVIzPzBzN{W=
H1299 NXTwNmtjU2mwYYPlJGF{e2G7 M4Oxb|IxKG2rbh?= MWfEUXNQ MlzrTY5pcWKrdH;yfUBi[3Srdnn0fUBi\2GrboP0JGhFSUNiZX76fY1mKHerdHigTWM2OCCxZjCwMlE6PCEQvF2= MWmxOFUzOTR{Mh?=
H1299 NGLZd4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLzO|IhcA>? MY\EUXNQ MoD1TWM2OD15LkK0JO69VQ>? M4\pdVE1PTJzNEKy
HeLa M2e4fGtqdmG|ZTDBd5NigQ>? NH3EeJU{OCCvaX6= MUXJcohq[mm2b4L5JINwdmOnboTyZZRqd25iYXfhbY5{fCCqaYP0c45mKGSnYXPleJlt[XOnIIfpeIghUUN3MDDv[kAxNjJ6IN88US=> NFu1RlEyPTZyM{m0PS=>
LOX-IMVI M1rX[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmTEOFghcA>? NGrGZopKSzVyPUGuN{DPxE1? NWLWXIdvOTV5MUW0O|A>
NCI-H226 NF3GfVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3v6PFQ5KGh? NHrvW5VKSzVyPUKuOkDPxE1? NV3iXpZIOTV5MUW0O|A>
RXF-631L MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHG0Opk1QCCq MVjJR|UxRTJizszN NWDiUo52OTV5MUW0O|A>
SNB-78 NFHFSXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\RfJVjPDhiaB?= Mkn0TWM2OD1zNjFOwG0> NUHVcJlkOTV5MUW0O|A>
St-4 NYHkPZFpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknWOFghcA>? NHyzNXZKSzVyPUWuNkDPxE1? MXexOVcyPTR5MB?=
ARP1 NVPPTnZDTnWwY4Tpc44hSXO|YYm= M3;BWFIh|ryP NGTHWII3KGh? NEj6XmlKdmS3Y4Tpc44hd2ZiUEKxW2FHOSCpZX7lJIV5eHKnc4Ppc44> MXixOFc{PDhyNh?=
CEM NXjkV4N6U2mwYYPlJGF{e2G7 MYWxJIg> MoLKSG1UVw>? MnjMTY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLkOzJO69VQ>? M3ntdFE3PDJyME[0
HCT15 NFfz[FdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\XcpQ1QCCq NXOxZYRlT0l3ME2wMlgzKM7:TR?= M{nxU|E3PzJ|MkK3
NCI-H23 NE\uWVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\jZWZ{PDhiaB?= NEC5R3RIUTVyPUCuPVIh|ryP NXnJV|Z7OTZ5MkOyNlc>
GM15850 NXPM[XhsU2mwYYPlJGF{e2G7 M4rMWFIvPSEQvF2= MWi5OkBp NGLCU5RFVVOR MoXGTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHjpd5RwdmViSEOgcJl{cW6nIEG0JIFk\XS7bHH0bY9vKG:oIF\YUkBo\W6n NW[2PVNYOTZ7MkGzOlc>
GM15850 NWPye|hMU2mwYYPlJGF{e2G7 MnfhNk42KM7:TR?= NIXRZ3M6PiCq MWLEUXNQ MV7Jcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iaHnzeI9v\SCKNDDsfZNqdmViNTDhZ4V1gWyjdHnvckBw\iCIWF6g[4Vv\Q>? M3zrclE3QTJzM{[3
GM15850 Ml;5T4lv[XOnIFHzd4F6 NXnvPFlHOi53IN88US=> NXfFdHpMQTZiaB?= NILLb3dFVVOR NU\6clhIUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFEzKGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l MYqxOlkzOTN4Nx?=
GM15850 M1rHZWtqdmG|ZTDBd5NigQ>? M2HJcVIvPSEQvF2= NYTrXpBNQTZiaB?= NXfFOZJqTE2VTx?= MnrITY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHjpd5RwdmViSEOgcJl{cW6nIEmgZYNmfHmuYYTpc44hd2ZiRmjOJIdmdmV? NIi1bVYyPjl{MUO2Oy=>
GM15850 MVrLbY5ie2ViQYPzZZk> MnXuNk42KM7:TR?= MV65OkBp NHvueZFFVVOR MXXJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iaHnzeI9v\SCKNDDsfZNqdmViODDhZ4V1gWyjdHnvckBw\iCIWF6g[4Vv\Q>? MkH6NVY6OjF|Nke=
GM15850 MlvWT4lv[XOnIFHzd4F6 MnvoNk42KM7:TR?= NU\ybnJLQTZiaB?= NH;McYVFVVOR MXfJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iaHnzeI9v\SCKNDDsfZNqdmViMU[gZYNmfHmuYYTpc44hd2ZiRmjOJIdmdmV? MkTiNVY6OjF|Nke=
U937 MV3GeY5kfGmxbjDBd5NigQ>? NEPCWng2KM7:TR?= NUOyNodzOjRiaB?= NWnUc5dSTE2VTx?= MXPD[YxtKGO7Y3zlJIFzemW|dDDifUBi[2O3bYXsZZRqd25iYYSgV{9IOi:PIIDoZZNm NGXrdpkyPzByNEexPC=>
H661 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HsZ|Q5KGh? MmjITWM2OD1zIN88US=> MWexO|E2PzByOR?=
U937 NFT6RXdHfW6ldHnvckBCe3OjeR?= NEDjbG82KM7:TR?= MUiyOEBp M{D2R2ROW09? M4\DWGlv[3KnYYPlJIlvKGirc4TvcoUhUDNiYXPleJlt[XSrb36= NWm2RXBbOTd2NEe3OVA>
U937 MoTPSpVv[3Srb36gRZN{[Xl? M{PaOlEh|ryP NUTD[YlHOjRiaB?= M1\zdGROW09? M3e5RmVn\mWldDDvckBidHCqYTD0eYJ2dGmwIHHj[ZR6dGG2aX;u MmT1NVc1PDd5NUC=
RAW264.7 MVjGeY5kfGmxbjDBd5NigQ>? M4Lre|ExKM7:TR?= MYWyOIg> MUH3ZZRmeg>? NFm5RoNKdmirYnn0bY9vKG:oIFzQV{1{fGmvdXzheIVlKFSQRnHsdIhiKHC{b3T1Z5Rqd25id3n0bEBKSzVyIH;mJFAvPzZizszN NFjBbZAyPzR5N{WxPC=>
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Primary bronchial epithelial cell NFjFcIdMcW6jc3WgRZN{[Xl? M3PSUFUh|ryP M3TRclI1KGh? M1;4TWROW09? MnjmTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwZIXjeIlwdiCxZjDteZRidnRiRnTlcJRiPTB6IFPGWHIheHKxdHXpckBieGmlYXygd5Vz\mGlZTDsc4NidGm8YYTpc44> NFXnTXAyQTl4Nke4PS=>
Primary bronchial epithelial cell MWjLbY5ie2ViQYPzZZk> NF7WNnEyKM7:TR?= MVO5OkBp NWj6fYYzTE2VTx?= NYS3b2xRUW6qaXLpeIlwdiCxZjDISGFEPyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDpckB{cG:{dDDjbZJkfWm2IHP1dpJmdnS| M3eyR|E6QTZ4N{i5
BxPC3 NHewbHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\qTVVZPzJiaB?= MlzyTWM2OD1{Lkeg{txO MlLzNlAyPDN5N{i=
CAL27 NWDtSpAzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvlO|IhcA>? M2TpN2lEPTB;Mz63NkDPxE1? MnnMNlAyPDN5N{i=
Capan1 NFvrZ|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYG3NkBp M3y4dWlEPTB;Nz6zJO69VQ>? NYTKfGtKOjBzNEO3O|g>
HCC827 NVK1dFdKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2n2R|czKGh? NUTmOIZLUUN3ME2xMlgh|ryP MYCyNFE1Ozd5OB?=
LNCAP NGPSZmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoX5O|IhcA>? NVLUSpg3UUN3ME2wMlU5KM7:TR?= NYGx[o0yOjBzNEO3O|g>
NCI-H2122 NWO1RYMzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{CxZ|czKGh? MoLYTWM2OD15LkWg{txO M2\iclIxOTR|N{e4
NCI-H358 NXe1V|B[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFXDTow4OiCq M2HuW2lEPTB;Mj61JO69VQ>? MXOyNFE1Ozd5OB?=
SCC15 M1;6c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWW0NWZKPzJiaB?= M{K0UmlEPTB;Mj60PUDPxE1? M1jVeVIxOTR|N{e4
SCC25 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXm3NkBp M1mzTWlEPTB;MT65N{DPxE1? MYOyNFE1Ozd5OB?=
SKHEP1 NUTVWXE3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXn0c3E6PzJiaB?= MXnJR|UxRTNwNE[g{txO NGXDVJAzODF2M{e3PC=>
BJ MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHMVVQyOTByIN88US=> MVO0PEBp Ml7nSG1UVw>? NYPZRo5lT3Kxd4ToJIlvcGmkaYTpc44h[XRiMD6wOUB1dyBzMECgeW0> NIDQdVkzODF2M{i0NC=>
MUF MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIm1ZWUyODBizszN MXe0PEBp Ml:zSG1UVw>? NGS0fmxIem:5dHigbY5pcWKrdHnvckBifCByLkC1JJRwKDFyMDD1US=> NV:zU4dKOjBzNEO4OFA>
Caco-2 MojnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fCS|ExOCEQvF2= NHfFRXM1QGh? NVuwXldpTE2VTx?= NEnJWm1KSzVyPUiuNUDPxE1? MVGyNFE1Ozh2MB?=
Caco-2 MnPNT4lv[XOnIFHzd4F6 MXi1JO69VQ>? NFvBPGY1KGh? NYLDcphETE2VTx?= NYrLVndZUW6mdXP0bY9vKG:oIFjERWMudWWmaXH0[YQhcGm|dH;u[UBi[2W2eXzheIlwdiCLQ{WwJI9nKDBwMEO3JO69VQ>? M{LjOVIxOTR|OESw
Caco-2 NGDDbpRMcW6jc3WgRZN{[Xl? NV:5VXVxOC5|MU[gcm0hfG9iM{GuOkDPxE1? NVPCcoM3PCCq NXK3SIR{TE2VTx?= MXjFfEB3cX[xIHnubIljcXSrb36gc4YhcHWvYX6gTGRCSzFid3n0bEBKSzVyIH;mJFAvOTF7IN88US=> NVrXPYNZOjBzNEO4OFA>
Caco-2 NYTH[|NWU2mwYYPlJGF{e2G7 M1\iUlAvOzF4IH7NJJRwKDNzLk[g{txO MXi0JIg> M3nremROW09? Mnz5SZghfmm4bzDpcohq[mm2aX;uJI9nKGi3bXHuJGhFSUN|IIfpeIghUUN3MDDv[kAxNjF2NzFOwG0> MYCyNFE1Ozh2MB?=
Caco-2 NYnJUWMzU2mwYYPlJGF{e2G7 MUi2MlMzKG6PIITvJFY{OiEQvF2= M3i1XVQhcA>? MVLEUXNQ M4n1PWV5KH[rdn:gbY5pcWKrdHnvckBw\iCqdX3hckBJTEGFNTD3bZRpKEmFNUCgc4YhOTJwNjFOwG0> MXuyNFE1Ozh2MB?=
Caco-2 NVHDe5BiU2mwYYPlJGF{e2G7 MnzMOk4{OiCwTTD0c{A3OzJizszN MVG0JIg> NWXiNoxzTE2VTx?= NFLwUopGgCC4aY\vJIlvcGmkaYTpc44hd2ZiaIXtZY4hUESDQ{ege4l1cCCLQ{WwJI9nKDRzIN88US=> MXiyNFE1Ozh2MB?=
Caco-2 Mli1T4lv[XOnIFHzd4F6 MnLPNE4{OTZibl2geI8hOzFwNjFOwG0> NXv1T24xPCCq Ml[wSG1UVw>? MWrFfEB3cX[xIHnubIljcXSrb36gc4YhcHWvYX6gTGRCSzZ? M{\wXFIxOTR|OESw
HepG2 M{HwTmtqdmG|ZTDBd5NigQ>? NI\EXFU2KM7:TR?= NFXqV|I3cA>? NVfHS5d6TE2VTx?= M372cGlv\HWldHnvckBw\iCKRFHDMY1m\GmjdHXkJIhqe3SxbnWgZYNmfHmuYYTpc44> MVuyNFE1Ozh2MB?=
HepG2 M3zuUGtqdmG|ZTDBd5NigQ>? NUDGRYhRPSEQvF2= MWO2bC=> NWK4[lZpTE2VTx?= NHPDOlhKdmS3Y4Tpc44hd2ZiSFTBR{1u\WSrYYTl[EBpcXO2b37lJIh6eGW{YXPleJlt[XSrb36= M4q4NFIxOTR|OESw
HepG2 M3njb2tqdmG|ZTDBd5NigQ>? M2fmUVUh|ryP MYi2bC=> NFnXRYpFVVOR M1qyWWlv\HWldHnvckBw\iCKRFHDMY1m\GmjdHXkJIFteGijLYT1ZpVtcW5iYXPleJlt[XSrb36= NYPqXYg5OjBzNEO4OFA>
HepG2 M3HRbGtqdmG|ZTDBd5NigQ>? MmDFOUDPxE1? NXL2cXVbPmh? NVXIfGM4TE2VTx?= NY\QNIRCUW6mdXP0bY9vKG:oIFjERWMudWWmaXH0[YQhUDNxSESgbIl{fG:wZTDhZ4V1gWyjdHnvci=> NUDhOoJUOjBzNEO4OFA>
COLO205 MoTTT4lv[XOnIFHzd4F6 MmLTNVAh|ryP MWiyOEBp NUHmbFBNTE2VTx?= MnPITY5pcWKrdHnvckBw\iCKRFHDNUBie3Onc4Pl[EBieyCrbnT1Z5Rqd25ib3[gbIl{fG:wZTDIN{Bi[2W2eXzheIlwdiC5aYToJGlEPTBib3[gNk4zKM7:TR?= NUDSXIZoOjB2NUGzO|g>
SCC4 MYDLbY5ie2ViQYPzZZk> NWTnPG0zOSEQvF2= MX[yOIg> M3G0WWlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjD0eYJ2dGmwIHHj[ZR6dGG2aX;u NYnCbIQ1OjB2NUKyNlU>
SCC4 M3XhTGtqdmG|ZTDBd5NigQ>? NF;UVIgyKM7:TR?= MWSyOIg> NVzmVpFEUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgZYNmfHmuYYTpc44> NHHUZpEzODR3MkKyOS=>
SCC4 NFnTWJpHfW6ldHnvckBCe3OjeR?= MlPaNUDPxE1? MnrhOUBucW5? MWPB[49vcXO2IHHjeIl3cXS7IHH0JHZFWiCjc4Pld5Nm\CCjczDpcoR2[3Srb36gc4YhS1mSMkSg[4Vv\SCneIDy[ZN{cW:w M1jW[lIxPDV{MkK1
NB4 NUXUV3BJTnWwY4Tpc44hSXO|YYm= NV\4VGpyPSEQvF2= MkezNlQhcA>? Mmq2SG1UVw>? NGT6[|NE\WyuIHP5Z4xmKGG{cnXzeEBie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDhZ4N2dXWuYYTpc44h[XRicILlMWcyKHCqYYPl NW\h[4txOjB2OUG0OFA>
NB4 M4\E[GtqdmG|ZTDBd5NigQ>? Mlq1OUDPxE1? NHW3fWUzPCCq NFrqWoVFVVOR MoX6TY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHHj[ZR6dGG2ZTD0eYJ2dGmwIHzleoVt NF;LcWwzODR7MUS0NC=>
NB4 MYjGeY5kfGmxbjDBd5NigQ>? NVzBfG05PSEQvF2= NV3QbpY4OjRiaB?= MU\EUXNQ M2H0PGlv\HWldHnvckBw\iCyMkHXRWYyN0OLUEGg[ZhxemW|c3nvci=> MoXXNlA1QTF2NEC=
NB4 M1vTc2tqdmG|ZTDBd5NigQ>? NH;Fdmg2KM7:TR?= MXGyOEBp MX\EUXNQ MUHJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iaHnzeI9v\SCKMzDhZ4V1gWyjdHnvci=> NFTtcpgzODR7MUS0NC=>
NUGC3 M3P6U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3WdoVuT0l3ME2yMlk1KM7:TR?= MViyNFg2ODl5MR?=
A549 NHr0enFHfW6ldHnvckBCe3OjeR?= NGr4T5U2KM7:TR?= MnToN{Bp NFTkSFVFVVOR NXPPb4JqUW6mdXP0bY9vKG:oIHH1eI9xcGGpeTDpckBpfW2jbjDBOVQ6KGOnbHzzJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIFzDN2lK M3fsUlIxQDV3MkC4
HUT78 Mm[zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTXO|IhcA>? NG\xbXpFVVOR Mmn1S2k2OD1yLkOg{txO MYSyNFg5PDJyOB?=
U937 NF:xdJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjOUJB2PzJiaB?= M2XzdGROW09? MVLHTVUxRTBwM{mg{txO NYe2WYtVOjB6OESyNFg>
A431 NFzjTXBEgXSxdH;4bYMhSXO|YYm= NEG2NZM4OiCq NYHSVIRyS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTR|MTDj[YxteyCxdnXy[ZhxemW|c3nu[{BGT0[UIIfpeIghUUN3MDDv[kA1NjJizszN MorLNlExQDB4Mkm=
A549 M1fkRmN6fG:2b4jpZ{BCe3OjeR?= NFO3Npg4OiCq MmfCR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVU1QSClZXzsd{BwfmW{ZYjwdoV{e2mwZzDISGFEKHerdHigTWM2OCCxZjCxMlgh|ryP MVOyNVA5ODZ{OR?=
CAL27 NF7iO3lEgXSxdH;4bYMhSXO|YYm= MVe3NkBp MnT2R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gR2FNOjdiY3XscJMhd3[ncnX4dJJme3OrbnegSWdHWiC5aYToJGlEPTBib3[gN{4zKM7:TR?= MnHDNlExQDB4Mkm=
HeLa NYrIbWFsS3m2b4TvfIlkKEG|c3H5 MoDIO|IhcA>? NITUfVREgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\UyjIHPlcIx{KG:4ZYLlfJBz\XO|aX7nJGhFSUNid3n0bEBKSzVyIH;mJFEvPSEQvF2= NWO5OZJ5OjFyOEC2Nlk>
Sf21 MWXLbY5ie2ViQYPzZZk> MXizJIg> MkDVTY5pcWKrdHnvckBw\iCIbHHnJJRi\2enZDDoeY1idiC{ZXPvcYJqdmGwdDDISGFEQCCneIDy[ZN{\WRid3n0bEBKSzVyIH;mJFEvOiEQvF2= NWLaOHVpOjFyOEC2Nlk>
SKBR3 MXzDfZRwfG:6aXOgRZN{[Xl? NE\KdnI4OiCq M2\HWWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNMSlJ|IHPlcIx{KG:4ZYLlfJBz\XO|aX7nJGhGWjJid3n0bEBKSzVyIH;mJFIvPiEQvF2= M4fZVFIyODhyNkK5
SKOV3 NFTKSlBEgXSxdH;4bYMhSXO|YYm= MYm3NkBp NF7CblhEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBUU0:YMzDj[YxteyCxdnXy[ZhxemW|c3nu[{BJTVJ{IIfpeIghUUN3MDDv[kAzNjJizszN NHy1T5EzOTB6ME[yPS=>
COR-L23 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWGxNEDPxE1? MXu3NkBp M{HKVGROW09? NHTCcmVIUTVyPUGuNUDPxE1? NUT5XVhGOjFyOEC2OFc>
DU145 M1rLfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4Hl[|ExKM7:TR?= M2jKUFczKGh? M1fWU2ROW09? NYD0ZZl4T0l3ME2xMlA2KM7:TR?= NX7HUlZLOjFyOEC2OFc>
LoVo NFXwT3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TGfVExKM7:TR?= MkDsO|IhcA>? NIi4TpJFVVOR NWTwZnM5T0l3ME2xMlch|ryP MmTQNlExQDB4NEe=
MCR5-SV2 NEfOPGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVLzRXlJOTBizszN MkT2O|IhcA>? NYG3Xlh4TE2VTx?= NUD0[ZQxT0l3ME2yMlEh|ryP MXeyNVA5ODZ2Nx?=
HCT116 M1riPWtqdmG|ZTDBd5NigQ>? MlnuN|Ah|ryP MYezNEBp M37CeGROW09? Mn;wTY5pcWKrdHnvckBw\iCKRFHDOkBie3Onc4Pl[EBieyCrbnT1Z5Rqd25ib3[gZYxxcGFvdIXieYxqdiCjY3X0fYxifGmxbh?= NETvSJQzOTB6ME[0Oy=>
HCT116 MmLpT4lv[XOnIFHzd4F6 MYOzNEDPxE1? NGSxPWk{OCCq M4e4dWROW09? M2fveGlvcGmkaYTpc44hd2ZiSFTBR|Eh[XO|ZYPz[YQh[XNiaX7keYN1cW:wIH;mJIhqe3SxbnWgTFNMQSCjY3X0fYxifGmxbh?= MYKyNVA5ODZ2Nx?=
U937 NIjXeotMcW6jc3WgRZN{[Xl? NU\mbGh6PSEQvF2= NIPUVJkzPCCq M3PkeGROW09? NGLLclZKdmirYnn0bY9vKG:oIHjpd5RwdmViYXPleJltfHKjboPm[ZJie2ViYYPz[ZN{\WRiYYOgbY5kemWjc3Wgc4Yh[WOndInsZZRqd25ib3[gbIl{fG:wZTDIN{BifCCNOR?= M3vOVFIyOjl{NEmy
U937 MWTLbY5ie2ViQYPzZZk> NWLQTJFOPSEQvF2= MnPyNlQhcA>? MmrBSG1UVw>? NFj6fGVKdmirYnn0bY9vKG:oIHjpd5RwdmViYXPleJltfHKjboPm[ZJie2ViYYPz[ZN{\WRiYYOgbY5kemWjc3Wgc4Yh[WOndInsZZRqd25ib3[gbIl{fG:wZTDIN{BifCCNMUi= NHLRR40zOTJ7MkS5Ni=>
U937 MlmxT4lv[XOnIFHzd4F6 MXO1JO69VQ>? NVLM[ppXOjRiaB?= M4HtRmROW09? MoDkTY5pcWKrdHnvckBw\iCqaYP0c45mKGGlZYT5cJRz[W6|ZnXyZZNmKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIH;mJJBidi2jY3X0fYxifGWmIHjpd5RwdmViSESgcIV3\Wx? MWiyNVI6OjR7Mh?=
U937 M2DrUWtqdmG|ZTDBd5NigQ>? M1:xclUh|ryP MYixOUBucW5? MXvEUXNQ M3PqSmlvcGmkaYTpc44hd2ZiaHnzeI9v\SCjY3X0fYx1emGwc3\ldoF{\SCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDv[kBpcXO2b37lJGg{KGGlZYT5cIF1cW:wIHzleoVt NEDDUFQzOTJ7MkS5Ni=>
A2780 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnEXWl4QTZiaB?= Mn;2SG1UVw>? NF;MU2NKSzVyPUGuOlIh|ryP MXWyNVY{PDR|MB?=
COLO205 MnvHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7pNXU6PiCq NWrUOIxGTE2VTx?= NIrBb3JKSzVyPUKuNVIh|ryP M1zMdlIyPjN2NEOw
Hep3B M4n1R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1T6ZlQ5KGh? M2X6dWROW09? Mon4S2k2OD1zLkKxJO69VQ>? MmTTNlE4OTJzNE[=
GM11272 NYrpOWYyTnWwY4Tpc44hSXO|YYm= Mlq3NVAxKG6P NYnvbo1LPzJiaB?= MoL3SG1UVw>? M3TqcHJm[WO2aY\heIlwdiCxZjDN[WNxOiCvdYThcpQh\XiycnXzd4lwdiCjdDCxNEB1dyBzMECgcm0> NWnUe2tvOjF6NEC3NVY>
CFBE41o Mly5T4lv[XOnIFHzd4F6 NV31OGVsPSEQvF2= M{XQOWROW09? M{TURmRwf25icnXneYxifGmxbjDv[kBJTEGFNzDheEAxNjJidH:gOUB2VQ>? NXvnWop5OjF7OES5OVg>
CFBE41o NVLISY1uTnWwY4Tpc44hSXO|YYm= NV\mfpJmOSEQvF2= MnTwNlQhcA>? MlzLSG1UVw>? MWnS[ZN1d3KjdHnvckBw\iCFRmTSJIRmdHSjRkWwPEBufXSjboSgeJJi\m[rY3vpcochfG9iY3XscEB{fXKoYXPlJIF{KGeueXPv[o9zdXN? MlXSNlE6QDR7NUi=
DU145 NXzFe3VvU2mwYYPlJGF{e2G7 NV\sSGx7Oi53IN88US=> M173ZVI1KGh? Mn\OSG1UVw>? MYfJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhfXC{ZXf1cIF1cW:wIH;mJJAzOXejZkGgdJJwfGWrbjDlfJBz\XO|aX;u MYeyNlI3ODF4Nh?=
DU145 Mn3LT4lv[XOnIFHzd4F6 MWK1JO69VQ>? MojxNlQhcA>? NYf2c5duTE2VTx?= MVvJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcGm|dH;u[UBJPCCjY3X0fYxifGmxbh?= NE[1RpEzOjJ4MEG2Oi=>
DU145 M1rROmtqdmG|ZTDBd5NigQ>? NETZVVk2KM7:TR?= MXmyOEBp NXrlWHpTTE2VTx?= MVfJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcGm|dH;u[UBJOyCqeYDldoFk\XS7bHH0bY9v NGPQT3kzOjJ4MEG2Oi=>
786-0 M4DEWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWK2MlIh|ryP MVu3NkBp NGfGUmpFVVOR NU[xNVhHT0l3ME2zMlIh|ryP NGLleJkzOjR|NU[2PS=>
A498 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGmwOFY3NjJizszN Mk\QO|IhcA>? MYDEUXNQ MnHwS2k2OD1zLk[g{txO NW\vXWVjOjJ2M{W2Olk>
A549/ATCC NGDp[41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVe2MlIh|ryP NFqyTVQ4OiCq MV;EUXNQ Mnn1S2k2OD1zLk[g{txO M3Sxd|IzPDN3Nk[5
ACHN NWHjToJyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTUOk4zKM7:TR?= Mn7wO|IhcA>? M3j1NGROW09? MXzHTVUxRTFwMzFOwG0> MoXqNlI1OzV4Nkm=
BT549 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV[2MlIh|ryP MnLRO|IhcA>? Mk[5SG1UVw>? NFXhW5pIUTVyPUGuN{DPxE1? NXjuW2NbOjJ2M{W2Olk>
EKVX MkPXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmrSOk4zKM7:TR?= NGPMeYw4OiCq MV7EUXNQ MmDFS2k2OD1zLkOg{txO MWqyNlQ{PTZ4OR?=
HCT15 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVm2MlIh|ryP MoPGO|IhcA>? NInDdJZFVVOR NYrVeGlbT0l3ME2yMlUh|ryP MmHkNlI1OzV4Nkm=
HOP92 NFPybpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\ORVM3NjJizszN MnXXO|IhcA>? NFLlZ5RFVVOR M4nPc2dKPTB;NDFOwG0> M1\BO|IzPDN3Nk[5
IGROV1 NIL1Uo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1fhUFYvOiEQvF2= M1;GNlczKGh? NEm2emZFVVOR M1zYU2dKPTB;MT6zJO69VQ>? NEjYcJIzOjR|NU[2PS=>
LOXIMVI NGryTIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFrVS5A3NjJizszN NG\ET4c4OiCq MkW1SG1UVw>? MXLHTVUxRTFizszN NV34XYtCOjJ2M{W2Olk>
M14 NVnh[5RRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXy2MlIh|ryP NGrLXXc4OiCq NVW1VHhCTE2VTx?= MVrHTVUxRTFwMzFOwG0> M4HjVVIzPDN3Nk[5
MALME-3M MkHtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\SZ|YvOiEQvF2= MXe3NkBp NIPm[4tFVVOR NHP2VoRIUTVyPUCuN|Ih|ryP M2HyTlIzPDN3Nk[5
MCF10A NULhN|g3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2rFeVYvOiEQvF2= MnW3OFghcA>? NFHPXHZFVVOR NFTjZoJIUTVyPUmuOkDPxE1? NVzFc4lvOjJ2M{W2Olk>
MDA-MB-435 NGrWNppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFW4TGk3NjJizszN NWnGfnEyPzJiaB?= M{\NPWROW09? M1LMUmdKPTB;MD61JO69VQ>? NHzJSHczOjR|NU[2PS=>
MDA-MB-468 M1vTTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;BXFJyPi5{IN88US=> NFHpfWE4OiCq NH\UcVFFVVOR NHThb2lIUTVyPUCuOlMh|ryP NVT5eHY2OjJ2M{W2Olk>
MOLT4 NInKdWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzqOk4zKM7:TR?= MkCyO|IhcA>? Mn\CSG1UVw>? NFjMNJdIUTVyPUCuOEDPxE1? Mm\JNlI1OzV4Nkm=
NCI-ADR-RES M4fnWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLKOk4zKM7:TR?= NW[3V3g1PzJiaB?= NIn0NIFFVVOR NWPMVndNT0l3ME2wMlE3KM7:TR?= MlXFNlI1OzV4Nkm=
NCI-H23 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW[2MlIh|ryP MWi3NkBp NH64c3NFVVOR NXPzW|ZST0l3ME2xJO69VQ>? MXOyNlQ{PTZ4OR?=
NCI-H322M NXz1OlhUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXG2MlIh|ryP MXq3NkBp NITvRYZFVVOR M2\t[2dKPTB;MD63PUDPxE1? MVuyNlQ{PTZ4OR?=
NCI-H460 NYnTRpFET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFe3epA3NjJizszN MoXrO|IhcA>? MkLlSG1UVw>? NUjE[lNRT0l3ME2wMlc6KM7:TR?= NVWzbIJpOjJ2M{W2Olk>
NCI-H522 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnr0Ok4zKM7:TR?= NULoN2FNPzJiaB?= MXXEUXNQ M3HOUmdKPTB;MD61JO69VQ>? MljaNlI1OzV4Nkm=
OVCAR3 NWLOephrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHXOk4zKM7:TR?= NUfP[VRqPzJiaB?= MmXFSG1UVw>? MlH2S2k2OD1zLkOg{txO Ml76NlI1OzV4Nkm=
OVCAR4 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHHzPWg3NjJizszN NXzFdHZoPzJiaB?= MYPEUXNQ MmHPS2k2OD12IN88US=> MWqyNlQ{PTZ4OR?=
OVCAR5 M{C2UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzCRWo3NjJizszN NYrP[2VCPzJiaB?= NYSxVYJoTE2VTx?= NUi4S|FjT0l3ME2wMlc6KM7:TR?= MUiyNlQ{PTZ4OR?=
OVCAR8 MoO4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFS0SXY3NjJizszN Mny5O|IhcA>? NVHzPG9LTE2VTx?= MlznS2k2OD1yLkWg{txO NEi3U3AzOjR|NU[2PS=>
RXF393 NXvxdGcyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1rs[lYvOiEQvF2= NW\3Z3I{PzJiaB?= MUHEUXNQ NID5cIFIUTVyPUGuN{DPxE1? MoC4NlI1OzV4Nkm=
SF268 MoT6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVn5Xow{Pi5{IN88US=> NXrUUWw5PzJiaB?= NHfPXXlFVVOR MWfHTVUxRTFwNjFOwG0> NF34XFgzOjR|NU[2PS=>
SF295 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2j2eVYvOiEQvF2= NFrFeHQ4OiCq M4LDPWROW09? NGHheGpIUTVyPUGuOkDPxE1? NG\L[HQzOjR|NU[2PS=>
SF539 MmrtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\SOk4zKM7:TR?= M4LIZ|czKGh? MX3EUXNQ MWDHTVUxRTJizszN MUKyNlQ{PTZ4OR?=
SK-MEL-2 M363WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjsOk4zKM7:TR?= MV:3NkBp M4Hhc2ROW09? NF:2S|dIUTVyPUGuN{DPxE1? NXH0[pRJOjJ2M{W2Olk>
SK-MEL-28 NWfRWGFDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWi2MlIh|ryP MUG3NkBp MVTEUXNQ MV3HTVUxRTFizszN NUTqV3dxOjJ2M{W2Olk>
SK-MEL-5 NHHic4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MojTOk4zKM7:TR?= MXG3NkBp MWHEUXNQ MXPHTVUxRTBwNkOg{txO MlfDNlI1OzV4Nkm=
SKOV3 MnrhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX62MlIh|ryP NGTITYU4OiCq MmX0SG1UVw>? MVvHTVUxRTFizszN M4jCdVIzPDN3Nk[5
SN12C MoHrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M37BdlYvOiEQvF2= Ml7yO|IhcA>? MWTEUXNQ NF\oZ45IUTVyPUKg{txO NGrOOmIzOjR|NU[2PS=>
SNB19 M2Xmbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnDboE3Pi5{IN88US=> NFTHOZo4OiCq MkfESG1UVw>? M2HmZmdKPTB;MD62N{DPxE1? MWiyNlQ{PTZ4OR?=
SNB75 NXLOUFNpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDoSINmPi5{IN88US=> NV\BS3BsPzJiaB?= M{nPOWROW09? MV\HTVUxRTBwN{mg{txO NF3IfXEzOjR|NU[2PS=>
SR M1WzPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVu2MlIh|ryP NH7kc4k4OiCq NGnlUlhFVVOR NV;zSFRqT0l3ME2wMlQh|ryP MWGyNlQ{PTZ4OR?=
T47D Mn[1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PmNVYvOiEQvF2= NYrUcHBXPzJiaB?= NYKzcGFSTE2VTx?= M2i5bmdKPTB;MD61JO69VQ>? NGnvenAzOjR|NU[2PS=>
TK10 NEm4UWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHf2W|A3NjJizszN NEP0U5c4OiCq NGHpS4pFVVOR NY\YeHJjT0l3ME2wMlY{KM7:TR?= M13sblIzPDN3Nk[5
UACC257 NHHRcINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXwOk4zKM7:TR?= NX7n[npOPzJiaB?= MoXvSG1UVw>? MX\HTVUxRTBwNTFOwG0> NH3r[2szOjR|NU[2PS=>
UACC62 Mkj5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLvOk4zKM7:TR?= NEiwU3U4OiCq NHvMNllFVVOR MmL4S2k2OD1yLkSg{txO MWWyNlQ{PTZ4OR?=
UO31 M{jGcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPXOk4zKM7:TR?= Mk[yO|IhcA>? MnPqSG1UVw>? M4HCW2dKPTB;MD61JO69VQ>? NEjufZgzOjR|NU[2PS=>
Hep3B NWLqXlRUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfFd|c1QCCq NXn6fXJzTE2VTx?= MkDyS2k2OD1yLk[5JO69VQ>? M4LEUlIzPDN7OE[z
BE(2)-C M4C0bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmO2O|IhcA>? MX\EUXNQ MoK2TWM4OD1{IN88US=> NF\4c|IzOjl|MkOxOi=>
Bel7402 M1X0SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\Od2g4OiCq M37CcWROW09? M3ns[mdKQTB;MUeg{txO NU\PRoJZOjNyNkGzO|Y>
Bel7404 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLQZpo4OiCq MnjnSG1UVw>? MWTHTVkxRTF6IN88US=> MWqyN|A3OTN5Nh?=
BGC823 NULZbJFCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1fE[|czKGh? NFP2cZdFVVOR MojGS2k6OD15LkWg{txO M3vtRVI{ODZzM{e2
MGC803 NVqzOpdRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\XO|IhcA>? M2HyS2ROW09? NXT6coFvT0l7ME2xNE45KM7:TR?= NV;FSVkxOjNyNkGzO|Y>
SGC7901 MmHJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYe3NkBp Mn3rSG1UVw>? MWTHTVkxRTlwNDFOwG0> MX:yN|A3OTN5Nh?=
SKHEP1 NGrjUVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkewO|IhcA>? Mn\2SG1UVw>? NUjGdIh{T0l7ME2xO{DPxE1? NXrxSFFXOjNyNkGzO|Y>
SMMC7721 NUXOSotrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XldlczKGh? NYracFNxTE2VTx?= MoHaS2k6OD1{MDFOwG0> Mnr4NlMxPjF|N{[=
NUGC3 MmjFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoCxNVAh|ryP MmSyS2k:Oi57NDFOwG0> MoH4NlMyPjN|M{K=
A2780 CisR MXPLbY5ie2ViQYPzZZk> Mo\RNVghcA>? NHLwXHFKdmirYnn0bY9vKG:oIFjERWMhf2m2aDDJR|UxKG:oIECuOFQh|ryP MYOyN|I2OjZyMx?=
CAL27 sens MkPmT4lv[XOnIFHzd4F6 MmfpNVghcA>? M4HEbGlvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD6zOkDPxE1? MVeyN|I2OjZyMx?=
CAL27 CisR NEDVW3pMcW6jc3WgRZN{[Xl? NEnIVlEyQCCq M1rwemlvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD62NUDPxE1? M2PKU|I{OjV{NkCz
KYSE-510 CisR NWnTO3IyU2mwYYPlJGF{e2G7 NHzTdXEyQCCq M2XOXGlvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD61PUDPxE1? M4\XcFI{OjV{NkCz
KYSE-510 sens MkfRT4lv[XOnIFHzd4F6 M{CydVE5KGh? MYDJcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwNzFOwG0> M3PHRlI{OjV{NkCz
MDA-MB-231 sens M4LhcGtqdmG|ZTDBd5NigQ>? MXmxPEBp M2q2fWlvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD62NUDPxE1? MnTNNlMzPTJ4MEO=
MDA-MB-231 CisR NGXSXnBMcW6jc3WgRZN{[Xl? NWjEWYszOThiaB?= NUn1e3dFUW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlYyKM7:TR?= M1HDRVI{OjV{NkCz
ES2 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnfoOFghcA>? MmfxSG1UVw>? M{jtfGlEPTB;MUKuO{DPxE1? M1HCflI{PDl|NES5
MDA-MB-231 MWfLbY5ie2ViQYPzZZk> M33IdFExKM7:TR?= NEPKZpo{OCCvaX6= NVTqc4M5TE2VTx?= Mn;lTY5pcWKrdHnvckBw\iCKRFHDNoE> MXKyN|Q6OzR2OR?=
MDA-MB-231 NWPWVHp2U2mwYYPlJGF{e2G7 NYPTOlh[OSEQvF2= MljwNlQhcA>? NUntcWVMTE2VTx?= M{LJemlvcGmkaYTpc44hd2ZiSFTBR|Yh[XO|ZYPz[YQh[XNiYXPleJlt[XSrb36gcIV3\Wy|IH;mJJR2[nWuaX6= NXX6eVVSOjN2OUO0OFk>
HS68 M{OwNWN6fG:2b4jpZ{BCe3OjeR?= MnHENVAh|ryP MU[3NkBp NWrSfmlWTE2VTx?= NX\0eZF[UUN3ME20MlYh|ryP MoS5NlM2PzB3NEK=
MEF MYLDfZRwfG:6aXOgRZN{[Xl? MYqxNEDPxE1? M4XSdlczKGh? NEXDd5pFVVOR MXfJR|UxRTRwNDFOwG0> NIjGcGMzOzV5MEW0Ni=>
BGC823 M{HP[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPVNYpQTE2VTx?= MX7HTVUxRTNwMEmg{txO Mn63NlM3ODF5ME[=
High5 MUjLbY5ie2ViQYPzZZk> M2XXWVI1KGh? NEPYN4NKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IFjERWM3KHerdHigTWM2OCCxZjCwMlA6KM7:TR?= MWSyN|YxOjV{Mx?=
High5 NEHSOYNMcW6jc3WgRZN{[Xl? MmDkNlQhcA>? M2rvZWlvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiSFTBR|Ehf2m2aDDJR|UxKG:oIECuNVIh|ryP MYmyN|YxOjV{Mx?=
High5 NUX1dVhsU2mwYYPlJGF{e2G7 MnHENlQhcA>? NITEXXpKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IFjERWM{KHerdHigTWM2OCCxZjCwMlE4KM7:TR?= NXTScoUxOjN4MEK1NlM>
A549 M4SzfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIS4Um5FVVOR NUXrbGQ1UUN3ME2xMlA4QSEQvF2= NHjDflIzOzZ2NEKxNC=>
HCT116 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLXSG1UVw>? MVTJR|UxRTBwN{W3JO69VQ>? MlvUNlM3PDR{MUC=
K562 NXfCT2JuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvvSG1UVw>? M{DPfGlEPTB;MD62OFUh|ryP M3XCS|I{PjR2MkGw
GBC-SD NXTnNnBLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV7HU3FZPSEQvF2= M2DXcVczKGh? MWHEUXNQ MXnJR|UxRTF2Lkig{txO M1PHTlI{PzB5Mk[w
HGC27 NIDXfoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPRfGI2KM7:TR?= NHvO[VM4OiCq MWXEUXNQ NFfreIZKSzVyPUWuOEDPxE1? NXXP[5pzOjN5MEeyOlA>
HL60 MUfLbY5ie2ViQYPzZZk> NHT5TGY2KM7:TR?= NX;jPYR4OjRiaB?= MYfEUXNQ M4nQT2lvcGmkaYTpc44hd2ZiSFTBRy=> MkfNNlM4ODd{NkC=
Vero NF;xV|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLV[Y5VPzJiaB?= NH7YVYxFVVOR NVG1bHp5UUN3ME2wMlkh|ryP M2nw[FI{Pzh4NEWy
NCI60 MUDDfZRwfG:6aXOgRZN{[Xl? MYe0PEBp NUTqbJFGTE2VTx?= MUnHTV0xNjV|IN88US=> NVLQVopxOjRyMUWzNlc>
SW620 MVrDfZRwfG:6aXOgRZN{[Xl? NVixb3ZWPDhiaB?= MX3EUXNQ NV3rdGRoT0l;MD61OEDPxE1? NHe4flYzPDBzNUOyOy=>
U251 NFjIcXREgXSxdH;4bYMhSXO|YYm= MX:0PEBp NX3neok2TE2VTx?= NIW5XJpIUT1zLkWzJO69VQ>? NUG5Wo9COjRyMUWzNlc>
KM12 NFnh[Y9EgXSxdH;4bYMhSXO|YYm= NWDORllQPDhiaB?= NXi0bWE6TE2VTx?= NFHsbGNIUT1zLki4JO69VQ>? MYeyOFAyPTN{Nx?=
Hs578T M2HoVmN6fG:2b4jpZ{BCe3OjeR?= MnrMOFghcA>? MkHmSG1UVw>? MoqwS2k:PC56MzFOwG0> NHvhTo8zPDBzNUOyOy=>
MDA-MB-231 M3jZVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXtV5E1QCCq MmXqTWM2OD1yLkG2JO69VQ>? MlLQNlQxQTVyMU[=
MCF7 NVvXdJF6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYD5W4UxPDhiaB?= MUfHTV0xNjR3IN88US=> M3TV[FI1OTF7NUW1
MDA-MB-435 NHXO[FlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXiOFghcA>? NIW5UGlIUT1yLki4JO69VQ>? MmSzNlQyOTl3NUW=
AsPC1 M3TnNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWezNEDPxE1? MVW0PEBp M{HEd2ROW09? NF3NUmlKSzVyPUOuOlYh|ryP MkSwNlQyQDV|N{i=
Jurkat E6.1 NFnsSVNMcW6jc3WgRZN{[Xl? M2P2dVIhcA>? MlL5SG1UVw>? NYnwdnRxUW6qaXLpeIlwdiCxZjDISGFEPCC5aYToJGlEPTBib3[gNE4xPCEQvF2= M4X2UlI1OjZzOE[y
KG1 MlzYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYG0PEBp MnnkTWM2OD1zLkG1JO69VQ>? Mly4NlQ2OjVyMEO=
HEL NIS1TmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4H1PVQ5KGh? M4LheWROW09? NHrsWVhKSzVyPUCuOFkh|ryP MXeyOFY6PDB3NR?=
HSC3 M361WGN6fG:2b4jpZ{BCe3OjeR?= M4ryd|EzKGh? M17EV2ROW09? MWfJR|UxRTBwN{Gg{txO NGHrPGMzPDd4NkW2NC=>
HT-29 Mo\jR5l1d3SxeHnjJGF{e2G7 NXj1VGFJOTJiaB?= NILBNJRFVVOR MoTwTWM2OD1yLkeyJO69VQ>? M3juW|I1PzZ4NU[w
KB M2ThOWN6fG:2b4jpZ{BCe3OjeR?= MkD0NVIhcA>? M{Xv[WROW09? Ml7iTWM2OD1yLke1JO69VQ>? MnO5NlQ4PjZ3NkC=
H460 Mn;XR5l1d3SxeHnjJGF{e2G7 NEX5cpQyOiCq M1[4b2ROW09? MlOwTWM2OD1yLkiyJO69VQ>? NIPaWZEzPDd4NkW2NC=>
MONE1 Mn7FR5l1d3SxeHnjJGF{e2G7 MmLRNVIhcA>? MoKzSG1UVw>? MWDJR|UxRTFwMUig{txO M3qyNlI1PzZ4NU[w
MKN45 M2DxOWN6fG:2b4jpZ{BCe3OjeR?= NWHTSmpHOTJiaB?= M1HTe2ROW09? MonUTWM2OD1zLkK1JO69VQ>? NV23[YVbOjR5Nk[1OlA>
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NCI-H1437 MmnDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTJwNEG4O|Mh|ryP MnrXV2FPT0WU
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NCI-H2170 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PCUmlEPTB;Mj61NFU1QSEQvF2= NIeyS3VUSU6JRWK=
Mo-T NVLVWYlxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLKemxmUUN3ME2yMlUxQTJ5IN88US=> MlHDV2FPT0WU
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COR-L23 NYLqcHpuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUnEdWdwUUN3ME2yMlU5PTZ4IN88US=> NYHXd|JRW0GQR1XS
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NCI-H2126 NIHFfI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3scopKSzVyPUKuOlA6QDRizszN NV7VPYcxW0GQR1XS
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NCI-H661 M2Dpb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHO2[GxKSzVyPUKuOlQxQDVizszN MnHBV2FPT0WU
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NCI-H510A M4XG[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\Fe2lEPTB;Mj62OFQzPiEQvF2= M1SwSHNCVkeHUh?=
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G-402 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTJwN{C0OVEh|ryP Mn;UV2FPT0WU
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NB12 M17J[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTJwN{G3NUDPxE1? NHXkZ3FUSU6JRWK=
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U-266 M2\0[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnZTWM2OD1{Lke3NVIyKM7:TR?= NYi0dlZOW0GQR1XS
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EGI-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLsTWM2OD1{LkixO|Q{KM7:TR?= M3zTWXNCVkeHUh?=
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NCI-H292 NFmxTYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XNXGlEPTB;Mj64OlU6PiEQvF2= MVvTRW5ITVJ?
8305C M321dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTJwOE[2OFUh|ryP M{fjNHNCVkeHUh?=
SNU-449 NGfIT4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETsUlVKSzVyPUKuPFkyQDJizszN MWfTRW5ITVJ?
LCLC-103H NGS3c2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTJwOUC0N|gh|ryP MYPTRW5ITVJ?
SW1573 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjGTGFKSzVyPUKuPVYxQDJizszN NU\WXJVKW0GQR1XS
MLMA MnH0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfSTWM2OD1{Lkm2O|E4KM7:TR?= MoPZV2FPT0WU
NCI-H1355 NHPWOGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\rTWM2OD1|LkCwO|k3KM7:TR?= MnXxV2FPT0WU
RMG-I MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTNwMEK1PVIh|ryP MXvTRW5ITVJ?
BB65-RCC M4H5Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nkS2lEPTB;Mz6wN|MyPCEQvF2= Mk\tV2FPT0WU
PC-3 NH\JeHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTNwMEO4O|Qh|ryP MUTTRW5ITVJ?
SF268 NXqwRpV4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1m0UmlEPTB;Mz6wOFUzOyEQvF2= MkPNV2FPT0WU
NCI-H810 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\XZoNKSzVyPUOuNFQ5OjNizszN MoqyV2FPT0WU
MEG-01 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDXNo93UUN3ME2zMlA3OTZ2IN88US=> NVSyRWxGW0GQR1XS
SW13 MlPDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfoc4FSUUN3ME2zMlA4QDR5IN88US=> Mnf0V2FPT0WU
RH-1 MlvtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3QTYE2UUN3ME2zMlExOjd6IN88US=> NEPUN3VUSU6JRWK=
GT3TKB NHrJZnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M320fmlEPTB;Mz6xNVI5OyEQvF2= MXnTRW5ITVJ?
TK10 NVHvN3RJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{P5bmlEPTB;Mz6xN|czPCEQvF2= M{jFbnNCVkeHUh?=
T-24 MmC5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LKbWlEPTB;Mz6xOVA4KM7:TR?= NGO3UG1USU6JRWK=
A498 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlz6TWM2OD1|LkKwPFcyKM7:TR?= MmfMV2FPT0WU
GR-ST MnrCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPxTWM2OD1|LkKyNVM6KM7:TR?= MXzTRW5ITVJ?
LB2518-MEL MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm\XTWM2OD1|LkKyN|k5KM7:TR?= NYHXbXFGW0GQR1XS
T47D M{TSdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml24TWM2OD1|LkKzOlI4KM7:TR?= NFniR2VUSU6JRWK=
NCI-H1651 NFrTOpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfDZZBKSzVyPUOuNlQ3PDRizszN M2TtfHNCVkeHUh?=
EC-GI-10 MmPNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYn3dIN7UUN3ME2zMlI3OTV|IN88US=> MoLWV2FPT0WU
HT-29 M2ruPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;qe2x5UUN3ME2zMlI3PjF2IN88US=> MmPNV2FPT0WU
GI-ME-N NHHMOJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3zTWM2OD1|LkK5OVEyKM7:TR?= MmrpV2FPT0WU
SW756 MlvSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4T6S2lEPTB;Mz6yPVYzQSEQvF2= M3Xl[XNCVkeHUh?=
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NCI-H1563 MmHrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmm4TWM2OD1|LkOzNFE5KM7:TR?= NF;rNXJUSU6JRWK=
DJM-1 NWPFRoZ7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXnTGpLUUN3ME2zMlM4Pjd2IN88US=> NEnIZ45USU6JRWK=
L-428 NUDtN|JJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NULIXYtqUUN3ME2zMlQxODR3IN88US=> MmH5V2FPT0WU
NCI-H2122 MonBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nle2lEPTB;Mz60NVMyOiEQvF2= MVTTRW5ITVJ?
Ca-Ski MkDUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFG1SpFKSzVyPUOuOFU1OyEQvF2= MkLMV2FPT0WU
639-V NIfXZ2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTNwNE[wOVch|ryP NEO3dJZUSU6JRWK=
SW1116 M3jTfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGTMeVRKSzVyPUOuOFYzPjlizszN M4ToWHNCVkeHUh?=
DMS-114 M4TFb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFf0PJpKSzVyPUOuOFcxPjZizszN NHH5VGZUSU6JRWK=
MZ2-MEL MmLTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\jc2lEPTB;Mz60O|Y5OSEQvF2= NFTsSVBUSU6JRWK=
COLO-829 NEPCdIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonFTWM2OD1|LkWwNFc{KM7:TR?= NXzPcY1tW0GQR1XS
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EW-13 M3XnZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYfmdZdJUUN3ME2zMlUzPTFizszN NYS4UWNGW0GQR1XS
RXF393 NGHNVm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTXTWM2OD1|LkWzNlk1KM7:TR?= MVvTRW5ITVJ?
CAL-62 NVLSZ|dkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFroemVKSzVyPUOuOVQ2OTRizszN M4\UbXNCVkeHUh?=
OCUB-M MmLLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;hTWM2OD1|LkW0OlY2KM7:TR?= NUfKTo5CW0GQR1XS
BT-474 NUTkRpdyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlS5TWM2OD1|Lk[zN|Eh|ryP NUHGUFJYW0GQR1XS
KYSE-180 NUjHNJJuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HsUWlEPTB;Mz62N|M4OiEQvF2= NUnwWHpZW0GQR1XS
NCI-H650 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTNwNkSyPFch|ryP NF\qbmdUSU6JRWK=
Detroit562 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HYbWlEPTB;Mz62OVAzOiEQvF2= M4XScHNCVkeHUh?=
SW48 MnPqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTNwNkW2OVch|ryP NXHDS3dNW0GQR1XS
KYSE-450 Mom4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTNwNki1PFIh|ryP NGP1U3ZUSU6JRWK=
KYSE-510 Mn7qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTNwN{KxPFEh|ryP MX3TRW5ITVJ?
GP5d MkjBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTNwN{K5OUDPxE1? NG\BNFNUSU6JRWK=
RPMI-7951 NVTnUpNST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPpe5pEUUN3ME2zMlc1PzJ|IN88US=> NGTHPIlUSU6JRWK=
Becker MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7GWWtKSzVyPUOuO|UxOTJizszN MWPTRW5ITVJ?
WM-115 MnSwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTNwN{ixPVUh|ryP MmP1V2FPT0WU
G-401 NV\EXGViT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTNwN{mwPFUh|ryP NV;lOJR[W0GQR1XS
PANC-08-13 NF7nfXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTNwN{m2NFIh|ryP MmjtV2FPT0WU
SW982 NYTSdpJsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3r0NmlEPTB;Mz64NFU2OSEQvF2= MnSwV2FPT0WU
D-263MG MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDFSHBKSzVyPUOuPFIxPTFizszN NXTGNmVHW0GQR1XS
KM-H2 M3LVbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3H0PWlEPTB;Mz64NlYzPCEQvF2= M{TVdHNCVkeHUh?=
SK-MEL-3 M3TZXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlf5TWM2OD1|LkiyPFQyKM7:TR?= Ml7GV2FPT0WU
NCI-H1581 MlvnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfvUpVlUUN3ME2zMlg1PDh6IN88US=> MV3TRW5ITVJ?
LS-123 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDSTWM2OD1|Lki3PVA6KM7:TR?= NGXRUHJUSU6JRWK=
CAKI-1 M1fJS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPqTWM2OD1|Lki5NFUzKM7:TR?= MXTTRW5ITVJ?
MEL-JUSO M4\LXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnvTWM2OD1|Lki5NVU{KM7:TR?= NI\2cI9USU6JRWK=
HCE-4 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4rrRmlEPTB;Mz65NVY3OyEQvF2= MoPqV2FPT0WU
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ETK-1 M333dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LofGlEPTB;Mz65OFY{PSEQvF2= MXPTRW5ITVJ?
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BHY MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjHTWM2OD12LkGyOFk2KM7:TR?= NXS1NW94W0GQR1XS
COR-L105 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHRS5BKSzVyPUSuNVMxPTFizszN M{nOdHNCVkeHUh?=
CAL-12T MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4LDRmlEPTB;ND6xN|ExOyEQvF2= MYDTRW5ITVJ?
SCH M1GzdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTRwMUW3OFMh|ryP MUXTRW5ITVJ?
CW-2 NYPPbpJQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIexZ|NKSzVyPUSuNVkxODFizszN MYnTRW5ITVJ?
HCC1806 M{n3PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\sfVJKSzVyPUSuNlA{OTJizszN MYXTRW5ITVJ?
KP-N-YN NVT2WZkxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLwc2ZVUUN3ME20MlIxQTJ5IN88US=> MoS1V2FPT0WU
T98G NUjnToZNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1nrdWlEPTB;ND6yNlE2PyEQvF2= MoDQV2FPT0WU
CAL-54 NVjaSoZmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnnTWM2OD12LkKyN|gyKM7:TR?= MXTTRW5ITVJ?
CAL-33 NY\DdIlYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;wTWM2OD12LkKzNFY1KM7:TR?= NEDzUnFUSU6JRWK=
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no-11 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLCTWM2OD17LkK2NFI5KM7:TR?= M4PuS3NCVkeHUh?=
KLE NIq5cFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzYTWM2OD17LkOyNlMzKM7:TR?= MWTTRW5ITVJ?
Calu-6 MnK1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfkR4JkUUN3ME25MlM4PTJ6IN88US=> MX7TRW5ITVJ?
LB831-BLC NUHkTlBkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rsNmlEPTB;OT60OVE4OSEQvF2= NYLNT4RHW0GQR1XS
SW684 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDzOY57UUN3ME25MlQ3OTF4IN88US=> NVni[mpvW0GQR1XS
SH-4 NWKw[pdST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGPtSoxKSzVyPUmuOFk{PjRizszN NGKwc3lUSU6JRWK=
IST-MES1 NFvPW49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFPCVGZKSzVyPUmuOVE3PDRizszN NIH1TGtUSU6JRWK=
Saos-2 M1LYV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\CTWM2OD17LkWyNVk2KM7:TR?= M4DP[XNCVkeHUh?=
NCI-H2087 M2f6fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4HjN2lEPTB;OT62O|M2OiEQvF2= NI\5UoxUSU6JRWK=
SCC-9 MnXHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXzJdoc5UUN3ME25MlcyQDF4IN88US=> MVTTRW5ITVJ?
MFE-280 NVi4UmR[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTlwN{K3PFUh|ryP MULTRW5ITVJ?
BEN MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTlwOEKxOVkh|ryP MmXrV2FPT0WU
CP50-MEL-B NEnDeXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkL5TWM2OD17LkmyOFMzKM7:TR?= NVz3XY11W0GQR1XS
SK-MEL-28 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWS4UHFpUUN3ME2xNE4xOTl|IN88US=> NFjadZNUSU6JRWK=
NCI-H2452 MmfES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTFyLkG2JO69VQ>? NXnYUZlXW0GQR1XS
NCI-H1395 NEi1W5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXONoRKSzVyPUGwMlE4QCEQvF2= MVXTRW5ITVJ?
NCI-H2052 NGC2fmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzpRVdKSzVyPUGwMlE5QDJizszN NW\F[pFXW0GQR1XS
A375 M4LZUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTFyLkK0OVIh|ryP MkDkV2FPT0WU
HCC38 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2rBPGlEPTB;MUCuN|IzKM7:TR?= NGPBSnVUSU6JRWK=
LK-2 MmPhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHaTWM2OD1zMD60NlA5KM7:TR?= M37WT3NCVkeHUh?=
SF126 NHXjWlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTFyLkS3Nlch|ryP NUfEVWpLW0GQR1XS
SK-MEL-1 NY\oRpBRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTFyLke4N|gh|ryP NVj1PFJDW0GQR1XS
ACN NFPJR3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjXVZhVUUN3ME2xNE45Pjd7IN88US=> NHPZV21USU6JRWK=
BB30-HNC MnPYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHJTWM2OD1zMD64O|EyKM7:TR?= MXXTRW5ITVJ?
NCI-H747 M4C0d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mne1TWM2OD1zMD64O|Q3KM7:TR?= MWDTRW5ITVJ?
KYSE-150 M3XxRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjofGZKSzVyPUGxMlA{QDdizszN NX\rZpdtW0GQR1XS
D-247MG MoS1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYHjd3pRUUN3ME2xNU4yODB7IN88US=> NVuwV4FNW0GQR1XS
BxPC-3 MkfKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3X1ZmlEPTB;MUGuN|c1PyEQvF2= MlXOV2FPT0WU
SK-MEL-30 NFjaWW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfrTWM2OD1zMT60NFc6KM7:TR?= MWXTRW5ITVJ?
CAS-1 NGS3bWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGrUdnpKSzVyPUGxMlQyODlizszN MkHyV2FPT0WU
no-10 M3XRdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4TKUWlEPTB;MUKuNVIyPyEQvF2= MX;TRW5ITVJ?
NCI-H2405 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DSdGlEPTB;MUKuNlA{PiEQvF2= Moj5V2FPT0WU
KGN M4TBOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVP1Z4RZUUN3ME2xNk4zQTBzIN88US=> M1\5TnNCVkeHUh?=
BB49-HNC MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTF{LkO5OVYh|ryP NUToTFhEW0GQR1XS
NCI-H1693 MonkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1i0TmlEPTB;MUKuOVgyPiEQvF2= NIC4fWRUSU6JRWK=
RO82-W-1 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XCWmlEPTB;MUOuNFY1QSEQvF2= MWHTRW5ITVJ?
CAL-85-1 NGDldnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWCybGt2UUN3ME2xN{41Ozl7IN88US=> NGe4cFlUSU6JRWK=
H-EMC-SS MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWK3OZUxUUN3ME2xN{46OTB2IN88US=> NYTyOHlMW0GQR1XS
SW1783 Mn3yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NELPPGtKSzVyPUG0MlI{QTFizszN NHnMOIhUSU6JRWK=
LB771-HNC M{XIVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYXPeG9xUUN3ME2xOE41OTlizszN M1HXfnNCVkeHUh?=
HCC70 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjEXVJzUUN3ME2xOE41OjN|IN88US=> NGXCcIhUSU6JRWK=
KNS-81-FD NUPCcWdyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TOS2lEPTB;MUSuO|A1PSEQvF2= MYDTRW5ITVJ?
KYSE-520 Mn\tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TjR2lEPTB;MUSuPVI4KM7:TR?= NV3Z[XV7W0GQR1XS
TGBC24TKB NVTVNIFCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTF2Lkm1N|kh|ryP NVTvU2dXW0GQR1XS
SNB75 NWP6e4JCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\TPWlEPTB;MUWuNFczQSEQvF2= NUD6dJliW0GQR1XS
SW872 MnrpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTF3LkKyNVgh|ryP M1zW[nNCVkeHUh?=
U031 MkHVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vvVWlEPTB;MUWuPFAzQCEQvF2= NV;uWXlQW0GQR1XS
ChaGo-K-1 NUC3SHF5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDab4RuUUN3ME2xOU45OzV7IN88US=> MUTTRW5ITVJ?
NCI-H441 M3PxSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXETWM2OD1zNj6wNFM6KM7:TR?= NHXPOWtUSU6JRWK=
TE-12 NInHUJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfCfW9IUUN3ME2xOk4yQDd|IN88US=> MkXSV2FPT0WU
NCI-H1755 M4LmN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTrRWxXUUN3ME2xOk42PzNizszN MUDTRW5ITVJ?
KNS-42 M3zWVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3jOXg2UUN3ME2xOk43PTh7IN88US=> NF;uRZlUSU6JRWK=
SK-PN-DW NXG2VpBbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjtepNXUUN3ME2xO{41OjBzIN88US=> M4T6TXNCVkeHUh?=
NCI-H226 MlnwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1r2RWlEPTB;MUeuPVM1PSEQvF2= NEXx[JdUSU6JRWK=
K-562 NGCzT3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7VWW9qUUN3ME2xPE43OzF5IN88US=> MkSwV2FPT0WU
A388 NGnNc5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;vW3FKSzVyPUG5MlA{ODNizszN Mk\OV2FPT0WU
ZR-75-30 NWnTdY9yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTF7LkC5Olgh|ryP NX:2WWU4W0GQR1XS
LU-135 NHy2fIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\6TWM2OD1zOT6yOlM3KM7:TR?= MlfWV2FPT0WU
NCI-H2029 NHjCWpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nxN2lEPTB;MUmuOlAzOSEQvF2= MlTPV2FPT0WU
HT-1197 NULxPVdFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1XtSWlEPTB;MUmuPVIzPyEQvF2= NEHpe4tUSU6JRWK=
IGR-1 MmTES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7vS5Y1UUN3ME2yNE4{OTF5IN88US=> M1PzXHNCVkeHUh?=
U-87-MG NUXOclhoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTJyLk[0NVMh|ryP NYnKdXZNW0GQR1XS
NCI-H1304 NEXaSIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXy5PJpkUUN3ME2yNE44PTBzIN88US=> MmLhV2FPT0WU
RCC10RGB MorVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nETGlEPTB;MkGuNlgzQSEQvF2= NH\vSWpUSU6JRWK=
NCI-H520 MlnJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXRfpdLUUN3ME2yNk44PjFzIN88US=> NUPSSJRUW0GQR1XS
SK-LU-1 NGjaU|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mkj3TWM2OD1{Mz6wO|E5KM7:TR?= NGD3cY9USU6JRWK=
UACC-893 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLNfHVKSzVyPUKzMlExOzhizszN MYjTRW5ITVJ?
NCI-H2347 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrwZotKSzVyPUKzMlI3PzRizszN M3;4SXNCVkeHUh?=
U-118-MG MmfqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTlbYJKSzVyPUKzMlczOTdizszN MnX2V2FPT0WU
NCI-H596 NWnZdWpVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTJ|LkmwOVUh|ryP NIPlXFZUSU6JRWK=
MZ1-PC NXy2[ZB3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfwXXBKSzVyPUK0MlY4PTlizszN NUmySGZrW0GQR1XS
SW1417 NFfBc2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XQPGlEPTB;MkWuNlQ6QCEQvF2= MWjTRW5ITVJ?
NCI-H82 M2LzXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXrGSHk2UUN3ME2yOk41Ojh6IN88US=> MofMV2FPT0WU
COLO-678 NWXEWpFUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHMTWM2OD1{Nz60PVE6KM7:TR?= MmTyV2FPT0WU
KURAMOCHI NVXOc5pOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jLfGlEPTB;MkiuNVI3KM7:TR?= MnjoV2FPT0WU
NCI-H1650 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXfiZ2RVUUN3ME2zNE4yQTJ2IN88US=> NH\oVW9USU6JRWK=
HCC1954 M3;VUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTNzLkO2OlYh|ryP MWrTRW5ITVJ?
GAK M3TTNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlHmTWM2OD1|Mj6yOlE3KM7:TR?= MVvTRW5ITVJ?
YAPC M1jFdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;xTWM2OD1|Mz63OlQ5KM7:TR?= M{HXZ3NCVkeHUh?=
NCI-H2228 M2XQd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTN2LkO2NFUh|ryP NU\FPWJ4W0GQR1XS
VMRC-RCZ Mm\KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTN4LkOwNlIh|ryP M1\ROnNCVkeHUh?=
NMC-G1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTYTWM2OD1|Nz6wOVI6KM7:TR?= NVS3dWxwW0GQR1XS
D-336MG MnTIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjHc5lkUUN3ME20NU45PDR{IN88US=> M3vycXNCVkeHUh?=
UACC-62 NUTVNZRHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDRXIlTUUN3ME20Nk42PTB3IN88US=> NHzjZZFUSU6JRWK=
C-33-A NIC3d|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH76XZhKSzVyPUS1MlMzPTZizszN Moi2V2FPT0WU
HCC1937 M1zEfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUf1S3k{UUN3ME20O{4yQTV6IN88US=> NEDZenRUSU6JRWK=
HDLM-2 NFXnepBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXufJpKSzVyPUS3MlIzQDdizszN M33mN3NCVkeHUh?=
NCI-H727 NY\BWIR{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGDBboRKSzVyPUS3MlI1PTFizszN MmPkV2FPT0WU
NY NFfqRXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrYTWM2OD12OT6zPVA5KM7:TR?= NEjjNohUSU6JRWK=
NCI-H2291 MlzkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2P1OmlEPTB;NEmuPFMxOSEQvF2= MUnTRW5ITVJ?

... Click to View More Cell Line Experimental Data

体内研究 Decitabine和Vorinostat都具有使肿瘤衰退的功能。然而, Decitabine 和 Vorinostat 联用使肿瘤衰退的效果更强。没有任何处理时,在野生型和Fasgld 小鼠中在肺肿瘤负担方面观察不到明显的区别。然而, Decitabine 和Vorinostat联用处理野生型小鼠,使肿瘤衰退比处理 Fasgld小鼠效果高很多。 Decitabine和Vorinostat使结肠癌细胞对FasL调节的肿瘤衰退敏感。低剂量Decitabine和Vorinostat处理,没有明显的肝脏毒性。[3]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:[4]
+ 展开

组蛋白去乙酰化酶活性测定:

为了进行 HDAC 实验24 × 104 dpm 乙醇溶液(1 mCi/ml)中提供的sup>3H-醋酸钠盐标记的组蛋白H4等份样, 加到每个试管中,试管中含悬浮在25 µL实验buffer(100 mM Tris-HCl pH 8, 2mM EDTA)中的200 µg全部HeLa细胞裂解液进行免疫沉淀获得的HDAC。加入不同浓度Vorinostat,在30oC下温育90分钟。加入20 µL 终止缓冲液(0.5 N HCl, 0.08 M AcOH)终止反应。加入0.8 mL TBME提取释放放入氚醋酸盐。在8,000 × g 转速下离心5分钟,600 µL 有机相(上相) 转移到包含3 mL闪烁液的闪烁瓶中。
细胞实验:[4]
+ 展开
  • Cell lines: NB4, NCI-H460和HCT-116肿瘤细胞系
  • Concentrations: 0 μM - 0.1 μM
  • Incubation Time: 48小时
  • Method: NB4, NCI-H460和HCT-116肿瘤细胞系生长在200 µL 96孔板中,约10%汇合,生长24小时后,覆盖孔中。使用多种浓度 Vorinostat或溶剂处理肿瘤细胞24小时。处理后,冲洗实验板,移除Vorinostat,温育48小时。使用sulphorodamine B 实验测定Vorinostat处理后存活细胞的分数。
    (Only for Reference)
动物实验:[3]
+ 展开
  • Animal Models: 携带CT26 细胞的Fasgld BALB/cByJ小鼠
  • Formulation: Dissolved in DMSO
  • Dosages: 25 mg/kg
  • Administration: 静脉注射
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 52 mg/mL (196.74 mM)
Ethanol 3 mg/mL (11.35 mM)
Water Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
5mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 264.3
化学式

C14H20N2O3

CAS号 149647-78-9
稳定性 powder
in solvent
别名 SAHA, MK0683, suberoylanilide hydroxamic acid

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01281176 Active not recruiting Adult Solid Neoplasm National Cancer Institute (NCI) February 9 2011 Phase 1
NCT01189266 Active not recruiting Anaplastic Astrocytoma|Anaplastic Oligoastrocytoma|Brain Stem Glioma|Childhood Glioblastoma|Giant Cell Glioblastoma|Gliosarcoma|Untreated Childhood Anaplastic Astrocytoma|Untreated Childhood Anaplastic Oligoastrocytoma|Untreated Childhood Brain Stem Glioma|Untreated Childhood Giant Cell Glioblastoma|Untreated Childhood Gliosarcoma National Cancer Institute (NCI) August 9 2010 Phase 1|Phase 2
NCT00703664 Completed Recurrent Mantle Cell Lymphoma|Recurrent Non-Hodgkin Lymphoma National Cancer Institute (NCI) July 9 2008 Phase 2
NCT03198559 Suspended HIV Infections The Peter Doherty Institute for Infection and Immunity|Merck Sharp & Dohme Corp.|The Alfred|University of Melbourne August 8 2017 Phase 1|Phase 2
NCT02538510 Active not recruiting Head and Neck Squamous Cell Carcinoma|Recurrent Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma|Recurrent Nasopharynx Carcinoma|Recurrent Salivary Gland Carcinoma|Squamous Cell Carcinoma Metastatic in the Neck With Occult Primary|Stage III Major Salivary Gland Carcinoma|Stage III Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma|Stage III Nasopharyngeal Carcinoma|Stage IV Nasopharyngeal Carcinoma|Stage IVA Major Salivary Gland Carcinoma|Stage IVA Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma|Stage IVB Major Salivary Gland Carcinoma|Stage IVB Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma|Stage IVC Major Salivary Gland Carcinoma|Stage IVC Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma University of Washington|National Cancer Institute (NCI) October 8 2015 Phase 1|Phase 2
NCT01983969 Completed Advanced Cancers|Lymphoma M.D. Anderson Cancer Center November 7 2013 Phase 1|Phase 2

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常见问题及建议解决方法

  • 问题 1:

    What’s the recommendation about reconstitution of the compound for in vivo animal study?

  • 回答:

    We recommend the following vehicle for S1047: 2% DMSO, 40% PEG 300, 5% Propylene glycol, 1% Tween 80 at 5 mg/mL.

HDAC Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID