Vorinostat (SAHA, MK0683)

目录号:S1047 别名: SAHA, MK0683, suberoylanilide hydroxamic acid

Vorinostat (SAHA, MK0683) Chemical Structure

Molecular Weight(MW): 264.3

Vorinostat (suberoylanilide hydroxamic acid, SAHA)是一种HDAC抑制剂,无细胞试验中IC50为~10 nM。

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客户购买Selleck的此次产品后发表的文献100篇:

客户使用该产品的20个实验数据:

  • Differential effects of HDAC inhibitors on histone and tubulin acetylation. Immunofluorescence analysis of histone H3 (K9ac/K14ac) and tubulin acetylation in HeLa cells treated for 4 h with vehicle, SAHA (10 μM), tacedinaline (50 μM), PCI-24781 (20 μM. (a) Mapping of histone acetylation in K562 cells treated with HDAC inhibitors by LC-MS/MS. Cells were treated with TSA (10 μM), SAHA (5 μM), PCI-24781 (2 μM), tacedinaline (50 μM) for 6 h. Histones were extracted from cells and acetylated peptides were quantified after isobaric tagging.

    Nat Biotechnol 2011 29, 255-265. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Activity of vorinostat in Jurkat and Peer T-ALL cell lines in an MTT cell viability assay. Cells were treated with increasing drug concentrations for 72 h. The data are plotted as the mean % of DMSO-treated control cells against the corresponding drug concentration. The error bars are the standard error. For each drug and cell line, 3-4 independent experiments were performed with 6 replicates at each drug concentration.

    Nature 2011 471, 235-9. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Western blot analysis of histone H3 acetylation in the spleen of untreated and vorinostat-treated hNF-E2 tg mice (n = 4 of each genotype).

    J Exp Med 2012 209, 35-50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    SAHA down-regulates c-FLIP expression and increases the sensitivity of CaP cells to undergo apoptosis in the presence of bicalutamide (A) Bar graph illustrating the sub-G0/G1 cell population in 22Rv1 (left panel) and LNCaP (right panel) cells in the absence and presence of 10μM bicalutamide, administered as a single agent or in ombination with increasing concentrations of the HDAC inhibitor, SAHA. (B) Immunoblots demonstrating the single agent activity of bicalutamide or SAHA, or effect upon their combined administration on the expression of c-FLIP and/or the processing of PARP. Equal protein loading was confirmed by GAPDH. (C) Bar graph illustrating the effect of bicalutamide and SAHA upon the induction of caspase-8 or caspase-3/7 activity in 22Rv1 cells (left panel) and LNCaP cells (right panel). (D) Immunoblots characterizing the impact of SAHA and/or bicalutamide upon the induction of PARP cleavage, in the absence or presence of the pan-caspase inhibitor, ZIETD. ZIETD was incubated with the cells for 12 h prior to the experiment. All data points shown in (A) and (C) represent the mean ± S.E.M. value, calculated from four independent experiments.

    Clin Cancer Res 2012 18, 3822-33. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Analyses of efficacy, potency and IC50 of HDAC inhibitors point toward HDACs 1–3 as relevant candidates for beta cell protection. Ranking and raw data on ITF drugs (Table 3) and commercial HDAC inhibitors (Table 4) underlying the heat maps of Fig. 1 (A and B). The HDAC inhibitor compounds were tested using a HDAC activity kit and recombinant proteins to determine IC50 values on each individual HDAC (right part of the table). Each drug was further tested using Real-Time Cell Analysis (RTCA) to score their maximal effective concentration (ECmax) as well as the corresponding rescue percentage of cytokine treated INS-1 cells. The drugs were ranked according to % rescue. * DMSO alone controls were included in each experiment, but not shown here. The results indicate that the highest concentrations of DMSO used here (1:1,000) were slightly potentiating the proliferation of the cells. The effects observed in this group of compounds were ascribed to the DMSO.?

    Diabetologia 2012 55, 2421-2431. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Proliferation o f HT29 and HCT116 cells after 48 h of butyrate or SAHA treatment. Proliferation measurements using the xCEL Ligence RTCA DP instrument (Roche) in cells treated with increasing doses of butyrate or SAHA, compared with control medium cells (0) (*P < 0.05). The mean ?SEM of three cell culture replicates is shown.

    Mol Carcinog 2012 52, 459-74. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Suberoylanilide hydroxyamic acid (SAHA) preserves CFP (+) expression in mouse optic nerves (MONs) from older mice. (a) CFP (+) mitochondria were longer and thicker in MONs from 12-month-old Thy-1 CFP mice (inset; scale bar = 2 μm). Oxygen–glucose deprivation (OGD) consistently reduced CFP pixel intensity in 12-month-old MONs despite longer and brighter CFP ( +) mitochondria (yellow arrows). (b) Blockade of AMPA/kain ate receptors with NBQX (30 μM), or pan-Histone deacetylase (HDAC) inhibition with SAHA (5 μM), effectively preserved CFP pixel intensity during OGD. The preservation of CFP (+) mitochondria correlates with protection of the CAP area during OGD and profound recovery.

    J Neurochem 2012 123 Suppl 2, 108-15. Vorinostat (SAHA, MK0683) purchased from Selleck.

    D and E, Regression of IL-13Ra 2-negative pancreatic tumors treated with SAHA and/or IL-13-PE. Mice were treated daily with i.p. injection of SAHA (25 mg/kg) from day 4 after tumor implantation for two weeks followed by i.t. injection of IL-13-PE (100 μ g/kg) from day 5 for two weeks. F and G, Regression of IL-13Ra 2-posotive pancreatic tumors (HS766T and MIA-PaCa2) treated with SAHA and/or IL-13-PE. The schedule of treatment was similar as in panel D and E. Statistical significances are shown by *: P < 0.05,†: P < 0.001.

    J Transl Med 2011 9, 37. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • IL-13Rα2 expression is upregulated in pancreatic tumors but not in organs of mice after treatment with HDAC inhibi tor, SAHA. A, qRT-PCR of human IL-13Rα2 in implanted pancreatic tumors after SAHA and IL-13-PE treatment. Tumors were harvested next day after IL-13-PE treatment and total RNA extracted. Data shown is ratio of human IL-13Rα2/β-actin expression and multiplied by 1000 for convenience. Bars , SD of triplicate determinations. B, qRT-PCR of mouse IL-13Rα2 in mice organs after SAHA and IL-13-PE treatment. Tissues were harvested at the same time point as in panel A and total RNA extracted. Data shown is ratio of mouse IL-13Rα2/β-actin expression and multiplied by 100 for convenience. C, IHC of human IL-13Rα2 in implanted pancreatic tumors after SAHA and IL-13-PE treatment. D, IHC of mouse IL-13Rα2 in mice organs after SAHA and IL-13-PE treatment. Liver, brain, kidney, pancreas, lung and spleen were fixed for immunostaining of mouse IL-13Rα2 as visualized by Alexa555. Nucleus was counterstained by DAPI.

    J Transl Med 2011 9, 37. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Vorinostat inhibits the tumor growth. NOD ⁄ SCID-B2m-/-mice were injected s.c. with 1×106 MyLa2059 cells into both flanks. When the mice had developed established palpable tumors treatment was initiated (day 1). The mice received either vehicle (black line) or 60 mg ⁄ kg vorinostat (grey line) i.p. five days a week. In total, there were four mice in the group receiving vehicle and three mice in the group receiving vorinostat. The length and width of the tumors were measured continuously until the experiment was terminated on day 20 post treatment initiation. The tumor volume was calculated using the formula V = (a×b2)/2, where a defines the length (mm) and b the width (mm) of the tumor. The histogram shows the average tumor volume per flank ± SEM. * denotes a significant difference (P < 0.05) in the average tumor volume per flank between mice treated with vehicle and vorinostat at the given time-point both by using a one-tailed two samples test with Welch, scorrection and a Mann-Whitney U test.

     

     

    Exp Dermatol 2010 19, 1096-1102. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • SAHA induces the down-regulation of cFLIP expression and promotes TRAIL-mediated activation of a mitochondrial-operated apoptotic pathway. a BT-474 cells were treated as indicated in Fig. 1 and the cells were then harvested to analyse caspase-8, Bid, caspase-9, caspase-3 and PARP expression, using GAPDH as the protein loading control. b BT-474 cells were treated with SAHA for 8 h at the doses indicated and subsequently, the cells were harvested and the apoptosis-related proteins were analysed in western blots as described in the "Materials and Methods". The results shown are representative of at least three independent experiments

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Treatment with SAHA sensitizes breast cancer cells to TRAILinduced apoptosis. BT-474 and MDA-MB-231 cells were incubated for 8 h with SAHA at the doses indicated. After this time, TRAIL (500 ng/ml) was added to some of the cultures for an additional 15 h. Apoptosis was measured as the percentage of cells with subG1 DNA content as described in the "Materials and methods". The results show the mean and S.E.M. of three independent experiments

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • SAHA facilitates the Itch/AIP4-independent proteasomal degradation of cFLIP proteins in breast cancer cells. a BT-474 cells were treated with SAHA (5 μM) for 8 h in the presence or absence of the proteasome inhibitors MG132 or epoxomicin (at the doses indicated), and they were then harvested and the cFLIP content was analysed in western blots. b BT-474 cells were transfected with either the siRNA oligonucleotides targeting Itch/AIP4 or the non-targeting RNA oligonucleotide (scrambled) for 48 h as described in the "Materials and Methods". Subsequently, the cells were treated with SAHA (5 μM) for 8 h and then cFLIP and Itch/AIP4 expression was analysed in immunoblots

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

    cFLIP down-regulation following SAHA treatment is responsible for the sensitization of breast cancer cells to TRAIL. a BT-474 cells were transfected with either different siRNAs directed against the cFLIP isoforms or the non-targeting RNA oligonucleotide (scrambled) as described in the "Materials and Methods". After 24 h, the cells were treated with TRAIL (500 ng/ml) for a further 15 h and apoptosis was then measured as the percentage of cells with subG1 DNA content. The results show the mean and S.E.M. of three independent experiments. To verify protein knockdown, cells were harvested 24 h after transfection and the cFLIP levels were assessed in immunoblots. b. BT-474 cells overexpressing Cflipl (pBABE-FLIPL) or control cells (pBABE) were treated with SAHA for 8 h at the doses indicated. After this time, TRAIL (500 ng/ml) was added to some cultures for 15 h. Apoptosis was measured as the percentage of cells with subG1 DNA content and the results show the mean and range of two independent experiments. Western blots show the cFLIP levels after SAHA treatment in pBABE and pBABE-FLIPL cells.

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • (a) Western blot of whole cell extracts demonstrates SAHA and NaB treatment result in increased levels of acetylated histone H3 compared to vehicle controls. (b) Light micrographs of HDACi/vehicle treated cultures illustrate the paucity of neurospheres in HDACi-treated cultures. (c) Quantitative analysis confirms SAHA and NaB inhibit the formation of neurospheres (diameter ≥ 50 μm) and increase the prevalence of small cell clusters (≥ 4 cell, diameter < 50 μm). (d) Flow cytometry using LIVE/DEAD cell stain confirms SAHA and NaB are minimally toxic compared to vehicle controls (n = 3). Scale bar = 100 μm.

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    (a) EdU flow cytometry of live cell-gated adult mouse NSCs demonstrates SAHA (**p < 0.01) and NaB (***p < 0.001) significantly inhibit DNA synthesis. (b) Analysis of DNA content by flow cytometry reveals significant accumulation of adult mouse NSCs in G1phase of the cell cycle following SAHA (*p < 0.05) and NaB (*p < 0.05) treatment. (c) Correspondingly the proportion of cells in G2/M phase is significantly reduced following SAHA (*p < 0.05) and NaB (*p < 0.05) treatment. (d) Fluorescence micrographs of HDACi/vehicle treated adult NSCs pulse-labeled with EdU for flow cytometry. Scale bar = 50 μm. Statistical comparisons performed using one-way ANOVA with post hoc Newman-Keuls multiple comparison tests.

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • (a) Immunofluorescence labeling of NeuN, GFAP and Olig2 cell fate markers reveals reduced expression of GFAP (*p < 0.001) and Olig2 (*p < 0.05) in adult mouse NSCs treated with SAHA for 48 hours under proliferation culture conditions and then induced to differentiate for 14 days in culture (two-way ANOVA with Bonferroni post-tests). (b) Western blot of β-catenin protein in nuclear and cytoplasmic fractions of adult mouse NSCs treated with HDACi/vehicle control under proliferation culture conditions. Gapdh and lamin A/C blots are included as loading controls. (c) SAHA and NaB do not significantly alter nuclear/cytoplasmic levels of β-catenin in adult mouse NSCs. Histogram of β-catenin Western blot signal intensities normalized to loading controls (n = 4).

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Morphological changes and histone H3 phosphorylation of HB cells treated with a combination of VX-680 and SAHA. HUH6 and HepT1 were incubated with VX-680 (6 μM) and SAHA (0.5 μM). Nuclei diameter (a) and cell diameter (b) were determined 72 h later by DAPI staining and microscopy. Data represent mean±SD of the diameters from 20 cells in each experiment. (* Two-way ANOVA, Bonferroni test, p \0.05). c Western blot analysis on HUH6 and HepT1 cells were carried out with an anti-phospho-Histone H3 (Ser 10) antibody (p-H3) 24 h after incubation with VX-680 (10 μM), SAHA (0.2 μM) or a combination of both. Controls were left untreated. Western blot analysis showed a decrease in p–H3 after treatment with VX-680 ( lane 2 ) relative to controls ( lane 1 ) and an increase when SAHA was added ( lane 3 ). For the combination of VX-680 and SAHA (lane 4 ) no p-H3 was detected.

    Pediatr Surg Int 2012 28, 579-89. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Vorinostat promotes C2C12 differentiation.In the image, the red is the myotube indicating differentiation ,the blue is the nuclei.

     

     

    Dr. Akihiko Yoshimura of Akihiko Yoshimura. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Western blot analysis of Acetyl-H3 and H3. 0-20μM SAHA was added.

     

     

    Dr. Zhang of Tianjin Medical University. Vorinostat (SAHA, MK0683) purchased from Selleck.

产品安全说明书

HDAC抑制剂选择性比较

生物活性

产品描述 Vorinostat (suberoylanilide hydroxamic acid, SAHA)是一种HDAC抑制剂,无细胞试验中IC50为~10 nM。
特性 Vorinostat是广谱HDAC活性抑制剂,抑制I和II类酶 。
靶点
HDAC [1]
(Cell-free assay)
~10 nM
体外研究

Vorinostat是小分子量(<300)线性肟酸,抑制HDAC活性,包括乙酰化组蛋白和非组蛋白的积累,抑制培养细胞的增殖,且抑制肿瘤生长。Vorinostat通过结合到酶的活性位点而抑制 HDAC活性。Vorinostat 抑制多种转化细胞增殖(包括 淋巴瘤,多发性骨髓瘤,白血病,和非小细胞肺癌),与对照组相比抑制生长达50% 时的浓度为0.5 到10μM。Vorinostat作用于淋巴瘤和白血病细胞,包括 Burkitt, B-细胞急性淋巴细胞白血病 (B-ALL), MCL, DLBCL, ATL和T-细胞,不同程度抑制细胞增殖。除了抑制转化细胞增殖, Vorinostat 也抑制正常细胞增殖,通过比较Vorinostat 作用于一组细胞系–正常人非纤维细胞(WI-38)和 SV40巨大T抗原转化WI-38(VA-13细胞)而得到证明。Vorinostat 抑制两种类型细胞增殖,这种作用存在剂量依赖性。但发现Vorinostat 对转化细胞具有选择毒性,包括使肿瘤细胞死亡,而对正常细胞只起抑制作用,不会使其死亡。[1] Genistein 和Vorinostat 联用效果比5-aza和Vorinostat 联用作用于诱导细胞死亡有效很多。Genistein和Vorinostat联用作用于ARCaP-E使增殖降低 80 %,作用于ARCaP-M细胞,增殖降低60 %以上。Genistein和Vorinostat 联用抑制细胞增殖具有协同效应。作用于ARCaP-E 细胞(820个基因 诱导和1046个基因抑制) ARCaP-M 细胞,Vorinostat比Genistein 影响更多基因。[2] Vorinostat作用于肿瘤细胞表面,提高Fas蛋白水平,这种作用存在剂量依赖性,且按0.75 μM剂量处理,提高达到一个稳定水平。[3] Vorinostat 抑制肿瘤细胞生长,包括NB4, H460 和HCT-116,IC50分别为0.7μM, 3.4μM和1.2 μM。[4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
A20 MlO1T4lv[XOnIFHzd4F6 NY\QTI9QOSCq MXvEUXNQ NETUeHhidnSrLVjERWMyKGGldHn2bZR6KHerdHigTWM2OCCxZjCwMlEyOiEQvF2= M2[xTFEyQTZyNEi5
Friend leukemic cell NYrVcog6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3[yZVUxKM7:TR?= NVm5cFMzPzJiaB?= MX3EUXNQ M1[5cWlEPTB;MD65PUDPxE1? M2Pw[FEzOTB7OUGz
K562 MVLLbY5ie2ViQYPzZZk> NYLaUIpiPiCq NXnvfWwxTE2VTx?= MknrTY5pcWKrdHnvckBw\iCqdX3hckBpcXO2b37lJIRm[WOndInsZZNmKCivaYj0eZJmKG:oIFjERWMyKGGwZDDISGFEOilid3n0bEBKSzVyIH;mJFAvODFizszN NFjPcWkyOjRzOUO4NC=>
HT1080 NH3USnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7iNJU4OiCq MonQSG1UVw>? MkDFTWM2OD1{LkSg{txO MVuxNlI4ODF5NR?=
H1299 Mm\kT4lv[XOnIFHzd4F6 M{jz[lIxKG2rbh?= M1zQXmROW09? NFTWUm5KdmirYnn0c5J6KGGldHn2bZR6KGGpYXnud5QhUESDQzDlcpp6dWVid3n0bEBKSzVyIH;mJFAvOTl2IN88US=> M{nzUVE1PTJzNEKy
H1299 NYT5eYpCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUm4SpllPzJiaB?= MkL1SG1UVw>? NXG2NGEzUUN3ME23MlI1KM7:TR?= M4rzRlE1PTJzNEKy
HeLa MXnLbY5ie2ViQYPzZZk> Mlf0N|AhdWmw M2ftZWlvcGmkaYTvdpkh[2:wY3XueJJifGmxbjDh[4FqdnO2IHjpd5RwdmViZHXhZ4V1gWyjc3Wge4l1cCCLQ{WwJI9nKDBwMkig{txO M2npelE2PjB|OUS5
LOX-IMVI NV3aXodWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnZOFghcA>? MoLtTWM2OD1zLkOg{txO M1\XWFE2PzF3NEew
NCI-H226 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHe4Zmo1QCCq MYrJR|UxRTJwNjFOwG0> M{jk[VE2PzF3NEew
RXF-631L MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYC0PEBp M4O1c2lEPTB;MjFOwG0> NGG1c3QyPTdzNUS3NC=>
SNB-78 NWHF[mRWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHEcpk1QCCq MVLJR|UxRTF4IN88US=> NGLIUVUyPTdzNUS3NC=>
St-4 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHQOWxSPDhiaB?= M3v2e2lEPTB;NT6yJO69VQ>? M2jib|E2PzF3NEew
ARP1 NFS5RWFHfW6ldHnvckBCe3OjeR?= MUKyJO69VQ>? MXW2JIg> NVLjTmFCUW6mdXP0bY9vKG:oIGCyNXdCTjFiZ3Xu[UBmgHC{ZYPzbY9v NX\kdllWOTR5M{S4NFY>
CEM M1jRN2tqdmG|ZTDBd5NigQ>? M33ENVEhcA>? MVrEUXNQ M2\3dmlvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD6zN{DPxE1? MljTNVY1OjByNkS=
HCT15 NHnvTpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfwOFghcA>? MVjHTVUxRTBwOEKg{txO MWCxOlczOzJ{Nx?=
NCI-H23 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4XoPVQ5KGh? MlTiS2k2OD1yLkmyJO69VQ>? MYmxOlczOzJ{Nx?=
GM15850 MljsT4lv[XOnIFHzd4F6 NEHxNFgzNjVizszN NY\1XWFzQTZiaB?= NFW1dWhFVVOR M1K1emlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIFizJIx6e2mwZTCxOEBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= Ml3jNVY6OjF|Nke=
GM15850 NIPXOZJMcW6jc3WgRZN{[Xl? MnLUNk42KM7:TR?= M{nYclk3KGh? NFO5dGlFVVOR NXvvdVAxUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFUh[WOndInsZZRqd25ib3[gSnhPKGenbnW= Mn;MNVY6OjF|Nke=
GM15850 NYq0PIZIU2mwYYPlJGF{e2G7 Mn;MNk42KM7:TR?= MlTaPVYhcA>? M3LL[2ROW09? NIXhfXlKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIOEBtgXOrbnWgNVIh[WOndInsZZRqd25ib3[gSnhPKGenbnW= M17i[VE3QTJzM{[3
GM15850 M1THdWtqdmG|ZTDBd5NigQ>? MkXXNk42KM7:TR?= MYq5OkBp NYDh[nZ4TE2VTx?= NX6wXGx[UW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFMhdHm|aX7lJFkh[WOndInsZZRqd25ib3[gSnhPKGenbnW= M{n4XlE3QTJzM{[3
GM15850 M1nkTGtqdmG|ZTDBd5NigQ>? NU\RZoo{Oi53IN88US=> M4[xcFk3KGh? MkWzSG1UVw>? NFX6RXJKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIOEBtgXOrbnWgPEBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= Ml3uNVY6OjF|Nke=
GM15850 MXrLbY5ie2ViQYPzZZk> NVLBOWRMOi53IN88US=> MYS5OkBp NGK1eoNFVVOR M1zDcGlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIFi0JIx6e2mwZTCxOkBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= NVq4[2diOTZ7MkGzOlc>
U937 MUDGeY5kfGmxbjDBd5NigQ>? Mn7TOUDPxE1? M3TXPFI1KGh? MnXXSG1UVw>? NWTXbZViS2WubDDjfYNt\SCjcoLld5Qh[nliYXPjeY12dGG2aX;uJIF1KFNxR{KvUUBxcGG|ZR?= MXyxO|AxPDdzOB?=
H661 MmC0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV:0PEBp MkjoTWM2OD1zIN88US=> NIHMcocyPzF3N{CwPS=>
U937 NWHFN|V6TnWwY4Tpc44hSXO|YYm= NXvDZlFPPSEQvF2= NYnGRo9COjRiaB?= Mme0SG1UVw>? Mo\BTY5kemWjc3WgbY4hcGm|dH;u[UBJOyCjY3X0fYxifGmxbh?= MYixO|Q1Pzd3MB?=
U937 NW\uNFRzTnWwY4Tpc44hSXO|YYm= Mnv0NUDPxE1? MnTrNlQhcA>? MUTEUXNQ MWPF[oZm[3Rib36gZYxxcGFidIXieYxqdiCjY3X0fYxifGmxbh?= NUXaeWZCOTd2NEe3OVA>
RAW264.7 M3\rUGZ2dmO2aX;uJGF{e2G7 NITmToQyOCEQvF2= NFPmOVYzPGh? NHfNS|R4[XSnch?= M4qxN2lvcGmkaYTpc44hd2ZiTGDTMZN1cW23bHH0[YQhXE6IYXzwbIEheHKxZIXjeIlwdiC5aYToJGlEPTBib3[gNE44PiEQvF2= MkDFNVc1Pzd3MUi=
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Primary bronchial epithelial cell MXHLbY5ie2ViQYPzZZk> NXftbWpTPSEQvF2= NVnVeZhnOjRiaB?= MkLKSG1UVw>? NX\F[XFUUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnu[JVkfGmxbjDv[kBufXSjboSgSoRmdHSjNUC4JGNHXFJicILveIVqdiCjcHnjZYwhe3W{ZnHj[UBtd2OjbHn6ZZRqd25? NHXZcJIyQTl4Nke4PS=>
Primary bronchial epithelial cell MnzoT4lv[XOnIFHzd4F6 MWWxJO69VQ>? M4C1dVk3KGh? NVXscXZLTE2VTx?= NXLXN3dWUW6qaXLpeIlwdiCxZjDISGFEPyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDpckB{cG:{dDDjbZJkfWm2IHP1dpJmdnS| M1\HN|E6QTZ4N{i5
BxPC3 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXG3NkBp MonTTWM2OD1{Lkeg{txO MXWyNFE1Ozd5OB?=
CAL27 NGjIc3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXK3NkBp M3j0TGlEPTB;Mz63NkDPxE1? NWXPO3Z5OjBzNEO3O|g>
Capan1 MofSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PhO|czKGh? NYrJXm5iUUN3ME23MlMh|ryP M3HYN|IxOTR|N{e4
HCC827 M2nPR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4HYOVczKGh? NELFOnBKSzVyPUGuPEDPxE1? NVn4RWVQOjBzNEO3O|g>
LNCAP NWTMSXhtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfDWWg4OiCq NYnvOlV3UUN3ME2wMlU5KM7:TR?= M4jlelIxOTR|N{e4
NCI-H2122 NG[5dmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmT4O|IhcA>? MXHJR|UxRTdwNTFOwG0> NFG5RWozODF2M{e3PC=>
NCI-H358 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLGO|IhcA>? NUm5bop[UUN3ME2yMlUh|ryP NHjnbIszODF2M{e3PC=>
SCC15 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFvWdm44OiCq M3i3NGlEPTB;Mj60PUDPxE1? M2\PW|IxOTR|N{e4
SCC25 NVu2WlNKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYO3NkBp M2DVbGlEPTB;MT65N{DPxE1? Mlz5NlAyPDN5N{i=
SKHEP1 NEDoOGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHOZpg4OiCq MnPxTWM2OD1|LkS2JO69VQ>? MXWyNFE1Ozd5OB?=
BJ NFPwT5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWGwdJJpOTByIN88US=> NUfDbJNCPDhiaB?= M1PBdmROW09? MU\Hdo94fGhiaX7obYJqfGmxbjDheEAxNjB3IITvJFExOCC3TR?= M4jLVFIxOTR|OESw
MUF NXTaRlNyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlTlNVAxKM7:TR?= NU\SO3dxPDhiaB?= NFHlUIhFVVOR MU\Hdo94fGhiaX7obYJqfGmxbjDheEAxNjB3IITvJFExOCC3TR?= NYjXNFhEOjBzNEO4OFA>
Caco-2 NYfSdXYxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm[5NVAxKM7:TR?= NX7LfJZoPDiq MVLEUXNQ NEXTO5JKSzVyPUiuNUDPxE1? NInCdYozODF2M{i0NC=>
Caco-2 MofYT4lv[XOnIFHzd4F6 MlTFOUDPxE1? NHWwV5E1KGh? M4j6ZWROW09? MnT6TY5lfWO2aX;uJI9nKEiGQVOtcYVlcWG2ZXSgbIl{fG:wZTDhZ4V1gWyjdHnvckBKSzVyIH;mJFAvODN5IN88US=> NVXzW48xOjBzNEO4OFA>
Caco-2 MYPLbY5ie2ViQYPzZZk> MnLkNE4{OTZibl2geI8hOzFwNjFOwG0> NYrkWWI5PCCq MWLEUXNQ MmTVSZghfmm4bzDpcohq[mm2aX;uJI9nKGi3bXHuJGhFSUNzIIfpeIghUUN3MDDv[kAxNjFzOTFOwG0> NV7kPY9tOjBzNEO4OFA>
Caco-2 NH[wVIhMcW6jc3WgRZN{[Xl? M4\kb|AvOzF4IH7NJJRwKDNzLk[g{txO Ml7kOEBp NYXadpNtTE2VTx?= NH60SZBGgCC4aY\vJIlvcGmkaYTpc44hd2ZiaIXtZY4hUESDQ{Oge4l1cCCLQ{WwJI9nKDBwMUS3JO69VQ>? NE[1PHAzODF2M{i0NC=>
Caco-2 NVPPcI9xU2mwYYPlJGF{e2G7 MmGwOk4{OiCwTTD0c{A3OzJizszN NYiyRm4yPCCq MUXEUXNQ MXfFfEB3cX[xIHnubIljcXSrb36gc4YhcHWvYX6gTGRCSzVid3n0bEBKSzVyIH;mJFEzNjZizszN NIDGdZozODF2M{i0NC=>
Caco-2 NYjMdoZmU2mwYYPlJGF{e2G7 MmHmOk4{OiCwTTD0c{A3OzJizszN NXPyRlhnPCCq NYDudpMxTE2VTx?= NHuxV5VGgCC4aY\vJIlvcGmkaYTpc44hd2ZiaIXtZY4hUESDQ{ege4l1cCCLQ{WwJI9nKDRzIN88US=> NFvVdlczODF2M{i0NC=>
Caco-2 NIHiO4xMcW6jc3WgRZN{[Xl? M2KwUVAvOzF4IH7NJJRwKDNzLk[g{txO MmjsOEBp MVnEUXNQ MlvXSZghfmm4bzDpcohq[mm2aX;uJI9nKGi3bXHuJGhFSUN4 M3;ySVIxOTR|OESw
HepG2 MXTLbY5ie2ViQYPzZZk> MofROUDPxE1? MmiwOog> MlfLSG1UVw>? NGixOnBKdmS3Y4Tpc44hd2ZiSFTBR{1u\WSrYYTl[EBpcXO2b37lJIFk\XS7bHH0bY9v MX2yNFE1Ozh2MB?=
HepG2 MmTKT4lv[XOnIFHzd4F6 NXLP[45GPSEQvF2= NEDS[W03cA>? MWLEUXNQ MkftTY5lfWO2aX;uJI9nKEiGQVOtcYVlcWG2ZXSgbIl{fG:wZTDofZBmemGlZYT5cIF1cW:w NECzR3MzODF2M{i0NC=>
HepG2 Mn64T4lv[XOnIFHzd4F6 MUe1JO69VQ>? NHzxVpI3cA>? MVTEUXNQ M{flW2lv\HWldHnvckBw\iCKRFHDMY1m\GmjdHXkJIFteGijLYT1ZpVtcW5iYXPleJlt[XSrb36= NUjQcGpPOjBzNEO4OFA>
HepG2 M4nwOmtqdmG|ZTDBd5NigQ>? MX[1JO69VQ>? NXrqN|JlPmh? M3z0eWROW09? NUXEOnZbUW6mdXP0bY9vKG:oIFjERWMudWWmaXH0[YQhUDNxSESgbIl{fG:wZTDhZ4V1gWyjdHnvci=> MWGyNFE1Ozh2MB?=
COLO205 M4naVmtqdmG|ZTDBd5NigQ>? NYDBUmdyOTBizszN NI\UUpgzPCCq MV3EUXNQ MXLJcohq[mm2aX;uJI9nKEiGQVOxJIF{e2W|c3XkJIF{KGmwZIXjeIlwdiCxZjDobZN1d26nIFizJIFk\XS7bHH0bY9vKHerdHigTWM2OCCxZjCyMlIh|ryP NYT4W|hsOjB2NUGzO|g>
SCC4 MX;LbY5ie2ViQYPzZZk> M4qwdlEh|ryP MYWyOIg> MoPBTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIIT1ZpVtcW5iYXPleJlt[XSrb36= MX6yNFQ2OjJ{NR?=
SCC4 MonPT4lv[XOnIFHzd4F6 NHnPWZAyKM7:TR?= M{f2UFI1cA>? NFjhblVKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDhZ4V1gWyjdHnvci=> M2DQ[|IxPDV{MkK1
SCC4 NUnEbJVITnWwY4Tpc44hSXO|YYm= NXLlVlkxOSEQvF2= MoDzOUBucW5? NEPMfFhC\2:waYP0JIFkfGm4aYT5JIF1KF[GUjDhd5Nme3OnZDDhd{BqdmS3Y4Tpc44hd2ZiQ2nQNlQh\2WwZTDlfJBz\XO|aX;u MkX4NlA1PTJ{MkW=
NB4 NV3zTYpnTnWwY4Tpc44hSXO|YYm= NYD2WJBGPSEQvF2= MoX5NlQhcA>? M2PReGROW09? NXjY[WRUS2WubDDjfYNt\SCjcoLld5Qh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gZYNkfW23bHH0bY9vKGG2IIDy[U1IOSCyaHHz[S=> NY[2OmFvOjB2OUG0OFA>
NB4 M1SwbWtqdmG|ZTDBd5NigQ>? MX[1JO69VQ>? NFXifXAzPCCq MVLEUXNQ MoXETY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHHj[ZR6dGG2ZTD0eYJ2dGmwIHzleoVt MnrrNlA1QTF2NEC=
NB4 NWfXbYZuTnWwY4Tpc44hSXO|YYm= MWW1JO69VQ>? NV;RcXU{OjRiaB?= M37vfmROW09? NFfQdZlKdmS3Y4Tpc44hd2ZicEKxW2FHOS:FSWCxJIV5eHKnc4Ppc44> MXuyNFQ6OTR2MB?=
NB4 MoCxT4lv[XOnIFHzd4F6 M16xWlUh|ryP M4fDOVI1KGh? MVzEUXNQ NV;GbplSUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFMh[WOndInsZZRqd25? MVmyNFQ6OTR2MB?=
NUGC3 M2XHfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHv2UXhIUTVyPUKuPVQh|ryP M{HsT|IxQDVyOUex
A549 NIfKOFVHfW6ldHnvckBCe3OjeR?= M2jxZVUh|ryP M1nHNlMhcA>? MoLaSG1UVw>? MVzJcoR2[3Srb36gc4Yh[XW2b4DoZYd6KGmwIHj1cYFvKEF3NEmgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hVEN|SVm= NHPsenkzODh3NUKwPC=>
HUT78 NUDneoVDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXq3NkBp MlHySG1UVw>? NXjGS2lPT0l3ME2wMlMh|ryP M4rJeFIxQDh2MkC4
U937 M3rDPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWK3NkBp NUPBVGRLTE2VTx?= MlOyS2k2OD1yLkO5JO69VQ>? Mo\rNlA5QDR{MEi=
A431 M4f3WGN6fG:2b4jpZ{BCe3OjeR?= M3fBNFczKGh? MY\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOFMyKGOnbHzzJI93\XKneIDy[ZN{cW6pIFXHSnIhf2m2aDDJR|UxKG:oIESuNkDPxE1? MWmyNVA5ODZ{OR?=
A549 MVfDfZRwfG:6aXOgRZN{[Xl? Mn20O|IhcA>? NX61Zpo1S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTV2OTDj[YxteyCxdnXy[ZhxemW|c3nu[{BJTEGFIIfpeIghUUN3MDDv[kAyNjhizszN M{LrSFIyODhyNkK5
CAL27 MV3DfZRwfG:6aXOgRZN{[Xl? NYL1d41FPzJiaB?= M3LP[WN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGNCVDJ5IHPlcIx{KG:4ZYLlfJBz\XO|aX7nJGVITlJid3n0bEBKSzVyIH;mJFMvOiEQvF2= MXOyNVA5ODZ{OR?=
HeLa NF\RSohEgXSxdH;4bYMhSXO|YYm= M1LTe|czKGh? NVf0e3drS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWOYTDj[YxteyCxdnXy[ZhxemW|c3nu[{BJTEGFIIfpeIghUUN3MDDv[kAyNjVizszN NFTp[IEzOTB6ME[yPS=>
Sf21 NHHafJFMcW6jc3WgRZN{[Xl? MUOzJIg> MmDoTY5pcWKrdHnvckBw\iCIbHHnJJRi\2enZDDoeY1idiC{ZXPvcYJqdmGwdDDISGFEQCCneIDy[ZN{\WRid3n0bEBKSzVyIH;mJFEvOiEQvF2= Mnv3NlExQDB4Mkm=
SKBR3 NYnweJVOS3m2b4TvfIlkKEG|c3H5 MUW3NkBp M3faU2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNMSlJ|IHPlcIx{KG:4ZYLlfJBz\XO|aX7nJGhGWjJid3n0bEBKSzVyIH;mJFIvPiEQvF2= NIHmXmozOTB6ME[yPS=>
SKOV3 NHjSZ3lEgXSxdH;4bYMhSXO|YYm= NYfhVpdqPzJiaB?= NFHVV|ZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBUU0:YMzDj[YxteyCxdnXy[ZhxemW|c3nu[{BJTVJ{IIfpeIghUUN3MDDv[kAzNjJizszN MXWyNVA5ODZ{OR?=
COR-L23 MlHTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY[xNEDPxE1? NF;kfok4OiCq M3q2O2ROW09? NFG5XZdIUTVyPUGuNUDPxE1? NYC3OXh1OjFyOEC2OFc>
DU145 MojnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTDOVBzOTBizszN MVW3NkBp NXrxeFJCTE2VTx?= MoDNS2k2OD1zLkC1JO69VQ>? NFy1PWMzOTB6ME[0Oy=>
LoVo NVfudYFFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NITsd44yOCEQvF2= NFrCWok4OiCq MXPEUXNQ M13tOGdKPTB;MT63JO69VQ>? NHLPUnQzOTB6ME[0Oy=>
MCR5-SV2 M{S4[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUSxNEDPxE1? NXPRbnc5PzJiaB?= MU\EUXNQ NYLrVVJPT0l3ME2yMlEh|ryP NWPQbJE1OjFyOEC2OFc>
HCT116 NIeyeotMcW6jc3WgRZN{[Xl? M{HkZVMxKM7:TR?= M4fYUVMxKGh? MWLEUXNQ NUTWWVczUW6qaXLpeIlwdiCxZjDISGFEPiCjc4Pld5Nm\CCjczDpcoR2[3Srb36gc4Yh[WyyaHGteJVjfWyrbjDhZ4V1gWyjdHnvci=> NFT4U44zOTB6ME[0Oy=>
HCT116 NH7DSYlMcW6jc3WgRZN{[Xl? NX7sO5RtOzBizszN NX;4XItsOzBiaB?= NYDvUVk1TE2VTx?= MWrJcohq[mm2aX;uJI9nKEiGQVOxJIF{e2W|c3XkJIF{KGmwZIXjeIlwdiCxZjDobZN1d26nIFizT|kh[WOndInsZZRqd25? M33BNFIyODhyNkS3
U937 M3y0PWtqdmG|ZTDBd5NigQ>? Ml7IOUDPxE1? NYTjOXRDOjRiaB?= NIjGUJpFVVOR MknNTY5pcWKrdHnvckBw\iCqaYP0c45mKGGlZYT5cJRz[W6|ZnXyZZNmKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIH;mJIFk\XS7bHH0bY9vKG:oIHjpd5RwdmViSEOgZZQhUzl? NVL5U41nOjF{OUK0PVI>
U937 M3nBZWtqdmG|ZTDBd5NigQ>? M{fBSlUh|ryP MnywNlQhcA>? M1TYR2ROW09? M2jTN2lvcGmkaYTpc44hd2ZiaHnzeI9v\SCjY3X0fYx1emGwc3\ldoF{\SCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDv[kBi[2W2eXzheIlwdiCxZjDobZN1d26nIFizJIF1KEtzOB?= MkLQNlEzQTJ2OUK=
U937 NVTKeVRiU2mwYYPlJGF{e2G7 NWnKWVFVPSEQvF2= NWW1TnFzOjRiaB?= M4HNW2ROW09? MU\Jcohq[mm2aX;uJI9nKGirc4TvcoUh[WOndInseJJidnOoZYLhd4Uh[XO|ZYPz[YQh[XNiaX7jdoVie2Vib3[gdIFvNWGlZYT5cIF1\WRiaHnzeI9v\SCKNDDs[ZZmdA>? NV:5bow{OjF{OUK0PVI>
U937 NXG4RVZpU2mwYYPlJGF{e2G7 NXqzPYM4PSEQvF2= NFzMdpMyPSCvaX6= NGfGO5NFVVOR NGTCfYpKdmirYnn0bY9vKG:oIHjpd5RwdmViYXPleJltfHKjboPm[ZJie2ViYYPz[ZN{\WRiYYOgbY5kemWjc3Wgc4YhcGm|dH;u[UBJOyCjY3X0fYxifGmxbjDs[ZZmdA>? MWGyNVI6OjR7Mh?=
A2780 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV:5OkBp M4nvTmROW09? NV\ZRmFPUUN3ME2xMlYzKM7:TR?= NIHxXpEzOTZ|NESzNC=>
COLO205 MmLRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXwbXU6PiCq MoPySG1UVw>? NXzqNlNYUUN3ME2yMlEzKM7:TR?= MoC1NlE3OzR2M{C=
Hep3B NVXNNHdET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHIOFghcA>? NWLjcoVMTE2VTx?= M4TxUGdKPTB;MT6yNUDPxE1? MUOyNVcyOjF2Nh?=
GM11272 NYfIR5ZwTnWwY4Tpc44hSXO|YYm= NHjEcWkyODBibl2= NVX1eIoxPzJiaB?= MW\EUXNQ MX7S[YFkfGm4YYTpc44hd2ZiTXXDdFIhdXW2YX70JIV5eHKnc4Ppc44h[XRiMUCgeI8hOTByIH7N MkOxNlE5PDB5MU[=
CFBE41o MWnLbY5ie2ViQYPzZZk> Mo\iOUDPxE1? NHLRb25FVVOR MnHKSI94diC{ZXf1cIF1cW:wIH;mJGhFSUN5IHH0JFAvOiC2bzC1JJVO M3S0OVIyQTh2OUW4
CFBE41o MknUSpVv[3Srb36gRZN{[Xl? Ml7qNUDPxE1? MmTINlQhcA>? NWrs[JVbTE2VTx?= NIDieYJT\XO2b4LheIlwdiCxZjDDSnRTKGSnbIThSlUxQCCvdYThcpQhfHKjZn\pZ4tqdmdidH:gZ4VtdCC|dYLmZYNmKGG|IHfsfYNw\m:{bYO= NV[1WldVOjF7OES5OVg>
DU145 NGLrOHdMcW6jc3WgRZN{[Xl? M3i4OFIvPSEQvF2= M2KxUVI1KGh? Ml;HSG1UVw>? Mn;zTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KHWycnXneYxifGmxbjDv[kBxOjG5YX[xJJBzd3SnaX6g[ZhxemW|c3nvci=> MnXTNlIzPjBzNk[=
DU145 M2n5VmtqdmG|ZTDBd5NigQ>? NWfTVIdMPSEQvF2= M4SyUlI1KGh? MkPvSG1UVw>? MmHBTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGirc4TvcoUhUDRiYXPleJlt[XSrb36= NYO2cYc6OjJ{NkCxOlY>
DU145 M1;BT2tqdmG|ZTDBd5NigQ>? NV\5UVZmPSEQvF2= MnLuNlQhcA>? NE\6dGdFVVOR MWPJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcGm|dH;u[UBJOyCqeYDldoFk\XS7bHH0bY9v M2jsWVIzOjZyMU[2
786-0 MljtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;k[Yg3NjJizszN NXTEZ3I6PzJiaB?= NHrM[XJFVVOR NWnBNldqT0l3ME2zMlIh|ryP NES2WFAzOjR|NU[2PS=>
A498 M{TkUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfq[pQ{Pi5{IN88US=> NYTwb2M6PzJiaB?= M2K0UWROW09? MnTMS2k2OD1zLk[g{txO MkPxNlI1OzV4Nkm=
A549/ATCC M2rmO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHWeJZKPi5{IN88US=> NHXCW5U4OiCq NVTr[246TE2VTx?= MlrGS2k2OD1zLk[g{txO MVmyNlQ{PTZ4OR?=
ACHN M2[2b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17lblYvOiEQvF2= M3zIbVczKGh? NX7wN3ZbTE2VTx?= NEjubnRIUTVyPUGuN{DPxE1? MmDwNlI1OzV4Nkm=
BT549 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3xeoE3NjJizszN MUe3NkBp NUHxcJJVTE2VTx?= NGXZWVdIUTVyPUGuN{DPxE1? M37RTlIzPDN3Nk[5
EKVX NWf3SYVFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUW2MlIh|ryP MkHFO|IhcA>? NYjaOmQ6TE2VTx?= M1fMUmdKPTB;MT6zJO69VQ>? MljTNlI1OzV4Nkm=
HCT15 NYHFRXVnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUnXeHFHPi5{IN88US=> NEGxPJM4OiCq NFfyS2tFVVOR NXvMeWg{T0l3ME2yMlUh|ryP M2fJeFIzPDN3Nk[5
HOP92 NVjFbHh5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYC2MlIh|ryP NET0THg4OiCq Ml;qSG1UVw>? MULHTVUxRTRizszN MmLTNlI1OzV4Nkm=
IGROV1 Mn7LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfyfmM3NjJizszN MYW3NkBp MYHEUXNQ Mlv2S2k2OD1zLkOg{txO Ml3HNlI1OzV4Nkm=
LOXIMVI M{Xt[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LMZlYvOiEQvF2= Mmq3O|IhcA>? NWjCZ4VHTE2VTx?= M3;LfWdKPTB;MTFOwG0> MUiyNlQ{PTZ4OR?=
M14 NILCbmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4W4U|YvOiEQvF2= M1XjN|czKGh? M1rl[mROW09? MlThS2k2OD1zLkOg{txO NULnNVNWOjJ2M{W2Olk>
MALME-3M MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU[2MlIh|ryP MmDFO|IhcA>? M4ruT2ROW09? MoXYS2k2OD1yLkOyJO69VQ>? MWKyNlQ{PTZ4OR?=
MCF10A MkfhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYO2MlIh|ryP NVX1SYFSPDhiaB?= MkHzSG1UVw>? NFy1NoNIUTVyPUmuOkDPxE1? MVKyNlQ{PTZ4OR?=
MDA-MB-435 M3S2cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;1bFYvOiEQvF2= MmS1O|IhcA>? MYDEUXNQ MVfHTVUxRTBwNTFOwG0> NE\QfHMzOjR|NU[2PS=>
MDA-MB-468 NHOz[IpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFv5b2U3NjJizszN M3rkb|czKGh? MX\EUXNQ M3vlPWdKPTB;MD62N{DPxE1? NWDleI1ROjJ2M{W2Olk>
MOLT4 NYC1PY82T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHLJTWo3NjJizszN NHLPT|E4OiCq MnvCSG1UVw>? NIOzdHhIUTVyPUCuOEDPxE1? NXrYWY97OjJ2M{W2Olk>
NCI-ADR-RES M3HoWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlyzOk4zKM7:TR?= M2HRVVczKGh? NF;lS2FFVVOR MWnHTVUxRTBwMU[g{txO NF7iZpEzOjR|NU[2PS=>
NCI-H23 Mn3vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYi2MlIh|ryP MWO3NkBp M{P4emROW09? NYXwVnhQT0l3ME2xJO69VQ>? M{fF[VIzPDN3Nk[5
NCI-H322M NUX2b4dET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{Tkc|YvOiEQvF2= MoriO|IhcA>? M3PMVmROW09? MWXHTVUxRTBwN{mg{txO NWDvTY1bOjJ2M{W2Olk>
NCI-H460 MnK5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYe2MlIh|ryP NYPWOXR4PzJiaB?= NXPzRYUxTE2VTx?= NFO4[|NIUTVyPUCuO|kh|ryP M3fCZ|IzPDN3Nk[5
NCI-H522 MnPTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfRc5pCPi5{IN88US=> NFe1PJA4OiCq MlW3SG1UVw>? MlnTS2k2OD1yLkWg{txO M1H4UlIzPDN3Nk[5
OVCAR3 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX[2MlIh|ryP NW\Qd3lTPzJiaB?= M4rkbWROW09? M4rkPWdKPTB;MT6zJO69VQ>? MUOyNlQ{PTZ4OR?=
OVCAR4 NVToZWp1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjFeYVTPi5{IN88US=> M1zNVFczKGh? M{DkdWROW09? M3HFUGdKPTB;NDFOwG0> NXLs[nd{OjJ2M{W2Olk>
OVCAR5 NVfqSGV1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH7FelU3NjJizszN NInnV2Y4OiCq M1PtNGROW09? NVm4WHVZT0l3ME2wMlc6KM7:TR?= MlLPNlI1OzV4Nkm=
OVCAR8 NGjyeYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHFNItqPi5{IN88US=> M{TJPFczKGh? Mn:1SG1UVw>? MY\HTVUxRTBwNTFOwG0> MnnRNlI1OzV4Nkm=
RXF393 MkC2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX[2MlIh|ryP MX63NkBp NUjjPHpsTE2VTx?= NVKwNWNoT0l3ME2xMlMh|ryP MV6yNlQ{PTZ4OR?=
SF268 MnvuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPGOk4zKM7:TR?= NFvIRpo4OiCq MX;EUXNQ NIeweJZIUTVyPUGuOkDPxE1? M33DVFIzPDN3Nk[5
SF295 M2\QUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXH1SmFGPi5{IN88US=> MXK3NkBp NInvdXFFVVOR NX\5[IJRT0l3ME2xMlYh|ryP MlmyNlI1OzV4Nkm=
SF539 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TpN|YvOiEQvF2= NY[4[I94PzJiaB?= NX[wOWhlTE2VTx?= NF\vW5NIUTVyPUKg{txO NUXsdItPOjJ2M{W2Olk>
SK-MEL-2 NIDrbW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEfwR5Y3NjJizszN NYnNTJhHPzJiaB?= M3f4eGROW09? MlOxS2k2OD1zLkOg{txO NVXiVnNQOjJ2M{W2Olk>
SK-MEL-28 NHr0Sm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\zbVYvOiEQvF2= NEn6eok4OiCq MV3EUXNQ NVy5OWlRT0l3ME2xJO69VQ>? M4XuUVIzPDN3Nk[5
SK-MEL-5 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjyUFk3NjJizszN NH2xd5I4OiCq NUPtT2RFTE2VTx?= MWjHTVUxRTBwNkOg{txO MkHnNlI1OzV4Nkm=
SKOV3 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\GNmhZPi5{IN88US=> MXO3NkBp MWnEUXNQ M3vEfWdKPTB;MTFOwG0> NYjES4d5OjJ2M{W2Olk>
SN12C MonrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXld3g3Pi5{IN88US=> MWC3NkBp NG\5NHRFVVOR NEXZZoZIUTVyPUKg{txO MniyNlI1OzV4Nkm=
SNB19 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPLOk4zKM7:TR?= MWq3NkBp NUntOIh[TE2VTx?= MXHHTVUxRTBwNkOg{txO M2nyOFIzPDN3Nk[5
SNB75 M4rMfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnvFOk4zKM7:TR?= M2PD[lczKGh? MnvLSG1UVw>? NI[1b|RIUTVyPUCuO|kh|ryP MY[yNlQ{PTZ4OR?=
SR M3TCdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXW2MlIh|ryP Mle0O|IhcA>? NYjZbJZpTE2VTx?= Ml7sS2k2OD1yLkSg{txO MoHrNlI1OzV4Nkm=
T47D M1;nWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPOOk4zKM7:TR?= NYr2PGRJPzJiaB?= Mmm3SG1UVw>? MlTjS2k2OD1yLkWg{txO NEDDU5kzOjR|NU[2PS=>
TK10 NGDlS4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUO2MlIh|ryP NE\2N484OiCq M1XTXGROW09? NYezcHYxT0l3ME2wMlY{KM7:TR?= NWXqNlM2OjJ2M{W2Olk>
UACC257 M1;UN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\sOk4zKM7:TR?= NVLMcnVJPzJiaB?= MVrEUXNQ NWLLU4ZFT0l3ME2wMlUh|ryP MmXvNlI1OzV4Nkm=
UACC62 NUPXfYpIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1fa[VYvOiEQvF2= MXO3NkBp MXHEUXNQ NH74WlZIUTVyPUCuOEDPxE1? NFfSZ2wzOjR|NU[2PS=>
UO31 M4XpSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPJOk4zKM7:TR?= M4PDWVczKGh? NIrrWIJFVVOR MV\HTVUxRTBwNTFOwG0> M33yfFIzPDN3Nk[5
Hep3B MkDXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\jOFghcA>? NVTBZ2E6TE2VTx?= MnW3S2k2OD1yLk[5JO69VQ>? NILhe4IzOjR|OUi2Ny=>
BE(2)-C MnHhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1TVe|czKGh? MonSSG1UVw>? NVzXeFJ4UUN5ME2yJO69VQ>? M3HlZlIzQTN{M{G2
Bel7402 M{D5RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYi3NkBp NGToV5RFVVOR NYjXTWZ7T0l7ME2xO{DPxE1? NX7IXo4{OjNyNkGzO|Y>
Bel7404 MkDPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jYPVczKGh? MmXBSG1UVw>? NXHrNHhLT0l7ME2xPEDPxE1? NHji[ZMzOzB4MUO3Oi=>
BGC823 MlzZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYi3NkBp NXTHW5JZTE2VTx?= MorSS2k6OD15LkWg{txO MlLFNlMxPjF|N{[=
MGC803 MlezS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVO3NkBp M3LuOWROW09? M334VWdKQTB;MUCuPEDPxE1? MnS4NlMxPjF|N{[=
SGC7901 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXG3NkBp NX\N[G93TE2VTx?= M2HpTmdKQTB;OT60JO69VQ>? MXuyN|A3OTN5Nh?=
SKHEP1 M3HrVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkT0O|IhcA>? M17ibGROW09? NYnMNIlST0l7ME2xO{DPxE1? MoTQNlMxPjF|N{[=
SMMC7721 NYe5dYFtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFHSNY84OiCq M{TPVWROW09? NHyyTmJIUTlyPUKwJO69VQ>? NFzmZ5AzOzB4MUO3Oi=>
NUGC3 NHzCcnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX:xNEDPxE1? M{PxNmdKRTJwOUSg{txO NXvJSXZiOjNzNkOzN|I>
A2780 CisR NUf5e|dzU2mwYYPlJGF{e2G7 MYWxPEBp NXe4Wnc6UW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlQ1KM7:TR?= M4CwUFI{OjV{NkCz
CAL27 sens NFqzXFZMcW6jc3WgRZN{[Xl? NYfpO3FJOThiaB?= M1y2c2lvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD6zOkDPxE1? NEH3[2YzOzJ3Mk[wNy=>
CAL27 CisR NXi1cYVYU2mwYYPlJGF{e2G7 NXPTblZrOThiaB?= NGO3WnZKdmirYnn0bY9vKG:oIFjERWMhf2m2aDDJR|UxKG:oIECuOlEh|ryP NYLLOZBuOjN{NUK2NFM>
KYSE-510 CisR NX7pc5U4U2mwYYPlJGF{e2G7 NX;FWlBWOThiaB?= MkHNTY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLkW5JO69VQ>? MWCyN|I2OjZyMx?=
KYSE-510 sens MlfmT4lv[XOnIFHzd4F6 MkLNNVghcA>? NX:3WldEUW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlch|ryP MmXyNlMzPTJ4MEO=
MDA-MB-231 sens NF61c2tMcW6jc3WgRZN{[Xl? NYXIPJV7OThiaB?= M1GxfWlvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD62NUDPxE1? NHzh[oUzOzJ3Mk[wNy=>
MDA-MB-231 CisR NVTPVJpnU2mwYYPlJGF{e2G7 M4S5[FE5KGh? M3qzfmlvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD62NUDPxE1? MoLyNlMzPTJ4MEO=
ES2 M2HGd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX60PEBp MlfKSG1UVw>? M3nFUmlEPTB;MUKuO{DPxE1? MV6yN|Q6OzR2OR?=
MDA-MB-231 NW\E[YNuU2mwYYPlJGF{e2G7 M2\WO|ExKM7:TR?= M2qwe|MxKG2rbh?= NEDke3lFVVOR NYPR[2RsUW6qaXLpeIlwdiCxZjDISGFEOmF? NXrVZ2tiOjN2OUO0OFk>
MDA-MB-231 MV3LbY5ie2ViQYPzZZk> NV7H[5pLOSEQvF2= NYXtUW1SOjRiaB?= NY\vVolQTE2VTx?= NYO5[IdPUW6qaXLpeIlwdiCxZjDISGFEPiCjc4Pld5Nm\CCjczDhZ4V1gWyjdHnvckBt\X[nbIOgc4YhfHWkdXzpci=> MUSyN|Q6OzR2OR?=
HS68 NGPBUWREgXSxdH;4bYMhSXO|YYm= NHrEUY8yOCEQvF2= MX63NkBp NFHLT4FFVVOR NInnbmJKSzVyPUSuOkDPxE1? NHPp[lYzOzV5MEW0Ni=>
MEF NGi0d|REgXSxdH;4bYMhSXO|YYm= M1nRfVExKM7:TR?= MWe3NkBp NHfDOpdFVVOR MYDJR|UxRTRwNDFOwG0> NGfuXFQzOzV5MEW0Ni=>
BGC823 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDzSG1UVw>? NXHRXodST0l3ME2zMlA6KM7:TR?= NX;QSoJ[OjN4MEG3NFY>
High5 MknXT4lv[XOnIFHzd4F6 MWmyOEBp NHLxSVBKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IFjERWM3KHerdHigTWM2OCCxZjCwMlA6KM7:TR?= MYSyN|YxOjV{Mx?=
High5 NXn4W2hXU2mwYYPlJGF{e2G7 M1\jUVI1KGh? MUnJcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KEiGQVOxJJdqfGhiSVO1NEBw\iByLkGyJO69VQ>? NWLkNmJZOjN4MEK1NlM>
High5 MlfLT4lv[XOnIFHzd4F6 MVGyOEBp MX7Jcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KEiGQVOzJJdqfGhiSVO1NEBw\iByLkG3JO69VQ>? M2XjbVI{PjB{NUKz
A549 NFTqWVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1u0bGROW09? NYrJRZBVUUN3ME2xMlA4QSEQvF2= NVPTWVhyOjN4NESyNVA>
HCT116 NInwT5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXkSG1UVw>? MmPVTWM2OD1yLke1O{DPxE1? M2TXc|I{PjR2MkGw
K562 M1PI[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTEUXNQ M3;UTGlEPTB;MD62OFUh|ryP M1PGVlI{PjR2MkGw
GBC-SD M1\vcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jpcFUh|ryP NELxSZg4OiCq NU\0epFrTE2VTx?= MnjITWM2OD1zND64JO69VQ>? MYiyN|cxPzJ4MB?=
HGC27 MmW4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTBPFU2KM7:TR?= NXfjVXljPzJiaB?= NGP0SnNFVVOR M4TLPGlEPTB;NT60JO69VQ>? MlX1NlM4ODd{NkC=
HL60 M4\BV2tqdmG|ZTDBd5NigQ>? M2j0VFUh|ryP NFLINZYzPCCq MVvEUXNQ NUDkSnlRUW6qaXLpeIlwdiCxZjDISGFE NFOyWIIzOzdyN{K2NC=>
Vero MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvXTJFZPzJiaB?= M1zEcGROW09? NHvxfodKSzVyPUCuPUDPxE1? MUGyN|c5PjR3Mh?=
NCI60 MXzDfZRwfG:6aXOgRZN{[Xl? M1mwV|Q5KGh? M3n4TWROW09? MnzVS2k:OC53MzFOwG0> MWSyOFAyPTN{Nx?=
SW620 M1PKeWN6fG:2b4jpZ{BCe3OjeR?= NFy2[281QCCq NWfDXY1PTE2VTx?= M4fZdWdKRTBwNUSg{txO MWCyOFAyPTN{Nx?=
U251 MV;DfZRwfG:6aXOgRZN{[Xl? M2DLNVQ5KGh? MknISG1UVw>? MV3HTV0yNjV|IN88US=> NV\WUGw4OjRyMUWzNlc>
KM12 NGLjUnZEgXSxdH;4bYMhSXO|YYm= MYq0PEBp MlH3SG1UVw>? MX3HTV0yNjh6IN88US=> NUTwNJREOjRyMUWzNlc>
Hs578T NHXzb4hEgXSxdH;4bYMhSXO|YYm= MkD5OFghcA>? M3;6Z2ROW09? NUHDO3dQT0l;ND64N{DPxE1? MWKyOFAyPTN{Nx?=
MDA-MB-231 MlzES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYi0PEBp MVPJR|UxRTBwMU[g{txO MlPGNlQxQTVyMU[=
MCF7 MnrUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV:0PEBp MkTvS2k:OC52NTFOwG0> M2XCXlI1OTF7NUW1
MDA-MB-435 M4LTSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY[0PEBp NUHybYxWT0l;MD64PEDPxE1? NIXxZokzPDFzOUW1OS=>
AsPC1 NVr4W|N1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1LsUlMxKM7:TR?= M3ezZVQ5KGh? MVrEUXNQ M4fn[WlEPTB;Mz62OkDPxE1? MkjmNlQyQDV|N{i=
Jurkat E6.1 NX\JSWdGU2mwYYPlJGF{e2G7 NILHT|QzKGh? M4jLfWROW09? M4\GR2lvcGmkaYTpc44hd2ZiSFTBR|Qhf2m2aDDJR|UxKG:oIECuNFQh|ryP NYnER5J1OjR{NkG4OlI>
KG1 NIPUemRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTSOFghcA>? M2jQRWlEPTB;MT6xOUDPxE1? NVLaOVJqOjR3MkWwNFM>
HEL M{jOfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVe0PEBp M1\xNmROW09? NX;QcGc{UUN3ME2wMlQ6KM7:TR?= NXLaeIJmOjR4OUSwOVU>
HSC3 MnWyR5l1d3SxeHnjJGF{e2G7 MoW3NVIhcA>? M2[4cWROW09? MY\JR|UxRTBwN{Gg{txO Mmj4NlQ4PjZ3NkC=
HT-29 Ml;HR5l1d3SxeHnjJGF{e2G7 MXSxNkBp NXPGTHdsTE2VTx?= NIr2U2xKSzVyPUCuO|Ih|ryP MoXuNlQ4PjZ3NkC=
KB MUHDfZRwfG:6aXOgRZN{[Xl? MkfWNVIhcA>? MnP1SG1UVw>? MnjJTWM2OD1yLke1JO69VQ>? M1vGO|I1PzZ4NU[w
H460 MkjaR5l1d3SxeHnjJGF{e2G7 NFvZSlEyOiCq MmmzSG1UVw>? MWrJR|UxRTBwOEKg{txO MVWyOFc3PjV4MB?=
MONE1 M2\sPWN6fG:2b4jpZ{BCe3OjeR?= Mm\QNVIhcA>? NY\GSXVPTE2VTx?= NWTIUZd{UUN3ME2xMlE5KM7:TR?= MlTYNlQ4PjZ3NkC=
MKN45 MXjDfZRwfG:6aXOgRZN{[Xl? NILsWmgyOiCq MnLhSG1UVw>? M3:5[GlEPTB;MT6yOUDPxE1? MU[yOFc3PjV4MB?=
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OVCAR-8 Mnn2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTFwNUS0O|ch|ryP MlW5V2FPT0WU
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TI-73 MlLpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfnT49KSzVyPUGuOVkxPiEQvF2= M{fEXnNCVkeHUh?=
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LCLC-97TM1 Mn\RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTJwMUS1PFMh|ryP MnrHV2FPT0WU
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GCT NX\pO4h{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkXlTWM2OD1{LkG3O|ch|ryP NHLkSYFUSU6JRWK=
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RH-18 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvwTWM2OD1{LkO1NFIzKM7:TR?= MlfQV2FPT0WU
NCI-H1155 M3yzZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTJwM{[3NlUh|ryP NXHoWpZ6W0GQR1XS
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NCI-H292 NWn1dVlTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUGwWVlqUUN3ME2yMlg3PTl4IN88US=> MV3TRW5ITVJ?
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LCLC-103H Mm\yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVT4e2NqUUN3ME2yMlkxPDN6IN88US=> NXjxVIJrW0GQR1XS
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NCI-H1355 MlXXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;MO|NGUUN3ME2zMlAxPzl4IN88US=> M4j0TXNCVkeHUh?=
RMG-I NEXaNmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2X6PWlEPTB;Mz6wNlU6OiEQvF2= NI\qcGNUSU6JRWK=
BB65-RCC MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTNwMEOzNVQh|ryP MXfTRW5ITVJ?
PC-3 NVH3S4xLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2rlfGlEPTB;Mz6wN|g4PCEQvF2= NFLMTVZUSU6JRWK=
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MEG-01 MkDnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\Jc2ZPUUN3ME2zMlA3OTZ2IN88US=> MVjTRW5ITVJ?
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T-24 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TCXGlEPTB;Mz6xOVA4KM7:TR?= M1TaUnNCVkeHUh?=
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LB2518-MEL M2DtfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXiXXlSUUN3ME2zMlIzOzl6IN88US=> NGn1TJBUSU6JRWK=
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NCI-H1651 M1j6W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;q[FlKSzVyPUOuNlQ3PDRizszN NV:wbHVqW0GQR1XS
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HT-29 M1XydGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXK4R|B6UUN3ME2zMlI3PjF2IN88US=> MoKwV2FPT0WU
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L-428 NVHPcZRYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHGN3gxUUN3ME2zMlQxODR3IN88US=> NIfwepZUSU6JRWK=
NCI-H2122 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHS5cYRKSzVyPUOuOFE{OTJizszN NV2yS5F5W0GQR1XS
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639-V Mke4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTNwNE[wOVch|ryP MX7TRW5ITVJ?
SW1116 M1XteWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGPmdFhKSzVyPUOuOFYzPjlizszN NYLodXFzW0GQR1XS
DMS-114 NYnrfZpoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTNwNEewOlYh|ryP MX;TRW5ITVJ?
MZ2-MEL M3LoTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vlemlEPTB;Mz60O|Y5OSEQvF2= M4LPNHNCVkeHUh?=
COLO-829 NVzHNoQzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlrYTWM2OD1|LkWwNFc{KM7:TR?= NIHzTXVUSU6JRWK=
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EW-13 MmC3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PV[mlEPTB;Mz61NlUyKM7:TR?= M3rqRnNCVkeHUh?=
RXF393 MoL4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVSyXmRPUUN3ME2zMlU{Ojl2IN88US=> MWPTRW5ITVJ?
CAL-62 M{HEWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnv6TWM2OD1|LkW0OVE1KM7:TR?= NVHoR2Q3W0GQR1XS
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BT-474 NXfNUFhVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHn2c5FKSzVyPUOuOlM{OSEQvF2= M4PNSXNCVkeHUh?=
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Detroit562 Ml24S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTNwNkWwNlIh|ryP NF;NWFVUSU6JRWK=
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KYSE-450 MnG2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnQS2ZjUUN3ME2zMlY5PTh{IN88US=> MlXEV2FPT0WU
KYSE-510 MkjrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3wN3lKSzVyPUOuO|IyQDFizszN MoG1V2FPT0WU
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RPMI-7951 NH3NTWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTNwN{S3NlMh|ryP MUDTRW5ITVJ?
Becker NX3wU2xqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTNwN{WwNVIh|ryP NI\ze3JUSU6JRWK=
WM-115 M2nBSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVq3eY5kUUN3ME2zMlc5OTl3IN88US=> MU\TRW5ITVJ?
G-401 NGHHR|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWX6TJJlUUN3ME2zMlc6ODh3IN88US=> NG\IU4xUSU6JRWK=
PANC-08-13 Ml7vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTNwN{m2NFIh|ryP NF7lbYxUSU6JRWK=
SW982 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTzTWM2OD1|LkiwOVUyKM7:TR?= M2jIenNCVkeHUh?=
D-263MG MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPMTWM2OD1|LkiyNFUyKM7:TR?= MnLTV2FPT0WU
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NCI-H1581 NF\1SldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXX6fVhUUUN3ME2zMlg1PDh6IN88US=> NFzhNotUSU6JRWK=
LS-123 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LxW2lEPTB;Mz64O|kxQSEQvF2= NWfpd4lNW0GQR1XS
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OVCAR-4 M17Q[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDI[IdvUUN3ME2zMlkzQDh7IN88US=> M{G1NnNCVkeHUh?=
ETK-1 M3OyUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYLCephbUUN3ME2zMlk1PjN3IN88US=> M{PacnNCVkeHUh?=
A2780 NVm2WpZmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn22TWM2OD12LkC1PVY3KM7:TR?= NXvBTo1sW0GQR1XS
LU-65 NEjGcVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\LTWM2OD12LkC3OlM{KM7:TR?= NWH2c2t7W0GQR1XS
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COR-L105 NYq0fJNzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTC[mI2UUN3ME20MlE{ODVzIN88US=> NWDEeWRNW0GQR1XS
CAL-12T MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTnVm5YUUN3ME20MlE{OTB|IN88US=> M1LNXHNCVkeHUh?=
SCH M{LyUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3XTWM2OD12LkG1O|Q{KM7:TR?= NF31W5JUSU6JRWK=
CW-2 Ml;kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHMTWM2OD12LkG5NFAyKM7:TR?= M1HUVnNCVkeHUh?=
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KP-N-YN MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;sTWM2OD12LkKwPVI4KM7:TR?= NWrNRVVkW0GQR1XS
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no-11 NX7iSIVwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PDRmlEPTB;OT6yOlAzQCEQvF2= NFr6Vm1USU6JRWK=
KLE MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTlwM{KyN|Ih|ryP MnHaV2FPT0WU
Calu-6 M3n6WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXQbXJKSzVyPUmuN|c2OjhizszN NYXsNpJqW0GQR1XS
LB831-BLC MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTaTWM2OD17LkS1NVcyKM7:TR?= MVPTRW5ITVJ?
SW684 NUDH[Vk3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTlwNE[xNVYh|ryP NFv2bmRUSU6JRWK=
SH-4 NXLlc3pkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTlwNEmzOlQh|ryP NHTlWW9USU6JRWK=
IST-MES1 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTlwNUG2OFQh|ryP NGjt[3FUSU6JRWK=
Saos-2 M3PnXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfNbZhKSzVyPUmuOVIyQTVizszN NXvLWlYzW0GQR1XS
NCI-H2087 M1WwUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUn2N5NRUUN3ME25MlY4OzV{IN88US=> Mn3qV2FPT0WU
SCC-9 NIjzfYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnPd5RKSzVyPUmuO|E5OTZizszN MYjTRW5ITVJ?
MFE-280 NETrN2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTJTWM2OD17LkeyO|g2KM7:TR?= MVnTRW5ITVJ?
BEN MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTlwOEKxOVkh|ryP MmnMV2FPT0WU
CP50-MEL-B NV36foQ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTlwOUK0N|Ih|ryP MX7TRW5ITVJ?
SK-MEL-28 NYjaSW9{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTFyLkCxPVMh|ryP NFvnVXNUSU6JRWK=
NCI-H2452 NYrUPHhRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PUd2lEPTB;MUCuNVYh|ryP NUnkdZRVW0GQR1XS
NCI-H1395 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HzOWlEPTB;MUCuNVc5KM7:TR?= NIPKSGhUSU6JRWK=
NCI-H2052 MmD2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTFyLkG4PFIh|ryP M{TvVnNCVkeHUh?=
A375 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTFyLkK0OVIh|ryP NHPnelNUSU6JRWK=
HCC38 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\0R|VTUUN3ME2xNE4{OjJizszN NUmxZXg{W0GQR1XS
LK-2 MkfOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTFyLkSyNFgh|ryP M2OxcnNCVkeHUh?=
SF126 MnPsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmroTWM2OD1zMD60O|I4KM7:TR?= MYfTRW5ITVJ?
SK-MEL-1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTFyLke4N|gh|ryP MYPTRW5ITVJ?
ACN MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmKyTWM2OD1zMD64Olc6KM7:TR?= M1XHb3NCVkeHUh?=
BB30-HNC M{LQPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\mRXBKSzVyPUGwMlg4OTFizszN M2PZXXNCVkeHUh?=
NCI-H747 M1;4O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTqTWM2OD1zMD64O|Q3KM7:TR?= NYXuN|N5W0GQR1XS
KYSE-150 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHJeXJtUUN3ME2xNU4xOzh5IN88US=> NHKzOXdUSU6JRWK=
D-247MG MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1nX[GlEPTB;MUGuNVAxQSEQvF2= NHTKVW9USU6JRWK=
BxPC-3 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1XPSGlEPTB;MUGuN|c1PyEQvF2= MYLTRW5ITVJ?
SK-MEL-30 NYXrS2V3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIP5TFBKSzVyPUGxMlQxPzlizszN NFf2[HdUSU6JRWK=
CAS-1 NIftZm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjVfYpSUUN3ME2xNU41OTB7IN88US=> NF3FUVdUSU6JRWK=
no-10 NXTmSoxKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1fSdWlEPTB;MUKuNVIyPyEQvF2= NVizUplkW0GQR1XS
NCI-H2405 NH\0bY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\o[YhKSzVyPUGyMlIxOzZizszN MXzTRW5ITVJ?
KGN MoL2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fkXmlEPTB;MUKuNlkxOSEQvF2= M2G0WHNCVkeHUh?=
BB49-HNC M1H5cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlK1TWM2OD1zMj6zPVU3KM7:TR?= MXHTRW5ITVJ?
NCI-H1693 NFTpSYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3fKW2lEPTB;MUKuOVgyPiEQvF2= NUfRcW5kW0GQR1XS
RO82-W-1 NVzWNZc6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTF|LkC2OFkh|ryP MnW2V2FPT0WU
CAL-85-1 M3G3OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M134WmlEPTB;MUOuOFM6QSEQvF2= MWPTRW5ITVJ?
H-EMC-SS NGnNcI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLl[4xKSzVyPUGzMlkyODRizszN MmPHV2FPT0WU
SW1783 NEfzPVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTF2LkKzPVEh|ryP NFyxdGNUSU6JRWK=
LB771-HNC M3LpUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFO2flRKSzVyPUG0MlQyQSEQvF2= MoLZV2FPT0WU
HCC70 M1vBNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPudpFnUUN3ME2xOE41OjN|IN88US=> MXXTRW5ITVJ?
KNS-81-FD NF\qTW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTDcY53UUN3ME2xOE44ODR3IN88US=> NHXWeWlUSU6JRWK=
KYSE-520 NF7ib4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\4TWM2OD1zND65Nlch|ryP NIjZW3BUSU6JRWK=
TGBC24TKB NHLib4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{K4S2lEPTB;MUSuPVU{QSEQvF2= MkTjV2FPT0WU
SNB75 M1nlTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml[zTWM2OD1zNT6wO|I6KM7:TR?= MXPTRW5ITVJ?
SW872 NVHlRlZ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIn2RmJKSzVyPUG1MlIzOThizszN MX;TRW5ITVJ?
U031 M1\OPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTF3LkiwNlgh|ryP NHfXNlRUSU6JRWK=
ChaGo-K-1 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUX2d3NuUUN3ME2xOU45OzV7IN88US=> NGHI[mZUSU6JRWK=
NCI-H441 Mkf5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PadmlEPTB;MU[uNFA{QSEQvF2= MX3TRW5ITVJ?
TE-12 MlyyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{DGdWlEPTB;MU[uNVg4OyEQvF2= NV3nS4NKW0GQR1XS
NCI-H1755 MnLaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTF4LkW3N{DPxE1? M3LzZnNCVkeHUh?=
KNS-42 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXy2UmhbUUN3ME2xOk43PTh7IN88US=> M1vNSHNCVkeHUh?=
SK-PN-DW NIDnNpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTF5LkSyNFEh|ryP NGX4N41USU6JRWK=
NCI-H226 NH6zXINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPkTWM2OD1zNz65N|Q2KM7:TR?= MX\TRW5ITVJ?
K-562 MkDPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWH6Zm9NUUN3ME2xPE43OzF5IN88US=> NHroT|hUSU6JRWK=
A388 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HQfmlEPTB;MUmuNFMxOyEQvF2= NX30dFU2W0GQR1XS
ZR-75-30 NHfUd|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PJWmlEPTB;MUmuNFk3QCEQvF2= MULTRW5ITVJ?
LU-135 NITOVXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;lTWM2OD1zOT6yOlM3KM7:TR?= M4HpenNCVkeHUh?=
NCI-H2029 MmTyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTF7Lk[wNlEh|ryP MmPwV2FPT0WU
HT-1197 NVG1V4tIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTF7LkmyNlch|ryP MnP1V2FPT0WU
IGR-1 M2T6WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnz1TWM2OD1{MD6zNVE4KM7:TR?= Mor4V2FPT0WU
U-87-MG NIDMTmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;yVVZFUUN3ME2yNE43PDF|IN88US=> M4nwXHNCVkeHUh?=
NCI-H1304 NYXUfIlMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTJyLke1NFEh|ryP NULOfYRDW0GQR1XS
RCC10RGB NGPJO25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmLFTWM2OD1{MT6yPFI6KM7:TR?= M1fsXHNCVkeHUh?=
NCI-H520 NYfhZZJwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonVTWM2OD1{Mj63OlEyKM7:TR?= MYXTRW5ITVJ?
SK-LU-1 NHvLfYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LVTGlEPTB;MkOuNFcyQCEQvF2= MWPTRW5ITVJ?
UACC-893 M4jwNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXFWpRKSzVyPUKzMlExOzhizszN MYPTRW5ITVJ?
NCI-H2347 MmTiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkDtTWM2OD1{Mz6yOlc1KM7:TR?= NEHEPYxUSU6JRWK=
U-118-MG NIDI[mxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MojNTWM2OD1{Mz63NlE4KM7:TR?= MYnTRW5ITVJ?
NCI-H596 NX7LZ3JLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTJ|LkmwOVUh|ryP NYLyO4JHW0GQR1XS
MZ1-PC NILoc49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFLUeW1KSzVyPUK0MlY4PTlizszN NWPEdI9MW0GQR1XS
SW1417 MlflS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2HUfmlEPTB;MkWuNlQ6QCEQvF2= NXW5cYozW0GQR1XS
NCI-H82 M2PVWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2T6bmlEPTB;Mk[uOFI5QCEQvF2= M4HsWnNCVkeHUh?=
COLO-678 M3XXOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTJ5LkS5NVkh|ryP NFfjTHNUSU6JRWK=
KURAMOCHI NIXDZmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;1TWM2OD1{OD6xNlYh|ryP MlzTV2FPT0WU
NCI-H1650 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnTJTWM2OD1|MD6xPVI1KM7:TR?= NWHGb2l[W0GQR1XS
HCC1954 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm\BTWM2OD1|MT6zOlY3KM7:TR?= MWLTRW5ITVJ?
GAK NX6wfG9yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkXxTWM2OD1|Mj6yOlE3KM7:TR?= NHO0dINUSU6JRWK=
YAPC NYXEd5pvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF:xVGhKSzVyPUOzMlc3PDhizszN M3nHe3NCVkeHUh?=
NCI-H2228 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\5TIdKSzVyPUO0MlM3ODVizszN Mn\UV2FPT0WU
VMRC-RCZ M1fOe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHLc5lKSzVyPUO2MlMxOjJizszN MVLTRW5ITVJ?
NMC-G1 NFXFRXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NULSNZdmUUN3ME2zO{4xPTJ7IN88US=> Mn3vV2FPT0WU
D-336MG M4XuR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXlc5NIUUN3ME20NU45PDR{IN88US=> NWTyT2w{W0GQR1XS
UACC-62 NWLnb|B3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vESWlEPTB;NEKuOVUxPSEQvF2= NXSz[Yo6W0GQR1XS
C-33-A MlfaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;aVmlEPTB;NEWuN|I2PiEQvF2= M2rsPHNCVkeHUh?=
HCC1937 NHe4O2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\4WHdKSzVyPUS3MlE6PThizszN MknEV2FPT0WU
HDLM-2 Mn\JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojlTWM2OD12Nz6yNlg4KM7:TR?= M3PJZnNCVkeHUh?=
NCI-H727 NEfyRVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHOdo9tUUN3ME20O{4zPDVzIN88US=> M{nJS3NCVkeHUh?=
NY Mo\uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M37hXGlEPTB;NEmuN|kxQCEQvF2= NG\FbodUSU6JRWK=
NCI-H2291 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTR7LkizNFEh|ryP NEfkfpZUSU6JRWK=

... Click to View More Cell Line Experimental Data

体内研究 Decitabine和Vorinostat都具有使肿瘤衰退的功能。然而, Decitabine 和 Vorinostat 联用使肿瘤衰退的效果更强。没有任何处理时,在野生型和Fasgld 小鼠中在肺肿瘤负担方面观察不到明显的区别。然而, Decitabine 和Vorinostat联用处理野生型小鼠,使肿瘤衰退比处理 Fasgld小鼠效果高很多。 Decitabine和Vorinostat使结肠癌细胞对FasL调节的肿瘤衰退敏感。低剂量Decitabine和Vorinostat处理,没有明显的肝脏毒性。[3]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:[4]
+ 展开

组蛋白去乙酰化酶活性测定:

为了进行 HDAC 实验24 × 104 dpm 乙醇溶液(1 mCi/ml)中提供的sup>3H-醋酸钠盐标记的组蛋白H4等份样, 加到每个试管中,试管中含悬浮在25 µL实验buffer(100 mM Tris-HCl pH 8, 2mM EDTA)中的200 µg全部HeLa细胞裂解液进行免疫沉淀获得的HDAC。加入不同浓度Vorinostat,在30oC下温育90分钟。加入20 µL 终止缓冲液(0.5 N HCl, 0.08 M AcOH)终止反应。加入0.8 mL TBME提取释放放入氚醋酸盐。在8,000 × g 转速下离心5分钟,600 µL 有机相(上相) 转移到包含3 mL闪烁液的闪烁瓶中。
细胞实验:[4]
+ 展开
  • Cell lines: NB4, NCI-H460和HCT-116肿瘤细胞系
  • Concentrations: 0 μM - 0.1 μM
  • Incubation Time: 48小时
  • Method: NB4, NCI-H460和HCT-116肿瘤细胞系生长在200 µL 96孔板中,约10%汇合,生长24小时后,覆盖孔中。使用多种浓度 Vorinostat或溶剂处理肿瘤细胞24小时。处理后,冲洗实验板,移除Vorinostat,温育48小时。使用sulphorodamine B 实验测定Vorinostat处理后存活细胞的分数。
    (Only for Reference)
动物实验:[3]
+ 展开
  • Animal Models: 携带CT26 细胞的Fasgld BALB/cByJ小鼠
  • Formulation: Dissolved in DMSO
  • Dosages: 25 mg/kg
  • Administration: 静脉注射
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 52 mg/mL (196.74 mM)
Ethanol 3 mg/mL (11.35 mM)
Water Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用:
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
5mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 264.3
化学式

C14H20N2O3

CAS号 149647-78-9
稳定性 powder
in solvent
别名 SAHA, MK0683, suberoylanilide hydroxamic acid

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01059552 Active, not recruiting Locally Advanced Non-small Cell Lung Cancer Fox Chase Cancer Center|National Comprehensive Cancer Network December 6, 2009 Phase 1
NCT02108002 Enrolling by invitation Von Hippel-Lindau Disease National Institute of Neurological Disorders and Stroke (NINDS)|National Institutes of Health Clinical Center (CC) March 5, 2014 Phase 1
NCT03022565 Not yet recruiting Uveal Melanoma Nicolas Acquavella|University of Miami Sylvester Comprehensive Cancer Center|University of Miami April 2017 --
NCT02943642 Not yet recruiting Mycosis Fungoides Angimmune LLC|City of Hope National Medical Center|Columbia University|Dana-Farber Cancer Institute|Feinberg School of Medicine, Northwestern University|H. Lee Moffitt Cancer Center and Research Institute|Ohio State University Comprehensive Cancer Center|Rush University Medical Center|Scott and White Hospital & Clinic|Yale University|Stanford University|Thomas Jefferson University|University of Arkansas|University of Colorado Denver School of Medicine Barbara Davis Center|University of Texas Southwestern Medical Center|University of Washington|Vanderbilt University School of Medicine|Washington University School of Medicine January 2017 Phase 2
NCT02836548 Recruiting Melanoma|Skin Neoplasms The Netherlands Cancer Institute June 2016 Phase 1|Phase 2
NCT02589145 Recruiting Lymphoma M.D. Anderson Cancer Center|Celgene Corporation June 2016 Phase 1|Phase 2

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常见问题及建议解决方法

  • 问题 1:

    What’s the recommendation about reconstitution of the compound for in vivo animal study?

  • 回答:

    We recommend the following vehicle for S1047: 2% DMSO, 40% PEG 300, 5% Propylene glycol, 1% Tween 80 at 5 mg/mL.

HDAC Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID