Vorinostat (SAHA, MK0683)

目录号:S1047 别名: SAHA, MK0683, suberoylanilide hydroxamic acid

Vorinostat (SAHA, MK0683) Chemical Structure

Molecular Weight(MW): 264.3

Vorinostat (suberoylanilide hydroxamic acid, SAHA)是一种HDAC抑制剂,无细胞试验中IC50为~10 nM。

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客户购买Selleck的此次产品后发表的文献100篇:

客户使用该产品的20个实验数据:

  • Differential effects of HDAC inhibitors on histone and tubulin acetylation. Immunofluorescence analysis of histone H3 (K9ac/K14ac) and tubulin acetylation in HeLa cells treated for 4 h with vehicle, SAHA (10 μM), tacedinaline (50 μM), PCI-24781 (20 μM. (a) Mapping of histone acetylation in K562 cells treated with HDAC inhibitors by LC-MS/MS. Cells were treated with TSA (10 μM), SAHA (5 μM), PCI-24781 (2 μM), tacedinaline (50 μM) for 6 h. Histones were extracted from cells and acetylated peptides were quantified after isobaric tagging.

    Nat Biotechnol 2011 29, 255-265. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Activity of vorinostat in Jurkat and Peer T-ALL cell lines in an MTT cell viability assay. Cells were treated with increasing drug concentrations for 72 h. The data are plotted as the mean % of DMSO-treated control cells against the corresponding drug concentration. The error bars are the standard error. For each drug and cell line, 3-4 independent experiments were performed with 6 replicates at each drug concentration.

    Nature 2011 471, 235-9. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Western blot analysis of histone H3 acetylation in the spleen of untreated and vorinostat-treated hNF-E2 tg mice (n = 4 of each genotype).

    J Exp Med 2012 209, 35-50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    SAHA down-regulates c-FLIP expression and increases the sensitivity of CaP cells to undergo apoptosis in the presence of bicalutamide (A) Bar graph illustrating the sub-G0/G1 cell population in 22Rv1 (left panel) and LNCaP (right panel) cells in the absence and presence of 10μM bicalutamide, administered as a single agent or in ombination with increasing concentrations of the HDAC inhibitor, SAHA. (B) Immunoblots demonstrating the single agent activity of bicalutamide or SAHA, or effect upon their combined administration on the expression of c-FLIP and/or the processing of PARP. Equal protein loading was confirmed by GAPDH. (C) Bar graph illustrating the effect of bicalutamide and SAHA upon the induction of caspase-8 or caspase-3/7 activity in 22Rv1 cells (left panel) and LNCaP cells (right panel). (D) Immunoblots characterizing the impact of SAHA and/or bicalutamide upon the induction of PARP cleavage, in the absence or presence of the pan-caspase inhibitor, ZIETD. ZIETD was incubated with the cells for 12 h prior to the experiment. All data points shown in (A) and (C) represent the mean ± S.E.M. value, calculated from four independent experiments.

    Clin Cancer Res 2012 18, 3822-33. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Analyses of efficacy, potency and IC50 of HDAC inhibitors point toward HDACs 1–3 as relevant candidates for beta cell protection. Ranking and raw data on ITF drugs (Table 3) and commercial HDAC inhibitors (Table 4) underlying the heat maps of Fig. 1 (A and B). The HDAC inhibitor compounds were tested using a HDAC activity kit and recombinant proteins to determine IC50 values on each individual HDAC (right part of the table). Each drug was further tested using Real-Time Cell Analysis (RTCA) to score their maximal effective concentration (ECmax) as well as the corresponding rescue percentage of cytokine treated INS-1 cells. The drugs were ranked according to % rescue. * DMSO alone controls were included in each experiment, but not shown here. The results indicate that the highest concentrations of DMSO used here (1:1,000) were slightly potentiating the proliferation of the cells. The effects observed in this group of compounds were ascribed to the DMSO.?

    Diabetologia 2012 55, 2421-2431. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Proliferation o f HT29 and HCT116 cells after 48 h of butyrate or SAHA treatment. Proliferation measurements using the xCEL Ligence RTCA DP instrument (Roche) in cells treated with increasing doses of butyrate or SAHA, compared with control medium cells (0) (*P < 0.05). The mean ?SEM of three cell culture replicates is shown.

    Mol Carcinog 2012 52, 459-74. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Suberoylanilide hydroxyamic acid (SAHA) preserves CFP (+) expression in mouse optic nerves (MONs) from older mice. (a) CFP (+) mitochondria were longer and thicker in MONs from 12-month-old Thy-1 CFP mice (inset; scale bar = 2 μm). Oxygen–glucose deprivation (OGD) consistently reduced CFP pixel intensity in 12-month-old MONs despite longer and brighter CFP ( +) mitochondria (yellow arrows). (b) Blockade of AMPA/kain ate receptors with NBQX (30 μM), or pan-Histone deacetylase (HDAC) inhibition with SAHA (5 μM), effectively preserved CFP pixel intensity during OGD. The preservation of CFP (+) mitochondria correlates with protection of the CAP area during OGD and profound recovery.

    J Neurochem 2012 123 Suppl 2, 108-15. Vorinostat (SAHA, MK0683) purchased from Selleck.

    D and E, Regression of IL-13Ra 2-negative pancreatic tumors treated with SAHA and/or IL-13-PE. Mice were treated daily with i.p. injection of SAHA (25 mg/kg) from day 4 after tumor implantation for two weeks followed by i.t. injection of IL-13-PE (100 μ g/kg) from day 5 for two weeks. F and G, Regression of IL-13Ra 2-posotive pancreatic tumors (HS766T and MIA-PaCa2) treated with SAHA and/or IL-13-PE. The schedule of treatment was similar as in panel D and E. Statistical significances are shown by *: P < 0.05,†: P < 0.001.

    J Transl Med 2011 9, 37. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • IL-13Rα2 expression is upregulated in pancreatic tumors but not in organs of mice after treatment with HDAC inhibi tor, SAHA. A, qRT-PCR of human IL-13Rα2 in implanted pancreatic tumors after SAHA and IL-13-PE treatment. Tumors were harvested next day after IL-13-PE treatment and total RNA extracted. Data shown is ratio of human IL-13Rα2/β-actin expression and multiplied by 1000 for convenience. Bars , SD of triplicate determinations. B, qRT-PCR of mouse IL-13Rα2 in mice organs after SAHA and IL-13-PE treatment. Tissues were harvested at the same time point as in panel A and total RNA extracted. Data shown is ratio of mouse IL-13Rα2/β-actin expression and multiplied by 100 for convenience. C, IHC of human IL-13Rα2 in implanted pancreatic tumors after SAHA and IL-13-PE treatment. D, IHC of mouse IL-13Rα2 in mice organs after SAHA and IL-13-PE treatment. Liver, brain, kidney, pancreas, lung and spleen were fixed for immunostaining of mouse IL-13Rα2 as visualized by Alexa555. Nucleus was counterstained by DAPI.

    J Transl Med 2011 9, 37. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Vorinostat inhibits the tumor growth. NOD ⁄ SCID-B2m-/-mice were injected s.c. with 1×106 MyLa2059 cells into both flanks. When the mice had developed established palpable tumors treatment was initiated (day 1). The mice received either vehicle (black line) or 60 mg ⁄ kg vorinostat (grey line) i.p. five days a week. In total, there were four mice in the group receiving vehicle and three mice in the group receiving vorinostat. The length and width of the tumors were measured continuously until the experiment was terminated on day 20 post treatment initiation. The tumor volume was calculated using the formula V = (a×b2)/2, where a defines the length (mm) and b the width (mm) of the tumor. The histogram shows the average tumor volume per flank ± SEM. * denotes a significant difference (P < 0.05) in the average tumor volume per flank between mice treated with vehicle and vorinostat at the given time-point both by using a one-tailed two samples test with Welch, scorrection and a Mann-Whitney U test.

     

     

    Exp Dermatol 2010 19, 1096-1102. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • SAHA induces the down-regulation of cFLIP expression and promotes TRAIL-mediated activation of a mitochondrial-operated apoptotic pathway. a BT-474 cells were treated as indicated in Fig. 1 and the cells were then harvested to analyse caspase-8, Bid, caspase-9, caspase-3 and PARP expression, using GAPDH as the protein loading control. b BT-474 cells were treated with SAHA for 8 h at the doses indicated and subsequently, the cells were harvested and the apoptosis-related proteins were analysed in western blots as described in the "Materials and Methods". The results shown are representative of at least three independent experiments

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Treatment with SAHA sensitizes breast cancer cells to TRAILinduced apoptosis. BT-474 and MDA-MB-231 cells were incubated for 8 h with SAHA at the doses indicated. After this time, TRAIL (500 ng/ml) was added to some of the cultures for an additional 15 h. Apoptosis was measured as the percentage of cells with subG1 DNA content as described in the "Materials and methods". The results show the mean and S.E.M. of three independent experiments

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • SAHA facilitates the Itch/AIP4-independent proteasomal degradation of cFLIP proteins in breast cancer cells. a BT-474 cells were treated with SAHA (5 μM) for 8 h in the presence or absence of the proteasome inhibitors MG132 or epoxomicin (at the doses indicated), and they were then harvested and the cFLIP content was analysed in western blots. b BT-474 cells were transfected with either the siRNA oligonucleotides targeting Itch/AIP4 or the non-targeting RNA oligonucleotide (scrambled) for 48 h as described in the "Materials and Methods". Subsequently, the cells were treated with SAHA (5 μM) for 8 h and then cFLIP and Itch/AIP4 expression was analysed in immunoblots

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

    cFLIP down-regulation following SAHA treatment is responsible for the sensitization of breast cancer cells to TRAIL. a BT-474 cells were transfected with either different siRNAs directed against the cFLIP isoforms or the non-targeting RNA oligonucleotide (scrambled) as described in the "Materials and Methods". After 24 h, the cells were treated with TRAIL (500 ng/ml) for a further 15 h and apoptosis was then measured as the percentage of cells with subG1 DNA content. The results show the mean and S.E.M. of three independent experiments. To verify protein knockdown, cells were harvested 24 h after transfection and the cFLIP levels were assessed in immunoblots. b. BT-474 cells overexpressing Cflipl (pBABE-FLIPL) or control cells (pBABE) were treated with SAHA for 8 h at the doses indicated. After this time, TRAIL (500 ng/ml) was added to some cultures for 15 h. Apoptosis was measured as the percentage of cells with subG1 DNA content and the results show the mean and range of two independent experiments. Western blots show the cFLIP levels after SAHA treatment in pBABE and pBABE-FLIPL cells.

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • (a) Western blot of whole cell extracts demonstrates SAHA and NaB treatment result in increased levels of acetylated histone H3 compared to vehicle controls. (b) Light micrographs of HDACi/vehicle treated cultures illustrate the paucity of neurospheres in HDACi-treated cultures. (c) Quantitative analysis confirms SAHA and NaB inhibit the formation of neurospheres (diameter ≥ 50 μm) and increase the prevalence of small cell clusters (≥ 4 cell, diameter < 50 μm). (d) Flow cytometry using LIVE/DEAD cell stain confirms SAHA and NaB are minimally toxic compared to vehicle controls (n = 3). Scale bar = 100 μm.

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    (a) EdU flow cytometry of live cell-gated adult mouse NSCs demonstrates SAHA (**p < 0.01) and NaB (***p < 0.001) significantly inhibit DNA synthesis. (b) Analysis of DNA content by flow cytometry reveals significant accumulation of adult mouse NSCs in G1phase of the cell cycle following SAHA (*p < 0.05) and NaB (*p < 0.05) treatment. (c) Correspondingly the proportion of cells in G2/M phase is significantly reduced following SAHA (*p < 0.05) and NaB (*p < 0.05) treatment. (d) Fluorescence micrographs of HDACi/vehicle treated adult NSCs pulse-labeled with EdU for flow cytometry. Scale bar = 50 μm. Statistical comparisons performed using one-way ANOVA with post hoc Newman-Keuls multiple comparison tests.

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • (a) Immunofluorescence labeling of NeuN, GFAP and Olig2 cell fate markers reveals reduced expression of GFAP (*p < 0.001) and Olig2 (*p < 0.05) in adult mouse NSCs treated with SAHA for 48 hours under proliferation culture conditions and then induced to differentiate for 14 days in culture (two-way ANOVA with Bonferroni post-tests). (b) Western blot of β-catenin protein in nuclear and cytoplasmic fractions of adult mouse NSCs treated with HDACi/vehicle control under proliferation culture conditions. Gapdh and lamin A/C blots are included as loading controls. (c) SAHA and NaB do not significantly alter nuclear/cytoplasmic levels of β-catenin in adult mouse NSCs. Histogram of β-catenin Western blot signal intensities normalized to loading controls (n = 4).

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Morphological changes and histone H3 phosphorylation of HB cells treated with a combination of VX-680 and SAHA. HUH6 and HepT1 were incubated with VX-680 (6 μM) and SAHA (0.5 μM). Nuclei diameter (a) and cell diameter (b) were determined 72 h later by DAPI staining and microscopy. Data represent mean±SD of the diameters from 20 cells in each experiment. (* Two-way ANOVA, Bonferroni test, p \0.05). c Western blot analysis on HUH6 and HepT1 cells were carried out with an anti-phospho-Histone H3 (Ser 10) antibody (p-H3) 24 h after incubation with VX-680 (10 μM), SAHA (0.2 μM) or a combination of both. Controls were left untreated. Western blot analysis showed a decrease in p–H3 after treatment with VX-680 ( lane 2 ) relative to controls ( lane 1 ) and an increase when SAHA was added ( lane 3 ). For the combination of VX-680 and SAHA (lane 4 ) no p-H3 was detected.

    Pediatr Surg Int 2012 28, 579-89. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Vorinostat promotes C2C12 differentiation.In the image, the red is the myotube indicating differentiation ,the blue is the nuclei.

     

     

    Dr. Akihiko Yoshimura of Akihiko Yoshimura. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Western blot analysis of Acetyl-H3 and H3. 0-20μM SAHA was added.

     

     

    Dr. Zhang of Tianjin Medical University. Vorinostat (SAHA, MK0683) purchased from Selleck.

产品安全说明书

HDAC抑制剂选择性比较

生物活性

产品描述 Vorinostat (suberoylanilide hydroxamic acid, SAHA)是一种HDAC抑制剂,无细胞试验中IC50为~10 nM。
特性 Vorinostat是广谱HDAC活性抑制剂,抑制I和II类酶 。
靶点
HDAC [1]
(Cell-free assay)
~10 nM
体外研究

Vorinostat是小分子量(<300)线性肟酸,抑制HDAC活性,包括乙酰化组蛋白和非组蛋白的积累,抑制培养细胞的增殖,且抑制肿瘤生长。Vorinostat通过结合到酶的活性位点而抑制 HDAC活性。Vorinostat 抑制多种转化细胞增殖(包括 淋巴瘤,多发性骨髓瘤,白血病,和非小细胞肺癌),与对照组相比抑制生长达50% 时的浓度为0.5 到10μM。Vorinostat作用于淋巴瘤和白血病细胞,包括 Burkitt, B-细胞急性淋巴细胞白血病 (B-ALL), MCL, DLBCL, ATL和T-细胞,不同程度抑制细胞增殖。除了抑制转化细胞增殖, Vorinostat 也抑制正常细胞增殖,通过比较Vorinostat 作用于一组细胞系–正常人非纤维细胞(WI-38)和 SV40巨大T抗原转化WI-38(VA-13细胞)而得到证明。Vorinostat 抑制两种类型细胞增殖,这种作用存在剂量依赖性。但发现Vorinostat 对转化细胞具有选择毒性,包括使肿瘤细胞死亡,而对正常细胞只起抑制作用,不会使其死亡。[1] Genistein 和Vorinostat 联用效果比5-aza和Vorinostat 联用作用于诱导细胞死亡有效很多。Genistein和Vorinostat联用作用于ARCaP-E使增殖降低 80 %,作用于ARCaP-M细胞,增殖降低60 %以上。Genistein和Vorinostat 联用抑制细胞增殖具有协同效应。作用于ARCaP-E 细胞(820个基因 诱导和1046个基因抑制) ARCaP-M 细胞,Vorinostat比Genistein 影响更多基因。[2] Vorinostat作用于肿瘤细胞表面,提高Fas蛋白水平,这种作用存在剂量依赖性,且按0.75 μM剂量处理,提高达到一个稳定水平。[3] Vorinostat 抑制肿瘤细胞生长,包括NB4, H460 和HCT-116,IC50分别为0.7μM, 3.4μM和1.2 μM。[4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
A20 NY[2e5VtU2mwYYPlJGF{e2G7 MnqyNUBp M2TK[2ROW09? NX;lVXdN[W62aT3ISGFEOSCjY4Tpeol1gSC5aYToJGlEPTBib3[gNE4yOTJizszN MnLaNVE6PjB2OEm=
Friend leukemic cell M{PkPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{ntdVUxKM7:TR?= NXrKOZVPPzJiaB?= MmfPSG1UVw>? NX[2NI5vUUN3ME2wMlk6KM7:TR?= M{nSPFEzOTB7OUGz
K562 M3zQWmtqdmG|ZTDBd5NigQ>? NYGzVpIyPiCq NVfRXXNSTE2VTx?= MkDITY5pcWKrdHnvckBw\iCqdX3hckBpcXO2b37lJIRm[WOndInsZZNmKCivaYj0eZJmKG:oIFjERWMyKGGwZDDISGFEOilid3n0bEBKSzVyIH;mJFAvODFizszN MkDXNVI1OTl|OEC=
HT1080 NFrGe4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV23NkBp M4L0[WROW09? MWLJR|UxRTJwNDFOwG0> M1Tuc|EzOjdyMUe1
H1299 MoriT4lv[XOnIFHzd4F6 M2LwZlIxKG2rbh?= M3zRNGROW09? MkPETY5pcWKrdH;yfUBi[3Srdnn0fUBi\2GrboP0JGhFSUNiZX76fY1mKHerdHigTWM2OCCxZjCwMlE6PCEQvF2= MmTPNVQ2OjF2MkK=
H1299 NYTnfJlTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MniyO|IhcA>? NET2colFVVOR Mkf6TWM2OD15LkK0JO69VQ>? NETidFkyPDV{MUSyNi=>
HeLa NWribYpGU2mwYYPlJGF{e2G7 MVqzNEBucW5? Mn[1TY5pcWKrdH;yfUBkd26lZX70doF1cW:wIHHnZYlve3RiaHnzeI9v\SCmZXHj[ZR6dGG|ZTD3bZRpKEmFNUCgc4YhOC5{ODFOwG0> M{TSVlE2PjB|OUS5
LOX-IMVI MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3m5TlQ5KGh? NGKz[m5KSzVyPUGuN{DPxE1? M4LoblE2PzF3NEew
NCI-H226 M1TreGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnx[lJZPDhiaB?= NUHofHZsUUN3ME2yMlYh|ryP M3vrSFE2PzF3NEew
RXF-631L NGXvNFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW[0PEBp MYTJR|UxRTJizszN NGi1[WQyPTdzNUS3NC=>
SNB-78 NXrVOnIzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{H3VVQ5KGh? M3jlU2lEPTB;MU[g{txO MXKxOVcyPTR5MB?=
St-4 M2DCWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnH3OFghcA>? NEHwfZpKSzVyPUWuNkDPxE1? MkXBNVU4OTV2N{C=
ARP1 NY\KRZUxTnWwY4Tpc44hSXO|YYm= NW\mbo9GOiEQvF2= NWnHV2N7PiCq NV\VZYp2UW6mdXP0bY9vKG:oIGCyNXdCTjFiZ3Xu[UBmgHC{ZYPzbY9v MX:xOFc{PDhyNh?=
CEM NHXRNXdMcW6jc3WgRZN{[Xl? NYLHOYc4OSCq M2jT[mROW09? MkDSTY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLkOzJO69VQ>? Mn3sNVY1OjByNkS=
HCT15 NXizOmV4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWC0PEBp M33pTmdKPTB;MD64NkDPxE1? MkHKNVY4OjN{Mke=
NCI-H23 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFvoOok1QCCq M4XadmdKPTB;MD65NkDPxE1? NE\HRnAyPjd{M{KyOy=>
GM15850 MXPLbY5ie2ViQYPzZZk> NYHUV2xrOi53IN88US=> M3jSe|k3KGh? MWfEUXNQ NE\1PHZKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIN{BtgXOrbnWgNVQh[WOndInsZZRqd25ib3[gSnhPKGenbnW= Mn7uNVY6OjF|Nke=
GM15850 MnTNT4lv[XOnIFHzd4F6 M2PBSlIvPSEQvF2= NEfNSJk6PiCq MVrEUXNQ NXLaepR[UW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFUh[WOndInsZZRqd25ib3[gSnhPKGenbnW= MonuNVY6OjF|Nke=
GM15850 M13lSGtqdmG|ZTDBd5NigQ>? M{K2S|IvPSEQvF2= NFn4eWU6PiCq MW\EUXNQ M2HuW2lvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIFi0JIx6e2mwZTCxNkBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= MXKxOlkzOTN4Nx?=
GM15850 NVTxSG4{U2mwYYPlJGF{e2G7 MoD2Nk42KM7:TR?= NGnyeHU6PiCq M{G2d2ROW09? NHXR[WpKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIN{BtgXOrbnWgPUBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= MWmxOlkzOTN4Nx?=
GM15850 MVzLbY5ie2ViQYPzZZk> MWSyMlUh|ryP NF7GWHM6PiCq NE\yRXhFVVOR MYPJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iaHnzeI9v\SCKNDDsfZNqdmViODDhZ4V1gWyjdHnvckBw\iCIWF6g[4Vv\Q>? Ml74NVY6OjF|Nke=
GM15850 MXPLbY5ie2ViQYPzZZk> NVHBUoJIOi53IN88US=> MWO5OkBp MlfxSG1UVw>? M4jpRWlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIFi0JIx6e2mwZTCxOkBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= NHq4R3kyPjl{MUO2Oy=>
U937 M2L6dWZ2dmO2aX;uJGF{e2G7 NHLIPGs2KM7:TR?= NFPkUJQzPCCq NX71dnJHTE2VTx?= NWS1TGJXS2WubDDjfYNt\SCjcoLld5Qh[nliYXPjeY12dGG2aX;uJIF1KFNxR{KvUUBxcGG|ZR?= NUfEV|VSOTdyMES3NVg>
H661 M33UPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\EeZl4PDhiaB?= M4LjeGlEPTB;MTFOwG0> MmGyNVcyPTdyMEm=
U937 NIC4UYdHfW6ldHnvckBCe3OjeR?= NFntU2k2KM7:TR?= Mo\kNlQhcA>? MUfEUXNQ MVnJcoNz\WG|ZTDpckBpcXO2b37lJGg{KGGlZYT5cIF1cW:w M1PBTlE4PDR5N{Ww
U937 NXK0Nnl6TnWwY4Tpc44hSXO|YYm= M{nKZ|Eh|ryP MUCyOEBp Ml3ZSG1UVw>? NXLOUpM3TW[oZXP0JI9vKGGucHjhJJR2[nWuaX6gZYNmfHmuYYTpc44> MXOxO|Q1Pzd3MB?=
RAW264.7 NU\wS5BKTnWwY4Tpc44hSXO|YYm= M2fiV|ExKM7:TR?= NETx[mQzPGh? NYLzWFl5f2G2ZYK= MnL2TY5pcWKrdHnvckBw\iCOUGOtd5RqdXWuYYTl[EBVVk[jbIDoZUBxem:mdXP0bY9vKHerdHigTWM2OCCxZjCwMlc3KM7:TR?= NWLocFZOOTd2N{e1NVg>
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CFBE41o- M4TzeGtqdmG|ZTDBd5NigQ>? M2fmZVUh|ryP M3HkcVI1KGh? MnfPSG1UVw>? NXrRVGs{UW6qaXLpeIlwdiCxZjDISGFEPyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDpckB{fGGkaXzpeJkhd2ZiRnTlcJRiPTB6IFPGWHIheHKxdHXpci=> NWHDZlRZOTl7Nk[3PFk>
CFBE41o- NVvsdJd4U2mwYYPlJGF{e2G7 NW\J[JhbPSEQvF2= NGHYVIYzPCCq NXrTPZdLTE2VTx?= NIfLSHNKdmirYnn0bY9vKG:oIFjERWM4KGG|c3Xzd4VlKGG|IHPvdpJm[3Srb36gc4YhdXW2YX70JGZl\Wy2YUWwPEBETlSUIITyZYZncWOtaX7nJJRwKGOnbHygd5Vz\mGlZTDhd{BodHmlb3\vdo0> NGnQcY4yQTl4Nke4PS=>
Primary bronchial epithelial cell MVrLbY5ie2ViQYPzZZk> MUC1JO69VQ>? MmD4NlQhcA>? M1vCcmROW09? MkftTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwZIXjeIlwdiCxZjDteZRidnRiRnTlcJRiPTB6IFPGWHIheHKxdHXpckBieGmlYXygd5Vz\mGlZTDsc4NidGm8YYTpc44> NEXUOmoyQTl4Nke4PS=>
Primary bronchial epithelial cell NHu4XXpMcW6jc3WgRZN{[Xl? NWXqU3pyOSEQvF2= NUDudVc1QTZiaB?= MYXEUXNQ M2jNPWlvcGmkaYTpc44hd2ZiSFTBR|ch[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gd4hwenRiY3nyZ5VqfCCldYLy[Y51ew>? NIfBS2oyQTl4Nke4PS=>
BxPC3 M3frT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEnLZlM4OiCq MX;JR|UxRTJwNzFOwG0> M2\KUVIxOTR|N{e4
CAL27 NVXzNphrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\wO|IhcA>? NUjwSHRvUUN3ME2zMlczKM7:TR?= MWeyNFE1Ozd5OB?=
Capan1 NXvi[FAzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX:3NkBp MnLVTWM2OD15LkOg{txO MYSyNFE1Ozd5OB?=
HCC827 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MluwO|IhcA>? M1TW[GlEPTB;MT64JO69VQ>? MYKyNFE1Ozd5OB?=
LNCAP Mn3wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorBO|IhcA>? NYDpUFZiUUN3ME2wMlU5KM7:TR?= MYGyNFE1Ozd5OB?=
NCI-H2122 NV;BOndvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF2zdFA4OiCq M2HPSWlEPTB;Nz61JO69VQ>? MX2yNFE1Ozd5OB?=
NCI-H358 MkXJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2HHZ|czKGh? NHy3ZotKSzVyPUKuOUDPxE1? NX:zeYoyOjBzNEO3O|g>
SCC15 MnH6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvXfpg4OiCq MlfaTWM2OD1{LkS5JO69VQ>? NXzsSWtUOjBzNEO3O|g>
SCC25 M1rsPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVjFT5B{PzJiaB?= MoTDTWM2OD1zLkmzJO69VQ>? NF7nNm4zODF2M{e3PC=>
SKHEP1 M1O3fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnNdGdiPzJiaB?= NEjVbYNKSzVyPUOuOFYh|ryP NVjCSJhwOjBzNEO3O|g>
BJ M2rlUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{S3NlExOCEQvF2= NHnx[FE1QCCq MXHEUXNQ NFq4d41Iem:5dHigbY5pcWKrdHnvckBifCByLkC1JJRwKDFyMDD1US=> NVjRTG9GOjBzNEO4OFA>
MUF NGnudHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4f4c|ExOCEQvF2= M2rHZVQ5KGh? NYrFXHFETE2VTx?= MmLYS5Jwf3SqIHnubIljcXSrb36gZZQhOC5yNTD0c{AyODBidV2= NGrPcnkzODF2M{i0NC=>
Caco-2 NXLXWFJqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUnZOYVwOTByIN88US=> NHLCPFQ1QGh? MYfEUXNQ Mo[5TWM2OD16LkGg{txO Mof0NlAyPDN6NEC=
Caco-2 NFXX[YxMcW6jc3WgRZN{[Xl? MUG1JO69VQ>? MXW0JIg> NFP0W5BFVVOR MXTJcoR2[3Srb36gc4YhUESDQz3t[YRq[XSnZDDobZN1d26nIHHj[ZR6dGG2aX;uJGlEPTBib3[gNE4xOzdizszN MUOyNFE1Ozh2MB?=
Caco-2 MUXLbY5ie2ViQYPzZZk> NED1[pcxNjNzNjDuUUB1dyB|MT62JO69VQ>? Mo\qOEBp MnHXSG1UVw>? NYrtTm84TXhidnn2c{BqdmirYnn0bY9vKG:oIHj1cYFvKEiGQVOxJJdqfGhiSVO1NEBw\iByLkGxPUDPxE1? NEDRTmYzODF2M{i0NC=>
Caco-2 NHP4VG5McW6jc3WgRZN{[Xl? MkD4NE4{OTZibl2geI8hOzFwNjFOwG0> MXm0JIg> M2D6d2ROW09? MoLGSZghfmm4bzDpcohq[mm2aX;uJI9nKGi3bXHuJGhFSUN|IIfpeIghUUN3MDDv[kAxNjF2NzFOwG0> MlLtNlAyPDN6NEC=
Caco-2 MnHHT4lv[XOnIFHzd4F6 NGXjR2M3NjN{IH7NJJRwKDZ|MjFOwG0> M3z5c|QhcA>? NEiy[lFFVVOR Mnv1SZghfmm4bzDpcohq[mm2aX;uJI9nKGi3bXHuJGhFSUN3IIfpeIghUUN3MDDv[kAyOi54IN88US=> M{W3PFIxOTR|OESw
Caco-2 NFXxbG9McW6jc3WgRZN{[Xl? NVTYdW9MPi5|MjDuUUB1dyB4M{Kg{txO NITNOng1KGh? NXPMS3hzTE2VTx?= Mlr1SZghfmm4bzDpcohq[mm2aX;uJI9nKGi3bXHuJGhFSUN5IIfpeIghUUN3MDDv[kA1OSEQvF2= NHzXeI0zODF2M{i0NC=>
Caco-2 NUX6e4RsU2mwYYPlJGF{e2G7 MV[wMlMyPiCwTTD0c{A{OS54IN88US=> NHzjW|A1KGh? MlHFSG1UVw>? NULnUW9oTXhidnn2c{BqdmirYnn0bY9vKG:oIHj1cYFvKEiGQVO2 NFfYUVUzODF2M{i0NC=>
HepG2 MmjjT4lv[XOnIFHzd4F6 NE\kU2k2KM7:TR?= MX22bC=> Ml76SG1UVw>? NHr4RWFKdmS3Y4Tpc44hd2ZiSFTBR{1u\WSrYYTl[EBpcXO2b37lJIFk\XS7bHH0bY9v M1XDU|IxOTR|OESw
HepG2 M1:xOmtqdmG|ZTDBd5NigQ>? NUW5fmdkPSEQvF2= M2r4Z|Zp MUDEUXNQ M2nWcWlv\HWldHnvckBw\iCKRFHDMY1m\GmjdHXkJIhqe3SxbnWgbJlx\XKjY3X0fYxifGmxbh?= NELKUVQzODF2M{i0NC=>
HepG2 M4\VbWtqdmG|ZTDBd5NigQ>? M{HNRlUh|ryP NHvWdoo3cA>? MlTTSG1UVw>? NYHhWmd2UW6mdXP0bY9vKG:oIFjERWMudWWmaXH0[YQh[WyyaHGteJVjfWyrbjDhZ4V1gWyjdHnvci=> NFK3VFEzODF2M{i0NC=>
HepG2 M1G4[WtqdmG|ZTDBd5NigQ>? M3nUWlUh|ryP MVW2bC=> MXXEUXNQ M4TiSmlv\HWldHnvckBw\iCKRFHDMY1m\GmjdHXkJGg{N0h2IHjpd5RwdmViYXPleJlt[XSrb36= MoDWNlAyPDN6NEC=
COLO205 NXn5bpRMU2mwYYPlJGF{e2G7 M4XZc|ExKM7:TR?= NIq4SJQzPCCq Mn;KSG1UVw>? M4r3U2lvcGmkaYTpc44hd2ZiSFTBR|Eh[XO|ZYPz[YQh[XNiaX7keYN1cW:wIH;mJIhqe3SxbnWgTFMh[WOndInsZZRqd25id3n0bEBKSzVyIH;mJFIvOiEQvF2= NIHOeIgzODR3MUO3PC=>
SCC4 M2nt[2tqdmG|ZTDBd5NigQ>? NEDsVI0yKM7:TR?= NVvmW4U4OjSq MYPJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5idIXieYxqdiCjY3X0fYxifGmxbh?= NILNT3gzODR3MkKyOS=>
SCC4 MUHLbY5ie2ViQYPzZZk> Mom5NUDPxE1? NFnOemszPGh? MknxTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHjpd5RwdmViYXPleJlt[XSrb36= NVrTO2tmOjB2NUKyNlU>
SCC4 NHPVcWxHfW6ldHnvckBCe3OjeR?= M4G2WlEh|ryP MYO1JI1qdg>? MnrqRYdwdmm|dDDhZ5Rqfmm2eTDheEBXTFJiYYPz[ZN{\WRiYYOgbY5lfWO2aX;uJI9nKEO\UEK0JIdmdmViZYjwdoV{e2mxbh?= MYiyNFQ2OjJ{NR?=
NB4 NFj3RZlHfW6ldHnvckBCe3OjeR?= NH7PW5c2KM7:TR?= NX3JRlVFOjRiaB?= MmfJSG1UVw>? MX3D[YxtKGO7Y3zlJIFzemW|dDDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiCjY3P1cZVt[XSrb36gZZQheHKnLVexJJBp[XOn MXWyNFQ6OTR2MB?=
NB4 MWPLbY5ie2ViQYPzZZk> MXe1JO69VQ>? Ml;1NlQhcA>? MXXEUXNQ NGXNZWhKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gZYNmfHmuYYTlJJR2[nWuaX6gcIV3\Wx? NXXqRZdjOjB2OUG0OFA>
NB4 Mm[3SpVv[3Srb36gRZN{[Xl? NF\NPHo2KM7:TR?= NV[2W5NoOjRiaB?= M4XFcWROW09? MXzJcoR2[3Srb36gc4YheDJzV1HGNU9EUVBzIHX4dJJme3Orb36= MWmyNFQ6OTR2MB?=
NB4 NULqe5VCU2mwYYPlJGF{e2G7 MmLWOUDPxE1? NIrIb2gzPCCq NEfBZ|NFVVOR NHPtO25KdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIN{Bi[2W2eXzheIlwdg>? MlnoNlA1QTF2NEC=
NUGC3 MmfDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPONXAyT0l3ME2yMlk1KM7:TR?= NXq5e|dEOjB6NUC5O|E>
A549 MnXOSpVv[3Srb36gRZN{[Xl? NIfJO|A2KM7:TR?= MlTxN{Bp M1PufGROW09? NVTZXWNUUW6mdXP0bY9vKG:oIHH1eI9xcGGpeTDpckBpfW2jbjDBOVQ6KGOnbHzzJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIFzDN2lK MkXQNlA5PTV{MEi=
HUT78 NF;IdVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrSO|IhcA>? NFzGRXpFVVOR MX;HTVUxRTBwMzFOwG0> MkjNNlA5QDR{MEi=
U937 MkPJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInWe3U4OiCq M4\EU2ROW09? NGDqdZdIUTVyPUCuN|kh|ryP MVyyNFg5PDJyOB?=
A431 MlnMR5l1d3SxeHnjJGF{e2G7 MV[3NkBp NF3xUXBEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPDNzIHPlcIx{KG:4ZYLlfJBz\XO|aX7nJGVITlJid3n0bEBKSzVyIH;mJFQvOiEQvF2= NEPDco8zOTB6ME[yPS=>
A549 NE\QNmFEgXSxdH;4bYMhSXO|YYm= Mly5O|IhcA>? NGHDUWNEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KG:4ZYLlfJBz\XO|aX7nJGhFSUNid3n0bEBKSzVyIH;mJFEvQCEQvF2= NXfuSo9HOjFyOEC2Nlk>
CAL27 NXrjSHFLS3m2b4TvfIlkKEG|c3H5 MnzyO|IhcA>? NXHz[ZZKS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hS0GOMkegZ4VtdHNib4\ldoV5eHKnc4PpcochTUeIUjD3bZRpKEmFNUCgc4YhOy5{IN88US=> MYmyNVA5ODZ{OR?=
HeLa NXHDSJRyS3m2b4TvfIlkKEG|c3H5 MX:3NkBp NHL2bmZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\UyjIHPlcIx{KG:4ZYLlfJBz\XO|aX7nJGhFSUNid3n0bEBKSzVyIH;mJFEvPSEQvF2= Mn7SNlExQDB4Mkm=
Sf21 MnL4T4lv[XOnIFHzd4F6 MVWzJIg> M3i3NWlvcGmkaYTpc44hd2ZiRnzh[{B1[WepZXSgbJVu[W5icnXjc41jcW6jboSgTGRCSzhiZYjwdoV{e2WmIIfpeIghUUN3MDDv[kAyNjJizszN NHHrPYEzOTB6ME[yPS=>
SKBR3 NITFUmlEgXSxdH;4bYMhSXO|YYm= MXm3NkBp NUWyZYR[S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW0uEUkOgZ4VtdHNib4\ldoV5eHKnc4PpcochUEWUMjD3bZRpKEmFNUCgc4YhOi54IN88US=> M3THXVIyODhyNkK5
SKOV3 NIfHdG1EgXSxdH;4bYMhSXO|YYm= Mn\HO|IhcA>? NFSwNGJEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBUU0:YMzDj[YxteyCxdnXy[ZhxemW|c3nu[{BJTVJ{IIfpeIghUUN3MDDv[kAzNjJizszN NE\5ZpAzOTB6ME[yPS=>
COR-L23 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LDOVExKM7:TR?= Mle4O|IhcA>? MUHEUXNQ M3fTOGdKPTB;MT6xJO69VQ>? NGrOPVIzOTB6ME[0Oy=>
DU145 M3[zSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXixNEDPxE1? M3LsZ|czKGh? NWPjNmpbTE2VTx?= MWnHTVUxRTFwMEWg{txO MV:yNVA5ODZ2Nx?=
LoVo NXPOeWd4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\CXlEyOCEQvF2= NFTa[Jk4OiCq MVXEUXNQ M{XvSWdKPTB;MT63JO69VQ>? MYiyNVA5ODZ2Nx?=
MCR5-SV2 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlf6NVAh|ryP M{[5NFczKGh? NYHOcpNPTE2VTx?= NV;wSWRLT0l3ME2yMlEh|ryP NFXxSJUzOTB6ME[0Oy=>
HCT116 MWnLbY5ie2ViQYPzZZk> MoTVN|Ah|ryP NWDDPGNDOzBiaB?= NVrXSWMxTE2VTx?= NUnKXW14UW6qaXLpeIlwdiCxZjDISGFEPiCjc4Pld5Nm\CCjczDpcoR2[3Srb36gc4Yh[WyyaHGteJVjfWyrbjDhZ4V1gWyjdHnvci=> MVGyNVA5ODZ2Nx?=
HCT116 NILzfFJMcW6jc3WgRZN{[Xl? Ml7GN|Ah|ryP NWnZOGY2OzBiaB?= M1XBemROW09? MYrJcohq[mm2aX;uJI9nKEiGQVOxJIF{e2W|c3XkJIF{KGmwZIXjeIlwdiCxZjDobZN1d26nIFizT|kh[WOndInsZZRqd25? NWrEPI56OjFyOEC2OFc>
U937 NEf2b21McW6jc3WgRZN{[Xl? MnKwOUDPxE1? NXnCb3Y3OjRiaB?= M3rMVmROW09? NH;nUpFKdmirYnn0bY9vKG:oIHjpd5RwdmViYXPleJltfHKjboPm[ZJie2ViYYPz[ZN{\WRiYYOgbY5kemWjc3Wgc4Yh[WOndInsZZRqd25ib3[gbIl{fG:wZTDIN{BifCCNOR?= MmfmNlEzQTJ2OUK=
U937 NX:4VoRVU2mwYYPlJGF{e2G7 Mkn3OUDPxE1? MYqyOEBp NXrxU2pyTE2VTx?= M{W1d2lvcGmkaYTpc44hd2ZiaHnzeI9v\SCjY3X0fYx1emGwc3\ldoF{\SCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDv[kBi[2W2eXzheIlwdiCxZjDobZN1d26nIFizJIF1KEtzOB?= NFv3TowzOTJ7MkS5Ni=>
U937 MVzLbY5ie2ViQYPzZZk> Mm\COUDPxE1? NXXqZoI{OjRiaB?= MUXEUXNQ NF3qfI9KdmirYnn0bY9vKG:oIHjpd5RwdmViYXPleJltfHKjboPm[ZJie2ViYYPz[ZN{\WRiYYOgbY5kemWjc3Wgc4YheGGwLXHj[ZR6dGG2ZXSgbIl{fG:wZTDIOEBt\X[nbB?= NE\xTZMzOTJ7MkS5Ni=>
U937 MnHxT4lv[XOnIFHzd4F6 MofZOUDPxE1? MWqxOUBucW5? MonDSG1UVw>? NIHyd3JKdmirYnn0bY9vKG:oIHjpd5RwdmViYXPleJltfHKjboPm[ZJie2ViYYPz[ZN{\WRiYYOgbY5kemWjc3Wgc4YhcGm|dH;u[UBJOyCjY3X0fYxifGmxbjDs[ZZmdA>? NIqwRWkzOTJ7MkS5Ni=>
A2780 MoDkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXu5OkBp NW\DelZLTE2VTx?= M3jzW2lEPTB;MT62NkDPxE1? M4TuNFIyPjN2NEOw
COLO205 MmrYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlXlPVYhcA>? M2TIbWROW09? NU\2XJBzUUN3ME2yMlEzKM7:TR?= NH3pXVAzOTZ|NESzNC=>
Hep3B MlTTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHPDNVg1QCCq MWDEUXNQ NHjLbnZIUTVyPUGuNlEh|ryP NXSySW1GOjF5MUKxOFY>
GM11272 NYLyPHpbTnWwY4Tpc44hSXO|YYm= NGrKUFUyODBibl2= M{K4XVczKGh? NITBPVFFVVOR NGnDb4VT\WGldHn2ZZRqd25ib3[gUYVEeDJibYX0ZY51KGW6cILld5Nqd25iYYSgNVAhfG9iMUCwJI5O NFrkO2YzOTh2MEexOi=>
CFBE41o MXHLbY5ie2ViQYPzZZk> NF;Ge402KM7:TR?= M2S2c2ROW09? Mn7KSI94diC{ZXf1cIF1cW:wIH;mJGhFSUN5IHH0JFAvOiC2bzC1JJVO NYPB[m1vOjF7OES5OVg>
CFBE41o NFeyTW5HfW6ldHnvckBCe3OjeR?= MYKxJO69VQ>? MYiyOEBp NIft[41FVVOR NVvpfXg3WmW|dH;yZZRqd25ib3[gR2ZVWiCmZXz0ZWY2ODhibYX0ZY51KHS{YX\mbYNscW6pIITvJINmdGxic4Xy[oFk\SCjczDncJlkd2[xcn3z MXiyNVk5PDl3OB?=
DU145 M4nGWWtqdmG|ZTDBd5NigQ>? NVzzRXFmOi53IN88US=> M{DGO|I1KGh? NXX4ZVNQTE2VTx?= NF;mN21KdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNidYDy[Yd2dGG2aX;uJI9nKHB{MYfh[lEheHKxdHXpckBmgHC{ZYPzbY9v MUGyNlI3ODF4Nh?=
DU145 M2jFWWtqdmG|ZTDBd5NigQ>? MnjEOUDPxE1? M4frZlI1KGh? NGe1OGtFVVOR M1[0cmlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCqaYP0c45mKEh2IHHj[ZR6dGG2aX;u MnzrNlIzPjBzNk[=
DU145 Mm[3T4lv[XOnIFHzd4F6 NGTRcXQ2KM7:TR?= NW\3ZnBlOjRiaB?= NX3iOm1bTE2VTx?= M3zNcWlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCqaYP0c45mKEh|IHj5dIVz[WOndInsZZRqd25? NF;3UmMzOjJ4MEG2Oi=>
786-0 M2O1VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWW1fXBoPi5{IN88US=> Mnn5O|IhcA>? M3nyc2ROW09? NHjEdFJIUTVyPUOuNkDPxE1? MmK1NlI1OzV4Nkm=
A498 MlfnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LjcFYvOiEQvF2= MkfTO|IhcA>? NF\RWVZFVVOR NW\sW3VmT0l3ME2xMlYh|ryP MmjrNlI1OzV4Nkm=
A549/ATCC MlLjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUX3VGl3Pi5{IN88US=> MnHXO|IhcA>? MlvjSG1UVw>? NWnTSVZKT0l3ME2xMlYh|ryP M3nWXVIzPDN3Nk[5
ACHN M2fIRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYWyUndMPi5{IN88US=> MWK3NkBp MYXEUXNQ NUflUYZyT0l3ME2xMlMh|ryP NGO3c2MzOjR|NU[2PS=>
BT549 M1vyOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzLcXA3NjJizszN MmrJO|IhcA>? NITwfnBFVVOR NUjaU2VsT0l3ME2xMlMh|ryP NG\S[4czOjR|NU[2PS=>
EKVX MoT3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGmxeIc3NjJizszN M1T3OVczKGh? M4DHNmROW09? M4HJVWdKPTB;MT6zJO69VQ>? NFP0cIQzOjR|NU[2PS=>
HCT15 M1e3[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3Trc|YvOiEQvF2= NFHZZ5Y4OiCq NIW4U|VFVVOR NWm1O|hYT0l3ME2yMlUh|ryP NYjMV4tbOjJ2M{W2Olk>
HOP92 NGnHelNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NELXS2I3NjJizszN NIDvWos4OiCq NFTOeldFVVOR NEnMbVVIUTVyPUSg{txO NXjJNYc4OjJ2M{W2Olk>
IGROV1 MormS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEL4T|c3NjJizszN MXi3NkBp NHnSWpVFVVOR MlPIS2k2OD1zLkOg{txO NUTNUZlHOjJ2M{W2Olk>
LOXIMVI MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrwb5k3NjJizszN MU[3NkBp MXfEUXNQ MkDCS2k2OD1zIN88US=> NVzMUZZYOjJ2M{W2Olk>
M14 NHnuW|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUK2MlIh|ryP NHPIWII4OiCq M{PO[GROW09? MkTSS2k2OD1zLkOg{txO NEjiboozOjR|NU[2PS=>
MALME-3M M2n5Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH24OVY3NjJizszN NX7Pc3I1PzJiaB?= Moj2SG1UVw>? M4T1OWdKPTB;MD6zNkDPxE1? NELufJAzOjR|NU[2PS=>
MCF10A NH7ET3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXsSIc3NjJizszN NEHsSYY1QCCq MWPEUXNQ MoLOS2k2OD17Lk[g{txO NEjzOlEzOjR|NU[2PS=>
MDA-MB-435 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknsOk4zKM7:TR?= NGPnZnM4OiCq M1LiS2ROW09? MmXQS2k2OD1yLkWg{txO MWOyNlQ{PTZ4OR?=
MDA-MB-468 MnjoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVm2MlIh|ryP MW[3NkBp MX;EUXNQ NX;OPFJXT0l3ME2wMlY{KM7:TR?= NETMUW8zOjR|NU[2PS=>
MOLT4 NYDCbJRyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHv5PJk3NjJizszN MlnXO|IhcA>? NEn2T25FVVOR MWTHTVUxRTBwNDFOwG0> NWXXc3V7OjJ2M{W2Olk>
NCI-ADR-RES MnHtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLHcpBRPi5{IN88US=> MnHJO|IhcA>? NIHkdlZFVVOR MWrHTVUxRTBwMU[g{txO MoTzNlI1OzV4Nkm=
NCI-H23 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUS2MlIh|ryP M33FRlczKGh? MXjEUXNQ M3Pw[2dKPTB;MTFOwG0> MUSyNlQ{PTZ4OR?=
NCI-H322M MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{jIbVYvOiEQvF2= NGL6cG44OiCq NFzHOItFVVOR MoLNS2k2OD1yLke5JO69VQ>? MUiyNlQ{PTZ4OR?=
NCI-H460 NGHxVHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XXW|YvOiEQvF2= M3P0fVczKGh? MXXEUXNQ M2\Re2dKPTB;MD63PUDPxE1? MX6yNlQ{PTZ4OR?=
NCI-H522 MlW5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXm2MlIh|ryP NV;aPIdDPzJiaB?= MoC0SG1UVw>? M2T3VmdKPTB;MD61JO69VQ>? MnPaNlI1OzV4Nkm=
OVCAR3 NEDye3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnsZ5k3NjJizszN MX[3NkBp M33oNWROW09? NVK0enl2T0l3ME2xMlMh|ryP M1TiU|IzPDN3Nk[5
OVCAR4 Ml22S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXvOk4zKM7:TR?= MXS3NkBp M4fTbmROW09? NH7GXI1IUTVyPUSg{txO M3HndlIzPDN3Nk[5
OVCAR5 NGT3bmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\YN3dtPi5{IN88US=> MUm3NkBp MX3EUXNQ M{nESWdKPTB;MD63PUDPxE1? MmnqNlI1OzV4Nkm=
OVCAR8 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1uwSFYvOiEQvF2= MmnMO|IhcA>? NVPYW2tSTE2VTx?= M4r0cGdKPTB;MD61JO69VQ>? M33TcVIzPDN3Nk[5
RXF393 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIiyTFg3NjJizszN NUXLWot7PzJiaB?= M4P4UGROW09? NULJZlhPT0l3ME2xMlMh|ryP NEXHVG0zOjR|NU[2PS=>
SF268 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvVWJpEPi5{IN88US=> MY[3NkBp NG\1XHhFVVOR NE\o[2xIUTVyPUGuOkDPxE1? NFLGVHIzOjR|NU[2PS=>
SF295 M4Ltbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWO2MlIh|ryP MlvTO|IhcA>? NUfLZmVqTE2VTx?= NF\LTm1IUTVyPUGuOkDPxE1? NEfBZpAzOjR|NU[2PS=>
SF539 NFjUWJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml[0Ok4zKM7:TR?= NY\rbFlkPzJiaB?= MXvEUXNQ MoS0S2k2OD1{IN88US=> NIfTWnczOjR|NU[2PS=>
SK-MEL-2 NUjPfYp[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFrGN4c3NjJizszN MX:3NkBp NHnTSmhFVVOR MYrHTVUxRTFwMzFOwG0> NGSzc2kzOjR|NU[2PS=>
SK-MEL-28 M3LzVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYi2MlIh|ryP MUi3NkBp NWnab|g2TE2VTx?= MmXyS2k2OD1zIN88US=> NFy4eXgzOjR|NU[2PS=>
SK-MEL-5 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFvIRpA3NjJizszN M1T1W|czKGh? MYjEUXNQ MXzHTVUxRTBwNkOg{txO NUTzV3NMOjJ2M{W2Olk>
SKOV3 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{LyU|YvOiEQvF2= NXrTdlYzPzJiaB?= MYjEUXNQ M{O2R2dKPTB;MTFOwG0> MYWyNlQ{PTZ4OR?=
SN12C NVjsdphnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUC2MlIh|ryP MXG3NkBp MVfEUXNQ NUXvflZlT0l3ME2yJO69VQ>? MXuyNlQ{PTZ4OR?=
SNB19 M{fnWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjUNHhPPi5{IN88US=> NVzGbJRtPzJiaB?= NXHrWm56TE2VTx?= MXXHTVUxRTBwNkOg{txO MXmyNlQ{PTZ4OR?=
SNB75 MnnjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX62MlIh|ryP Mkn6O|IhcA>? MXnEUXNQ NF\adohIUTVyPUCuO|kh|ryP MY[yNlQ{PTZ4OR?=
SR NUPJNphrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHWU4M3Pi5{IN88US=> NYf4bnpIPzJiaB?= MmP1SG1UVw>? M{DvbGdKPTB;MD60JO69VQ>? MmLNNlI1OzV4Nkm=
T47D M4X4V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHfvdm83NjJizszN NHXKbG84OiCq M4rIVmROW09? NYrmT3JLT0l3ME2wMlUh|ryP NUjMXJBUOjJ2M{W2Olk>
TK10 MnfhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfFOk4zKM7:TR?= NUHzVJp5PzJiaB?= M2TGSGROW09? NELNVpBIUTVyPUCuOlMh|ryP NXLCSHFrOjJ2M{W2Olk>
UACC257 MkfHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;F[VYvOiEQvF2= MYS3NkBp M1XwZWROW09? M4fySGdKPTB;MD61JO69VQ>? M3q3RVIzPDN3Nk[5
UACC62 NH\USm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXmzdWpvPi5{IN88US=> Mn;6O|IhcA>? MmnhSG1UVw>? NFq0c3lIUTVyPUCuOEDPxE1? NITSXZEzOjR|NU[2PS=>
UO31 NXHlZnJTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHwUIM3NjJizszN MXW3NkBp NIXxT21FVVOR NYjrT5dZT0l3ME2wMlUh|ryP M2rQW|IzPDN3Nk[5
Hep3B M{\6Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkL3OFghcA>? NIrobo5FVVOR NXrEb|VYT0l3ME2wMlY6KM7:TR?= MVSyNlQ{QTh4Mx?=
BE(2)-C NX7pS|M2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX:3NkBp MWDEUXNQ MYfJR|cxRTJizszN NYe1d2F2OjJ7M{KzNVY>
Bel7402 NUDYR484T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jsWVczKGh? Mkm4SG1UVw>? M1y5XWdKQTB;MUeg{txO NVzT[FNbOjNyNkGzO|Y>
Bel7404 MmXGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInVemc4OiCq MWfEUXNQ Mn\jS2k6OD1zODFOwG0> MofwNlMxPjF|N{[=
BGC823 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnkcY9OPzJiaB?= NFrCW2tFVVOR NGm1c3RIUTlyPUeuOUDPxE1? MlLmNlMxPjF|N{[=
MGC803 M{fLd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljQO|IhcA>? Mn6zSG1UVw>? M2Tac2dKQTB;MUCuPEDPxE1? MViyN|A3OTN5Nh?=
SGC7901 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jEcVczKGh? NFWyb|dFVVOR MnHYS2k6OD17LkSg{txO M3vVPVI{ODZzM{e2
SKHEP1 Mni4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkCzO|IhcA>? MofhSG1UVw>? NHXlT4JIUTlyPUG3JO69VQ>? M3HLeVI{ODZzM{e2
SMMC7721 M4HCSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPjO|IhcA>? MV;EUXNQ MUfHTVkxRTJyIN88US=> NICxfZAzOzB4MUO3Oi=>
NUGC3 MljES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX31O5RFOTBizszN NH7KWWVIUT1{Lkm0JO69VQ>? M4r3SVI{OTZ|M{Oy
A2780 CisR MXzLbY5ie2ViQYPzZZk> MUixPEBp MlS1TY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLkS0JO69VQ>? NHS1XlEzOzJ3Mk[wNy=>
CAL27 sens MX3LbY5ie2ViQYPzZZk> MXSxPEBp NF\LUodKdmirYnn0bY9vKG:oIFjERWMhf2m2aDDJR|UxKG:oIECuN|Yh|ryP Mk\JNlMzPTJ4MEO=
CAL27 CisR MVjLbY5ie2ViQYPzZZk> M1;mdlE5KGh? M4O1fGlvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD62NUDPxE1? NWP1flRzOjN{NUK2NFM>
KYSE-510 CisR NIrs[|lMcW6jc3WgRZN{[Xl? M{m4W|E5KGh? NWHWeG1sUW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlU6KM7:TR?= NFTWbVkzOzJ3Mk[wNy=>
KYSE-510 sens MUnLbY5ie2ViQYPzZZk> MlS1NVghcA>? MkPHTY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLkeg{txO Ml\oNlMzPTJ4MEO=
MDA-MB-231 sens NU\GVWpJU2mwYYPlJGF{e2G7 NUi2RXlsOThiaB?= MWPJcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwNkGg{txO NUnMbZhjOjN{NUK2NFM>
MDA-MB-231 CisR NF;4NJRMcW6jc3WgRZN{[Xl? MWKxPEBp MWHJcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwNkGg{txO M2PZT|I{OjV{NkCz
ES2 NVK4W|BoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWm0PEBp MkO2SG1UVw>? MXjJR|UxRTF{Lkeg{txO NFfWc40zOzR7M{S0PS=>
MDA-MB-231 NVXHVFh5U2mwYYPlJGF{e2G7 MkTuNVAh|ryP M2PrWVMxKG2rbh?= MVLEUXNQ Ml3WTY5pcWKrdHnvckBw\iCKRFHDNoE> MlzoNlM1QTN2NEm=
MDA-MB-231 NY\yRWcxU2mwYYPlJGF{e2G7 MXOxJO69VQ>? MXuyOEBp NV;DRZRJTE2VTx?= MkLjTY5pcWKrdHnvckBw\iCKRFHDOkBie3Onc4Pl[EBieyCjY3X0fYxifGmxbjDs[ZZmdHNib3[geJVjfWyrbh?= M4DGUVI{PDl|NES5
HS68 MkXRR5l1d3SxeHnjJGF{e2G7 NUDwVmFbOTBizszN MkXsO|IhcA>? NIm5bo1FVVOR NGTSNG1KSzVyPUSuOkDPxE1? MUKyN|U4ODV2Mh?=
MEF MljxR5l1d3SxeHnjJGF{e2G7 Mo\sNVAh|ryP MnfUO|IhcA>? M1S5eGROW09? NH\5SYJKSzVyPUSuOEDPxE1? MYOyN|U4ODV2Mh?=
BGC823 MkLmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITaW5ZFVVOR MUDHTVUxRTNwMEmg{txO MV:yN|YxOTdyNh?=
High5 MUfLbY5ie2ViQYPzZZk> MWqyOEBp NV7zfG1xUW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDISGFEPiC5aYToJGlEPTBib3[gNE4xQSEQvF2= NYTw[GJNOjN4MEK1NlM>
High5 MoHyT4lv[XOnIFHzd4F6 MXyyOEBp NG[4N4xKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IFjERWMyKHerdHigTWM2OCCxZjCwMlEzKM7:TR?= NGjjdo0zOzZyMkWyNy=>
High5 NGHsRWdMcW6jc3WgRZN{[Xl? MoO0NlQhcA>? NEfwenpKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IFjERWM{KHerdHigTWM2OCCxZjCwMlE4KM7:TR?= MoH6NlM3ODJ3MkO=
A549 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3fGN2ROW09? NVPXfYlnUUN3ME2xMlA4QSEQvF2= NVXQfZlMOjN4NESyNVA>
HCT116 NVjuWnJ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDESG1UVw>? MVHJR|UxRTBwN{W3JO69VQ>? MmK2NlM3PDR{MUC=
K562 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;ZXXFFTE2VTx?= MlfKTWM2OD1yLk[0OUDPxE1? NG\4NIczOzZ2NEKxNC=>
GBC-SD NX;IUHhDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\UVXY2KM7:TR?= MmjBO|IhcA>? NWnmUoNiTE2VTx?= NHLHNXpKSzVyPUG0Mlgh|ryP MnLQNlM4ODd{NkC=
HGC27 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEj2S4g2KM7:TR?= NIPPSZM4OiCq M1GzZWROW09? MnTjTWM2OD13LkSg{txO M4e1SlI{PzB5Mk[w
HL60 MkTZT4lv[XOnIFHzd4F6 NEjzWok2KM7:TR?= NH3vPZkzPCCq NWK1TJlOTE2VTx?= Mk\2TY5pcWKrdHnvckBw\iCKRFHD M37tVVI{PzB5Mk[w
Vero NEPmRpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnz4O|IhcA>? MUTEUXNQ MUTJR|UxRTBwOTFOwG0> NEfwZ3YzOzd6NkS1Ni=>
NCI60 MXzDfZRwfG:6aXOgRZN{[Xl? MlftOFghcA>? MlTPSG1UVw>? MVHHTV0xNjV|IN88US=> NV7CXFJoOjRyMUWzNlc>
SW620 MnXMR5l1d3SxeHnjJGF{e2G7 NFH4Z|I1QCCq MUfEUXNQ M2nhUmdKRTBwNUSg{txO NF;FNI8zPDBzNUOyOy=>
U251 MVTDfZRwfG:6aXOgRZN{[Xl? MmDMOFghcA>? NVXId2ZTTE2VTx?= NX65codxT0l;MT61N{DPxE1? NHi0Z48zPDBzNUOyOy=>
KM12 MmDlR5l1d3SxeHnjJGF{e2G7 MXy0PEBp NYnQPWNmTE2VTx?= NEDjWVdIUT1zLki4JO69VQ>? MkG5NlQxOTV|Mke=
Hs578T MWfDfZRwfG:6aXOgRZN{[Xl? NHLae2Y1QCCq M2G1PGROW09? M1vNeWdKRTRwOEOg{txO NFLR[nEzPDBzNUOyOy=>
MDA-MB-231 M{fETWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPvN3M1QCCq MV;JR|UxRTBwMU[g{txO MXGyOFA6PTBzNh?=
MCF7 NXzaeGdHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnLyOFghcA>? NFfEeo9IUT1yLkS1JO69VQ>? NILseFMzPDFzOUW1OS=>
MDA-MB-435 NWDz[Y1HT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1:3S|Q5KGh? MVHHTV0xNjh6IN88US=> NXzSVIpmOjRzMUm1OVU>
AsPC1 M{jYS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlflN|Ah|ryP MWm0PEBp NXzhN|U4TE2VTx?= NUXicWVWUUN3ME2zMlY3KM7:TR?= NWS5e29NOjRzOEWzO|g>
Jurkat E6.1 NEjqRo1McW6jc3WgRZN{[Xl? NUXLVodGOiCq MYDEUXNQ NEfxVmxKdmirYnn0bY9vKG:oIFjERWM1KHerdHigTWM2OCCxZjCwMlA1KM7:TR?= M2O3R|I1OjZzOE[y
KG1 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWK0PEBp M{G5PGlEPTB;MT6xOUDPxE1? MYmyOFUzPTByMx?=
HEL NUjyR2c6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3z4bFQ5KGh? NFHpc|ZFVVOR NEDVV2lKSzVyPUCuOFkh|ryP MoT1NlQ3QTRyNUW=
HSC3 NUTYXJFXS3m2b4TvfIlkKEG|c3H5 MV2xNkBp NEjqU4dFVVOR MkTnTWM2OD1yLkexJO69VQ>? NFjPc3MzPDd4NkW2NC=>
HT-29 MYfDfZRwfG:6aXOgRZN{[Xl? M1GxOFEzKGh? NWjrNIVUTE2VTx?= MXnJR|UxRTBwN{Kg{txO NEXjSpIzPDd4NkW2NC=>
KB M3\CZmN6fG:2b4jpZ{BCe3OjeR?= MWOxNkBp MkDYSG1UVw>? NWXUT4NEUUN3ME2wMlc2KM7:TR?= MYeyOFc3PjV4MB?=
H460 M4jFSWN6fG:2b4jpZ{BCe3OjeR?= MnfNNVIhcA>? MV7EUXNQ M4Tkb2lEPTB;MD64NkDPxE1? MYCyOFc3PjV4MB?=
MONE1 MUXDfZRwfG:6aXOgRZN{[Xl? M2\hWlEzKGh? M3nIZ2ROW09? MkKyTWM2OD1zLkG4JO69VQ>? NEjZ[VgzPDd4NkW2NC=>
MKN45 MUHDfZRwfG:6aXOgRZN{[Xl? MXuxNkBp NFPoSmhFVVOR MmfDTWM2OD1zLkK1JO69VQ>? MWWyOFc3PjV4MB?=
TSGH MoL1R5l1d3SxeHnjJGF{e2G7 MXWxNkBp NYHkeWJkTE2VTx?= NWLoWFQ{UUN3ME2yMlA6KM7:TR?= M1HySlI1PzZ4NU[w
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Ca9-22 NHT0dZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33MeGlEPTB;MT6wOVExPyEQvF2= M3HYXHNCVkeHUh?=
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NCI-H526 NHv2fo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7LO5ZlUUN3ME2xMlA5OjlzIN88US=> NGHVNnZUSU6JRWK=
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NTERA-S-cl-D1 MlraS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYfXWHp6UUN3ME2xMlMyPzZzIN88US=> M1WwfnNCVkeHUh?=
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HCC1419 M2nKSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXPeI46UUN3ME2xMlM1ODJ5IN88US=> Mo\wV2FPT0WU
NCI-H69 MmjsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfqZpVKSzVyPUGuN|QyOTJizszN MV;TRW5ITVJ?
DEL MkXKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{DFVmlEPTB;MT6zOVE3OiEQvF2= M4TMfXNCVkeHUh?=
LXF-289 M{XXPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTFwM{WyOEDPxE1? MYHTRW5ITVJ?
EW-11 M{LmZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPaXpV6UUN3ME2xMlM3ODJ4IN88US=> M37tSnNCVkeHUh?=
KP-4 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlX5TWM2OD1zLkO3NFg2KM7:TR?= NVPITY54W0GQR1XS
NOS-1 NUPTPIxmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXSc2pCUUN3ME2xMlQyOTl2IN88US=> NYrSd|lPW0GQR1XS
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LAMA-84 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPHOZdKUUN3ME2xMlQ{QTR3IN88US=> MUjTRW5ITVJ?
ES5 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjLfFdKSzVyPUGuOFQ{KM7:TR?= MojHV2FPT0WU
HuO9 M1\HZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1u4TWlEPTB;MT60OVM3OiEQvF2= NHf6NoVUSU6JRWK=
COLO-684 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTFwNE[xNVgh|ryP MnK2V2FPT0WU
EW-24 NYW1fI81T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTFwNE[1N|Eh|ryP MUjTRW5ITVJ?
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NCI-H1770 NWTiTYdCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoLFTWM2OD1zLkS4OVM3KM7:TR?= M2r3cXNCVkeHUh?=
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YH-13 M3fBWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWC3[GdVUUN3ME2xMlQ6QDl2IN88US=> NWfYc4x3W0GQR1XS
H4 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;4UHFKSzVyPUGuOVA6OTJizszN MorpV2FPT0WU
OVCAR-8 MojPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\nO2NJUUN3ME2xMlU1PDd5IN88US=> M1u5[nNCVkeHUh?=
NCI-H23 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTFwNUS2OFUh|ryP NWWzbZVGW0GQR1XS
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COR-L88 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljSTWM2OD1zLkW2OFI1KM7:TR?= NFuzUZFUSU6JRWK=
TI-73 M2\1fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHfqZZZKSzVyPUGuOVkxPiEQvF2= Mn:4V2FPT0WU
RT-112 M4\FRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHvWdodKSzVyPUGuOVkzQDRizszN MmLlV2FPT0WU
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HT55 Mnu5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlniTWM2OD1zLk[1NVMyKM7:TR?= Mo\QV2FPT0WU
IA-LM MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLvTWM2OD1zLk[5Nlc5KM7:TR?= NIDDPFlUSU6JRWK=
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MHH-ES-1 NHGxNWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGS4cYFKSzVyPUGuO|A1OzVizszN NETIN4FUSU6JRWK=
CAL-27 NIXCe2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHvU4w2UUN3ME2xMlcxPjJzIN88US=> Mkf1V2FPT0WU
COLO-800 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTFwN{GxO|kh|ryP NFTqPXlUSU6JRWK=
HCE-T NGLvbnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHzTWM2OD1zLkexOUDPxE1? MVHTRW5ITVJ?
CAMA-1 NYS0dId2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTFwN{G5O|Eh|ryP M{mwcnNCVkeHUh?=
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NH-12 NHyxNmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NULocndRUUN3ME2xMlczPjlzIN88US=> NULyeG1EW0GQR1XS
TCCSUP M4nxR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;KTWM2OD1zLkeyPFI6KM7:TR?= M2jUfnNCVkeHUh?=
MDA-MB-361 MorjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7MN4ZKSzVyPUGuO|MyPTdizszN Mn\4V2FPT0WU
EW-16 M1jBUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\HTWM2OD1zLke0NVA4KM7:TR?= MmH1V2FPT0WU
SNU-423 M2SycWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFi2VHJKSzVyPUGuO|U5OjdizszN MmmwV2FPT0WU
Daoy MoXUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPCVXVKSzVyPUGuO|Y{OTlizszN MoPZV2FPT0WU
ES4 M4nr[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTFwN{i3OFEh|ryP MkDBV2FPT0WU
PFSK-1 MlnHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLOVnlZUUN3ME2xMlgxOzdizszN MYXTRW5ITVJ?
ES3 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVS2U2NyUUN3ME2xMlgzPjhzIN88US=> NH\lVlhUSU6JRWK=
ONS-76 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjzTWM2OD1zLkiyPFk4KM7:TR?= MV;TRW5ITVJ?
JVM-3 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrOZm9KSzVyPUGuPFU1PTFizszN M4PGe3NCVkeHUh?=
OS-RC-2 NV7UVpd1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\lXGlEPTB;MT64O|E2OSEQvF2= MXvTRW5ITVJ?
COLO-320-HSR MlPlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoX5TWM2OD1zLki4NVk4KM7:TR?= NFTlWpFUSU6JRWK=
HN MlrBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHx[WRKSzVyPUGuPFg4OjVizszN M4fScXNCVkeHUh?=
HT MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTFwOEi5OFch|ryP MY\TRW5ITVJ?
LoVo M{DyeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH:4NGtKSzVyPUGuPFk5OSEQvF2= NISzcYtUSU6JRWK=
CGTH-W-1 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HYZ2lEPTB;MT64PVk1PiEQvF2= NFPWUYhUSU6JRWK=
NB6 MnTIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInZbIlKSzVyPUGuPVEzQThizszN NH65VnlUSU6JRWK=
EW-22 MnfJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnOwTWM2OD1zLkmyPFg4KM7:TR?= NX20cIJKW0GQR1XS
ES6 M3LCWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV7aem9SUUN3ME2xMlk{PjNzIN88US=> M2G1e3NCVkeHUh?=
SCC-15 M{HZRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33UNmlEPTB;MT65N|gyQSEQvF2= MWnTRW5ITVJ?
HL-60 M{LsOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYi5XXJ5UUN3ME2xMlk{QTB{IN88US=> MmC2V2FPT0WU
human HOP-92 NXixOWRoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHH1XlJKSzVyPUGuPVQxPjVizszN NUXNcmRlW0GQR1XS
SW626 NG\hS4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LH[GlEPTB;MT65OFg6QSEQvF2= M33uWHNCVkeHUh?=
HEC-1 NIDMb5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTFwOUWzOkDPxE1? NXS1XIxVW0GQR1XS
LB2241-RCC NIPicJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVS0Xnc6UUN3ME2xMlk5OjNzIN88US=> NWDlZ2JJW0GQR1XS
Ramos-2G6-4C10 NHvISXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTFwOUm0PVMh|ryP MmO3V2FPT0WU
A101D Mnu1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlj3TWM2OD1{LkKwN|A{KM7:TR?= MknHV2FPT0WU
NCI-H446 M3e4RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXni[VNkUUN3ME2yMlA1PTl7IN88US=> Mn\pV2FPT0WU
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HSC-2 NYixZ5FKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDHXos1UUN3ME2yMlEzQDl6IN88US=> NU\ifmhwW0GQR1XS
LCLC-97TM1 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX3LcoN{UUN3ME2yMlE1PTh|IN88US=> MlrzV2FPT0WU
DMS-273 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkfHTWM2OD1{LkG0PFM4KM7:TR?= MXPTRW5ITVJ?
TE-8 NUezNodFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTJwMUW3OlUh|ryP NHfsfpRUSU6JRWK=
DSH1 MmTDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrtd29WUUN3ME2yMlE3Ozl6IN88US=> MWDTRW5ITVJ?
CAL-51 NHzQRodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTJwMU[2PVkh|ryP MVHTRW5ITVJ?
IST-SL1 MmL5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWS3O5dMUUN3ME2yMlE3QDR2IN88US=> MVHTRW5ITVJ?
GCT MonqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmC5TWM2OD1{LkG3O|ch|ryP NW\QdHo2W0GQR1XS
SW948 MoCxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULUVWFIUUN3ME2yMlE5PDV4IN88US=> M1njPXNCVkeHUh?=
NOMO-1 NIC0d3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTJwMUmzNVch|ryP NET3[IlUSU6JRWK=
C8166 NY\xRZVtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1rE[mlEPTB;Mj6yNVM{PCEQvF2= M4H4VXNCVkeHUh?=
OC-314 NGLjZZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnwO4pRUUN3ME2yMlI{OjV7IN88US=> M1L2SXNCVkeHUh?=
CAL-39 M3TkeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzNT3dbUUN3ME2yMlI{PjJ4IN88US=> Ml65V2FPT0WU
MDA-MB-453 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fCb2lEPTB;Mj6yOFI4PSEQvF2= MWfTRW5ITVJ?
A673 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnofFUxUUN3ME2yMlI2QDZ{IN88US=> MlnZV2FPT0WU
HTC-C3 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH[wVGFKSzVyPUKuNlY5PSEQvF2= MVzTRW5ITVJ?
NCI-H1666 M17iV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIC4eWlKSzVyPUKuNlgyOTFizszN NX7jXWRsW0GQR1XS
PSN1 NWPiZYZ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYTHfXJiUUN3ME2yMlI5QTF|IN88US=> M2HHPXNCVkeHUh?=
GI-1 NEfCbFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\oeoFtUUN3ME2yMlMxPTR|IN88US=> M3vMSXNCVkeHUh?=
HuH-7 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLkTWM2OD1{LkOwOlM4KM7:TR?= NVXudpVJW0GQR1XS
JAR M4rvT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV:zTWNtUUN3ME2yMlMyQTh5IN88US=> MVLTRW5ITVJ?
5637 NUOwWG5IT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFnJbY1KSzVyPUKuN|IyOjlizszN M4X3ZnNCVkeHUh?=
GB-1 NGjpeYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3POpRKSzVyPUKuN|I{OzVizszN MYXTRW5ITVJ?
KP-N-YS M33FO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\ITWM2OD1{LkOyOlE2KM7:TR?= MXPTRW5ITVJ?
OAW-42 NFHyN5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTJwM{O0NVYh|ryP NF7YN5BUSU6JRWK=
8-MG-BA MlHBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mne1TWM2OD1{LkOzPVA3KM7:TR?= M1;3NXNCVkeHUh?=
RH-18 MojsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTJwM{WwNlIh|ryP MWjTRW5ITVJ?
NCI-H1155 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTJwM{[3NlUh|ryP M3\oeXNCVkeHUh?=
NB17 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTJwM{iyOFMh|ryP MXrTRW5ITVJ?
NCI-H1437 M4C2R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX[2Vpk2UUN3ME2yMlQyQDd|IN88US=> MX\TRW5ITVJ?
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HT-1080 NGCwTIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXNTWM2OD1{LkS0PFY1KM7:TR?= NULBdZlkW0GQR1XS
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RPMI-2650 NHXOWHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jmRmlEPTB;Mj62OFE1OyEQvF2= NXjQXFlSW0GQR1XS
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BPH-1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTJwNkW4OUDPxE1? NUjnWXVnW0GQR1XS
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SK-HEP-1 MlnxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlz1TWM2OD1{Lke0N|kyKM7:TR?= NGPYVpVUSU6JRWK=
U-266 M{DKcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTJwN{exNlEh|ryP Mn[wV2FPT0WU
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PC-14 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTJwOEC1NUDPxE1? Moq3V2FPT0WU
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8305C NV62NFk{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYSz[3c2UUN3ME2yMlg3PjR3IN88US=> Mn;LV2FPT0WU
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LCLC-103H M1fDZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXTaZ3ZkUUN3ME2yMlkxPDN6IN88US=> MlXjV2FPT0WU
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NCI-H1355 M2LKOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHtU4lQUUN3ME2zMlAxPzl4IN88US=> M4nUPXNCVkeHUh?=
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GR-ST M37NfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXwN3d3UUN3ME2zMlIzOTN7IN88US=> NVTWTIZEW0GQR1XS
LB2518-MEL M2HPOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFOzb41KSzVyPUOuNlI{QThizszN NXjzfYNoW0GQR1XS
T47D M3PWTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3FNZBMUUN3ME2zMlI{PjJ5IN88US=> NUfQTXBjW0GQR1XS
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HT-29 NHTwR4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfBfllKSzVyPUOuNlY3OTRizszN MUTTRW5ITVJ?
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NCI-H2122 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTNwNEGzNVIh|ryP MYTTRW5ITVJ?
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COLO-829 M4jmemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHq5eVlKSzVyPUOuOVAxPzNizszN MUHTRW5ITVJ?
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EW-13 NHHQW4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTNwNUK1NUDPxE1? NInwfmxUSU6JRWK=
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CAL-62 MknDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{G1WWlEPTB;Mz61OFUyPCEQvF2= NFvnTFRUSU6JRWK=
OCUB-M MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvIZlRKSzVyPUOuOVQ3PjVizszN NUTKPJRRW0GQR1XS
BT-474 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYP5UJZxUUN3ME2zMlY{OzFizszN MnG2V2FPT0WU
KYSE-180 NI\IV4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17kR2lEPTB;Mz62N|M4OiEQvF2= NXzOfGVnW0GQR1XS
NCI-H650 Mk[xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M33H[GlEPTB;Mz62OFI5PyEQvF2= NF:0e5BUSU6JRWK=
Detroit562 NF\leFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HQNmlEPTB;Mz62OVAzOiEQvF2= NWTWe|M4W0GQR1XS
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KYSE-510 Mmf4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUXreZF4UUN3ME2zMlczOThzIN88US=> M1nIc3NCVkeHUh?=
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RPMI-7951 MmnaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTFeVRKSzVyPUOuO|Q4OjNizszN M3HXVHNCVkeHUh?=
Becker MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17QVmlEPTB;Mz63OVAyOiEQvF2= NXKzZph4W0GQR1XS
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G-401 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLDTWM2OD1|Lke5NFg2KM7:TR?= NY\BdnNJW0GQR1XS
PANC-08-13 NIjifWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7SeIR6UUN3ME2zMlc6PjB{IN88US=> NGfQbIVUSU6JRWK=
SW982 Mnf4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\rb2lEPTB;Mz64NFU2OSEQvF2= MkL0V2FPT0WU
D-263MG NVjqcXlUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInnXINKSzVyPUOuPFIxPTFizszN NWTaT4NsW0GQR1XS
KM-H2 M{Hn[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHvTbG1KSzVyPUOuPFI3OjRizszN NEKwfYpUSU6JRWK=
SK-MEL-3 NImxcWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XiOWlEPTB;Mz64Nlg1OSEQvF2= MYXTRW5ITVJ?
NCI-H1581 NFXHPGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4TwOmlEPTB;Mz64OFQ5QCEQvF2= NXP1OIR5W0GQR1XS
LS-123 NIDRcolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjvPG5wUUN3ME2zMlg4QTB7IN88US=> NVW3cmZ{W0GQR1XS
CAKI-1 NGTlNI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTNwOEmwOVIh|ryP MnfwV2FPT0WU
MEL-JUSO M33POGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjsTWM2OD1|Lki5NVU{KM7:TR?= M{TST3NCVkeHUh?=
HCE-4 MoG1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jCN2lEPTB;Mz65NVY3OyEQvF2= NV:2[XpxW0GQR1XS
TE-10 NV;SW4x2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1z3SGlEPTB;Mz65NlAyKM7:TR?= MVfTRW5ITVJ?
OVCAR-4 NH;6N|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LTZWlEPTB;Mz65Nlg5QSEQvF2= M{jleXNCVkeHUh?=
ETK-1 NYf5e|VvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3wcGliUUN3ME2zMlk1PjN3IN88US=> NGjHfHdUSU6JRWK=
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LU-65 M{LReGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TqN2lEPTB;ND6wO|Y{OyEQvF2= M2P5fHNCVkeHUh?=
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COR-L105 NVvPPZZPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TEc2lEPTB;ND6xN|A2OSEQvF2= Ml7uV2FPT0WU
CAL-12T Mkn2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTRwMUOxNFMh|ryP NFXOO|NUSU6JRWK=
SCH MnTYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DQXGlEPTB;ND6xOVc1OyEQvF2= M4DvN3NCVkeHUh?=
CW-2 NFrmfYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLhV|RNUUN3ME20MlE6ODBzIN88US=> M{LF[3NCVkeHUh?=
HCC1806 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTRwMkCzNVIh|ryP NFe4NHVUSU6JRWK=
KP-N-YN NHPNUINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEftU2dKSzVyPUSuNlA6OjdizszN NHvlRndUSU6JRWK=
T98G NFzUS|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnjTWM2OD12LkKyNVU4KM7:TR?= NHXKWolUSU6JRWK=
CAL-54 NX[zb2lxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjIWYhuUUN3ME20MlIzOzhzIN88US=> MV3TRW5ITVJ?
CAL-33 MoPLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDGWYFKSzVyPUSuNlMxPjRizszN M3HZcXNCVkeHUh?=
SNU-C2B M{HjSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTRwMkS3Olkh|ryP NYr2UplFW0GQR1XS
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Calu-6 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnWNoR7UUN3ME25MlM4PTJ6IN88US=> MmDJV2FPT0WU
LB831-BLC MojwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2mxU2lEPTB;OT60OVE4OSEQvF2= MWLTRW5ITVJ?
SW684 NUDWWIE4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTlwNE[xNVYh|ryP MlXnV2FPT0WU
SH-4 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInEb4RKSzVyPUmuOFk{PjRizszN MnzYV2FPT0WU
IST-MES1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\ldYdUUUN3ME25MlUyPjR2IN88US=> M4fXN3NCVkeHUh?=
Saos-2 NVXydHVQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\XPWlEPTB;OT61NlE6PSEQvF2= NXe0S3d5W0GQR1XS
NCI-H2087 NWm0R|BMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFnsV2JKSzVyPUmuOlc{PTJizszN MWDTRW5ITVJ?
SCC-9 NGrwN2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17ie2lEPTB;OT63NVgyPiEQvF2= M3G0XHNCVkeHUh?=
MFE-280 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nlcGlEPTB;OT63Nlc5PSEQvF2= MUHTRW5ITVJ?
BEN M2DidWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LpXWlEPTB;OT64NlE2QSEQvF2= NHPXd2VUSU6JRWK=
CP50-MEL-B NXyxNVZkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTlwOUK0N|Ih|ryP MWnTRW5ITVJ?
SK-MEL-28 MnLqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfifXpKSzVyPUGwMlAyQTNizszN NIrkVldUSU6JRWK=
NCI-H2452 NV:w[XVtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\UeW1zUUN3ME2xNE4yPiEQvF2= NITBb|VUSU6JRWK=
NCI-H1395 M3uwZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLoNm5KSzVyPUGwMlE4QCEQvF2= M37NXnNCVkeHUh?=
NCI-H2052 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnTLTWM2OD1zMD6xPFgzKM7:TR?= M2fYcXNCVkeHUh?=
A375 NIXxVlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFL3bYZKSzVyPUGwMlI1PTJizszN M4W1XHNCVkeHUh?=
HCC38 MkTFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nMXmlEPTB;MUCuN|IzKM7:TR?= M1X2c3NCVkeHUh?=
LK-2 Mk\PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn63TWM2OD1zMD60NlA5KM7:TR?= NGnKWohUSU6JRWK=
SF126 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17mPGlEPTB;MUCuOFczPyEQvF2= NVLRfWhjW0GQR1XS
SK-MEL-1 NH\DVYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTFyLke4N|gh|ryP MUjTRW5ITVJ?
ACN M3LpeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTFyLki2O|kh|ryP NFPRWXNUSU6JRWK=
BB30-HNC NEPwXmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlT4TWM2OD1zMD64O|EyKM7:TR?= M2LNZXNCVkeHUh?=
NCI-H747 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NITUc49KSzVyPUGwMlg4PDZizszN NUTSXJNqW0GQR1XS
KYSE-150 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTqTWM2OD1zMT6wN|g4KM7:TR?= NF3xc|VUSU6JRWK=
D-247MG MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3F[HpMUUN3ME2xNU4yODB7IN88US=> M3vJRXNCVkeHUh?=
BxPC-3 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTFzLkO3OFch|ryP M3XCbnNCVkeHUh?=
SK-MEL-30 NFvOR3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rERmlEPTB;MUGuOFA4QSEQvF2= Mo\qV2FPT0WU
CAS-1 MkXtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYf1dZBrUUN3ME2xNU41OTB7IN88US=> M{LoenNCVkeHUh?=
no-10 NGHHXZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV[3R3FtUUN3ME2xNk4yOjF5IN88US=> NWfkWVBqW0GQR1XS
NCI-H2405 M2\5dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTF{LkKwN|Yh|ryP M{TiT3NCVkeHUh?=
KGN NX;ob2dOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEOwTnhKSzVyPUGyMlI6ODFizszN MXLTRW5ITVJ?
BB49-HNC NWHnSnkzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4n0S2lEPTB;MUKuN|k2PiEQvF2= MmXZV2FPT0WU
NCI-H1693 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoGzTWM2OD1zMj61PFE3KM7:TR?= M3XQN3NCVkeHUh?=
RO82-W-1 NVPVXGtrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXflXHA6UUN3ME2xN{4xPjR7IN88US=> M1T1b3NCVkeHUh?=
CAL-85-1 MlHpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3STWM2OD1zMz60N|k6KM7:TR?= MXnTRW5ITVJ?
H-EMC-SS NIj0Z|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTF|LkmxNFQh|ryP NVG2eIhNW0GQR1XS
SW1783 M4jJZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYL1bpRRUUN3ME2xOE4zOzlzIN88US=> NITINFRUSU6JRWK=
LB771-HNC NU\ZdnlvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjhTWM2OD1zND60NVkh|ryP NUH0c21WW0GQR1XS
HCC70 NG\zTZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvKTWM2OD1zND60NlM{KM7:TR?= NV3o[FlLW0GQR1XS
KNS-81-FD M1\j[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmP5TWM2OD1zND63NFQ2KM7:TR?= MYLTRW5ITVJ?
KYSE-520 Mke4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\3c2lKSzVyPUG0MlkzPyEQvF2= NWD6OXdOW0GQR1XS
TGBC24TKB M{Duemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofNTWM2OD1zND65OVM6KM7:TR?= M1jH[HNCVkeHUh?=
SNB75 M{[0WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGPjbINKSzVyPUG1MlA4OjlizszN M1rlN3NCVkeHUh?=
SW872 M4naSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjTTWM2OD1zNT6yNlE5KM7:TR?= NEfyS5FUSU6JRWK=
U031 MkXoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTF3LkiwNlgh|ryP MXzTRW5ITVJ?
ChaGo-K-1 NWD4bnl{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\4VGZKSzVyPUG1Mlg{PTlizszN NVHYXHJXW0GQR1XS
NCI-H441 MonpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{mxXGlEPTB;MU[uNFA{QSEQvF2= NEH1VldUSU6JRWK=
TE-12 M2fkSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HEfWlEPTB;MU[uNVg4OyEQvF2= M1HV[3NCVkeHUh?=
NCI-H1755 Mm\RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrrNZBKSzVyPUG2MlU4OyEQvF2= M{LBc3NCVkeHUh?=
KNS-42 NFfHcVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrRS45RUUN3ME2xOk43PTh7IN88US=> MYPTRW5ITVJ?
SK-PN-DW MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUixRploUUN3ME2xO{41OjBzIN88US=> MVrTRW5ITVJ?
NCI-H226 NWiyXGl7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3nSFRKSzVyPUG3Mlk{PDVizszN NX;nPG1WW0GQR1XS
K-562 NEXDPYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIe5OHRKSzVyPUG4MlY{OTdizszN MWTTRW5ITVJ?
A388 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX7UbmxLUUN3ME2xPU4xOzB|IN88US=> MV\TRW5ITVJ?
ZR-75-30 M3[4SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTF7LkC5Olgh|ryP M1HDPHNCVkeHUh?=
LU-135 M4naeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M13IUGlEPTB;MUmuNlY{PiEQvF2= M4fxcXNCVkeHUh?=
NCI-H2029 NFj5[5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXTiNXN7UUN3ME2xPU43ODJzIN88US=> Mk\ZV2FPT0WU
HT-1197 MlPDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jleGlEPTB;MUmuPVIzPyEQvF2= MYDTRW5ITVJ?
IGR-1 MnruS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PKemlEPTB;MkCuN|EyPyEQvF2= NW\qVHA5W0GQR1XS
U-87-MG M{i4U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTJyLk[0NVMh|ryP NH3QbFdUSU6JRWK=
NCI-H1304 M{PRTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTJyLke1NFEh|ryP MX3TRW5ITVJ?
RCC10RGB NWTwU4pOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nvZ2lEPTB;MkGuNlgzQSEQvF2= NVvqNo9CW0GQR1XS
NCI-H520 M1zUNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFLMT2tKSzVyPUKyMlc3OTFizszN MWPTRW5ITVJ?
SK-LU-1 MnnDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fNfGlEPTB;MkOuNFcyQCEQvF2= Mm[1V2FPT0WU
UACC-893 NWTLdWxxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoezTWM2OD1{Mz6xNFM5KM7:TR?= NXzpWIZEW0GQR1XS
NCI-H2347 NYe5VZlwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTJ|LkK2O|Qh|ryP NIPLNZpUSU6JRWK=
U-118-MG NYLlfXZDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnfTTWM2OD1{Mz63NlE4KM7:TR?= MWPTRW5ITVJ?
NCI-H596 NF\Td25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYribmRxUUN3ME2yN{46ODV3IN88US=> M{fQdHNCVkeHUh?=
MZ1-PC MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTJ2Lk[3OVkh|ryP NYOxe5R5W0GQR1XS
SW1417 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVe5XoNbUUN3ME2yOU4zPDl6IN88US=> M2O2NnNCVkeHUh?=
NCI-H82 M1;ifGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTJ4LkSyPFgh|ryP NIHwRpBUSU6JRWK=
COLO-678 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTJ5LkS5NVkh|ryP M2q2N3NCVkeHUh?=
KURAMOCHI MnvhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTJ6LkGyOkDPxE1? MX7TRW5ITVJ?
NCI-H1650 NHXmUIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm[5TWM2OD1|MD6xPVI1KM7:TR?= M1K4TXNCVkeHUh?=
HCC1954 NFzOS4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHRRopVUUN3ME2zNU4{PjZ4IN88US=> NGXzTm1USU6JRWK=
GAK M1;wZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjlTWM2OD1|Mj6yOlE3KM7:TR?= NYnzZpAzW0GQR1XS
YAPC MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTN|Lke2OFgh|ryP NFrFU3BUSU6JRWK=
NCI-H2228 NGPDXW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXIWFZKSzVyPUO0MlM3ODVizszN NViyNoJ[W0GQR1XS
VMRC-RCZ MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnDZnh{UUN3ME2zOk4{ODJ{IN88US=> MYDTRW5ITVJ?
NMC-G1 NGLHfJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTN5LkC1Nlkh|ryP M{O2cXNCVkeHUh?=
D-336MG MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nXeGlEPTB;NEGuPFQ1OiEQvF2= MnH1V2FPT0WU
UACC-62 NHTUNG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTR{LkW1NFUh|ryP MV3TRW5ITVJ?
C-33-A MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3xTWM2OD12NT6zNlU3KM7:TR?= NXvRVlZiW0GQR1XS
HCC1937 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3Tre2lEPTB;NEeuNVk2QCEQvF2= M3j1bHNCVkeHUh?=
HDLM-2 NHHhboZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTR5LkKyPFch|ryP MWnTRW5ITVJ?
NCI-H727 MlrTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTR5LkK0OVEh|ryP NELPWI5USU6JRWK=
NY MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHv5boVKSzVyPUS5MlM6ODhizszN M4[zZXNCVkeHUh?=
NCI-H2291 NITDcnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUj6OVJMUUN3ME20PU45OzBzIN88US=> Mn[2V2FPT0WU

... Click to View More Cell Line Experimental Data

体内研究 Decitabine和Vorinostat都具有使肿瘤衰退的功能。然而, Decitabine 和 Vorinostat 联用使肿瘤衰退的效果更强。没有任何处理时,在野生型和Fasgld 小鼠中在肺肿瘤负担方面观察不到明显的区别。然而, Decitabine 和Vorinostat联用处理野生型小鼠,使肿瘤衰退比处理 Fasgld小鼠效果高很多。 Decitabine和Vorinostat使结肠癌细胞对FasL调节的肿瘤衰退敏感。低剂量Decitabine和Vorinostat处理,没有明显的肝脏毒性。[3]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:[4]
+ 展开

组蛋白去乙酰化酶活性测定:

为了进行 HDAC 实验24 × 104 dpm 乙醇溶液(1 mCi/ml)中提供的sup>3H-醋酸钠盐标记的组蛋白H4等份样, 加到每个试管中,试管中含悬浮在25 µL实验buffer(100 mM Tris-HCl pH 8, 2mM EDTA)中的200 µg全部HeLa细胞裂解液进行免疫沉淀获得的HDAC。加入不同浓度Vorinostat,在30oC下温育90分钟。加入20 µL 终止缓冲液(0.5 N HCl, 0.08 M AcOH)终止反应。加入0.8 mL TBME提取释放放入氚醋酸盐。在8,000 × g 转速下离心5分钟,600 µL 有机相(上相) 转移到包含3 mL闪烁液的闪烁瓶中。
细胞实验:[4]
+ 展开
  • Cell lines: NB4, NCI-H460和HCT-116肿瘤细胞系
  • Concentrations: 0 μM - 0.1 μM
  • Incubation Time: 48小时
  • Method: NB4, NCI-H460和HCT-116肿瘤细胞系生长在200 µL 96孔板中,约10%汇合,生长24小时后,覆盖孔中。使用多种浓度 Vorinostat或溶剂处理肿瘤细胞24小时。处理后,冲洗实验板,移除Vorinostat,温育48小时。使用sulphorodamine B 实验测定Vorinostat处理后存活细胞的分数。
    (Only for Reference)
动物实验:[3]
+ 展开
  • Animal Models: 携带CT26 细胞的Fasgld BALB/cByJ小鼠
  • Formulation: Dissolved in DMSO
  • Dosages: 25 mg/kg
  • Administration: 静脉注射
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 52 mg/mL (196.74 mM)
Ethanol 3 mg/mL (11.35 mM)
Water Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用:
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
5mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 264.3
化学式

C14H20N2O3

CAS号 149647-78-9
稳定性 powder
in solvent
别名 SAHA, MK0683, suberoylanilide hydroxamic acid

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01059552 Active, not recruiting Locally Advanced Non-small Cell Lung Cancer Fox Chase Cancer Center|National Comprehensive Cancer Network December 6, 2009 Phase 1
NCT02108002 Enrolling by invitation Von Hippel-Lindau Disease National Institute of Neurological Disorders and Stroke (NINDS)|National Institutes of Health Clinical Center (CC) March 5, 2014 Phase 1
NCT03022565 Not yet recruiting Uveal Melanoma Nicolas Acquavella|University of Miami Sylvester Comprehensive Cancer Center|University of Miami April 2017 --
NCT02943642 Not yet recruiting Mycosis Fungoides Angimmune LLC|City of Hope National Medical Center|Columbia University|Dana-Farber Cancer Institute|Feinberg School of Medicine, Northwestern University|H. Lee Moffitt Cancer Center and Research Institute|Ohio State University Comprehensive Cancer Center|Rush University Medical Center|Scott and White Hospital & Clinic|Yale University|Stanford University|Thomas Jefferson University|University of Arkansas|University of Colorado Denver School of Medicine Barbara Davis Center|University of Texas Southwestern Medical Center|University of Washington|Vanderbilt University School of Medicine|Washington University School of Medicine January 2017 Phase 2
NCT02836548 Recruiting Melanoma|Skin Neoplasms The Netherlands Cancer Institute June 2016 Phase 1|Phase 2
NCT02589145 Recruiting Lymphoma M.D. Anderson Cancer Center|Celgene Corporation June 2016 Phase 1|Phase 2

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常见问题及建议解决方法

  • 问题 1:

    What’s the recommendation about reconstitution of the compound for in vivo animal study?

  • 回答:

    We recommend the following vehicle for S1047: 2% DMSO, 40% PEG 300, 5% Propylene glycol, 1% Tween 80 at 5 mg/mL.

HDAC Signaling Pathway Map

HDAC Inhibitors with Unique Features

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID