Vorinostat (SAHA, MK0683)

目录号:S1047 别名: SAHA, MK0683, suberoylanilide hydroxamic acid

Vorinostat (SAHA, MK0683) Chemical Structure

Molecular Weight(MW): 264.3

Vorinostat (suberoylanilide hydroxamic acid, SAHA)是一种HDAC抑制剂,无细胞试验中IC50为~10 nM。

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客户购买Selleck的此次产品后发表的文献100篇:

客户使用该产品的20个实验数据:

  • Differential effects of HDAC inhibitors on histone and tubulin acetylation. Immunofluorescence analysis of histone H3 (K9ac/K14ac) and tubulin acetylation in HeLa cells treated for 4 h with vehicle, SAHA (10 μM), tacedinaline (50 μM), PCI-24781 (20 μM. (a) Mapping of histone acetylation in K562 cells treated with HDAC inhibitors by LC-MS/MS. Cells were treated with TSA (10 μM), SAHA (5 μM), PCI-24781 (2 μM), tacedinaline (50 μM) for 6 h. Histones were extracted from cells and acetylated peptides were quantified after isobaric tagging.

    Nat Biotechnol 2011 29, 255-265. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Activity of vorinostat in Jurkat and Peer T-ALL cell lines in an MTT cell viability assay. Cells were treated with increasing drug concentrations for 72 h. The data are plotted as the mean % of DMSO-treated control cells against the corresponding drug concentration. The error bars are the standard error. For each drug and cell line, 3-4 independent experiments were performed with 6 replicates at each drug concentration.

    Nature 2011 471, 235-9. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Western blot analysis of histone H3 acetylation in the spleen of untreated and vorinostat-treated hNF-E2 tg mice (n = 4 of each genotype).

    J Exp Med 2012 209, 35-50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    SAHA down-regulates c-FLIP expression and increases the sensitivity of CaP cells to undergo apoptosis in the presence of bicalutamide (A) Bar graph illustrating the sub-G0/G1 cell population in 22Rv1 (left panel) and LNCaP (right panel) cells in the absence and presence of 10μM bicalutamide, administered as a single agent or in ombination with increasing concentrations of the HDAC inhibitor, SAHA. (B) Immunoblots demonstrating the single agent activity of bicalutamide or SAHA, or effect upon their combined administration on the expression of c-FLIP and/or the processing of PARP. Equal protein loading was confirmed by GAPDH. (C) Bar graph illustrating the effect of bicalutamide and SAHA upon the induction of caspase-8 or caspase-3/7 activity in 22Rv1 cells (left panel) and LNCaP cells (right panel). (D) Immunoblots characterizing the impact of SAHA and/or bicalutamide upon the induction of PARP cleavage, in the absence or presence of the pan-caspase inhibitor, ZIETD. ZIETD was incubated with the cells for 12 h prior to the experiment. All data points shown in (A) and (C) represent the mean ± S.E.M. value, calculated from four independent experiments.

    Clin Cancer Res 2012 18, 3822-33. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Analyses of efficacy, potency and IC50 of HDAC inhibitors point toward HDACs 1–3 as relevant candidates for beta cell protection. Ranking and raw data on ITF drugs (Table 3) and commercial HDAC inhibitors (Table 4) underlying the heat maps of Fig. 1 (A and B). The HDAC inhibitor compounds were tested using a HDAC activity kit and recombinant proteins to determine IC50 values on each individual HDAC (right part of the table). Each drug was further tested using Real-Time Cell Analysis (RTCA) to score their maximal effective concentration (ECmax) as well as the corresponding rescue percentage of cytokine treated INS-1 cells. The drugs were ranked according to % rescue. * DMSO alone controls were included in each experiment, but not shown here. The results indicate that the highest concentrations of DMSO used here (1:1,000) were slightly potentiating the proliferation of the cells. The effects observed in this group of compounds were ascribed to the DMSO.?

    Diabetologia 2012 55, 2421-2431. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Proliferation o f HT29 and HCT116 cells after 48 h of butyrate or SAHA treatment. Proliferation measurements using the xCEL Ligence RTCA DP instrument (Roche) in cells treated with increasing doses of butyrate or SAHA, compared with control medium cells (0) (*P < 0.05). The mean ?SEM of three cell culture replicates is shown.

    Mol Carcinog 2012 52, 459-74. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Suberoylanilide hydroxyamic acid (SAHA) preserves CFP (+) expression in mouse optic nerves (MONs) from older mice. (a) CFP (+) mitochondria were longer and thicker in MONs from 12-month-old Thy-1 CFP mice (inset; scale bar = 2 μm). Oxygen–glucose deprivation (OGD) consistently reduced CFP pixel intensity in 12-month-old MONs despite longer and brighter CFP ( +) mitochondria (yellow arrows). (b) Blockade of AMPA/kain ate receptors with NBQX (30 μM), or pan-Histone deacetylase (HDAC) inhibition with SAHA (5 μM), effectively preserved CFP pixel intensity during OGD. The preservation of CFP (+) mitochondria correlates with protection of the CAP area during OGD and profound recovery.

    J Neurochem 2012 123 Suppl 2, 108-15. Vorinostat (SAHA, MK0683) purchased from Selleck.

    D and E, Regression of IL-13Ra 2-negative pancreatic tumors treated with SAHA and/or IL-13-PE. Mice were treated daily with i.p. injection of SAHA (25 mg/kg) from day 4 after tumor implantation for two weeks followed by i.t. injection of IL-13-PE (100 μ g/kg) from day 5 for two weeks. F and G, Regression of IL-13Ra 2-posotive pancreatic tumors (HS766T and MIA-PaCa2) treated with SAHA and/or IL-13-PE. The schedule of treatment was similar as in panel D and E. Statistical significances are shown by *: P < 0.05,†: P < 0.001.

    J Transl Med 2011 9, 37. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • IL-13Rα2 expression is upregulated in pancreatic tumors but not in organs of mice after treatment with HDAC inhibi tor, SAHA. A, qRT-PCR of human IL-13Rα2 in implanted pancreatic tumors after SAHA and IL-13-PE treatment. Tumors were harvested next day after IL-13-PE treatment and total RNA extracted. Data shown is ratio of human IL-13Rα2/β-actin expression and multiplied by 1000 for convenience. Bars , SD of triplicate determinations. B, qRT-PCR of mouse IL-13Rα2 in mice organs after SAHA and IL-13-PE treatment. Tissues were harvested at the same time point as in panel A and total RNA extracted. Data shown is ratio of mouse IL-13Rα2/β-actin expression and multiplied by 100 for convenience. C, IHC of human IL-13Rα2 in implanted pancreatic tumors after SAHA and IL-13-PE treatment. D, IHC of mouse IL-13Rα2 in mice organs after SAHA and IL-13-PE treatment. Liver, brain, kidney, pancreas, lung and spleen were fixed for immunostaining of mouse IL-13Rα2 as visualized by Alexa555. Nucleus was counterstained by DAPI.

    J Transl Med 2011 9, 37. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Vorinostat inhibits the tumor growth. NOD ⁄ SCID-B2m-/-mice were injected s.c. with 1×106 MyLa2059 cells into both flanks. When the mice had developed established palpable tumors treatment was initiated (day 1). The mice received either vehicle (black line) or 60 mg ⁄ kg vorinostat (grey line) i.p. five days a week. In total, there were four mice in the group receiving vehicle and three mice in the group receiving vorinostat. The length and width of the tumors were measured continuously until the experiment was terminated on day 20 post treatment initiation. The tumor volume was calculated using the formula V = (a×b2)/2, where a defines the length (mm) and b the width (mm) of the tumor. The histogram shows the average tumor volume per flank ± SEM. * denotes a significant difference (P < 0.05) in the average tumor volume per flank between mice treated with vehicle and vorinostat at the given time-point both by using a one-tailed two samples test with Welch, scorrection and a Mann-Whitney U test.

     

     

    Exp Dermatol 2010 19, 1096-1102. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • SAHA induces the down-regulation of cFLIP expression and promotes TRAIL-mediated activation of a mitochondrial-operated apoptotic pathway. a BT-474 cells were treated as indicated in Fig. 1 and the cells were then harvested to analyse caspase-8, Bid, caspase-9, caspase-3 and PARP expression, using GAPDH as the protein loading control. b BT-474 cells were treated with SAHA for 8 h at the doses indicated and subsequently, the cells were harvested and the apoptosis-related proteins were analysed in western blots as described in the "Materials and Methods". The results shown are representative of at least three independent experiments

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Treatment with SAHA sensitizes breast cancer cells to TRAILinduced apoptosis. BT-474 and MDA-MB-231 cells were incubated for 8 h with SAHA at the doses indicated. After this time, TRAIL (500 ng/ml) was added to some of the cultures for an additional 15 h. Apoptosis was measured as the percentage of cells with subG1 DNA content as described in the "Materials and methods". The results show the mean and S.E.M. of three independent experiments

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • SAHA facilitates the Itch/AIP4-independent proteasomal degradation of cFLIP proteins in breast cancer cells. a BT-474 cells were treated with SAHA (5 μM) for 8 h in the presence or absence of the proteasome inhibitors MG132 or epoxomicin (at the doses indicated), and they were then harvested and the cFLIP content was analysed in western blots. b BT-474 cells were transfected with either the siRNA oligonucleotides targeting Itch/AIP4 or the non-targeting RNA oligonucleotide (scrambled) for 48 h as described in the "Materials and Methods". Subsequently, the cells were treated with SAHA (5 μM) for 8 h and then cFLIP and Itch/AIP4 expression was analysed in immunoblots

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

    cFLIP down-regulation following SAHA treatment is responsible for the sensitization of breast cancer cells to TRAIL. a BT-474 cells were transfected with either different siRNAs directed against the cFLIP isoforms or the non-targeting RNA oligonucleotide (scrambled) as described in the "Materials and Methods". After 24 h, the cells were treated with TRAIL (500 ng/ml) for a further 15 h and apoptosis was then measured as the percentage of cells with subG1 DNA content. The results show the mean and S.E.M. of three independent experiments. To verify protein knockdown, cells were harvested 24 h after transfection and the cFLIP levels were assessed in immunoblots. b. BT-474 cells overexpressing Cflipl (pBABE-FLIPL) or control cells (pBABE) were treated with SAHA for 8 h at the doses indicated. After this time, TRAIL (500 ng/ml) was added to some cultures for 15 h. Apoptosis was measured as the percentage of cells with subG1 DNA content and the results show the mean and range of two independent experiments. Western blots show the cFLIP levels after SAHA treatment in pBABE and pBABE-FLIPL cells.

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • (a) Western blot of whole cell extracts demonstrates SAHA and NaB treatment result in increased levels of acetylated histone H3 compared to vehicle controls. (b) Light micrographs of HDACi/vehicle treated cultures illustrate the paucity of neurospheres in HDACi-treated cultures. (c) Quantitative analysis confirms SAHA and NaB inhibit the formation of neurospheres (diameter ≥ 50 μm) and increase the prevalence of small cell clusters (≥ 4 cell, diameter < 50 μm). (d) Flow cytometry using LIVE/DEAD cell stain confirms SAHA and NaB are minimally toxic compared to vehicle controls (n = 3). Scale bar = 100 μm.

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    (a) EdU flow cytometry of live cell-gated adult mouse NSCs demonstrates SAHA (**p < 0.01) and NaB (***p < 0.001) significantly inhibit DNA synthesis. (b) Analysis of DNA content by flow cytometry reveals significant accumulation of adult mouse NSCs in G1phase of the cell cycle following SAHA (*p < 0.05) and NaB (*p < 0.05) treatment. (c) Correspondingly the proportion of cells in G2/M phase is significantly reduced following SAHA (*p < 0.05) and NaB (*p < 0.05) treatment. (d) Fluorescence micrographs of HDACi/vehicle treated adult NSCs pulse-labeled with EdU for flow cytometry. Scale bar = 50 μm. Statistical comparisons performed using one-way ANOVA with post hoc Newman-Keuls multiple comparison tests.

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • (a) Immunofluorescence labeling of NeuN, GFAP and Olig2 cell fate markers reveals reduced expression of GFAP (*p < 0.001) and Olig2 (*p < 0.05) in adult mouse NSCs treated with SAHA for 48 hours under proliferation culture conditions and then induced to differentiate for 14 days in culture (two-way ANOVA with Bonferroni post-tests). (b) Western blot of β-catenin protein in nuclear and cytoplasmic fractions of adult mouse NSCs treated with HDACi/vehicle control under proliferation culture conditions. Gapdh and lamin A/C blots are included as loading controls. (c) SAHA and NaB do not significantly alter nuclear/cytoplasmic levels of β-catenin in adult mouse NSCs. Histogram of β-catenin Western blot signal intensities normalized to loading controls (n = 4).

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Morphological changes and histone H3 phosphorylation of HB cells treated with a combination of VX-680 and SAHA. HUH6 and HepT1 were incubated with VX-680 (6 μM) and SAHA (0.5 μM). Nuclei diameter (a) and cell diameter (b) were determined 72 h later by DAPI staining and microscopy. Data represent mean±SD of the diameters from 20 cells in each experiment. (* Two-way ANOVA, Bonferroni test, p \0.05). c Western blot analysis on HUH6 and HepT1 cells were carried out with an anti-phospho-Histone H3 (Ser 10) antibody (p-H3) 24 h after incubation with VX-680 (10 μM), SAHA (0.2 μM) or a combination of both. Controls were left untreated. Western blot analysis showed a decrease in p–H3 after treatment with VX-680 ( lane 2 ) relative to controls ( lane 1 ) and an increase when SAHA was added ( lane 3 ). For the combination of VX-680 and SAHA (lane 4 ) no p-H3 was detected.

    Pediatr Surg Int 2012 28, 579-89. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Vorinostat promotes C2C12 differentiation.In the image, the red is the myotube indicating differentiation ,the blue is the nuclei.

     

     

    Dr. Akihiko Yoshimura of Akihiko Yoshimura. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Western blot analysis of Acetyl-H3 and H3. 0-20μM SAHA was added.

     

     

    Dr. Zhang of Tianjin Medical University. Vorinostat (SAHA, MK0683) purchased from Selleck.

产品安全说明书

HDAC抑制剂选择性比较

生物活性

产品描述 Vorinostat (suberoylanilide hydroxamic acid, SAHA)是一种HDAC抑制剂,无细胞试验中IC50为~10 nM。
特性 Vorinostat是广谱HDAC活性抑制剂,抑制I和II类酶 。
靶点
HDAC [1]
(Cell-free assay)
~10 nM
体外研究

Vorinostat是小分子量(<300)线性肟酸,抑制HDAC活性,包括乙酰化组蛋白和非组蛋白的积累,抑制培养细胞的增殖,且抑制肿瘤生长。Vorinostat通过结合到酶的活性位点而抑制 HDAC活性。Vorinostat 抑制多种转化细胞增殖(包括 淋巴瘤,多发性骨髓瘤,白血病,和非小细胞肺癌),与对照组相比抑制生长达50% 时的浓度为0.5 到10μM。Vorinostat作用于淋巴瘤和白血病细胞,包括 Burkitt, B-细胞急性淋巴细胞白血病 (B-ALL), MCL, DLBCL, ATL和T-细胞,不同程度抑制细胞增殖。除了抑制转化细胞增殖, Vorinostat 也抑制正常细胞增殖,通过比较Vorinostat 作用于一组细胞系–正常人非纤维细胞(WI-38)和 SV40巨大T抗原转化WI-38(VA-13细胞)而得到证明。Vorinostat 抑制两种类型细胞增殖,这种作用存在剂量依赖性。但发现Vorinostat 对转化细胞具有选择毒性,包括使肿瘤细胞死亡,而对正常细胞只起抑制作用,不会使其死亡。[1] Genistein 和Vorinostat 联用效果比5-aza和Vorinostat 联用作用于诱导细胞死亡有效很多。Genistein和Vorinostat联用作用于ARCaP-E使增殖降低 80 %,作用于ARCaP-M细胞,增殖降低60 %以上。Genistein和Vorinostat 联用抑制细胞增殖具有协同效应。作用于ARCaP-E 细胞(820个基因 诱导和1046个基因抑制) ARCaP-M 细胞,Vorinostat比Genistein 影响更多基因。[2] Vorinostat作用于肿瘤细胞表面,提高Fas蛋白水平,这种作用存在剂量依赖性,且按0.75 μM剂量处理,提高达到一个稳定水平。[3] Vorinostat 抑制肿瘤细胞生长,包括NB4, H460 和HCT-116,IC50分别为0.7μM, 3.4μM和1.2 μM。[4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
A20 M2[yc2tqdmG|ZTDBd5NigQ>? M{\qfVEhcA>? NX\1Z2NtTE2VTx?= MkW3ZY51cS2KRFHDNUBi[3Srdnn0fUB4cXSqIFnDOVAhd2ZiMD6xNVIh|ryP M{nBZlEyQTZyNEi5
Friend leukemic cell M3zsbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWK1NEDPxE1? MmnyO|IhcA>? NGqxOllFVVOR M2fEeGlEPTB;MD65PUDPxE1? NF;ZV20yOjFyOUmxNy=>
K562 MmLOT4lv[XOnIFHzd4F6 NX;oXWtuPiCq MYfEUXNQ M4rKNmlvcGmkaYTpc44hd2ZiaIXtZY4hcGm|dH;u[UBl\WGlZYT5cIF{\SBqbXn4eJVz\SCxZjDISGFEOSCjbnSgTGRCSzJrIIfpeIghUUN3MDDv[kAxNjBzIN88US=> MUmxNlQyQTN6MB?=
HT1080 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXH4OZJuPzJiaB?= NFTheGhFVVOR M{PHXmlEPTB;Mj60JO69VQ>? NF[0em8yOjJ5MEG3OS=>
H1299 MmDDT4lv[XOnIFHzd4F6 NEPsc3kzOCCvaX6= MXfEUXNQ M1:4eGlvcGmkaYTvdpkh[WO2aY\peJkh[WejaX7zeEBJTEGFIHXufplu\SC5aYToJGlEPTBib3[gNE4yQTRizszN NISzPXgyPDV{MUSyNi=>
H1299 MkGxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXIV5g1PzJiaB?= NXu5NpZLTE2VTx?= NVrU[3BFUUN3ME23MlI1KM7:TR?= MlfHNVQ2OjF2MkK=
HeLa MUnLbY5ie2ViQYPzZZk> MWKzNEBucW5? MkXyTY5pcWKrdH;yfUBkd26lZX70doF1cW:wIHHnZYlve3RiaHnzeI9v\SCmZXHj[ZR6dGG|ZTD3bZRpKEmFNUCgc4YhOC5{ODFOwG0> NYfabIxzOTV4MEO5OFk>
LOX-IMVI MmLVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvvd2o1QCCq M3zRVWlEPTB;MT6zJO69VQ>? M2HsOlE2PzF3NEew
NCI-H226 M3zMeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXrcJY1QCCq NVnjNHlxUUN3ME2yMlYh|ryP M4H2XVE2PzF3NEew
RXF-631L MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPaNY9[PDhiaB?= Mkf5TWM2OD1{IN88US=> NUO4PYRIOTV5MUW0O|A>
SNB-78 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF3lN|Y1QCCq MmrDTWM2OD1zNjFOwG0> MV6xOVcyPTR5MB?=
St-4 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYG0PEBp Mme1TWM2OD13LkKg{txO MlrqNVU4OTV2N{C=
ARP1 NXjWZoNuTnWwY4Tpc44hSXO|YYm= MkXHNkDPxE1? M1LoVlYhcA>? MUfJcoR2[3Srb36gc4YhWDJzV1HGNUBo\W6nIHX4dJJme3Orb36= NXLR[HBCOTR5M{S4NFY>
CEM NVPIc2VzU2mwYYPlJGF{e2G7 NILaN3gyKGh? NUfWfnF1TE2VTx?= NH2xTldKdmirYnn0bY9vKG:oIFjERWMhf2m2aDDJR|UxKG:oIECuN|Mh|ryP NFTBTJcyPjR{MEC2OC=>
HCT15 M{TYOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zrNlQ5KGh? NWfNeVJST0l3ME2wMlgzKM7:TR?= M2C2clE3PzJ|MkK3
NCI-H23 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojGOFghcA>? NW\GVJpCT0l3ME2wMlkzKM7:TR?= M1zudVE3PzJ|MkK3
GM15850 NInCcVRMcW6jc3WgRZN{[Xl? NWDMVYx[Oi53IN88US=> NITjU2o6PiCq MXHEUXNQ NHvFN2FKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIN{BtgXOrbnWgNVQh[WOndInsZZRqd25ib3[gSnhPKGenbnW= MXixOlkzOTN4Nx?=
GM15850 NXzWcHhtU2mwYYPlJGF{e2G7 NUjPPZBYOi53IN88US=> M3jCdlk3KGh? Mn6xSG1UVw>? MXnJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iaHnzeI9v\SCKNDDsfZNqdmViNTDhZ4V1gWyjdHnvckBw\iCIWF6g[4Vv\Q>? MUKxOlkzOTN4Nx?=
GM15850 MYXLbY5ie2ViQYPzZZk> MnXyNk42KM7:TR?= NEjJ[pI6PiCq Mlr1SG1UVw>? Mmn6TY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHjpd5RwdmViSESgcJl{cW6nIEGyJIFk\XS7bHH0bY9vKG:oIF\YUkBo\W6n NX3yTG5UOTZ7MkGzOlc>
GM15850 MXLLbY5ie2ViQYPzZZk> M{i2c|IvPSEQvF2= MXu5OkBp Mo\DSG1UVw>? MV3Jcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iaHnzeI9v\SCKMzDsfZNqdmViOTDhZ4V1gWyjdHnvckBw\iCIWF6g[4Vv\Q>? NHXUN3IyPjl{MUO2Oy=>
GM15850 M1HEdGtqdmG|ZTDBd5NigQ>? NEXyeIUzNjVizszN MYS5OkBp Ml7OSG1UVw>? NVfoPHVOUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFgh[WOndInsZZRqd25ib3[gSnhPKGenbnW= M1G0b|E3QTJzM{[3
GM15850 MXXLbY5ie2ViQYPzZZk> NGi2cGgzNjVizszN MV65OkBp MYHEUXNQ M3n1VWlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIFi0JIx6e2mwZTCxOkBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= MUKxOlkzOTN4Nx?=
U937 MlG3SpVv[3Srb36gRZN{[Xl? Mm\nOUDPxE1? NInBU44zPCCq M2\UeWROW09? NFniO|dE\WyuIHP5Z4xmKGG{cnXzeEBjgSCjY3P1cZVt[XSrb36gZZQhWy:JMj;NJJBp[XOn MnW3NVcxODR5MUi=
H661 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWTZVJE4PDhiaB?= M2HXTmlEPTB;MTFOwG0> MoHhNVcyPTdyMEm=
U937 NXrMS3kzTnWwY4Tpc44hSXO|YYm= M3LJ[VUh|ryP MWeyOEBp MoT3SG1UVw>? MWHJcoNz\WG|ZTDpckBpcXO2b37lJGg{KGGlZYT5cIF1cW:w NV\v[VFNOTd2NEe3OVA>
U937 Mm\vSpVv[3Srb36gRZN{[Xl? NYOyRlRPOSEQvF2= NELtOWYzPCCq MkfmSG1UVw>? MUTF[oZm[3Rib36gZYxxcGFidIXieYxqdiCjY3X0fYxifGmxbh?= M3qxclE4PDR5N{Ww
RAW264.7 NGnMS4xHfW6ldHnvckBCe3OjeR?= M1HjdFExKM7:TR?= MoHWNlRp NUXYdFRof2G2ZYK= MXTJcohq[mm2aX;uJI9nKEySUz3zeIlufWyjdHXkJHRPTmGucHjhJJBzd2S3Y4Tpc44hf2m2aDDJR|UxKG:oIECuO|Yh|ryP NH7pNoQyPzR5N{WxPC=>
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LNCAP NVPI[FVDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlO3O|IhcA>? MlHJTWM2OD1yLkW4JO69VQ>? M3\HN|IxOTR|N{e4
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SKHEP1 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHXXHY4OiCq NILmfIRKSzVyPUOuOFYh|ryP MoDENlAyPDN5N{i=
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Caco-2 M{\memdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{P2eVExOCEQvF2= M3v5WFQ5cA>? NUW1epl5TE2VTx?= NH3n[mZKSzVyPUiuNUDPxE1? MXGyNFE1Ozh2MB?=
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HepG2 MVLLbY5ie2ViQYPzZZk> M{K3[|Uh|ryP MVG2bC=> M4TxTmROW09? MoLuTY5lfWO2aX;uJI9nKEiGQVOtcYVlcWG2ZXSgZYxxcGFvdIXieYxqdiCjY3X0fYxifGmxbh?= NF74TXAzODF2M{i0NC=>
HepG2 Mlu5T4lv[XOnIFHzd4F6 NX\sZlRjPSEQvF2= NUK2ZW9xPmh? MVHEUXNQ M2PZdGlv\HWldHnvckBw\iCKRFHDMY1m\GmjdHXkJGg{N0h2IHjpd5RwdmViYXPleJlt[XSrb36= NIXqPYYzODF2M{i0NC=>
COLO205 NUHkSWo6U2mwYYPlJGF{e2G7 MV:xNEDPxE1? MX[yOEBp M4rLfmROW09? NFjKd3pKdmirYnn0bY9vKG:oIFjERWMyKGG|c3Xzd4VlKGG|IHnu[JVkfGmxbjDv[kBpcXO2b37lJGg{KGGlZYT5cIF1cW:wIIfpeIghUUN3MDDv[kAzNjJizszN MVOyNFQ2OTN5OB?=
SCC4 M2D6OGtqdmG|ZTDBd5NigQ>? M{DUXVEh|ryP MXGyOIg> NXvoUplPUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJJR2[nWuaX6gZYNmfHmuYYTpc44> NE\ndpUzODR3MkKyOS=>
SCC4 NFPaboFMcW6jc3WgRZN{[Xl? MUKxJO69VQ>? M2TjbFI1cA>? NFzlWVJKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDhZ4V1gWyjdHnvci=> NVP6N3B[OjB2NUKyNlU>
SCC4 NUPnXmJbTnWwY4Tpc44hSXO|YYm= NYHWfHd7OSEQvF2= MnfpOUBucW5? MWjB[49vcXO2IHHjeIl3cXS7IHH0JHZFWiCjc4Pld5Nm\CCjczDpcoR2[3Srb36gc4YhS1mSMkSg[4Vv\SCneIDy[ZN{cW:w M{Lhd|IxPDV{MkK1
NB4 M{TWZ2Z2dmO2aX;uJGF{e2G7 Mle3OUDPxE1? NU\xdmhmOjRiaB?= Ml2zSG1UVw>? NVrD[no1S2WubDDjfYNt\SCjcoLld5Qh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gZYNkfW23bHH0bY9vKGG2IIDy[U1IOSCyaHHz[S=> MmLpNlA1QTF2NEC=
NB4 MlqzT4lv[XOnIFHzd4F6 M3v6clUh|ryP NFPZNIwzPCCq M1\GVmROW09? M{HNcWlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDhZ4V1gWyjdHWgeJVjfWyrbjDs[ZZmdA>? MV6yNFQ6OTR2MB?=
NB4 M4LyNGZ2dmO2aX;uJGF{e2G7 NFvMS2Q2KM7:TR?= MkfQNlQhcA>? MorESG1UVw>? NIDxNXJKdmS3Y4Tpc44hd2ZicEKxW2FHOS:FSWCxJIV5eHKnc4Ppc44> MX2yNFQ6OTR2MB?=
NB4 NYDvc2ZRU2mwYYPlJGF{e2G7 M4fYe|Uh|ryP Mmq5NlQhcA>? NUe1XI9kTE2VTx?= NXPiRocxUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFMh[WOndInsZZRqd25? MXeyNFQ6OTR2MB?=
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A431 NYfTZnB7S3m2b4TvfIlkKEG|c3H5 NVPoS5pQPzJiaB?= M3q4PWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE1OzFiY3XscJMhd3[ncnX4dJJme3OrbnegSWdHWiC5aYToJGlEPTBib3[gOE4zKM7:TR?= M3W3T|IyODhyNkK5
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CAL27 NWfxPY93S3m2b4TvfIlkKEG|c3H5 NWfSb2JYPzJiaB?= NFvSTYxEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBESUx{NzDj[YxteyCxdnXy[ZhxemW|c3nu[{BGT0[UIIfpeIghUUN3MDDv[kA{NjJizszN NFHpSoczOTB6ME[yPS=>
HeLa MlGwR5l1d3SxeHnjJGF{e2G7 M{DyWlczKGh? MYPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[WxiKGOnbHzzJI93\XKneIDy[ZN{cW6pIFjERWMhf2m2aDDJR|UxKG:oIEGuOUDPxE1? Mn3GNlExQDB4Mkm=
Sf21 NGrPXVdMcW6jc3WgRZN{[Xl? M{i0clMhcA>? Mn\ZTY5pcWKrdHnvckBw\iCIbHHnJJRi\2enZDDoeY1idiC{ZXPvcYJqdmGwdDDISGFEQCCneIDy[ZN{\WRid3n0bEBKSzVyIH;mJFEvOiEQvF2= NITF[ZkzOTB6ME[yPS=>
SKBR3 MXTDfZRwfG:6aXOgRZN{[Xl? MV[3NkBp MVPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTT2JTOyClZXzsd{BwfmW{ZYjwdoV{e2mwZzDISXIzKHerdHigTWM2OCCxZjCyMlYh|ryP MnTmNlExQDB4Mkm=
SKOV3 NVXCR|RSS3m2b4TvfIlkKEG|c3H5 NULKZ3hoPzJiaB?= MULDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTT29XOyClZXzsd{BwfmW{ZYjwdoV{e2mwZzDISXIzKHerdHigTWM2OCCxZjCyMlIh|ryP NXvNbVM{OjFyOEC2Nlk>
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DU145 Mn34S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TzTlExKM7:TR?= NUPBRYx3PzJiaB?= MonmSG1UVw>? M2ToW2dKPTB;MT6wOUDPxE1? M2jJflIyODhyNkS3
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MCR5-SV2 MmPsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHXNVAh|ryP MWG3NkBp MWrEUXNQ M3PDdmdKPTB;Mj6xJO69VQ>? MlmzNlExQDB4NEe=
HCT116 MnOwT4lv[XOnIFHzd4F6 M13vdlMxKM7:TR?= NYTG[W9KOzBiaB?= M4rkdWROW09? NGTlfmpKdmirYnn0bY9vKG:oIFjERWM3KGG|c3Xzd4VlKGG|IHnu[JVkfGmxbjDv[kBidHCqYT30eYJ2dGmwIHHj[ZR6dGG2aX;u NHPSRmMzOTB6ME[0Oy=>
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U937 NVnURmx4U2mwYYPlJGF{e2G7 M2jyNlUh|ryP NH32cHcyPSCvaX6= NI\2TpJFVVOR NGjhflNKdmirYnn0bY9vKG:oIHjpd5RwdmViYXPleJltfHKjboPm[ZJie2ViYYPz[ZN{\WRiYYOgbY5kemWjc3Wgc4YhcGm|dH;u[UBJOyCjY3X0fYxifGmxbjDs[ZZmdA>? MmjoNlEzQTJ2OUK=
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COLO205 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\ib3djQTZiaB?= NXSz[|N{TE2VTx?= NFXsR21KSzVyPUKuNVIh|ryP NXPFcnNiOjF4M{S0N|A>
Hep3B M2r6bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWW0PEBp MkHtSG1UVw>? M{TuR2dKPTB;MT6yNUDPxE1? MVGyNVcyOjF2Nh?=
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DU145 MWjLbY5ie2ViQYPzZZk> M3XHdlIvPSEQvF2= NWnXfopwOjRiaB?= NIPT[m1FVVOR MnGxTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KHWycnXneYxifGmxbjDv[kBxOjG5YX[xJJBzd3SnaX6g[ZhxemW|c3nvci=> Mo\DNlIzPjBzNk[=
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DU145 NEnsOGxMcW6jc3WgRZN{[Xl? M2rERlUh|ryP Mm\zNlQhcA>? MX\EUXNQ MWLJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcGm|dH;u[UBJOyCqeYDldoFk\XS7bHH0bY9v NUjPO211OjJ{NkCxOlY>
786-0 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\wfpI3NjJizszN M3rJflczKGh? NWfoe4F4TE2VTx?= NInRc4lIUTVyPUOuNkDPxE1? M1HBZVIzPDN3Nk[5
A498 MlHpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjWWY5KPi5{IN88US=> NEXyTYY4OiCq M1XGfGROW09? MojMS2k2OD1zLk[g{txO M3fDNlIzPDN3Nk[5
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BT549 Mn7US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3oOk4zKM7:TR?= Mn\NO|IhcA>? M1nhXmROW09? MmLxS2k2OD1zLkOg{txO NHPJUGczOjR|NU[2PS=>
EKVX M1\oOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPKTXlvPi5{IN88US=> NHXvR5A4OiCq MorvSG1UVw>? MUPHTVUxRTFwMzFOwG0> NH32fGozOjR|NU[2PS=>
HCT15 NVPrUmlzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFnHPVU3NjJizszN NGjOeYY4OiCq M{nCNmROW09? MmTpS2k2OD1{LkWg{txO M1nrTFIzPDN3Nk[5
HOP92 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TwNFYvOiEQvF2= MnyyO|IhcA>? M{W0WmROW09? MWTHTVUxRTRizszN MoLBNlI1OzV4Nkm=
IGROV1 M{Dmb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFjPd2I3NjJizszN NFe0PZg4OiCq M4jl[GROW09? MnvGS2k2OD1zLkOg{txO NEfVR|AzOjR|NU[2PS=>
LOXIMVI M1r1TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUC2MlIh|ryP MY[3NkBp MWDEUXNQ MnTMS2k2OD1zIN88US=> NU\3[3NvOjJ2M{W2Olk>
M14 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDUOk4zKM7:TR?= M2qwe|czKGh? M2exRmROW09? MnrzS2k2OD1zLkOg{txO MnX2NlI1OzV4Nkm=
MALME-3M MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXfVWHRuPi5{IN88US=> NGfEc2w4OiCq NUexfllOTE2VTx?= Ml;wS2k2OD1yLkOyJO69VQ>? MlLUNlI1OzV4Nkm=
MCF10A MmjUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVG2MlIh|ryP NVzWS|ZoPDhiaB?= NY\DTIx5TE2VTx?= M4DLXmdKPTB;OT62JO69VQ>? NFq3eGwzOjR|NU[2PS=>
MDA-MB-435 NXLuc2RwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHYOk4zKM7:TR?= NGe3WW04OiCq MVnEUXNQ NYHHcppGT0l3ME2wMlUh|ryP MX[yNlQ{PTZ4OR?=
MDA-MB-468 NYfwRXJLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnDZXFIPi5{IN88US=> M1nWRlczKGh? NVvFUFg1TE2VTx?= M3r6SWdKPTB;MD62N{DPxE1? NV;6VGJIOjJ2M{W2Olk>
MOLT4 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\NOk4zKM7:TR?= MV23NkBp NVrZUmRKTE2VTx?= NUXsdVg1T0l3ME2wMlQh|ryP MXeyNlQ{PTZ4OR?=
NCI-ADR-RES MlHIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjYe5pMPi5{IN88US=> M1;oXlczKGh? NGrW[HRFVVOR Mki0S2k2OD1yLkG2JO69VQ>? NVPNVo1uOjJ2M{W2Olk>
NCI-H23 M3rIfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYjIXol7Pi5{IN88US=> M3TMVVczKGh? NU\KO21iTE2VTx?= NG\BbW1IUTVyPUGg{txO MWqyNlQ{PTZ4OR?=
NCI-H322M MmOzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nNSlYvOiEQvF2= NHPucZo4OiCq Mk[ySG1UVw>? NFvzdIlIUTVyPUCuO|kh|ryP M{jFSlIzPDN3Nk[5
NCI-H460 NW\ObVlST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17WVVYvOiEQvF2= M1HiW|czKGh? MUTEUXNQ NVfYT2FHT0l3ME2wMlc6KM7:TR?= NEHjdYEzOjR|NU[2PS=>
NCI-H522 M13QRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2S4OFYvOiEQvF2= NFXCc5A4OiCq M2HHXmROW09? MkXES2k2OD1yLkWg{txO MkPSNlI1OzV4Nkm=
OVCAR3 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUC2MlIh|ryP M3fQ[VczKGh? MXLEUXNQ M4fnOmdKPTB;MT6zJO69VQ>? MXmyNlQ{PTZ4OR?=
OVCAR4 NWezXYhnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXS2MlIh|ryP MYK3NkBp MnHHSG1UVw>? MknsS2k2OD12IN88US=> MoXXNlI1OzV4Nkm=
OVCAR5 MnfKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nKVVYvOiEQvF2= NEfLWFM4OiCq MkHPSG1UVw>? MojxS2k2OD1yLke5JO69VQ>? M3zNd|IzPDN3Nk[5
OVCAR8 M4C0d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTVcXdoPi5{IN88US=> M2W3OlczKGh? MYTEUXNQ NYHzR|FQT0l3ME2wMlUh|ryP MkP6NlI1OzV4Nkm=
RXF393 NEjYV5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;OcFYvOiEQvF2= MnLCO|IhcA>? MnPhSG1UVw>? NUXybohxT0l3ME2xMlMh|ryP MoTVNlI1OzV4Nkm=
SF268 NXfHZXlET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlzvOk4zKM7:TR?= MXW3NkBp NXzMbWV5TE2VTx?= M{H5WGdKPTB;MT62JO69VQ>? Mn\BNlI1OzV4Nkm=
SF295 NV[5cFZmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{DXfFYvOiEQvF2= NGnWcIQ4OiCq MU\EUXNQ MnTGS2k2OD1zLk[g{txO NXuycHdVOjJ2M{W2Olk>
SF539 MkjWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vTOVYvOiEQvF2= MkPIO|IhcA>? NWTRe4VRTE2VTx?= NWPRe5lRT0l3ME2yJO69VQ>? MlvoNlI1OzV4Nkm=
SK-MEL-2 Mk\qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWG2MlIh|ryP NHrCd3I4OiCq M1;qXWROW09? NEDwXpNIUTVyPUGuN{DPxE1? NHrjXpQzOjR|NU[2PS=>
SK-MEL-28 MnjRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYe2MlIh|ryP MWC3NkBp MoLzSG1UVw>? MYLHTVUxRTFizszN NWLxR5Z[OjJ2M{W2Olk>
SK-MEL-5 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mki4Ok4zKM7:TR?= NWG0VYlKPzJiaB?= NH\xZ41FVVOR Mle5S2k2OD1yLk[zJO69VQ>? NEHGfWczOjR|NU[2PS=>
SKOV3 M2\U[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXP2cYRsPi5{IN88US=> NH\QOYY4OiCq NUXRdpFRTE2VTx?= NYT6cIRZT0l3ME2xJO69VQ>? M1fYfVIzPDN3Nk[5
SN12C MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWm2MlIh|ryP MUW3NkBp NYXkVJd2TE2VTx?= M{Pac2dKPTB;MjFOwG0> NUHUZmNuOjJ2M{W2Olk>
SNB19 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojjOk4zKM7:TR?= NW[3Z4wzPzJiaB?= NH63WWxFVVOR Mny3S2k2OD1yLk[zJO69VQ>? M2jzcVIzPDN3Nk[5
SNB75 NWCwVVNTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mle5Ok4zKM7:TR?= Mof3O|IhcA>? NVHOdYh1TE2VTx?= MXnHTVUxRTBwN{mg{txO M1u0NlIzPDN3Nk[5
SR M1\Hd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jYdVYvOiEQvF2= NVnLXWM3PzJiaB?= NHTRcm9FVVOR NXr5d5ZiT0l3ME2wMlQh|ryP M4XxVlIzPDN3Nk[5
T47D MnnNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4T1O|YvOiEQvF2= M{TKUlczKGh? MYPEUXNQ M{jqc2dKPTB;MD61JO69VQ>? MlruNlI1OzV4Nkm=
TK10 MmG3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHnLdm83NjJizszN NGTOTpY4OiCq M2njWWROW09? NEnRblRIUTVyPUCuOlMh|ryP NEXjXG8zOjR|NU[2PS=>
UACC257 NHq4RWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvFU5RUPi5{IN88US=> NFrtWG04OiCq MnP1SG1UVw>? M3TYb2dKPTB;MD61JO69VQ>? M3:1PVIzPDN3Nk[5
UACC62 M2L1PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3H1VlYvOiEQvF2= M1;2OVczKGh? MV7EUXNQ Mkn0S2k2OD1yLkSg{txO NXG1W4ptOjJ2M{W2Olk>
UO31 M{HDRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\3[VZlPi5{IN88US=> M4mySlczKGh? NVfWU4ZNTE2VTx?= NEf3N2JIUTVyPUCuOUDPxE1? M1LqN|IzPDN3Nk[5
Hep3B NEPKXItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGLrclI1QCCq NIrIc4FFVVOR MXHHTVUxRTBwNkmg{txO MlrMNlI1Ozl6NkO=
BE(2)-C MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYq3NkBp Mmr2SG1UVw>? MkiwTWM4OD1{IN88US=> MnPrNlI6OzJ|MU[=
Bel7402 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;FOFczKGh? NXHCZo5TTE2VTx?= MVzHTVkxRTF5IN88US=> MV[yN|A3OTN5Nh?=
Bel7404 NWGz[3l6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYS3NkBp M2[1e2ROW09? M1nxRWdKQTB;MUig{txO MlfoNlMxPjF|N{[=
BGC823 M1nxWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEK3fYg4OiCq NUfsPGpXTE2VTx?= NIm5OIlIUTlyPUeuOUDPxE1? M2nNdVI{ODZzM{e2
MGC803 NU\m[XJET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13T[FczKGh? MWLEUXNQ MXzHTVkxRTFyLkig{txO NVz3N4ZDOjNyNkGzO|Y>
SGC7901 MmfwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3ZO|IhcA>? MUTEUXNQ M4LpfmdKQTB;OT60JO69VQ>? MoryNlMxPjF|N{[=
SKHEP1 M3;BTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH7qfGw4OiCq M3P4dWROW09? NUXi[lRxT0l7ME2xO{DPxE1? M{HLPFI{ODZzM{e2
SMMC7721 Mo\MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mme1O|IhcA>? NEHYdJRFVVOR NFjKZYlIUTlyPUKwJO69VQ>? NI\pfokzOzB4MUO3Oi=>
NUGC3 MkGzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2i1[|ExKM7:TR?= NYLBSpFrT0l;Mj65OEDPxE1? M{fad|I{OTZ|M{Oy
A2780 CisR NWT2UmhTU2mwYYPlJGF{e2G7 NVWwbFJZOThiaB?= M2TxS2lvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD60OEDPxE1? M4fOXlI{OjV{NkCz
CAL27 sens NYf2eGgyU2mwYYPlJGF{e2G7 NX\OXYt6OThiaB?= MkTlTY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLkO2JO69VQ>? NYrFWGx{OjN{NUK2NFM>
CAL27 CisR NHPNVHFMcW6jc3WgRZN{[Xl? NHjMPXQyQCCq NH:4SnlKdmirYnn0bY9vKG:oIFjERWMhf2m2aDDJR|UxKG:oIECuOlEh|ryP NGnyT2IzOzJ3Mk[wNy=>
KYSE-510 CisR M3vxSWtqdmG|ZTDBd5NigQ>? M1jLN|E5KGh? MkO1TY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLkW5JO69VQ>? M2D4SFI{OjV{NkCz
KYSE-510 sens NYnrbYxsU2mwYYPlJGF{e2G7 M4THN|E5KGh? MmTmTY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLkeg{txO NXntTpdSOjN{NUK2NFM>
MDA-MB-231 sens MojaT4lv[XOnIFHzd4F6 NH3nOpAyQCCq MWfJcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwNkGg{txO NGracVkzOzJ3Mk[wNy=>
MDA-MB-231 CisR NIj2fnpMcW6jc3WgRZN{[Xl? MoXsNVghcA>? NIC2O5FKdmirYnn0bY9vKG:oIFjERWMhf2m2aDDJR|UxKG:oIECuOlEh|ryP MV6yN|I2OjZyMx?=
ES2 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnj4OFghcA>? NXjEbZdrTE2VTx?= MXXJR|UxRTF{Lkeg{txO NFL4VoszOzR7M{S0PS=>
MDA-MB-231 Mm\qT4lv[XOnIFHzd4F6 NF\qWXAyOCEQvF2= MmLmN|AhdWmw MX3EUXNQ Mnv2TY5pcWKrdHnvckBw\iCKRFHDNoE> NWf0Z|BvOjN2OUO0OFk>
MDA-MB-231 NV\2PYdOU2mwYYPlJGF{e2G7 NWO4NI9vOSEQvF2= MkLzNlQhcA>? M3vvNWROW09? M2fDe2lvcGmkaYTpc44hd2ZiSFTBR|Yh[XO|ZYPz[YQh[XNiYXPleJlt[XSrb36gcIV3\Wy|IH;mJJR2[nWuaX6= M{\oVFI{PDl|NES5
HS68 MYHDfZRwfG:6aXOgRZN{[Xl? M1\YO|ExKM7:TR?= M2i2OVczKGh? M4PadmROW09? NYHsUnpyUUN3ME20MlYh|ryP NWrsfldWOjN3N{C1OFI>
MEF NGfldZpEgXSxdH;4bYMhSXO|YYm= NUjKfWdTOTBizszN MXq3NkBp NH;qXY9FVVOR NWH2U5VvUUN3ME20MlQh|ryP MnrsNlM2PzB3NEK=
BGC823 MnO4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlz5SG1UVw>? NX\HZ4pTT0l3ME2zMlA6KM7:TR?= M2DsT|I{PjBzN{C2
High5 MkHST4lv[XOnIFHzd4F6 M3nqOVI1KGh? M1\BTmlvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiSFTBR|Yhf2m2aDDJR|UxKG:oIECuNFkh|ryP NH3BV3AzOzZyMkWyNy=>
High5 MWjLbY5ie2ViQYPzZZk> MYmyOEBp MVTJcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KEiGQVOxJJdqfGhiSVO1NEBw\iByLkGyJO69VQ>? NFnTWWQzOzZyMkWyNy=>
High5 M2fkO2tqdmG|ZTDBd5NigQ>? M1:zXVI1KGh? MX3Jcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KEiGQVOzJJdqfGhiSVO1NEBw\iByLkG3JO69VQ>? M{DtU|I{PjB{NUKz
A549 NWP4eZJkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXEUXNQ M{jFOmlEPTB;MT6wO|kh|ryP NGnlVoYzOzZ2NEKxNC=>
HCT116 MkDVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{K0S2ROW09? MluxTWM2OD1yLke1O{DPxE1? NIDYfXkzOzZ2NEKxNC=>
K562 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zW[GROW09? NWfoOnlxUUN3ME2wMlY1PSEQvF2= M2izXVI{PjR2MkGw
GBC-SD Mn\NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1KwclUh|ryP MkfEO|IhcA>? MXPEUXNQ NFTS[W9KSzVyPUG0Mlgh|ryP NIW0TFEzOzdyN{K2NC=>
HGC27 MlnYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXicok2KM7:TR?= NGfkNpc4OiCq M3LEWGROW09? MYXJR|UxRTVwNDFOwG0> NVfFdVk2OjN5MEeyOlA>
HL60 M33tR2tqdmG|ZTDBd5NigQ>? M4D1[FUh|ryP M3Xzc|I1KGh? MnzxSG1UVw>? NXn0eFlSUW6qaXLpeIlwdiCxZjDISGFE MVqyN|cxPzJ4MB?=
Vero NIjnfY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG[5cY84OiCq MkDySG1UVw>? M{D5WmlEPTB;MD65JO69VQ>? NWHscZVKOjN5OE[0OVI>
NCI60 MlzNR5l1d3SxeHnjJGF{e2G7 M4H6[VQ5KGh? M1rLRWROW09? MVHHTV0xNjV|IN88US=> MoqwNlQxOTV|Mke=
SW620 M2GzTGN6fG:2b4jpZ{BCe3OjeR?= MoDTOFghcA>? MYXEUXNQ MnzpS2k:OC53NDFOwG0> MYCyOFAyPTN{Nx?=
U251 MoTXR5l1d3SxeHnjJGF{e2G7 NWnjUHFIPDhiaB?= MYfEUXNQ MmHUS2k:OS53MzFOwG0> MWKyOFAyPTN{Nx?=
KM12 NVXX[|FqS3m2b4TvfIlkKEG|c3H5 M1[1RVQ5KGh? M4e3UGROW09? MX7HTV0yNjh6IN88US=> NH3TWmQzPDBzNUOyOy=>
Hs578T NVOyXoVNS3m2b4TvfIlkKEG|c3H5 NYHtXHJ2PDhiaB?= MWPEUXNQ NWTITo9oT0l;ND64N{DPxE1? M{XTeVI1ODF3M{K3
MDA-MB-231 NWfyZZY3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3YOFghcA>? NYq2dW57UUN3ME2wMlE3KM7:TR?= MWqyOFA6PTBzNh?=
MCF7 MnXYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYK0PEBp MUDHTV0xNjR3IN88US=> NXG4SlN1OjRzMUm1OVU>
MDA-MB-435 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkP1OFghcA>? NFvid5FIUT1yLki4JO69VQ>? MoCzNlQyOTl3NUW=
AsPC1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknsN|Ah|ryP M4Xtd|Q5KGh? M3G1fWROW09? NHi1[oZKSzVyPUOuOlYh|ryP MUOyOFE5PTN5OB?=
Jurkat E6.1 NWLjNIVvU2mwYYPlJGF{e2G7 MnLHNkBp M1TJcmROW09? MWDJcohq[mm2aX;uJI9nKEiGQVO0JJdqfGhiSVO1NEBw\iByLkC0JO69VQ>? M1vOfFI1OjZzOE[y
KG1 NFq4[HBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDIZVA1QCCq NFzZeIxKSzVyPUGuNVUh|ryP MXuyOFUzPTByMx?=
HEL MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXK0PEBp MlW4SG1UVw>? MYrJR|UxRTBwNEmg{txO MUKyOFY6PDB3NR?=
HSC3 M13T[GN6fG:2b4jpZ{BCe3OjeR?= Mk[0NVIhcA>? MXLEUXNQ NH3IWYxKSzVyPUCuO|Eh|ryP NEL4[5YzPDd4NkW2NC=>
HT-29 MVXDfZRwfG:6aXOgRZN{[Xl? MWexNkBp MlHVSG1UVw>? NFu3O|lKSzVyPUCuO|Ih|ryP MnW0NlQ4PjZ3NkC=
KB NHzqPY1EgXSxdH;4bYMhSXO|YYm= MWSxNkBp M3vLS2ROW09? MonZTWM2OD1yLke1JO69VQ>? NVvze4lxOjR5Nk[1OlA>
H460 MUPDfZRwfG:6aXOgRZN{[Xl? M{Sxc|EzKGh? NIrqNXlFVVOR NVT5enVFUUN3ME2wMlgzKM7:TR?= MWWyOFc3PjV4MB?=
MONE1 NVS3eFJzS3m2b4TvfIlkKEG|c3H5 NX72fWhnOTJiaB?= M4XMUGROW09? MVfJR|UxRTFwMUig{txO MnjtNlQ4PjZ3NkC=
MKN45 MmriR5l1d3SxeHnjJGF{e2G7 MorVNVIhcA>? MXzEUXNQ NFK1d5dKSzVyPUGuNlUh|ryP MUKyOFc3PjV4MB?=
TSGH NHz5XlFEgXSxdH;4bYMhSXO|YYm= M33tPVEzKGh? Mlj1SG1UVw>? NFLuO|lKSzVyPUKuNFkh|ryP Mnu3NlQ4PjZ3NkC=
HL60 NWD1W|JRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV[2XWJMPzJiaB?= NG\tSHRFVVOR MVXHTVUxRTBwOUOg{txO Mmf4NlQ6ODB3MEC=
HEK293 MnXUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LhcFczKGh? MU\EUXNQ MoHLS2k2OD1zMzFOwG0> MnPBNlQ6ODB3MEC=
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Ca9-22 NF\XdHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGXZd4xKSzVyPUGuNFUyODdizszN NXfodYJZW0GQR1XS
NBsusSR MnXpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofLTWM2OD1zLkC1NVY3KM7:TR?= NWG0N5ZSW0GQR1XS
NB13 M1m3dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVL6RWVsUUN3ME2xMlA2PTBzIN88US=> NFfUc4hUSU6JRWK=
SF295 NVnkTHNiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXjWXFYUUN3ME2xMlA3PjJ2IN88US=> NWXp[VFPW0GQR1XS
U-2-OS NV;YUIZIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIX6VodKSzVyPUGuNFc6OTFizszN MnznV2FPT0WU
NCI-H526 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTFwMEiyPVEh|ryP Ml3BV2FPT0WU
KMOE-2 MkHFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Moj2TWM2OD1zLkC5OFIzKM7:TR?= NUjEU|hWW0GQR1XS
RCM-1 MlPaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULnV2xjUUN3ME2xMlEzOTB{IN88US=> NEDIVINUSU6JRWK=
MC116 M1LsbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTFwMUO2NlEh|ryP NULKUYd4W0GQR1XS
NCI-H1092 NFfCUXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\IcWlEPTB;MT6xOVQxPiEQvF2= NX:zS4hZW0GQR1XS
EW-3 NVfrVphLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfiRWFKSzVyPUGuNVczOTJizszN NVfKVpNvW0GQR1XS
HCT-116 MkLDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2XVbGlEPTB;MT6xO|c2KM7:TR?= NWXBToZKW0GQR1XS
MC-IXC Mn[zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nxemlEPTB;MT6xO|g5OSEQvF2= Mm\IV2FPT0WU
LB1047-RCC MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDtV4ZbUUN3ME2xMlE5OzF{IN88US=> M4jXUnNCVkeHUh?=
VM-CUB-1 NEK1dJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTFwMUmxNFgh|ryP NXTrTFhSW0GQR1XS
NB5 M2HQN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVKxPJE5UUN3ME2xMlE6QDV4IN88US=> MorXV2FPT0WU
SKG-IIIa NHHiS5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnkTWM2OD1zLkKzOFY1KM7:TR?= NHvSVGFUSU6JRWK=
HO-1-N-1 MlHkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoW1TWM2OD1zLkKzPFM2KM7:TR?= M{\r[nNCVkeHUh?=
EFO-27 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2[2TmlEPTB;MT6yOVA1OyEQvF2= NX7iVm1uW0GQR1XS
MHH-NB-11 NFHsdI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHVTWM2OD1zLkK4N|I6KM7:TR?= MoLuV2FPT0WU
SW620 NGDMUJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrmWI5NUUN3ME2xMlI6ODF6IN88US=> MWjTRW5ITVJ?
MOLT-16 NX33W4pGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPSTWM2OD1zLkK5O|k4KM7:TR?= NWHYOXVuW0GQR1XS
NTERA-S-cl-D1 MnnxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFWyOopKSzVyPUGuN|E4PjFizszN Mk\nV2FPT0WU
VA-ES-BJ NFTq[phIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnCZmVQUUN3ME2xMlMzPDd5IN88US=> Ml7MV2FPT0WU
HCC1419 NV3CUYoyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjLVI8{UUN3ME2xMlM1ODJ5IN88US=> MV3TRW5ITVJ?
NCI-H69 MnPkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17oN2lEPTB;MT6zOFEyOiEQvF2= MYHTRW5ITVJ?
DEL NUnGNHlET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTFwM{WxOlIh|ryP Mk[1V2FPT0WU
LXF-289 Mn3zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHNO5k4UUN3ME2xMlM2OjRizszN MWnTRW5ITVJ?
EW-11 NWrVZ491T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHtTWM2OD1zLkO2NFI3KM7:TR?= MlrlV2FPT0WU
KP-4 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjBcGpnUUN3ME2xMlM4ODh3IN88US=> MUHTRW5ITVJ?
NOS-1 NVr4e4RST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTYU|hKSzVyPUGuOFEyQTRizszN M3foV3NCVkeHUh?=
SK-NEP-1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkD2TWM2OD1zLkSxOlk{KM7:TR?= MmnmV2FPT0WU
LAMA-84 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\UWmlEPTB;MT60N|k1PSEQvF2= NXrHZnJwW0GQR1XS
ES5 M3\HUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mki5TWM2OD1zLkS0N{DPxE1? NYP0[VBjW0GQR1XS
HuO9 NYT2fFdsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvaeVhKSzVyPUGuOFU{PjJizszN NIfJb2JUSU6JRWK=
COLO-684 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPtTlZMUUN3ME2xMlQ3OTF6IN88US=> M1yzXHNCVkeHUh?=
EW-24 NYrRVXlwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVmyU|NbUUN3ME2xMlQ3PTNzIN88US=> NX74emo6W0GQR1XS
BV-173 M1jZXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTFwNEeyPVEh|ryP NH3wWHpUSU6JRWK=
NCI-H1770 NEjyO2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4n0NWlEPTB;MT60PFU{PiEQvF2= Mn7VV2FPT0WU
HuP-T4 M2D4NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTFwNEmzJO69VQ>? MVLTRW5ITVJ?
TYK-nu NVzGR2o5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fuVWlEPTB;MT60PVg2OSEQvF2= NGLzeXJUSU6JRWK=
YH-13 M2rD[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTFwNEm4PVQh|ryP NIezcoFUSU6JRWK=
H4 MlToS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTFwNUC5NVIh|ryP NHjCclJUSU6JRWK=
OVCAR-8 NGXiWVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHVTWM2OD1zLkW0OFc4KM7:TR?= MnnkV2FPT0WU
NCI-H23 M1q2XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTFwNUS2OFUh|ryP NHywVVRUSU6JRWK=
ES7 NUH3VGdIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;5Z2lEPTB;MT61OFc4OyEQvF2= NH;VfmpUSU6JRWK=
COR-L88 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;lTWM2OD1zLkW2OFI1KM7:TR?= NHL1PZdUSU6JRWK=
TI-73 NX7qUJdiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlLUTWM2OD1zLkW5NFYh|ryP M3rFNHNCVkeHUh?=
RT-112 Mn;oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW[0[2c{UUN3ME2xMlU6Ojh2IN88US=> NY\Qb4tVW0GQR1XS
HuO-3N1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3nVOmlEPTB;MT61PVM5PSEQvF2= MXXTRW5ITVJ?
HC-1 NHPhSIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XvbGlEPTB;MT61PVg3PiEQvF2= M4LydnNCVkeHUh?=
HT55 NEK5eW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3ETWM2OD1zLk[1NVMyKM7:TR?= NGPjPZdUSU6JRWK=
IA-LM MoLlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTnTWM2OD1zLk[5Nlc5KM7:TR?= M4T1cnNCVkeHUh?=
EM-2 NHnLTnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjKcJhFUUN3ME2xMlcxODF2IN88US=> MX7TRW5ITVJ?
MHH-ES-1 NEP5cYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M172cWlEPTB;MT63NFQ{PSEQvF2= M4WyUnNCVkeHUh?=
CAL-27 Ml;OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHqeolKSzVyPUGuO|A3OjFizszN M1jOcHNCVkeHUh?=
COLO-800 NITCOWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PKO2lEPTB;MT63NVE4QSEQvF2= M3G4dHNCVkeHUh?=
HCE-T NXPzTVl{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1n0WmlEPTB;MT63NVUh|ryP MknVV2FPT0WU
CAMA-1 MoL5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnTVTWM2OD1zLkexPVcyKM7:TR?= M{POOHNCVkeHUh?=
LOXIMVI M{n4Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzOWplGUUN3ME2xMlczOTFizszN MWXTRW5ITVJ?
NH-12 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFnYb4ZKSzVyPUGuO|I3QTFizszN NI\JNZFUSU6JRWK=
TCCSUP NXLtXmFYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVzZTm02UUN3ME2xMlczQDJ7IN88US=> MYXTRW5ITVJ?
MDA-MB-361 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTFwN{OxOVch|ryP NH61NJZUSU6JRWK=
EW-16 NGrKS3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX32c49XUUN3ME2xMlc1OTB5IN88US=> NFLIOVBUSU6JRWK=
SNU-423 MkTIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLVb25KSzVyPUGuO|U5OjdizszN MmrsV2FPT0WU
Daoy Mo\kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTFwN{[zNVkh|ryP NYmxbWVpW0GQR1XS
ES4 Moq4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTFwN{i3OFEh|ryP M2TicnNCVkeHUh?=
PFSK-1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NETMU5FKSzVyPUGuPFA{PyEQvF2= MnvSV2FPT0WU
ES3 NGm0[HhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTvOIljUUN3ME2xMlgzPjhzIN88US=> MmnxV2FPT0WU
ONS-76 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3[3RWlEPTB;MT64Nlg6PyEQvF2= NIjEV2RUSU6JRWK=
JVM-3 NV\ISZptT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV7rWXUyUUN3ME2xMlg2PDVzIN88US=> MXzTRW5ITVJ?
OS-RC-2 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mor1TWM2OD1zLki3NVUyKM7:TR?= MnH0V2FPT0WU
COLO-320-HSR MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGf6Z4RKSzVyPUGuPFgyQTdizszN NVS2bWJ6W0GQR1XS
HN M1HQdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfhbYtuUUN3ME2xMlg5PzJ3IN88US=> MljtV2FPT0WU
HT MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\QTGlEPTB;MT64PFk1PyEQvF2= NISwPFZUSU6JRWK=
LoVo MoW5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTFwOEm4NUDPxE1? NV[5PZhKW0GQR1XS
CGTH-W-1 M3G0fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3ziUGlEPTB;MT64PVk1PiEQvF2= M2XpUXNCVkeHUh?=
NB6 NEXaVoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTFwOUGyPVgh|ryP NIHzSXVUSU6JRWK=
EW-22 NHPnT2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH:xdoRKSzVyPUGuPVI5QDdizszN MVHTRW5ITVJ?
ES6 NHn6dXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLsS|M4UUN3ME2xMlk{PjNzIN88US=> NWLiTlBWW0GQR1XS
SCC-15 NV;nfpRET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoruTWM2OD1zLkmzPFE6KM7:TR?= NEfyUI1USU6JRWK=
HL-60 MmLsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfmTWM2OD1zLkmzPVAzKM7:TR?= NFftN2NUSU6JRWK=
human HOP-92 NWS4b3RVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DVZ2lEPTB;MT65OFA3PSEQvF2= M3z5SnNCVkeHUh?=
SW626 Mof6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjpTWM2OD1zLkm0PFk6KM7:TR?= NX\SWoFnW0GQR1XS
HEC-1 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHXR3h6UUN3ME2xMlk2OzZizszN NYfPNIR2W0GQR1XS
LB2241-RCC NGK3eYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDmbY9LUUN3ME2xMlk5OjNzIN88US=> NVW3TFJUW0GQR1XS
Ramos-2G6-4C10 MoeyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHqyXY9KSzVyPUGuPVk1QTNizszN NX7zO3RKW0GQR1XS
A101D MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\xe4s4UUN3ME2yMlIxOzB|IN88US=> NUPrUIFEW0GQR1XS
NCI-H446 NFXIVVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTJwMES1PVkh|ryP MlfxV2FPT0WU
SBC-5 NGfrb4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTyb|hPUUN3ME2yMlA3OTR5IN88US=> MoK4V2FPT0WU
HOS NUPkVZZvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTJwMEe2OVMh|ryP NIrpWlhUSU6JRWK=
K5 MnL4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTJwMEe4NVEh|ryP NYrGZZZyW0GQR1XS
HLE MlfPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mor4TWM2OD1{LkC4OVI6KM7:TR?= M2P3dHNCVkeHUh?=
HSC-2 M{PrR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M12yb2lEPTB;Mj6xNlg6QCEQvF2= MXXTRW5ITVJ?
LCLC-97TM1 NYLaT|NzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPIbmhqUUN3ME2yMlE1PTh|IN88US=> MmfPV2FPT0WU
DMS-273 M{[3[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLSTWM2OD1{LkG0PFM4KM7:TR?= Mn;lV2FPT0WU
TE-8 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTJwMUW3OlUh|ryP NGO4cFZUSU6JRWK=
DSH1 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGG0VXJKSzVyPUKuNVY{QThizszN M{f2fXNCVkeHUh?=
CAL-51 NW\SSVE2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13kUWlEPTB;Mj6xOlY6QSEQvF2= MV;TRW5ITVJ?
IST-SL1 MmX3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnJTWM2OD1{LkG2PFQ1KM7:TR?= NILDRo9USU6JRWK=
GCT MkDtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTJwMUe3O{DPxE1? M3fCTHNCVkeHUh?=
SW948 NFnDeHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTJwMUi0OVYh|ryP M2\nTHNCVkeHUh?=
NOMO-1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTJwMUmzNVch|ryP NXO3PItMW0GQR1XS
C8166 NGPxNotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXP[mtKSzVyPUKuNlE{OzRizszN NHnFXmNUSU6JRWK=
OC-314 MlfKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjUXXV7UUN3ME2yMlI{OjV7IN88US=> MWHTRW5ITVJ?
CAL-39 NGfHd|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfyTWM2OD1{LkKzOlI3KM7:TR?= MUPTRW5ITVJ?
MDA-MB-453 M{DiWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXTvenZrUUN3ME2yMlI1Ojd3IN88US=> NX7POYlPW0GQR1XS
A673 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{f0UGlEPTB;Mj6yOVg3OiEQvF2= NUnsRYRKW0GQR1XS
HTC-C3 NFHt[phIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rENmlEPTB;Mj6yOlg2KM7:TR?= NHLFSW1USU6JRWK=
NCI-H1666 MoKyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXx[JpKSzVyPUKuNlgyOTFizszN Mlj0V2FPT0WU
PSN1 NIP4[Y5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TBfWlEPTB;Mj6yPFkyOyEQvF2= NV7oN3VEW0GQR1XS
GI-1 M4nWdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3rsWWlEPTB;Mj6zNFU1OyEQvF2= MYLTRW5ITVJ?
HuH-7 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTJwM{C2N|ch|ryP MXXTRW5ITVJ?
JAR MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDHb2lGUUN3ME2yMlMyQTh5IN88US=> NETVZ5dUSU6JRWK=
5637 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml[yTWM2OD1{LkOyNVI6KM7:TR?= M{XDWXNCVkeHUh?=
GB-1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\kbIRKSzVyPUKuN|I{OzVizszN MmfkV2FPT0WU
KP-N-YS MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4X2NmlEPTB;Mj6zNlYyPSEQvF2= MofzV2FPT0WU
OAW-42 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvyfJp5UUN3ME2yMlM{PDF4IN88US=> NWjyNZBtW0GQR1XS
8-MG-BA NELlOJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvpTWM2OD1{LkOzPVA3KM7:TR?= NX3rPIhnW0GQR1XS
RH-18 NXL4TlJWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlz4TWM2OD1{LkO1NFIzKM7:TR?= MkfXV2FPT0WU
NCI-H1155 M2LLPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTJwM{[3NlUh|ryP MmfpV2FPT0WU
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KLE NVe1SVU2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLO[4lKSzVyPUmuN|IzOzJizszN NYLOeGhzW0GQR1XS
Calu-6 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHGTWM2OD17LkO3OVI5KM7:TR?= M2PCW3NCVkeHUh?=
LB831-BLC M3\hbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTlwNEWxO|Eh|ryP MWDTRW5ITVJ?
SW684 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1v6fmlEPTB;OT60OlEyPiEQvF2= M{DhZXNCVkeHUh?=
SH-4 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIHJeFlKSzVyPUmuOFk{PjRizszN NGi0ZWJUSU6JRWK=
IST-MES1 M2Pmbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHzbnFKSzVyPUmuOVE3PDRizszN MXTTRW5ITVJ?
Saos-2 NHjjc|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTlwNUKxPVUh|ryP NUWzOYRkW0GQR1XS
NCI-H2087 NYK0cnBQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjaPY9SUUN3ME25MlY4OzV{IN88US=> NIHlfllUSU6JRWK=
SCC-9 NHLUfVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;MbHhzUUN3ME25MlcyQDF4IN88US=> MlqwV2FPT0WU
MFE-280 MkPrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XsZ2lEPTB;OT63Nlc5PSEQvF2= M2XFPHNCVkeHUh?=
BEN M4XsUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnrWoprUUN3ME25MlgzOTV7IN88US=> NHvmNHVUSU6JRWK=
CP50-MEL-B NF;R[2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPmc2FLUUN3ME25MlkzPDN{IN88US=> MWDTRW5ITVJ?
SK-MEL-28 NWnBTWY{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTFyLkCxPVMh|ryP NFix[4dUSU6JRWK=
NCI-H2452 M3zWbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTFyLkG2JO69VQ>? MkjQV2FPT0WU
NCI-H1395 NILVXXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1W5TmlEPTB;MUCuNVc5KM7:TR?= Ml7RV2FPT0WU
NCI-H2052 M{[wemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rCOmlEPTB;MUCuNVg5OiEQvF2= NVzUcmd6W0GQR1XS
A375 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;5doVKSzVyPUGwMlI1PTJizszN NUfTPZUxW0GQR1XS
HCC38 M3nlT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTFyLkOyNkDPxE1? NVvDT3RFW0GQR1XS
LK-2 NIPPbpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzzXplKSzVyPUGwMlQzODhizszN MYPTRW5ITVJ?
SF126 NHjFemJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTFyLkS3Nlch|ryP NG\tUJdUSU6JRWK=
SK-MEL-1 NIjid2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTFyLke4N|gh|ryP NHHyPW1USU6JRWK=
ACN M3vDT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTFyLki2O|kh|ryP M{nCbHNCVkeHUh?=
BB30-HNC NXTLUYZmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHGw[nNKSzVyPUGwMlg4OTFizszN MW\TRW5ITVJ?
NCI-H747 M4G5Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTFyLki3OFYh|ryP M{fUfHNCVkeHUh?=
KYSE-150 MkjPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3X[lhKSzVyPUGxMlA{QDdizszN MVfTRW5ITVJ?
D-247MG Mm\BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnFTJpKSzVyPUGxMlExODlizszN Mln0V2FPT0WU
BxPC-3 NEL4SpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTFzLkO3OFch|ryP M3PHUnNCVkeHUh?=
SK-MEL-30 NXPjTolDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTFzLkSwO|kh|ryP NGDoW4JUSU6JRWK=
CAS-1 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDRe4dbUUN3ME2xNU41OTB7IN88US=> NV\VOYJtW0GQR1XS
no-10 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3iRlhTUUN3ME2xNk4yOjF5IN88US=> MV;TRW5ITVJ?
NCI-H2405 NIGzWJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTF{LkKwN|Yh|ryP MlzkV2FPT0WU
KGN M4LScGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\Nco5EUUN3ME2xNk4zQTBzIN88US=> NY[wWYd{W0GQR1XS
BB49-HNC MnrsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTF{LkO5OVYh|ryP MVrTRW5ITVJ?
NCI-H1693 NHvzOolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXwe5ZKSzVyPUGyMlU5OTZizszN MmfXV2FPT0WU
RO82-W-1 MlTSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLHTWM2OD1zMz6wOlQ6KM7:TR?= M1LOZ3NCVkeHUh?=
CAL-85-1 NFnXVpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1zRUWlEPTB;MUOuOFM6QSEQvF2= NHXQZ5ZUSU6JRWK=
H-EMC-SS M{DqZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfD[oFKSzVyPUGzMlkyODRizszN M37QeHNCVkeHUh?=
SW1783 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVy1UWxyUUN3ME2xOE4zOzlzIN88US=> Mm\oV2FPT0WU
LB771-HNC M3WzcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWSwRWdWUUN3ME2xOE41OTlizszN MXLTRW5ITVJ?
HCC70 NWHTW3JuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjPR3VHUUN3ME2xOE41OjN|IN88US=> MUDTRW5ITVJ?
KNS-81-FD MlW1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2f0SGlEPTB;MUSuO|A1PSEQvF2= NELqNYlUSU6JRWK=
KYSE-520 M2jZOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2CzUGlEPTB;MUSuPVI4KM7:TR?= NIfuT2NUSU6JRWK=
TGBC24TKB MmfVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\tTWM2OD1zND65OVM6KM7:TR?= M4TEN3NCVkeHUh?=
SNB75 NIPL[ZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2G0NWlEPTB;MUWuNFczQSEQvF2= MXLTRW5ITVJ?
SW872 NVjZelgzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4foVGlEPTB;MUWuNlIyQCEQvF2= NFrm[lZUSU6JRWK=
U031 NG\IUJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;mXFhKSzVyPUG1MlgxOjhizszN Mlr6V2FPT0WU
ChaGo-K-1 MoPJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTF3LkizOVkh|ryP NFr1[3RUSU6JRWK=
NCI-H441 MmXvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDSTWM2OD1zNj6wNFM6KM7:TR?= MmrZV2FPT0WU
TE-12 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkOwTWM2OD1zNj6xPFc{KM7:TR?= MVLTRW5ITVJ?
NCI-H1755 NVL6OINvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnV[|ZQUUN3ME2xOk42PzNizszN M1;uc3NCVkeHUh?=
KNS-42 NImyWJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYH2eYliUUN3ME2xOk43PTh7IN88US=> NIjBdJFUSU6JRWK=
SK-PN-DW NETC[JpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIW5OGFKSzVyPUG3MlQzODFizszN NF;DRWVUSU6JRWK=
NCI-H226 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHkU3FWUUN3ME2xO{46OzR3IN88US=> M1rCVXNCVkeHUh?=
K-562 NHjHcHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHBVHZOUUN3ME2xPE43OzF5IN88US=> NVXURZB7W0GQR1XS
A388 NInZb|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTF7LkCzNFMh|ryP NYHNZZg{W0GQR1XS
ZR-75-30 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkfITWM2OD1zOT6wPVY5KM7:TR?= MWPTRW5ITVJ?
LU-135 M{L6Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlWwTWM2OD1zOT6yOlM3KM7:TR?= NX7ONJpTW0GQR1XS
NCI-H2029 M{DyXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnETWM2OD1zOT62NFIyKM7:TR?= NHfMdndUSU6JRWK=
HT-1197 MlzNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTF7LkmyNlch|ryP NF3EeYlUSU6JRWK=
IGR-1 Mn;BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTwTWM2OD1{MD6zNVE4KM7:TR?= MUXTRW5ITVJ?
U-87-MG M3zndmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;pTWM2OD1{MD62OFE{KM7:TR?= Ml3RV2FPT0WU
NCI-H1304 M4[5dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTJyLke1NFEh|ryP M4n5RnNCVkeHUh?=
RCC10RGB M4DMWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGLXfWNKSzVyPUKxMlI5OjlizszN NIfHc2lUSU6JRWK=
NCI-H520 Mn[zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1T1WmlEPTB;MkKuO|YyOSEQvF2= NEHmcZVUSU6JRWK=
SK-LU-1 NVXYNms{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\OTo9zUUN3ME2yN{4xPzF6IN88US=> NX;F[HJvW0GQR1XS
UACC-893 Mmf5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\5T|FKSzVyPUKzMlExOzhizszN MmXSV2FPT0WU
NCI-H2347 MlzHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTJ|LkK2O|Qh|ryP M3LCfHNCVkeHUh?=
U-118-MG NVzGdINDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUe0fWZMUUN3ME2yN{44OjF5IN88US=> MUjTRW5ITVJ?
NCI-H596 MlfNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTJ|LkmwOVUh|ryP NHPCU2lUSU6JRWK=
MZ1-PC MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTJ2Lk[3OVkh|ryP MlrvV2FPT0WU
SW1417 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmW1TWM2OD1{NT6yOFk5KM7:TR?= MlvOV2FPT0WU
NCI-H82 NYnmfW4yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTJ4LkSyPFgh|ryP M4K4WHNCVkeHUh?=
COLO-678 NVu1NFF4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{GxOmlEPTB;MkeuOFkyQSEQvF2= MVHTRW5ITVJ?
KURAMOCHI Mnj3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkXTTWM2OD1{OD6xNlYh|ryP M3jhfHNCVkeHUh?=
NCI-H1650 MkfTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX2zfplrUUN3ME2zNE4yQTJ2IN88US=> MX7TRW5ITVJ?
HCC1954 NV7SNItlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXR[|JKSzVyPUOxMlM3PjZizszN MV;TRW5ITVJ?
GAK MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHsRpFKSzVyPUOyMlI3OTZizszN NWXxfpBZW0GQR1XS
YAPC NFexSY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1S4cWlEPTB;M{OuO|Y1QCEQvF2= NGO1SlRUSU6JRWK=
NCI-H2228 MknPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEOycoZKSzVyPUO0MlM3ODVizszN NYi3emRjW0GQR1XS
VMRC-RCZ NWfZSmVVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWH5WHFMUUN3ME2zOk4{ODJ{IN88US=> NFfkWlVUSU6JRWK=
NMC-G1 M1rm[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTN5LkC1Nlkh|ryP MVLTRW5ITVJ?
D-336MG NVf1O3BoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jqUmlEPTB;NEGuPFQ1OiEQvF2= NETRbJRUSU6JRWK=
UACC-62 NWXDbZdPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTR{LkW1NFUh|ryP MVrTRW5ITVJ?
C-33-A M{Xjb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\jemNKSzVyPUS1MlMzPTZizszN NECxS2NUSU6JRWK=
HCC1937 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\pWJRKSzVyPUS3MlE6PThizszN NITLd2RUSU6JRWK=
HDLM-2 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXjeHNKSzVyPUS3MlIzQDdizszN MlHSV2FPT0WU
NCI-H727 MkixS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TzVWlEPTB;NEeuNlQ2OSEQvF2= MXjTRW5ITVJ?
NY NVzCN5pWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HhTWlEPTB;NEmuN|kxQCEQvF2= NH\2NndUSU6JRWK=
NCI-H2291 NHzUTmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTQfG5[UUN3ME20PU45OzBzIN88US=> MljOV2FPT0WU

... Click to View More Cell Line Experimental Data

体内研究 Decitabine和Vorinostat都具有使肿瘤衰退的功能。然而, Decitabine 和 Vorinostat 联用使肿瘤衰退的效果更强。没有任何处理时,在野生型和Fasgld 小鼠中在肺肿瘤负担方面观察不到明显的区别。然而, Decitabine 和Vorinostat联用处理野生型小鼠,使肿瘤衰退比处理 Fasgld小鼠效果高很多。 Decitabine和Vorinostat使结肠癌细胞对FasL调节的肿瘤衰退敏感。低剂量Decitabine和Vorinostat处理,没有明显的肝脏毒性。[3]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:[4]
+ 展开

组蛋白去乙酰化酶活性测定:

为了进行 HDAC 实验24 × 104 dpm 乙醇溶液(1 mCi/ml)中提供的sup>3H-醋酸钠盐标记的组蛋白H4等份样, 加到每个试管中,试管中含悬浮在25 µL实验buffer(100 mM Tris-HCl pH 8, 2mM EDTA)中的200 µg全部HeLa细胞裂解液进行免疫沉淀获得的HDAC。加入不同浓度Vorinostat,在30oC下温育90分钟。加入20 µL 终止缓冲液(0.5 N HCl, 0.08 M AcOH)终止反应。加入0.8 mL TBME提取释放放入氚醋酸盐。在8,000 × g 转速下离心5分钟,600 µL 有机相(上相) 转移到包含3 mL闪烁液的闪烁瓶中。
细胞实验:[4]
+ 展开
  • Cell lines: NB4, NCI-H460和HCT-116肿瘤细胞系
  • Concentrations: 0 μM - 0.1 μM
  • Incubation Time: 48小时
  • Method: NB4, NCI-H460和HCT-116肿瘤细胞系生长在200 µL 96孔板中,约10%汇合,生长24小时后,覆盖孔中。使用多种浓度 Vorinostat或溶剂处理肿瘤细胞24小时。处理后,冲洗实验板,移除Vorinostat,温育48小时。使用sulphorodamine B 实验测定Vorinostat处理后存活细胞的分数。
    (Only for Reference)
动物实验:[3]
+ 展开
  • Animal Models: 携带CT26 细胞的Fasgld BALB/cByJ小鼠
  • Formulation: Dissolved in DMSO
  • Dosages: 25 mg/kg
  • Administration: 静脉注射
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 52 mg/mL (196.74 mM)
Ethanol 3 mg/mL (11.35 mM)
Water Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用:
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
5mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 264.3
化学式

C14H20N2O3

CAS号 149647-78-9
稳定性 powder
in solvent
别名 SAHA, MK0683, suberoylanilide hydroxamic acid

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01059552 Active, not recruiting Locally Advanced Non-small Cell Lung Cancer Fox Chase Cancer Center|National Comprehensive Cancer Network December 6, 2009 Phase 1
NCT02108002 Enrolling by invitation Von Hippel-Lindau Disease National Institute of Neurological Disorders and Stroke (NINDS)|National Institutes of Health Clinical Center (CC) March 5, 2014 Phase 1
NCT03022565 Not yet recruiting Uveal Melanoma Nicolas Acquavella|University of Miami Sylvester Comprehensive Cancer Center|University of Miami April 2017 --
NCT02943642 Not yet recruiting Mycosis Fungoides Angimmune LLC|City of Hope National Medical Center|Columbia University|Dana-Farber Cancer Institute|Feinberg School of Medicine, Northwestern University|H. Lee Moffitt Cancer Center and Research Institute|Ohio State University Comprehensive Cancer Center|Rush University Medical Center|Scott and White Hospital & Clinic|Yale University|Stanford University|Thomas Jefferson University|University of Arkansas|University of Colorado Denver School of Medicine Barbara Davis Center|University of Texas Southwestern Medical Center|University of Washington|Vanderbilt University School of Medicine|Washington University School of Medicine January 2017 Phase 2
NCT02836548 Recruiting Melanoma|Skin Neoplasms The Netherlands Cancer Institute June 2016 Phase 1|Phase 2
NCT02589145 Recruiting Lymphoma M.D. Anderson Cancer Center|Celgene Corporation June 2016 Phase 1|Phase 2

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常见问题及建议解决方法

  • 问题 1:

    What’s the recommendation about reconstitution of the compound for in vivo animal study?

  • 回答:

    We recommend the following vehicle for S1047: 2% DMSO, 40% PEG 300, 5% Propylene glycol, 1% Tween 80 at 5 mg/mL.

HDAC Signaling Pathway Map

HDAC Inhibitors with Unique Features

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID